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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

697 results in Negative / Null Result Report for "aging" · page 14 of 24

Negative / Null Result ReportOpen accessMedicine

Association of LR treatment response category with outcome of patients with hepatocellular carcinoma on explant pathology.

Khurana A, Chai N, Gibson A et al. · 2025 · Abdominal radiology (New York)

Objectives Liver transplant (LT) is an effective treatment for hepatocellular carcinoma (HCC) in appropriately selected patients. Locoregional therapy (LRT) is often performed to extend a patient's eligibility for LT. Imaging has a modest…

View details →DOI: 10.1007/s00261-025-04811-4
Negative / Null Result ReportMedicine

Chronic estrogen supplementation in the aging castrated male rat is not associated with renal injury or activation of the renin angiotensin system.

Mallette JH, Crudup BF, Oudomrath Speyrer A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

The biological effects of chronic estrogen supplementation on renal function and injury with aging in men are unknown. Using an experimental model of feminizing hormone therapy (FHT) induced by 17β-estradiol (E2) (5 mg/kg sc)…

View details →DOI: 10.1152/japplphysiol.00052.2026
Negative / Null Result ReportOpen accessMedicine

Error-related potentials during multitasking involving sensorimotor control: an ERP and offline decoding study for brain-computer interface.

Yasuhara M, Nambu I · 2025 · Frontiers in human neuroscience

Humans achieve efficient behaviors by perceiving and responding to errors. Error-related potentials (ErrPs) are electrophysiological responses that occur upon perceiving errors. Leveraging ErrPs to improve the accuracy of brain-computer…

View details →DOI: 10.3389/fnhum.2025.1516721
Negative / Null Result ReportOpen accessMedicine

Impacts of sarcopenia and resistance exercise training on mitochondrial quality control proteins.

Springer-Sapp CB, Ogbara OO, Addison O et al. · 2025 · The Journal of frailty & aging

Background The progression of sarcopenia with aging may be related to mitochondrial dysfunction due in part to altered mitochondrial dynamics (fusion, fission, mitophagy, and biogenesis). Previous work has identified altered expression of…

View details →DOI: 10.1016/j.tjfa.2025.100090
Negative / Null Result ReportMedicine

Comprehensive multimodal prediction of Alzheimer's disease.

Khan F, Pandit D, Lalan S et al. · 2026 · Biomedical physics & engineering express

Alzheimer's disease (AD) classification using machine learning has increasingly relied on multimodal inputs such as Magnetic Resonance Imaging (MRI), cognitive assessments, and biological markers. This study evaluates whether integrating…

View details →DOI: 10.1088/2057-1976/ae4630
Negative / Null Result ReportMedicine

Exploring factors influencing the ecological host range of Trissolcus japonicus: foraging strategy and nontarget host use.

Paul RL, Porter DC, Mutschler-Aldine S et al. · 2026 · Environmental entomology

Evaluation of potential classical biological control agents typically begins with laboratory testing for their fundamental host range. These experiments are intended to evaluate the propensity for nontarget attack but often do so in highly…

View details →DOI: 10.1093/ee/nvaf125
Negative / Null Result ReportOpen accessMedicine

From Evidence to Practice: Implementation and Evaluation of the Discontinuation of Patient Contact Shielding in Paediatric Radiography.

Ryan E, Norynberg K, Connor P et al. · 2026 · Journal of medical radiation sciences

Introduction Patient contact shielding has been used in paediatric radiography as standard practice for decades. Contemporary evidence no longer supports its use in routine clinical practice. The Medical Imaging Department of an Australian…

View details →DOI: 10.1002/jmrs.70053
Negative / Null Result Report

Bumblebees do not prefer consistent floral scents over variable ones

Armand M, Zeilmann L, Weinzettl C et al. · 2025 · Preprint

Abstract To attract pollinators, flowering plants evolve diverse sensory traits into compelling signals. Floral scent, in particular, plays a key role in drawing bees from a distance and shaping their foraging choices. Scent composition…

View details →DOI: 10.21203/rs.3.rs-6292403/v1
Negative / Null Result Report

Bumblebees do not prefer consistent floral scents over variable ones

Armand M, Zeilmann L, Weinzettl C et al. · 2025 · Preprint

ABSTRACT To attract pollinators, flowering plants evolve diverse sensory traits into compelling signals. Floral scent, in particular, plays a key role in drawing bees from a distance and shaping their foraging choices. Scent composition…

View details →DOI: 10.1101/2025.03.15.643418
Negative / Null Result ReportMedicine

Soil aggregation alterations under soil microplastic and biochar addition and aging process.

Li H, Yang L, Luo C et al. · 2025 · Environmental pollution (Barking, Essex : 1987)

Soil microplastics (MPs) are a substantial threat to soil health, particularly by disrupting soil aggregation. Additionally, MPs undergo aging processes in the soil, which may significantly alter their long-term impacts on soil structure.…

View details →DOI: 10.1016/j.envpol.2025.125655
Negative / Null Result ReportMedicine

Multi-parametric magnetic resonance imaging of the prostate in Victoria, Australia; unintended consequences of changing Medicare Benefits Schedule access.

