Negative / Null Result ReportOpen accessMedicine
Joan Hermosura, Everett Lohman, Brenda Bartnik-Olson et al. · 2024 · PLoS ONE
Objectives The main purpose of this research study was to compare mean modified straight-leg raise test (mSLR) and hamstring muscle length (HL) between chronic non-specific low back pain (LBP) and healthy subjects to understand the possibility of neuropathic causes in LBP population as it may impact the diagnosis and treatment of LBP. Another purpose was to compare mean mSLR between those with lumbar nerve root impingement and those without as determine by magnetic resonance imaging (MRI). Methods The design of the study is cross sectional and included 32 subjects with ages ranging from 18-50
View details →DOI: 10.1371/journal.pone.0298257 Negative / Null Result ReportOpen accessMedicine
Rudhir Jaga, Dinell Behari, Anton P Doubell et al. · 2022 · African Journal of Emergency Medicine
Introduction: Intended for use by prehospital first responders, the Lubo TM cervical collar is an adjustable, radiolucent, single-use device that incorporates a mechanical jaw thrust mechanism. The combination enables non-invasive airway management in cases of trauma where cervical motion restriction is necessary. The potential benefits include use as an airway adjuvant maintaining upper airway patency, reducing provider task loading. The limited research on the device efficacy and safety requires further investigation.Methods: A randomized, crossover, interventional study was performed to com
View details →DOI: 10.1016/j.afjem.2022.07.008 Negative / Null Result ReportOpen accessBiology (General)
Kevin Hoffseth, Emily Busse, Josue Jaramillo et al. · 2021 · Frontiers in Cell and Developmental Biology
Mouse digit amputation provides a useful model of bone growth after injury, in that the injury promotes intramembranous bone formation in an adult animal. The digit tip is composed of skin, nerves, blood vessels, bones, and tendons, all of which regenerate after digit tip amputation, making it a powerful model for multi-tissue regeneration. Bone integrity relies upon a balanced remodeling between bone resorption and formation, which, when disrupted, results in changes to bone architecture and biomechanics, particularly during aging. In this study, we used recently developed techniques to evalu
View details →DOI: 10.3389/fcell.2021.749055 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Naoki Akizue, Tomoaki Matsumura, Daisuke Maruoka et al. · 2018 · Endoscopy International Open
Background and study aims Endoscopic submucosal dissection (ESD) requires advanced skills to perform safely without complications. The current study evaluated the usefulness of a novel three-dimensional (3D) imaging system in ESD using porcine stomachs. Methods Four endoscopists (two trainees and two experts) performed eight ESD procedures using both 3D and 2D images. The usefulness of 3D image versus 2D image was evaluated by visibility and procedure time. In addition, occurrence of eyestrain and dizziness in 3D image was assessed. Results En bloc resection was successfully achieved, without
View details →DOI: 10.1055/a-0761-9649 Negative / Null Result ReportOpen access
Igwe, Nwobueze olru · 2023
This paper tried to examine correlation with different imaging techniques and aortic stenosis severity. There was no significant correlation found between the diastolic AVA area and AR, although a positive tendency was observed between the…
Negative / Null Result ReportOpen access
Wood, Joanne M. · 2002
It has been suggested that over 90% of the sensory information for driving is visual. Despite this belief, traditional studies have failed to demonstrate that increased crash rates arise from impaired vision. However, more recent studies…
Negative / Null Result ReportOpen access
Wanying Xie, Christopher Cheng, Anthony Goh Whatt et al. · 2014
We present a case of a 63-year-old gentleman, who had an initial negative prostate needle biopsy, but persistently elevated prostate-specific antigen levels. An magnetic resonance imaging study of the prostate failed to demonstrate the…
View details →DOI: 10.4103/1450-1147.144824 Negative / Null Result ReportOpen access
I. G. Rusakov, R. V. Ulianov, E. V. Filonenko et al. · 2015
The main challenge of treating non-muscle invasive bladder cancer is multifocal tumors. Current methods of diagnosis are failed to detect all superficial flat tumor lesions in bladder mucosa. The use of fluorescence imaging with…
