Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Remonda Raafat Ragheb, Rodayana Atef, Kareem Abdou et al. · 2026 · AAPS PharmSciTech
Abstract Venous thromboembolism (VTE) and pulmonary embolism (PE), remains a major global health burden, necessitating prolonged and reliable anticoagulant therapy. Although Apixaban (APX) is a cornerstone oral anticoagulant for VTE management, its therapeutic performance is limited by poor aqueous solubility and low oral bioavailability. To overcome these challenges, this study introduces a hybrid niosomal delivery system designed to enhance the absorption and systemic persistence of APX. The system was engineered by integrating hybrid of surfactants together with cholesterol to form a stable
View details →DOI: 10.1208/s12249-026-03374-xCited by 9 Negative / Null Result ReportOpen accessNursing
Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer et al. · 2025 · Pharmaceutics
Selenium nanoparticles (SeNPs) have emerged as promising metal-based nanoparticles for drug delivery due to their unique physicochemical properties, intrinsic bioactivity, and biocompatibility. SeNPs offer a lower toxicity, higher bioavailability, and flexibility to be customized for surface chemistry compared to traditional selenium compounds. Advances in synthetic strategies, including chemical reduction, green biosynthesis, and surface functionalization with polymers, peptides, or ligands, have improved their stability, targeting capability, and circulation time. SeNP-based systems have dem
View details →DOI: 10.3390/pharmaceutics17121556Cited by 9 Negative / Null Result ReportOpen accessMedicine
Patrick Highton, Mark P. Funnell, Pankaj Gupta et al. · 2025 · Diabetologia
Abstract Medication adherence is critical for optimal glycaemic management and the prevention of complications in type 2 diabetes mellitus. Despite its importance, non-adherence remains a prevalent issue, with global estimates suggesting that approximately 38% of people with type 2 diabetes do not take their medications as prescribed, although estimates vary widely due to a range of patient-related, socioeconomic, condition-related (e.g. chronicity, severity of comorbidities) and healthcare system factors. This review synthesises the current evidence on the prevalence of non-adherence in type
View details →DOI: 10.1007/s00125-025-06617-xCited by 9 Negative / Null Result ReportOpen accessMedicine
Emanuel J. Novais, Olivia K. Ottone, Sanjana Jagannath et al. · 2026 · Bone Research
Genetic background is a major determinant of disc degeneration, a leading cause of chronic back pain and disability. Herein, we demonstrate that premature disc cell senescence contributes to early-onset degeneration in SM/J mice and test two systemic senotherapeutic strategies to mitigate it: Navitoclax (Nav.) and a cocktail of Dasatinib and Quercetin (DQ). While Nav. treatment did not improve severe degeneration in SM/J mice or senescence status, DQ-treated mice showed lower grades of degeneration and a decreased abundance of senescence markers, including p19ARF, p21, and the senescence-assoc
View details →DOI: 10.1038/s41413-026-00526-4Cited by 9 Negative / Null Result ReportOpen accessMedicine
Fiyinfoluwa Demilade Ojeniyi, Adeola Oluwakemi Ayoola, Olajumoke Ibitoye et al. · 2025 · Scientific Reports
Rapid diagnostic tests (RDTs) have revolutionized malaria diagnosis, playing a crucial role in improving timely treatment and supporting surveillance efforts, especially in resource-limited settings. However, the performance of RDTs can…
View details →DOI: 10.1038/s41598-025-97259-xCited by 9 Negative / Null Result ReportOpen accessMedicine
Niklas Mattsson-Carlgren, Sebastian Palmqvist, Kanta Horie et al. · 2026 · The Lancet Neurology
BACKGROUND: Alzheimer's disease pathology can be accurately identified with blood biomarkers (core 1 biomarkers), including plasma p-tau217 tests. Biomarkers that change longitudinally after diagnosis (core 2 biomarkers) can increase confidence that Alzheimer's disease pathology is contributing to cognitive symptoms. Plasma eMTBR-tau243 reflects tau tangle pathology and is a promising core 2 biomarker. We aimed to examine whether, among patients positive for plasma p-tau217, plasma eMTBR-tau243 improves classification of established Alzheimer's disease and predicts cognitive decline and tau ta
View details →DOI: 10.1016/s1474-4422(26)00029-3Cited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Rong Yuan, Tajul Ariffin Masron, Yujie Chen et al. · 2025 · International Journal of Environmental Science and Technology
Abstract The alarming rate of environmental degradation worldwide has prompted a renewed focus on government effectiveness as an essential factor affecting environmental quality. Few studies have demonstrated the role of government effectiveness in environmental degradation under the influence of economic development. Consequently, this study aims to investigate the effect of government effectiveness and how it impacts environmental degradation using panel data from 61 regions from 2007 to 2021 and the generalized method of moments (GMM) estimator. The results show that improving government ef
