Negative / Null Result ReportMedicine
Cioe PA, Stang GS, Azam D et al. · 2025 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Introduction Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of…
View details →DOI: 10.1093/ntr/ntaf123 Negative / Null Result ReportOpen accessMedicine
Kant N, Garssen SH, Vernooij CA et al. · 2024 · Internal and emergency medicine
In Acute Admission Wards, vital signs are commonly measured only intermittently. This may result in failure to detect early signs of patient deterioration and impede timely identification of patient stability, ultimately leading to…
View details →DOI: 10.1007/s11739-024-03582-y Negative / Null Result ReportOpen accessMedicine
Ruiz-López A, Montalvo-Alonso JJ, Martín-Rivas I et al. · 2026 · Nutrients
Background/Objectives : Caffeine is a well-established ergogenic aid in many strength- and endurance-based sports, but its efficacy in sport climbing remains underexplored despite the sport's unique physical demands on grip strength,…
View details →DOI: 10.3390/nu18020284 Negative / Null Result ReportOpen accessMedicine
Mohammadi F, Razmjooei N, Mohsenpour MA et al. · 2025 · BMC nutrition
Background and aim Probiotics play an important role in the control and treatment of non-alcoholic fatty liver disease (NAFLD). Kefir drink is a fermented beverage and has indicated some beneficial health effects. The aim of this study was…
View details →DOI: 10.1186/s40795-024-00989-w Negative / Null Result ReportMedicine
Brongers K, Hoekstra T, Wilming L et al. · 2024 · Disability and rehabilitation
Purpose As the effect evaluation of our randomized controlled trial the "Comprehensive Approach of Reintegration for clients with Multiple problems" (CARm) showed no superior effect on re-integration into paid employment of the clients…
View details →DOI: 10.1080/09638288.2023.2264765 Negative / Null Result ReportOpen accessMedicine
Levin ME, Mukasa MN, Bowers EM et al. · 2025 · Behavioral sciences (Basel, Switzerland)
Adherence challenges are common among digital mental health interventions (DMHIs). Single-session DMHIs may help by providing a low-intensity intervention that takes less time to complete. This pilot randomized controlled trial sought to…
View details →DOI: 10.3390/bs15010075 Negative / Null Result ReportOpen accessMedicine
Lunde P, Finbråten HS, Pripp AH et al. · 2025 · International journal of cardiology. Cardiovascular risk and prevention
Background and aims Adherence to treatment is a significant challenge for patients with cardiac disease. Optimizing health literacy (HL) is essential in this context. Mobile health (mHealth) interventions have been suggested to improve…
View details →DOI: 10.1016/j.ijcrp.2025.200445 Negative / Null Result ReportOpen accessMedicine
Mayer L, Lichtblau M, Furian M et al. · 2025 · Journal of the American Heart Association
Background Exposure to high altitude triggers hypoxic pulmonary vasoconstriction with a rise in pulmonary artery pressure (PAP). This may lead to symptomatic pulmonary hypertension with impaired right heart function and exercise capacity.…
View details →DOI: 10.1161/jaha.125.041941 Negative / Null Result ReportOpen accessMedicine
Ouerghi N, Abassi W, Jebabli N et al. · 2026 · Sports (Basel, Switzerland)
The study investigated the effects of high-intensity interval training (HIIT) on cardiorespiratory fitness, hormonal, and psychological markers in adolescents. Twenty-eight healthy male adolescents were randomized to a HIIT group or a…
View details →DOI: 10.3390/sports14050209 Negative / Null Result ReportOpen accessMedicine
Treat T, Jones D, Lorenzano N et al. · 2026 · Journal of periodontology
Background Evidence for whether and how non-surgical periodontal treatment (NSPT) improves systemic outcomes remains equivocal. Inconclusive findings may in part be due to design variations of randomized controlled trials (RCTs) in this…
View details →DOI: 10.1002/jper.24-0847 Negative / Null Result ReportMedicine
Pascoe B, Cocks K, Clarke N et al. · 2026 · Schizophrenia research
Cognitive impairment associated with schizophrenia (CIAS) is a fundamental symptom of the disorder, which significantly affects individuals' daily functioning and overall quality of life. Currently available antipsychotic drugs have little…
View details →DOI: 10.1016/j.schres.2026.03.028 Negative / Null Result ReportMedicine
Kloura C, Jensen MM, Ekblond TS et al. · 2026 · Diabetes research and clinical practice
Aim The aim of this exploratory analysis was to investigate effects of time-restricted eating (TRE) on glycemic control and variability in adults with prediabetes. Methods This study utilized data from the Restricted Eating Time (RESET)…
View details →DOI: 10.1016/j.diabres.2026.113276 Negative / Null Result ReportMedicine
Cai Y, Ren X, Ding C · 2026 · Intensive & critical care nursing
Objectives To assess the effects of various non-pharmacological interventions on long-term outcomes associated with Post-Intensive Care Syndrome (PICS) in intensive care unit (ICU) survivors, based on existing systematic reviews and…
View details →DOI: 10.1016/j.iccn.2025.104326 Negative / Null Result ReportMedicine
Stanley M, Huang K, Garlich J et al. · 2025 · Journal of orthopaedic trauma
Objectives To compare time, fluoroscopic utilization, and number of misses for placement of far interlocking screws in tibial and femoral nails using a targeting arm (Targeter) versus perfect circle technique (Control). Methods . Design…
View details →DOI: 10.1097/bot.0000000000003066 Negative / Null Result ReportMedicine
Singh D, Kodali PB, Sharma G et al. · 2025 · Medical acupuncture
Abstract This study aimed to investigate the effects of an integrated acupuncture (IA) protocol on blood pressure (BP), depression, anxiety, stress scores, and heart rate variability (HRV) in hypertensive patients. Abstract The study was a…