View details →DOI: 10.24931/2413-9432-2015-4-3-29-35 Negative / Null Result ReportOpen accessPhysics
Agnès Ferté, Kevin Hong · 2023 · arXiv
We highlight the role of weak lensing measurements from current and upcoming stage-IV imaging surveys in the search for cosmic inflation, specifically in measuring the scalar spectral index $n_s$. To do so, we combine the Dark Energy Survey 3 years of observation weak lensing and clustering data with BICEP/Keck, Planck and Sloan Digital Sky Survey data in $rΛ$CDM where $r$ is the tensor-to-scalar ratio. While there is no significant improvement in constraining power, we obtain a 1$σ$ shift on $n_s$. Additionally, we forecast a weak lensing and clustering data vector from the 10-year Legacy Sur
Negative / Null Result ReportOpen accessComputer Science
H. C. Eggers, B. Buschbeck · 2013 · arXiv
A detailed understanding of all effects and influences on higher-order correlations is essential. At low charged multiplicity, the effect of a nonpoissonian multiplicity distribution can significantly distort correlations. Evidently, the reference samples with respect to which correlations are measured should yield a null result in the absence of correlations. We show how the careful specification of desired properties necessarily leads to an average-of-multinomials reference sample. The resulting internal cumulants and their averaging over several multiplicities fulfil all requirements of cor
Negative / Null Result ReportOpen accessPhysics
K. E. Belle, N. Sanghi, S. B. Howell et al. · 2004 · arXiv
Circumbinary (CB) disks have been proposed as a mechanism to extract orbital angular momentum from cataclysmic variables (CVs) during their evolution. As proposed by Taam & Spruit, these disks extend outwards to several a.u. and should be detected observationally via their infrared flux or by absorption lines in the ultraviolet spectra of the CV. We have made use of archival HST/STIS spectra as well as our own near-IR imaging to search for observational evidence of such CB disks in seven CVs. Based on the null result, we place an upper limit on the column density of the disk of N_H~10^17 cm^-2
Negative / Null Result ReportOpen accessPhysics
Peter R. Allen, David W. Koerner, Michael W. McElwain et al. · 2006 · arXiv
We present the results of a deep-imaging search for wide companions to low-mass stars and brown dwarfs using NSFCam on IRTF. We searched a sample of 132 M7-L8 dwarfs to magnitude limits of $J \sim 20.5$ and $K \sim 18.5$, corresponding to secondary-primary mass ratios of $\sim 0.5$. No companions were found with separations between $2{\arcsec}$ to $31{\arcsec}$ ($\sim$40 AU to $\sim$1000 AU). This null result implies a wide companion frequency below 2.3% at the 95% confidence level within the sensitivity limits of the survey. Preliminary modeling efforts indicate that we could have detected 85
Negative / Null Result ReportOpen accessPhysics
P. N. Wilkinson, D. R. Henstock, I. W. A. Browne et al. · 2001 · arXiv
Using Very Long Baseline Interferometry we have searched a sample of 300 compact radio sources for examples of multiple imaging produced by gravitational lensing; no multiple images were found with separations in the angular range 1.5--50 milliarcsec. This null result allows us to place a limit on the cosmological abundance of intergalactic supermassive compact objects in the mass range $\sim 10^{6}$ to $\sim 10^{8}$M$_{\odot}$; such objects cannot make up more than $\sim 1%$ of the closure density (95% confidence). A uniformly distributed population of supermassive black holes forming soon af
Negative / Null Result ReportOpen accessPhysics
Saloome Siavoshi, Ashish V. Orpe, Arshad Kudrolli · 2005 · arXiv
We investigate the effective friction encountered by a mass sliding on a granular layer as a function of bed thickness and boundary roughness conditions. The observed friction has minima for a small number of layers before it increases and saturates to a value which depends on the roughness of the sliding surface. We use an index-matched interstitial liquid to probe the internal motion of the grains with fluorescence imaging in a regime where the liquid has no significant effect on the measured friction. The shear profiles obtained as a function of depth show decrease in slip near the sliding
Negative / Null Result ReportOpen accessEngineering
Rancy Chepchirchir, Jill Sunday, Raymond Confidence et al. · 2025 · arXiv
