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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

741 results for "aging" · page 17 of 25

Negative / Null Result ReportOpen accessMedicine

Longitudinal Changes in Cognition and Brain Imaging in Persons With Human Immunodeficiency Virus.

Kennedy J, Cooley SA, Roman Fox J et al. · 2026 · The Journal of infectious diseases

Background As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This…

View details →DOI: 10.1093/infdis/jiag029
Negative / Null Result ReportOpen accessMedicine

Does mRNA-based COVID-19 vaccination in the subacute phase lead to microstructural brain changes? A prospective pilot MRI study using T1 relaxometry.

Willems R, Cappelletti M, Schüre JR et al. · 2026 · Scientific reports

Messenger ribonucleic acid (mRNA)-based vaccines delivered via lipid nanoparticles (LNP) were pivotal in managing the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. While mild systemic reactions are common after…

View details →DOI: 10.1038/s41598-026-56181-6
Negative / Null Result ReportOpen accessMedicine

Association of caffeine levels with myocardial perfusion during pharmacological stress cardiac magnetic resonance imaging.

Iribarren A, Obrutu O, Maughan J et al. · 2026 · American heart journal plus : cardiology research and practice

Background Caffeine, a nonselective adenosine A2 receptor antagonist, blunts adenosine-induced coronary hyperemia. Despite recommended abstinence before adenosine stress cardiac magnetic resonance imaging (CMRi), residual caffeine may…

View details →DOI: 10.1016/j.ahjo.2025.100709
Negative / Null Result ReportMedicine

Intrinsically nonlocal metamaterials.

Ware A, LaMountain J, White RC et al. · 2026 · Nature communications

The electromagnetic response of materials serves as the foundation for a broad range of vital applications, from imaging, to sensing, to classical and quantum communications. Here we demonstrate, theoretically and experimentally, a…

View details →DOI: 10.1038/s41467-026-74396-z
Negative / Null Result ReportOpen accessMedicine

Longitudinal five-year follow-up by muscle MRI and high-resolution nerve ultrasound in hereditary neuropathies.

Vockert KL, Winter N, Kirschmann FS et al. · 2026 · Neurological research and practice

Background and aims Hereditary polyneuropathies are rare heterogeneous neurological disorders that cause progressive muscle weakness and disability. As new therapies emerge, sensitive imaging biomarkers to monitor disease progression are…

View details →DOI: 10.1186/s42466-026-00508-1
Negative / Null Result ReportMedicine

Cinnamon-loaded PVA/gelatin/starch electrospun fibers as novel sustainable nanocomposites for active food packaging.

Vencato AA, Juchem ALM, Clerici NJ et al. · 2026 · International journal of biological macromolecules

This study produced six formulations using polyvinyl alcohol (PVA) blended with gelatin or gelatin-starch, incorporating cinnamon powder (CP) or cinnamon essential oil (CEO). Homogeneous nanofibers with diameters ranging from 367 to 532 nm…

View details →DOI: 10.1016/j.ijbiomac.2026.153149
Negative / Null Result ReportMedicine

CT-Derived Radiomic Features for the Non-Invasive Differentiation of Mediastinal Lymphadenopathy in Lung Cancer and Sarcoidosis.

Doğan D, Öksüz C, Çakır Ö et al. · 2026 · Biomedicines

Background/Objectives: Differentiating mediastinal lymphadenopathy associated with lung cancer from sarcoidosis remains a clinical challenge because of overlapping imaging findings. This study evaluated whether CT-derived radiomic…

View details →DOI: 10.3390/biomedicines14061327
Negative / Null Result ReportMedicine

Clinical and Neuroimaging Predictors of Outcome and Impact of Surgical Intervention in Cryptococcal Meningitis: An Observational Study.

Qian MY, He LY, Lan P et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

This study aimed to identify predictors of outcomes and evaluate the therapeutic impact of surgical intervention in CM patients, with a specific focus on the growing HIV-negative population in East Asia. We conducted a single-center…

View details →DOI: 10.1016/j.ijid.2026.108923
Negative / Null Result ReportMedicine

Combination of color-Doppler ultrasound and MRI to improve lacrimal gland lesion characterization: A machine learning approach.