View details →DOI: 10.1089/acu.2024.0065 Replication FailureMedicine
Rymaszewska J, Szcześniak D, Maciaszek J et al. · 2026 · Journal of affective disorders
The exploration of Theta Burst Stimulation (TBS) in Obsessive-compulsive disorder (OCD) treatment is still in its nascent stages, and these initial findings underscore the need for further research to optimize stimulation parameters and…
View details →DOI: 10.1016/j.jad.2025.120073 Negative / Null Result ReportMedicine
Young RP, Ward RC, Scott RJ et al. · 2025 · Annals of the American Thoracic Society
Rationale: Current eligibility criteria for lung cancer (LC) screening are derived from randomized controlled trials and largely based on age and smoking history. However, the individualized benefits of screening are highly variable and…
View details →DOI: 10.1513/annalsats.202411-1235oc Negative / Null Result ReportOpen accessMedicine
Lang X, Zhao Y, Zhu Y et al. · 2025 · Risk management and healthcare policy
Background To assess the consequence of different degrees of missing primary endpoint data for randomized controlled trials and to find the influence factors. Methods PubMed, Cochrane Library, EMBASE and ClinicalTrials.gov were searched up…
View details →DOI: 10.2147/rmhp.s511449 Negative / Null Result ReportMedicine
Anand M, Kashyap R, Bhat P et al. · 2026 · BMC sports science, medicine & rehabilitation
Background Prolonged sedentary work is associated with hamstring tightness, reduced flexibility, and functional limitations among information technology (IT) professionals. Comparative evidence for static stretching and myofascial release…
View details →DOI: 10.1186/s13102-026-01818-2 Negative / Null Result Report
Tatsuki O · 2026 · Preprint
Abstract Background Discrepancies between observational and randomized controlled trial (RCT) meta-analyses are typically attributed to confounding. An alternative explanation — that RCTs systematically exclude high-risk patients, causing…
View details →DOI: 10.21203/rs.3.rs-9420092/v1 Negative / Null Result ReportMedicine
Kavakli, Bozkurt, Diri et al. · 2026 · Surgical endoscopy
Conventional abdominal wall blocks primarily target somatic afferent nerves and may therefore provide limited relief for the peritoneal component of postoperative pain. This study aimed to investigate whether a laparoscopic-guided deep…
View details →DOI: 10.1007/s00464-026-12973-5 Negative / Null Result ReportMedicine
Muto, Ohtake · 2026 · Journal of occupational and environmental medicine
To evaluate whether nudge emails increased early registration for an occupational health support program among employees advised to act after annual health checkups. In this stratified randomized controlled trial, 871 employees with no…
View details →DOI: 10.1097/jom.0000000000003791 Negative / Null Result ReportMedicine
Sajatovic, Still, Burant et al. · 2026 · International journal of aging & human development
This 6-month randomized controlled trial compared TEAM, a group intervention to reduce stroke risk versus a 6-month wait-list control in Black men with stroke or transient ischemic attack. The primary outcome was the change from baseline…
View details →DOI: 10.1177/00914150261458217 Negative / Null Result ReportMedicine
Asif, Rais, Anwar et al. · 2026 · Pakistan journal of medical sciences
To compare the efficacy of different nasal continuous positive airway pressure (NCPAP) weaning strategies in preterm infants presenting with respiratory distress syndrome (RDS). This randomized controlled trial was conducted at the…
View details →DOI: 10.12669/pjms.42.5.15003 Negative / Null Result ReportMedicine
Gee Lim, Feng Ng, Fen Beh · 2026 · Turkish journal of physical medicine and rehabilitation
This study aims to assess the feasibility of this pilot study's design and implementation and to compare the effect of active and passive music therapy interventions and standard care on cognition in neurorehabilitation. Participants aged…
View details →DOI: 10.5606/tftrd.2026.15231 Negative / Null Result ReportMedicine
Coellar, Keshvani, Jain et al. · 2026 · American journal of preventive cardiology
Medication non-adherence following acute coronary syndrome (ACS) is common, especially among underserved populations. The use of fixed-dose combination pills (polypills) may improve both adherence and prescription practices. This…
View details →DOI: 10.1016/j.ajpc.2026.101499 Negative / Null Result ReportMedicine
Rajvanshi, Kumar, Goyal et al. · 2026 · Pediatric pulmonology
Flexible fibreoptic bronchoscopy (FFB) is widely used in pediatric pulmonology, though hypoxemia remains a primary concern during the procedure. High-flow nasal cannula (HFNC) has shown potential in reducing hypoxemia in adults undergoing…
View details →DOI: 10.1002/ppul.71683 Negative / Null Result ReportMedicine
Naoumova, Nawaia, Krekmanova · 2026 · European journal of orthodontics
Extraction of mandibular primary second molars in patients with congenitally missing second premolars may influence oral health-related quality of life (OHRQoL), yet this has not been previously investigated. To assess the impact of…
View details →DOI: 10.1093/ejo/cjag048 Negative / Null Result ReportMedicine
Mohammed, Naser, Abozaid · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Composite resin placement technique may influence marginal integrity, polymerization stress distribution, and long-term clinical performance of posterior restorations. This randomized controlled clinical trial evaluated the 24-month…
View details →DOI: 10.1111/jerd.70202 Negative / Null Result ReportMedicine
Niu, Bao, Zhao · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
This study aimed to systematically evaluate the efficacy and safety of different doses of domperidone (DOM) combined with esomeprazole (ESM) in the treatment of reflux esophagitis, providing a basis for precise clinical medication. This…
View details →DOI: 10.1093/dote/doag053 