In Sub-Saharan Africa (SSA), the utilization of lower-quality Magnetic Resonance Imaging (MRI) technology raises questions about the applicability of machine learning methods for clinical tasks. This study aims to provide a robust deep learning-based brain tumor segmentation (BraTS) method tailored for the SSA population using a threefold approach. Firstly, the impact of domain shift from the SSA training data on model efficacy was examined, revealing no significant effect. Secondly, a comparative analysis of 3D and 2D full-resolution models using the nnU-Net framework indicates similar perfor
Negative / Null Result ReportOpen accessPhysics
Peter Erwin, Linda S. Sparke · 2002 · arXiv
We present results from an imaging survey of an unbiased sample of thirty-eight early-type (S0--Sa), low-inclination, optically barred galaxies in the field. Our goal was to find and characterize central stellar and gaseous structures: secondary bars, inner disks, and nuclear rings. Bars inside bars are surprisingly common: at least one quarter of the sample galaxies (possibly as many as 40%) are double-barred, with no preference for Hubble type or the strength of the primary bar. A typical secondary bar is ~12% of the size of its primary bar and 240--750 pc in radius. We see no significant ef
Negative / Null Result ReportOpen accessPhysics
D. Apai, M. R. Meyer, P. Hinz et al. · 2007 · arXiv
We present results from two high-contrast imaging surveys that exploit a novel technique, L-band angular differential imaging. Our first survey targeted 21 young stars in the Beta Pic and Tuc-Hor moving groups with VLT/NACO reaching typical sensitivities of 20 AU. The statistical analysis of the null result demonstrates that the giant planet population is truncated at 30 AU or less (90% confidence level). Our second, on-going MMT/Clio survey utilizes the unique sensitivity achieved in the L-band for old planets to probe all M-dwarf stars within 6 pc. The proximity of these targe
Negative / Null Result ReportOpen accessPlant culture
J. Harb, A. A. Saquet, R. Bisharat et al. · 2012 · Journal of Applied Botany and Food Quality
Biochemical and quality changes of sweet cherries cv. Regina were assessed over three consecutive years after storage in different modified atmosphere packaging (MAP) liners, with or without hydrocooling, compared to regular atmosphere (RA) storage. All plastic liners used in the experiment resulted in CO2-enrichment and O2-reduction inside packages, with the following impact on fruit quality after five weeks of storage: improved retention of fruit firmness and red color of skin, no significant effect on acidity and total soluble solids, and minimal loss of fruit weight. Fruit decay was absent
Negative / Null Result ReportOpen accessPhysics
H. C. Eggers, B. Buschbeck · 2013 · Advances in High Energy Physics
A detailed understanding of all effects and influences on higher-order correlations is essential. At low charged multiplicity, the effect of a non-Poissonian multiplicity distribution can significantly distort correlations. Evidently, the reference samples with respect to which correlations are measured should yield a null result in the absence of correlations. We show how the careful specification of desired properties necessarily leads to an average-of-multinomials reference sample. The resulting internal cumulants and their averaging over several multiplicities fulfill all requirements of c
View details →DOI: 10.1155/2013/230515 Negative / Null Result ReportOpen accessMedicine
Xavier Jannot, Alpha Oumar Diallo, Judicaelle Didierjean et al. · 2025 · European Journal of Case Reports in Internal Medicine
We report the case of a 75-year-old woman admitted to the emergency department for confusion, gait disturbances and mutism associated with an inflammatory syndrome occurring 3 weeks after acute carbon monoxide intoxication. The main hypothesis upon arrival was infectious meningoencephalitis, and the patient was put on acyclovir and antibiotics in meningeal doses. After a short stay in intensive care, the patient’s condition did not improve, and the revaluation of her case history and imaging studies led to the diagnosis of post-interval syndrome secondary to carbon monoxide intoxication after
View details →DOI: 10.12890/2025_005235 Short NoteOpen accessMedical physics. Medical radiology. Nuclear medicine
Farhana Ebrahim Suleman, Margaret Kisansa · 2010 · South African Journal of Radiology