Riehm A, Senicourt L, O'Shaughnessy E et al. · 2026 · Diagnostic and interventional imaging

Purpose The purpose of this study was to develop a machine learning-based algorithm based on a combination of magnetic resonance imaging (MRI) and color-Doppler ultrasound (CDUS) to characterize lacrimal gland lesions. Materials and…

View details →DOI: 10.1016/j.diii.2026.06.001
Negative / Null Result Report

Gd-EOB-DTPA-Enhanced MRI Combined with ALBI Score and AFP for Predicting Histologic Grade in Hepatocellular Carcinoma: A Multicenter Study from Vietnam

Nguyen Van H, Vu Dang L, Nguyen The A et al. · 2026 · Preprint

Objectives: Histologic grade is an important prognostic factor in hepatocellular carcinoma (HCC). Gd-EOB-DTPA-enhanced MRI may provide noninvasive im-aging markers related to tumour differentiation. This study aimed to evaluate the…

View details →DOI: 10.20944/preprints202605.0460.v1
Negative / Null Result ReportMedicine

Development of a Prognostic Prediction Model for Clinically Significant Prostate Cancer Based on Lesion Zone and Apparent Diffusion Coefficient Value Quantification.

Ashouri R, Reynolds PS, Rajavel S et al. · 2026 · Urology

Objective To guide biopsy decision making via a predictive model for clinically significant prostate cancer (csPCa) in men with positive imaging (PI-RADS 3-5). We aim to elucidate the influence of zone on the predictive accuracy of PI-RADS…

View details →DOI: 10.1016/j.urology.2026.01.028
Negative / Null Result ReportMedicine

Exploratory Evaluation of Photon-Counting CT for Bone Marrow Edema Detection Across Multiple Joints: A Pilot Study.

Shahzadi, Reimann, Schneider et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

To retrospectively evaluate the diagnostic performance and confidence of photon-counting computed tomography (PCCT) for detecting bone marrow edema (BME) in trauma patients, using magnetic resonance imaging (MRI) as the reference standard.…

View details →DOI: 10.1055/a-2888-7989
Negative / Null Result ReportMedicine

Prospective MRI-Based Comparison of Graft Maturation After ACL Reconstruction Using Quadriceps Versus Hamstring Tendon Autograft.

Erden, Ağır, Kayaalp et al. · 2026 · Orthopaedic journal of sports medicine

Biological graft maturation after anterior cruciate ligament (ACL) reconstruction is a prolonged and heterogeneous process that may not directly correlate with clinical recovery. Magnetic resonance imaging (MRI)-based signal intensity…

View details →DOI: 10.1177/23259671261449148
Negative / Null Result ReportMedicine

Amide proton transfer-weighted magnetic resonance imaging for predicting histopathology and biomarkers in rectal adenocarcinoma.

Liu, Cui, Sun et al. · 2026 · Quantitative imaging in medicine and surgery

Preoperative evaluation of histopathological features and biomarkers is critical for personalized treatment of rectal adenocarcinoma. Amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI) is a promising noninvasive…

View details →DOI: 10.21037/qims-2025-1-2596
Negative / Null Result ReportMedicine

Effect of Irreversible Compression on the Pulmonary Nodule Detection Rate in Chest Radiographs Using AI Software.

Kohzai, Yamamoto, Matsushita et al. · 2026 · Diagnostics (Basel, Switzerland)

Objectives : Whereas irreversible compression of Digital Imaging and Communications in Medicine (DICOM) files can reduce data size, research on its impact on diagnostic ability when using artificial intelligence (AI) software is limited.…

View details →DOI: 10.3390/diagnostics16111637
Negative / Null Result ReportMedicine

Association Between Temporomandibular Joint Morphology and Mandibular Growth in Adolescents With Facial Asymmetry: An Magnetic Resonance Imaging and Cone-Beam Computed Tomography Study.

