Negative / Null Result ReportOpen accessMedicine
Zevallos-Morales A, Romani-Huacani E, Psoter KJ et al. · 2025 · Frontiers in public health
Background Peru has one of the highest burdens of asthma in the world, as well as large gaps in access to evidence-based treatments. Studies often overlook the ways in which the research context and data collection activities interact and…
View details →DOI: 10.3389/fpubh.2025.1710746 Negative / Null Result ReportOpen accessMedicine
Kracht CL, Falkenhain K, Flanagan EW et al. · 2026 · JMIR mental health
Background Household chaos is an emerging risk factor for childhood obesity development, especially in families with lower socioeconomic status (SES). It is unclear if changes in household chaos, especially in pregnancy, may mediate the…
View details →DOI: 10.2196/74146 Negative / Null Result ReportOpen accessMedicine
Lee GJ, Morrell HER, Adams M et al. · 2026 · The journal of nutrition, health & aging
Background With the rising incidence of neurodegenerative diseases and aging of the global population, it is important to investigate foods that may preserve cognitive function with advancing years. Avocados are rich in fiber, carotenoids,…
View details →DOI: 10.1016/j.jnha.2026.100847 Negative / Null Result ReportOpen accessMedicine
Nicolaou L, Reuland CJ, Yang M et al. · 2026 · Lancet regional health. Americas
Background Household air pollution (HAP) is a major global health risk. Observational studies link HAP exposure to impaired child growth, but randomized controlled trial (RCT) evidence is inconsistent. Methods We followed children born…
View details →DOI: 10.1016/j.lana.2026.101382 Negative / Null Result ReportOpen accessMedicine
Li S, Mahr C, Kataria R et al. · 2026 · JACC. Advances
Background Landmark randomized controlled trials like DanGer Shock, IABP-SHOCK II, and ECLS-SHOCK guide infarct-related cardiogenic shock (CS) management with temporary mechanical circulatory support (tMCS), but strict enrollment criteria…
View details →DOI: 10.1016/j.jacadv.2026.102723 Failed Experiment ReportOpen accessMedicine
Georgiadis AG, Schavee PE, Koester TM et al. · 2025 · JB & JS open access
Background Cast removal may produce pain or anxiety in children. Virtual reality (VR) has been studied in other pediatric settings, but little evidence exists for its use during pediatric cast removal. Methods A randomized controlled trial…
View details →DOI: 10.2106/jbjs.oa.24.00244 Negative / Null Result ReportOpen accessMedicine
Terpstra JA, van Beugen S, van der Vaart R et al. · 2026 · Internet interventions
Background Rheumatic and musculoskeletal diseases have a high burden. We aimed to evaluate the effectiveness of a therapist-guided internet-based cognitive-behavioral therapy (iCBT) on pain coping and secondary physical, psychological, and…
View details →DOI: 10.1016/j.invent.2026.100908 Negative / Null Result ReportMedicine
Wilkie DJ, Yao Y, Ezenwa MO et al. · 2020 · Journal of pain and symptom management
Context Unrelieved cancer pain at the end of life interferes with achieving patient-centered goals. Objective To compare effects of usual hospice care and PAINRelieveIt® on pain outcomes in patients and their lay caregivers. Methods In a…
View details →DOI: 10.1016/j.jpainsymman.2019.10.028 Negative / Null Result ReportOpen accessMedicine
Witzel S, Statland JM, Steinacker P et al. · 2024 · European journal of neurology
Background and purpose Rasagiline might be disease modifying in patients with amyotrophic lateral sclerosis (ALS). The aim was to evaluate the effect of rasagiline 2 mg/day on neurofilament light chain (NfL), a prognostic biomarker in ALS.…
View details →DOI: 10.1111/ene.16154 Negative / Null Result ReportOpen accessMedicine
Shepard S, Anderson JM, Heigle B et al. · 2023 · Journal of orthopaedic surgery and research