View details →DOI: 10.1007/s13762-025-06560-9Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yuko Shimizu‐Motohashi · 2025 · Brain and Development
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder caused by variants of the DMD that leads to progressive muscle degeneration. Recent advances in gene therapy have opened new therapeutic avenues, particularly through the use of adeno-associated virus (AAV)-mediated micro-dystrophin delivery. Delandistrogene moxeparvovec, the first FDA-approved gene therapy for DMD, has demonstrated transgene expression and potential functional improvement in early phase trials, although its long-term efficacy, durability, and safety remain unconfirmed. Immune-mediated toxicities including
View details →DOI: 10.1016/j.braindev.2025.104424Cited by 9 Negative / Null Result ReportOpen accessEngineering
Mingqi Wang, Yulin Ye, Ruqiang Yuan et al. · 2025 · Cancer Cell International
The limited clinical translation of preclinical anticancer drug efficacy underscores the urgent need for advanced models that faithfully replicate tumor pathophysiology. While three-dimensional (3D) tumor cultures improve the fidelity of…
View details →DOI: 10.1186/s12935-025-04064-7Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Janet Quint, Pei Zhu, Rekha Balu et al. · 2015 · SSRN Electronic Journal
Success for All (SFA) combines a challenging elementary reading program, whole-school reform elements, and an emphasis on continuous improvement. In 2010, the Success for All Foundation (SFAF) received a scale-up grant under the U.S.…
Negative / Null Result ReportMedicine
William R. Cleek, Nicholas J. Johnson, Bjorn Watsjold et al. · 2019 · Shock
STUDY OBJECTIVE: The quick sequential organ failure assessment (qSOFA) was proposed to identify infected patients at risk for mortality, an indication of sepsis, in nonintensive care unit settings. This study tests whether qSOFA improves…
View details →DOI: 10.1097/shk.0000000000001496Cited by 9 Negative / Null Result ReportOpen accessHealth Professions
Hailey Miller, Sandy Askew, Miriam B. Berger et al. · 2024 · Hypertension
BACKGROUND: Dietary Approaches to Stop Hypertension (DASH) is a recommended first-line treatment for adults with hypertension, yet adherence to DASH is low. To evaluate the efficacy of a digital health intervention (DHI), compared with…
View details →DOI: 10.1161/hypertensionaha.124.23887Cited by 9 Negative / Null Result ReportSocial Sciences
Won Fy Lee, Clea McNeely, Janet E. Rosenbaum et al. · 2020 · Journal of Research on Educational Effectiveness
We examined the effect on attendance of a truancy court-diversion program for elementary students. Truancy court-diversion programs represent a shift from a law-and-order approach toward a public health model to address school absenteeism.…
View details →DOI: 10.1080/19345747.2020.1760976Cited by 9 Negative / Null Result Report
Chun Wang, David J. Weiss · 2017 · Applied Psychological Measurement
The measurement of individual change has been an important topic in both education and psychology. For instance, teachers are interested in whether students have significantly improved (e.g., learned) from instruction, and counselors are…
View details →DOI: 10.1177/0146621617726787Cited by 8 Negative / Null Result Report
Ryuhei Wada, Jiro Takeuchi, Tsukasa Nakamura et al. · 2020 · Applied Clinical Informatics
Abstract Background Medication dose adjustment is crucial for patients with renal dysfunction (RD). The assessment of renal function is generally mandatory; however, the renal function may change during the hospital stay and the manual…
View details →DOI: 10.1055/s-0040-1721056Cited by 8 Negative / Null Result Report
Margareth Chiharu Iwata, Livia Porquere, Isabel C. Espósito Sorpreso et al. · 2015 · Revista da Associação Médica Brasileira
Summary Objective: Objective: to compare clinical and laboratory parameters in women with polycystic ovary syndrome (PCOS) using metformin or combined oral contraceptive (COC) after 6 months. Methods: retrospective study analyzing records…
View details →DOI: 10.1590/1806-9282.61.03.215Cited by 8 Negative / Null Result Report
Lohanna STRAUHS-NITSCH, Marcela Ferro CAMPIOLO, Daphne Benatti Gonçalves MORSOLETTO et al. · 2020 · Arquivos de Gastroenterologia
ABSTRACT BACKGROUND: Chronic hepatitis C still figures as an important cause of morbidity among the Brazilian population, and is closely associated with metabolic disturbances, including insulin resistance (IR), which can be evaluated by…
View details →DOI: 10.1590/s0004-2803.202000000-50Cited by 8 Negative / Null Result Report
Lin Li, Mingming Tang, Dan Nie et al. · 2020 · International Journal of Gynecology & Obstetrics
Abstract Objective To compare outcomes and prognosis among women with type I endometrial cancer undergoing hysterectomy and bilateral salpingo‐oophorectomy (H‐BSO) with or without systematic pelvic lymphadenectomy (PLD) or para‐aortic…