Gordon P, Urquhart E, Oad S et al. · 2024 · Australian health review : a publication of the Australian Hospital Association

Objective To assess whether prostate biopsy rates have altered with the July 2018 change in Australian Medicare Benefits Schedule (MBS) rebates supporting multiparametric magnetic resonance imaging (mpMRI) for diagnosing prostate cancer.…

View details →DOI: 10.1071/ah24024
Negative / Null Result ReportOpen accessMedicine

STRATEGIC-1: multiple-line, randomized, open-label GERCOR-PRODIGE-39 phase III trial in unresectable RAS/BRAF wild-type metastatic colorectal cancer.

Chibaudel B, Dourthe LM, André T et al. · 2026 · Signal transduction and targeted therapy

Managing unresectable metastatic colorectal cancer (mCRC) requires a comprehensive strategy. While chemotherapy, anti-angiogenic, and anti-epidermal growth factor receptor (EGFR) agents are available, strategy trials are needed to optimize…

View details →DOI: 10.1038/s41392-026-02639-y
Negative / Null Result ReportMedicine

EXPRESS: Lack of Association Between Inner Ear FLAIR Suppression on MRI and Laterality of Clinical Signs in Feline Idiopathic Vestibular Syndrome.

Putzer M, De Decker S, Gutierrez Quintana R et al. · 2026 · Journal of feline medicine and surgery

ObjectivesThe underlying aetiology of feline idiopathic vestibular syndrome (IVS) remains unclear. In humans, specific magnetic resonance imaging (MRI) sequences are used to demonstrate differences in endolymph composition between…

View details →DOI: 10.1177/1098612x261445137
Negative / Null Result ReportMedicine

The role of susceptibility weighted imaging as a substitute to post-contrast T1-weighed images in detection of active multiple sclerosis lesions.

Rashad Ali F, Teiba MK, Sheha AS et al. · 2026 · Clinical radiology

Background and purpose Magnetic susceptibility levels of multiple sclerosis plaques increase as they convert from the active enhancing stage to the chronic or inactive nonenhancing stages. The purpose of our study was to discern whether a…

View details →DOI: 10.1016/j.crad.2025.107127
Negative / Null Result ReportMedicine

Lack of association between chronological age and fisher group and poor outcomes in older patients with severe-grade aneurysmal subarachnoid hemorrhage: a nationwide registry study in Japan.

Suzuki K, Sato H, Sorimachi T et al. · 2025 · Neurosurgical review

Older age and Fisher group scores predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, among aging societies, treatment indications and decisions in older patients with severe-grade aSAH (World…

View details →DOI: 10.1007/s10143-025-03638-3
Negative / Null Result ReportMedicine

It is time to appreciate the value of processed foods

Fitzgerald M · 2024 · Trends in Food Science & Technology.

The messaging around processed food recently is that it is unhealthy and associated with the onset of chronic disease. However, food is processed for many reasons that range from preservation to safety, and then more recently in response…

Negative / Null Result ReportOpen accessMedicine

MRI-Based Evaluation of PRP Therapy in Knee Osteoarthritis: WORMS and Synovial Changes at 6 Months.

Wakayama T, Saita Y, Uchino S et al. · 2025 · Journal of clinical medicine

Objective: Platelet-rich plasma (PRP) therapy has become a popular treatment for knee osteoarthritis. We aimed to determine the outcomes of knee osteoarthritis patients following PRP therapy using magnetic resonance imaging (MRI) findings…

View details →DOI: 10.3390/jcm14186408
Negative / Null Result ReportOpen accessMedicine

Frailty as Predictor for Early Functional Outcomes After Radical Prostatectomy.

Stankovic M, Weber C, Koser M et al. · 2025 · Journal of frailty, sarcopenia and falls

Objectives While chronological aging does not necessarily impair oncological outcomes after radical prostatectomy, the role of frailty remains less clear. This study aimed to evaluate whether frailty significantly affects early continence…

View details →DOI: 10.22540/jfsf-10-028
Negative / Null Result ReportOpen accessMedicine

Histological signatures of hormone replacement therapy in the endometrium.

Abdalla M · 2026 · Frontiers in medicine

Background Hormone replacement therapy (HRT) is widely prescribed for managing menopausal symptoms, yet its effects on the endometrium remain clinically important. While large-scale studies have established that estrogen-only HRT increases…

View details →DOI: 10.3389/fmed.2026.1718508
Negative / Null Result ReportOpen accessMedicine

Lack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone.

Errigo A, Dore MP, Mocci G et al. · 2024 · Scientific reports

More than two decades ago, in the central-eastern region of the Mediterranean island of Sardinia, a mountain area was identified where the population displays exceptional longevity, especially among men (the Longevity Blue Zone, LBZ). This…

View details →DOI: 10.1038/s41598-024-80497-w
Negative / Null Result ReportOpen accessMedicine

Association between systolic blood pressure trajectories and successful aging in middle-aged and elderly Chinese individuals: a longitudinal study.

Xin Y, Qian X, Yang Y · 2025 · BMC public health

Background This study aimed to prospectively assess the relationship between systolic blood pressure (SBP) trajectories and successful aging in middle-aged and elderly Chinese individuals. Methods A total of 1,960 participants from the…

View details →DOI: 10.1186/s12889-025-25709-2