Wang, Guo · 2026 · The Journal of craniofacial surgery

To investigate the growth and developmental characteristics of the temporomandibular joint (TMJ) in adolescents with facial asymmetry and its relationship with mandibular morphological changes. A total of 20 patients aged 8 to 20 years…

View details →DOI: 10.1097/scs.0000000000013021
Negative / Null Result ReportMedicine

MRI Evaluation of Graft Remodeling After Transphyseal Anterior Cruciate Ligament Reconstruction in Pediatric Patients: A 5-Year Follow-up.

de Pesters, Staali, Laval et al. · 2026 · Orthopaedic journal of sports medicine

Anterior cruciate ligament (ACL) reconstruction (ACLR) is increasingly performed in children and adolescents, yet mid- to long-term graft ligamentization remains poorly understood. To characterize the magnetic resonance imaging (MRI)…

View details →DOI: 10.1177/23259671261447204
Negative / Null Result ReportMedicine

Thoracic Duct Branch Identification Is Comparable Between T2-W 3D Fat-Suppressed Magnetic Resonance Imaging and Computed Tomography Lymphangiography in Normal Dogs.

Griffith, Hecht, Lux et al. · 2026 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

In dogs with chylothorax that are refractory to medical management, surgical intervention is often recommended. Computed tomographic lymphangiography (CTL) is the most commonly used preoperative imaging study, but it has the disadvantages…

View details →DOI: 10.1111/vru.70198
Negative / Null Result ReportMedicine

Outcome of segmentectomy vs. lobectomy in patients with cT1a-b N0 lung cancer and postoperative N1 upstaging.

Kaman, Stork, Okumus et al. · 2026 · Langenbeck's archives of surgery

Segmentectomy is offered in selected patients with clinical T1a-b N0 M0 lung cancer. In case of positive N1 lymph node at fresh frozen section, conversion to lobectomy is recommended. Indication for redo surgery and completion lobectomy in…

View details →DOI: 10.1007/s00423-026-04089-0
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Assessment of Subclinical Left Ventricular Dysfunction in Patients with Chronic Mitral Regurgitation Using Torsional Parameters Described by Tissue Doppler Imaging

Zahra Ojaghi-Haghighi, Atoosa Mostafavi, Hassan Moladoust et al. · 2015 · Journal of Tehran University Heart Center

Background: Left ventricular (LV) twist is due to oppositely directed apical and basal rotation and has been proposed as a sensitive marker of LV function. We sought to assess the impact of chronic pure mitral regurgitation (MR) on the torsional mechanics of the left human ventricle using tissue Doppler imaging. Methods: Nineteen severe MR patients with a normal LV ejection fraction and 16 non-MR controls underwent conventional echocardiography and apical and basal short-axis color Doppler myocardial imaging (CDMI). LV rotation at the apical and basal short-axis levels was calculated from the

Negative / Null Result ReportOpen accessMedicine

Comparison of Mobilisation with Movement and Cryotherapy in Shoulder Impingement Syndrome-A Randomised Clinical Trial

Saumya Srivastava, Charu Eapen, Harramb Mittal · 2018 · Journal of Clinical and Diagnostic Research

Introduction: Shoulder Impingement Syndrome (SIS) is one of the common cause of shoulder ailment which leads to pain and restriction of the movements. Though Mobilisation with Movement and cryotherapy, both are found to be effective in managing SIS, there is no comparison done between the two treatments. Aim: To compare the effectiveness of Mobilisation With Movement (MWM) and cryotherapy in SIS. Materials and Methods: A randomised clinical trial was conducted on 22 subjects who aged between 18-64 years, and those who had a positive painful arc, three positive tests out of five i.e., Neer’s Im

View details →DOI: 10.7860/jcdr/2018/34624.12091
Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system

The Effect of Hyperhomocysteinemia on Motor Symptoms, Cognitive Status, and Vascular Risk in Patients with Parkinson’s Disease

Bilge Kocer, Hayat Guven, Isik Conkbayir et al. · 2016 · Parkinson's Disease

Factors related with hyperhomocysteinemia (HHcy) and the impact of HHcy in Parkinson’s disease (PD) are not well understood. We investigated the factors associated with increased levels of homocysteine (Hcy) and the relationship between HHcy and motor symptoms, cognitive status, and vascular risk in patients with Parkinson’s disease. Among 60 patients (29 males, 48.3%) with PD, the stage of the disease, the severity of clinical symptoms, and the patients’ cognitive status were measured using a modified Hoehn and Yahr Staging Scale (mHY), Unified Parkinson’s Disease Rating Scale (UPDRS) II and

View details →DOI: 10.1155/2016/1589747