View details →DOI: 10.1002/ijgo.13228Cited by 8 Negative / Null Result Report
Josh W. Newbury, Bryan Saunders, Lewis A. Gough · 2022 · International Journal of Sport Nutrition and Exercise Metabolism
The potential ergogenic benefits of caffeine (CAF) are well known within the athletic community, often leading to its use in adolescent swimming cohorts to enhance their performance. However, it has previously been reported that CAF has…
View details →DOI: 10.1123/ijsnem.2022-0042Cited by 8 Negative / Null Result Report
Jingbin Wang, Huiling Qiao, Jing Liu et al. · 2022 · International Journal of Environmental Research and Public Health
The environmental effects of national new areas have been an important topic but received little attention in academia. This study conducts a quasi-natural experiment using panel data of China’s 282 prefecture-level cities from 2006 to…
View details →DOI: 10.3390/ijerph192013623Cited by 8 Negative / Null Result Report
Li-Yang Kuo, Chun-Yu Chen, Kai-Cheng Lin · 2022 · Scientific Reports
Abstract This study aims to investigate whether an augmented wire in the treatment of patella distal pole fracture could improve knee range of motion (ROM) and radiographic features. Thirty-five consecutive patients with patellar distal…
View details →DOI: 10.1038/s41598-022-13641-zCited by 8 Negative / Null Result Report
Denis Yongmin Joe, Frederick Dongchuhl Oh · 2016 · Contemporary Economic Policy
In this study, we investigate whether foreign equity participation fostered the growth of Korea's credit rating industry during the 2002–2013 period. We find that the rating quality deteriorated steadily even though the foreign ownership…
View details →DOI: 10.1111/coep.12176Cited by 8 Negative / Null Result Report
Kim K. Johnson, Carole Bennett, Haresh Rochani · 2020 · Journal of the American Psychiatric Nurses Association
Objective: Patients with somatic symptom disorders (SSD) are prevalent in primary care, urgent care, and emergency rooms and present with reduced quality of life, increased disability, and suicidality . Criteria for SSD include (1) somatic…
View details →DOI: 10.1177/1078390320960524Cited by 7 Negative / Null Result Report
Xiao-Li Dong, Si-Si Cao, Li-Ping Zhou et al. · 2016 · The American Journal of Chinese Medicine
Our previous studies found that different extracts or fractions of Fructus ligustri lucidi (FLL) played different roles in altering the regulation of bone and mineral metabolism in different animal models. The present study was designed to…
View details →DOI: 10.1142/s0192415x16500695Cited by 7 Negative / Null Result Report
N. Vargas Jurado, A. E. Tanner, S. R. Blevins et al. · 2014 · Grass and Forage Science
Abstract Feed intake and diet choice affect production efficiency in livestock. Plant waxes, in particular n ‐alkanes, have been used as markers to predict intake and diet preferences. Still, when n ‐alkane profiles of plants within mixed…
View details →DOI: 10.1111/gfs.12134Cited by 7 Negative / Null Result Report
Helen E Tilbrook, Taeko Becque, Hannah Buckley et al. · 2014 · Journal of Evaluation in Clinical Practice
Abstract Rationale Attrition is a threat to the validity of randomized trials. Few randomized studies have been conducted within randomized trials to test methods of reducing attrition. Aim To test whether using yellow post‐it notes on…
View details →DOI: 10.1111/jep.12284Cited by 7 Negative / Null Result Report
Pedro Perim, Nathan Gobbi, Breno Duarte et al. · 2021 · European Journal of Sport Science
ABSTRACT This study investigated the effect of beta‐alanine supplementation on short‐duration sprints and final 4‐km simulated uphill cycling time‐trial performance during a comprehensive and novel exercise protocol representative of the…
View details →DOI: 10.1080/17461391.2021.1940304Cited by 7 Negative / Null Result Report
Roberta De Bei, Lukas Papagiannis, Sigfredo Fuentes et al. · 2020 · OENO One
Aim: Shoot thinning is a common canopy management practice used to obtain a desired shoot density and to improve canopy microclimate. Since thinning is often carried out manually, the cost can be high. In this study the effect of severe…
View details →DOI: 10.20870/oeno-one.2020.54.3.2984Cited by 7 Negative / Null Result Report
J. Elijah Powell, Erick V.S. Motta, Joanito Liberti et al. · 2025 · Royal Society Open Science
The western honeybee, Apis mellifera, harbours a simple and distinct microbiota that has been linked to various positive outcomes for the host. Among these cited benefits is improved weight gain for bees that have been inoculated with…
View details →DOI: 10.1098/rsos.242151Cited by 7 Negative / Null Result Report
Fan Liu, Jordon Hogg, Susie Kracht et al. · 2019 · Animal Production Science
Context Lactoferrin is a non-haem binding protein that possesses antimicrobial, antioxidant and anti-inflammatory properties. A previous study showed lactoferrin supplementation from early gestation to weaning improved lactation…
View details →DOI: 10.1071/an18286Cited by 6 