Purpose To our knowledge, no study has quantified the rate of discontinuation and nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity fractures. Methods We searched ClinicalTrials.gov on September 9th,…
View details →DOI: 10.1186/s13018-023-03698-5 Negative / Null Result ReportOpen accessMedicine
Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine
Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…
View details →DOI: 10.3389/fmed.2023.1224865 Negative / Null Result ReportMedicine
Sanderson C, Hardy J, Spruyt O et al. · 2013 · Journal of pain and symptom management
Placebo and nocebo effects are known to contribute significantly to the response to symptom control, including analgesia. Clinical trial methodologies using placebo controls are designed to identify the magnitude of these effects in the…
View details →DOI: 10.1016/j.jpainsymman.2012.12.005 Failed Experiment ReportMedicine
Hennigar SR, Miller KM, Murphy RD et al. · 2026 · The Journal of nutrition
Background Iron deficiency (ID) is associated with decreased appetite and altered mood, which can contribute to feelings of early satiety and reduced overall well-being. Few studies have examined differences in appetite, satiety, and mood…
View details →DOI: 10.1016/j.tjnut.2026.101559 Negative / Null Result ReportMedicine
Kleckner AS, Zhou Y, Diaz-Mercado Y et al. · 2026 · Chronobiology international
Circadian rest-activity rhythms, or a person's consistency in their daily activity and rest patterns, can be quantified using various parametric and non-parametric methods. However, these methods are seldom applied to understand symptoms…
View details →DOI: 10.1080/07420528.2026.2669594 Negative / Null Result ReportMedicine
Bhattacharjee B, Ghosh S, Basu N et al. · 2026 · Journal of integrative and complementary medicine
Objectives To assess the feasibility of conducting a randomized controlled trial and to explore preliminary effects of individualized homoeopathic medicines (IHMs) compared with placebo in patients with temporomandibular joint dysfunction…
View details →DOI: 10.1177/27683605261458121 Negative / Null Result ReportMedicine
Kultanaruangnonth M, Chatrung L, Tansawet A et al. · 2026 · World journal of emergency surgery : WJES
Background Surgical site infections (SSIs) remain a major concern after abdominal surgery, with incidences of 15-22%. Intraoperative wound irrigation (IOWI) before closure is routinely performed to reduce bacterial contamination, but the…
View details →DOI: 10.1186/s13017-026-00705-y Negative / Null Result ReportOpen accessMedicine
Arslan Çarpar K, Yılmaz T · 2026 · BMC oral health
BACKGROUND: This study aimed to compare the plaque removal efficacy of manual and powered toothbrushes around attachments in patients undergoing clear aligner therapy under standardized, single-brushing conditions. METHODS: This…
View details →DOI: 10.1186/s12903-026-08395-3 Negative / Null Result ReportOpen accessMedicine
Agarwal P, Kumar P, Chugh VK et al. · 2026 · Cureus
Background and aim Postoperative pain following root canal treatment (RCT) can be influenced by the obturation technique, as variations in apical sealing and material extrusion may affect periapical tissue response. The aim of this study…
View details →DOI: 10.7759/cureus.107873 Negative / Null Result ReportMedicine
Soenarti S, Sitorus S, Nugroho MB et al. · 2026 · Rehabilitacion
Sarcopenia represents a leading cause of functional decline in older adults. This randomized controlled trial examined whether the addition of ankle weights to a Nordic walking protocol yields superior outcomes compared with standard…
View details →DOI: 10.1016/j.rh.2026.100998 Negative / Null Result ReportMedicine
Lewis MN, Feola N, Watson K et al. · 2025 · PRiMER (Leawood, Kan.)