Macrodystrophia lipomatosa (MDL) is described as a rare, non-hereditary, congenital condition presenting with localized macrodactyly and a proliferation of mesenchymal elements. There is in particular a marked increase in fibroadipose tissue(1). We describe two cases presenting to our department in a six month period, with a history of disproportionately large limbs since birth. While our first case demonstrated all the typical features of MDL, our second case failed to demonstrate osseous gigantism although the other features of MDL were present. An extensive search of the literature failed t
View details →DOI: 10.4102/sajr.v14i2.425 Negative / Null Result ReportMedicine
Van Gent JM, Clements TW, Gurney JM et al. · 2025 · The journal of trauma and acute care surgery
Background Empiric cryoprecipitate administration has recently failed to show survival benefit in hemorrhaging trauma patients. However, a recent Trauma Quality Improvement Program query suggested a survival benefit in massive transfusions…
View details →DOI: 10.1097/ta.0000000000004643 Negative / Null Result Report
Perdue MV, Geeraert BL, Manning KY et al. · 2024 · Preprint
Numerous studies have linked reading ability to white matter microstructure using diffusion tensor imaging, but recent large studies have failed to show consistency. Fiber-specific diffusion-weighted magnetic resonance imaging (dMRI)…
View details →DOI: 10.1101/2024.09.24.614799 Negative / Null Result ReportMedicine
Taheri F, Tanha AS, Aboutorabi RB et al. · 2026 · Clinical nuclear medicine
A 78-year-old woman with medullary thyroid carcinoma (MTC) demonstrated persistently elevated serum calcitonin despite prior surgery and radiotherapy. 99mTc-octreotide imaging failed to detect skeletal metastases, while 68Ga-FAPI PET/CT…
View details →DOI: 10.1097/rlu.0000000000006450 Failed Experiment ReportMedicine
Zeidan AM, Aakko S, Stahl M et al. · 2026 · Expert review of anticancer therapy
Introduction Higher-risk myelodysplastic syndromes (HR-MDS) remain an area of high unmet need in which multiple randomized late-stage trials have failed to improve outcomes beyond hypomethylating agent monotherapy, despite encouraging…
View details →DOI: 10.1080/14737140.2026.2640238 Negative / Null Result ReportMedicine
Diz-Lopes M, Rovetta CF, Pollastri F et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
We evaluated how romosozumab affects bone structure, density, and strength at the wrist over 12 months. Volumetric bone mineral density did not increase, but high-resolution quantitative computed tomography imaging showed modest…
View details →DOI: 10.1007/s00198-026-08113-3 Negative / Null Result ReportMedicine
Hüther A, Sherman CL, Sumaroka A et al. · 2026 · Ophthalmic genetics
Purpose To describe the phenotype of a patient with bi-allelic pathogenic variants in NR2E3 that did not result in an overt enhanced S-cone syndrome (ESCS) phenotype. Methods The patient underwent a comprehensive ophthalmic exam, imaging…
View details →DOI: 10.1080/13816810.2026.2635611 Negative / Null Result ReportOpen accessMedicine
Caio Gonçalves de Souza, Márcio Passini Gonçalves de Souza, Vanda Jorgetti et al. · 2015 · Acta Ortopédica Brasileira
OBJECTIVE: To determine whether there is a difference on the bone architecture in patients with femoral neck fracture compared to patients with intertrochanteric fractures and assess the importance of aging on bone microarchitecture in patients with proximal femoral fracture.METHODS: Biopsy of the iliac crest was made in seventeen patients between 55 and 90 years old who were admitted to the emergency room with fractures of the proximal end of the femur. After a small fragment was removed, we made a histomorphometric analysis of it.RESULTS: There was no significant difference between patients
View details →DOI: 10.1590/1413-78522015230201056 Negative / Null Result ReportMedicine
Chen, Zhao, Sun et al. · 2026 · BMC nephrology
We aimed to evaluate the application value of multiparametric diffusion weighted magnetic resonance imaging (MRI) for the assessment and risk stratification of renal histopathological injuries in patients with IgA nephropathy (IgAN), as an…
View details →DOI: 10.1186/s12882-026-05062-1 Negative / Null Result Report
Hwang Tan, Pramod Chandru · 2026 · Emergency Medicine Australasia
ABSTRACT Objective Overuse of CT Pulmonary Angiography (CTPA) remains a challenge in emergency medicine. Some institutions resort to radiologist vetting to reduce unnecessary imaging. This is a pilot study that aims to investigate the…
View details →DOI: 10.1111/1742-6723.70237 