A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
78 results in Failed Experiment Report for "Mpro" · page 2 of 3
Gerpe C, Toscano MJ · 2024 · Journal of Applied Poultry Research.
The aim of our study was to investigate the effects of two interventions (i.e., two treatments across two independent experiments, each with its own control) that were thought to reduce fractures and stress related responses (e.g., changes…
Kang A, Tian X, Mi Z et al. · 2026 · Environmental science & technology
Improving carbon productivity is essential for simultaneously achieving sustainable development goals and tackling climate change. While the Global Value Chains (GVCs) division enhances productive efficiency, its impact on carbon…
Davis MP, Ulrich A, Segal R et al. · 2024 · Cancers
Background: Chemotherapy-induced peripheral neuropathy (CIPN) from oxaliplatin and taxane drugs is a bothersome toxicity. Palmitoylethanolamide (PEA) has been reported to improve myelinated nerve fiber function in patients experiencing…
Awawdeh MS · 2024 · Journal of advanced veterinary and animal research
Objective The current study investigated the effects of supplying ruminally protected amino acids (AA) (lysine, L; and methionine, M) and dietary protein levels on the performance of late-nursing ewes. Materials and methods Thirty-one…
Srivastava S, Kharkar VR, More S et al. · 2024 · Journal of clinical and experimental dentistry
Background Absorbable gelatin sponges are able to reduce the incidence of post-extraction complications when soaked with antimicrobial agents. However, the drawbacks associated with the injudicious use of antibiotics warrant the need to…
Grover V, Acharya SR, Chatra A et al. · 2026 · BMC oral health
BACKGROUND: Resin-based composites (RBCs) are commonly used in restorative dentistry, but bleaching agents may compromise their mechanical integrity. The effect of in-office bleaching with 25% hydrogen peroxide (HP) on the flexural…
Anfosso M, Schubert M, Cremers JF et al. · 2026 · Andrology
Background Non-obstructive azoospermia (NOA) represents the most severe form of male infertility. Hypogonadism is common in NOA patients, and normal testosterone (T) levels are considered essential for spermatogenesis. Fertility-preserving…
Bleckwedel J, Nieva RE, González V et al. · 2026 · Preprint
Soybean ( Glycine max [L.] Merr.) productivity is frequently compromised by soil-borne pathogens. Macrophomina phaseolina (Mp), the causal agent of charcoal rot, can produce important soybean yield losses especially when hot and dry…
Wang Y, Wu Q, Li L et al. · 2026 · The Journal of pharmacy and pharmacology
Objective Forsythiae Fructus, the fruit of Forsythia suspensa (Thunb.) Vahl, is a traditional Chinese medicine widely used for clearing heat and detoxifying and for treating inflammatory conditions such as fever and respiratory infection.…
Dragan E, Ghinea M, Haba D et al. · 2025 · Dentistry journal
Background: Maxillary sinus floor augmentation (MSFA) is frequently required for implant placement in the atrophic posterior maxilla. However, limited bone quality and volume can compromise long-term success. Strontium ranelate (SrR), a…
Zampino S, Hosler R, Brown K et al. · 2026 · The Journal of cardiovascular nursing
Background Reiki plus manual therapy are utilized to improve relaxation, sleep, emotional state, and pain. Evidence within hospital settings was limited, and previous studies had weak designs. Objective The purpose of this study was to…
Looman MI, Klau MM, Schoenmakers TM et al. · 2026 · Journal of sleep research
While time in bed restriction is a core treatment mechanism of Sleep Restriction Therapy (SRT), empirical research has not yielded a relationship between insomnia improvement and adherence to the prescribed time in bed. We coin this…
Fortugno P, Foti F, Caparra P et al. · 2026 · Preprint
Bergamot-derived products have gained increasing interest as dietary supplements in small animal nutrition, due to their potential to improve meat quality, and provide functional bioactive compounds. This paper investigated the effects of…
Matiya DJ, Tutt K, Wakefield JG et al. · 2026 · Preprint
The greater wax moth, Galleria mellonella , is an increasingly important invertebrate model for infection biology, yet silk extrusion during handling complicates larval injections and hampers survival assessment. Here, we develop and…
Bradley A, Gmiro Y, Stoakes A et al. · 2026 · Preprint
Concerns about the impact of social media on young adult mental health persists despite weak and inconclusive empirical evidence. This study aimed to replicate a highly-cited study showing improved well-being after limiting time on social…
Coker JA, Sun R, Polzer PM et al. · 2026 · ACS chemical biology