Introduction Poster displays are commonly used to present scholarly activity. Most current research evaluates posters' visual appeal. Isolated studies looking at knowledge transfer have evaluated standalone posters. The innovation of…
View details →DOI: 10.22454/primer.2025.182427 Negative / Null Result ReportMedicine
McKay NJ, Horvatits EJ, Jean M et al. · 2024 · Physiology & behavior
It is well known that a large portion of the population elevates their intake of high energy-dense foods during times of stress; however, it is understudied whether stress affects the reinforcing value of a food reward. Further knowledge…
View details →DOI: 10.1016/j.physbeh.2024.114531 Negative / Null Result ReportOpen accessMedicine
Kazemipour S, Yamin JB, Moore D et al. · 2026 · Pain reports
Introduction More than three-fourths of people with fibromyalgia complain of cognitive difficulties, including memory and attention problems, which result in impaired job performance and disability. Cognitive behavioral therapy (CBT) is…
View details →DOI: 10.1097/pr9.0000000000001378 Negative / Null Result ReportOpen accessMedicine
Siengsukon CF, Hand LK, Nelson E et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction Insomnia is associated with increased risk for Alzheimer's disease (AD). It is unknown how cognitive behavioral therapy for insomnia (CBT-I) impacts two hallmarks of AD progression, cognitive performance and beta-amyloid (Aβ)…
View details →DOI: 10.1002/alz.71591 Negative / Null Result ReportOpen accessMedicine
Renwick JRM, Preobrazenski N, Giudice MD et al. · 2024 · International journal of exercise science
The purpose of the current study was to test the hypothesis that individual response classification for surrogate markers of cardiorespiratory fitness (CRF) will agree with response classification for VO 2peak . Surrogate markers of CRF…
View details →DOI: 10.70252/pvyg1833 Negative / Null Result ReportOpen accessMedicine
Kjeldsted E, Ammitzbøll G, Lænkholm AV et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Preclinical studies have indicated that physical exercise may enhance chemotherapy efficacy. However, clinical trials are needed to investigate these findings. We hypothesized that an exercise program during neoadjuvant…
View details →DOI: 10.1158/1078-0432.ccr-25-0416 Negative / Null Result ReportMedicine
Legrand FD, Jeandet P, Polidori G et al. · 2025 · Psychology of sport and exercise
This randomized controlled trial investigated the impact of a brief session of group-based running on feelings of energy and fatigue, comparing exercise in a local nature reserve versus an outdoor built environment, and a sedentary control…
View details →DOI: 10.1016/j.psychsport.2024.102760 Negative / Null Result Report
Lukenda K, Sülzenbrück S, Sutter C · 2024 · Preprint
This study investigates the impact of expressive writing on work stress, employing a 2 x 3 x 2 factorial design. Participants, pre-selected for high stress levels, were randomly assigned to either an experimental or control group and…
View details →DOI: 10.31234/osf.io/7z8uc Negative / Null Result ReportMedicine
Atthakitmongkol T, Chotiyaputta W, Lertwattanarak R et al. · 2026 · Journal of the Formosan Medical Association = Taiwan yi zhi
Background Tenofovir disoproxil fumarate (TDF) is an important drug to treat chronic hepatitis B (CHB) patients. However, long-term TDF therapy decreases renal function and bone mineral density (BMD). This study compared bone turnover…
View details →DOI: 10.1016/j.jfma.2026.04.084 Negative / Null Result ReportMedicine
Kerwin E, Dorinsky P, Patel M et al. · 2022 · The Journal of asthma : official journal of the Association for the Care of Asthma
Objective To evaluate the efficacy and safety of three doses of glycopyrrolate metered dose inhaler (GP MDI) in patients with uncontrolled asthma despite treatment with inhaled corticosteroid/long-acting β 2 -agonists (ICS/LABA) with or…
View details →DOI: 10.1080/02770903.2021.1938603 Replication FailureMedicine
Mirsharifi MS, Shirdel S, Ghaderi E et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)
OBJECTIVE: This study aimed to evaluate the effect of vitamin D supplementation on in vitro fertilization (IVF) outcomes in poor responder women with vitamin D deficiency, focusing on fertilization rates, oocyte quality, and pregnancy…
View details →DOI: 10.1007/s43032-025-02022-2 