Point mutations in the exonuclease (ExoN) site of nonstructural protein 14 (NSP14) compromise the fitness of betacoronaviruses such as SARS-CoV-2, implicating NSP14 ExoN inhibition as an antiviral strategy. However, there are no advanced…
Allard A, Clavien C · 2023 · PloS one
The recent replicability crisis in social and biomedical sciences has highlighted the need for improvement in the honest transmission of scientific content. We present the results of two studies investigating whether nudges and soft social…
de Zeeuw D · 2020 · Journal of nephrology
Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will…
Coxon AT, Johanns TM, Dunn GP · 2020 · Missouri medicine
Glioblastoma is a devastating disease with a dismal prognosis. While recent advancements in cancer immunotherapy have led to improvements in treating other types of cancer, patients with glioblastoma have not benefited from these new…
Kawamura T, Koyama S, Karaushi H et al. · 2026 · Preprint
Introduction: The Gram stain is a fundamental and widely used technique in clinical microbiology for its simplicity and diagnostic value, particularly in bacterial meningitis. However, its reliability can be compromised by contamination…
He X, Kratochwil N, Ariño-Estrada G et al. · 2026 · Physics in medicine and biology
Positron emission tomography (PET) image quality is partially determined by PET detector performance, which can be improved by increasing the optical photon harvest from scintillator to photodetector. Due to the steep index mismatch at…
Hennigar SR, Miller KM, Murphy RD et al. · 2026 · The Journal of nutrition
Background Iron deficiency (ID) is associated with decreased appetite and altered mood, which can contribute to feelings of early satiety and reduced overall well-being. Few studies have examined differences in appetite, satiety, and mood…
Huang J, Deng X, Zhou L et al. · 2026 · BMC medical research methodology
Background Evidence quality assessment is critical for informed public health decision-making, but manual approaches are time-consuming and subject to variability. Automated support tools have been proposed to improve efficiency and…
Melendez Vassall I, Mannino JE, Watters P et al. · 2026 · Advances in neonatal care : official journal of the National Association of Neonatal Nurses
Metabolic bone disease (MBD) is a disorder affecting bone mineralization that leads to short and long-term consequences. A daily exercise regimen consisting of passive range of motion (ROM) and gentle compression of upper and lower…
Miranda MC, Hyde J, Salazar K et al. · 2024 · microPublication biology
Prenatal stress is hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined that prenatal stress in rats decreases levels of Dpysl2, which is found to be inactivated in schizophrenic patients. UNC-33 ,…
Li Q, Yu H, Du S et al. · 2025 · The CRISPR journal
CRISPR-Cas9 genome editing holds tremendous potential for accelerating genetic improvements in aquaculture. The success of the CRISPR-Cas9 system relies on the specificity and efficiency of engineered single-guide RNAs (sgRNAs). In this…
Brant M, Barrick C, Muno L et al. · 2025 · Brain sciences
Background : Gait disturbance in Parkinson's Disease (PD) significantly impacts quality of life and is not completely mitigated by dopaminergic treatment. Auditory cueing has been shown to help improve certain aspects of gait, but its…
Jiménez-Martínez J, Alarcón-López F, Chirosa-Ríos LJ et al. · 2025 · Frontiers in sports and active living
Background Rehabilitation programs following an anterior cruciate ligament (ACL) injury tend to focus on improving conditional aspects such as biomechanics. Recently, some studies have analyzed the relationship between cognition and ACL…
Washino T, Nikaido T, Burrow MF et al. · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology
Background/aims Adhesive procedures performed after dental trauma are often carried out in emergency settings with compromised isolation due to bleeding, limited access, and patient cooperation. This study evaluated how variation in…
Md. Karimul Islam, Nishad Nasrin, Jannatul Naim et al. · 2023 · Humanities & Social Sciences Communications
Abstract Beggars have largely been leading miserable lives in the lower stratum of society since time immemorial. Government or private-led policies are rarely undertaken to improve the lives of this unfortunate societal segment. The local governments in divisional cities of Bangladesh have adopted a series of interventions aimed at improving the socioeconomic wellbeing of beggars and equipping them with alternative livelihood management options. We evaluated the effectiveness of this intervention (the rehabilitation of beggars) in the Khulna City Corporation (KCC) area, Bangladesh; we gathere