A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
459 results in Negative / Null Result Report for "randomized controlled trial" · page 10 of 16
Sasidharan S, Philips CA, Philips CA et al. · 2026 · Hepatology communications
Background Fatigue affects 60%-80% of patients with cirrhosis, yet no universally effective pharmacologic therapy exists. Taurine, an amino sulfonic acid with antioxidant and membrane-stabilizing properties, may address metabolic…
Martineau AR · 2026 · Current opinion in infectious diseases
Purpose of review This review summarizes findings of recent Phase 3 randomized controlled trials (RCTs) and meta-analyses investigating effectiveness of vitamin D supplementation for prevention and treatment of tuberculosis or acute…
Wang Y, Sha S, Gwenzi T et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)
Background & aims Vitamin D insufficiency and deficiency are common worldwide and linked to adverse health outcomes, including higher all-cause mortality. Two large randomized controlled trials (VITAL and D-Health), conducted in mostly…
Vinceti M, Vicentini M, Ottone M et al. · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Background Consistent evidence from randomized controlled trials has shown that overexposure to selenium induces type 2 diabetes. However, uncertainties remain about the specific species and doses of selenium that trigger such diabetogenic…
Hornsby G, Pu C, Badamikar A et al. · 2025 · Preprint
ABSTRACT Introduction While improving water, sanitation, and hygiene (WASH) service delivery in schools supports the Sustainable Development Goals, rigorous trials have recently reported inconsistent effects of WASH in schools (WinS)…
Harding JF, Walzer J, Piatt R et al. · 2025 · Contraception
Objectives It is important to identify programs that can work in multiple contexts to support adolescent parents in achieving their reproductive health goals. A randomized controlled trial in Ohio in 2012 found that the Teen Options to…
Suberry A, Okun S, Ayalon L · 2026 · The Gerontologist
Background and objectives Ageism often emerges in childhood, yet rigorously evaluated school-based interventions-especially in multicultural settings-are scarce. The study evaluated the efficacy of a 90-min educational intervention to…
Watkins K, Ladabaum U, Olsen E et al. · 2024 · iGIE : innovation, investigation and insights
Background and aims The progress of artificial intelligence (AI) in endoscopy is at a crossroads. The positive results of randomized controlled trials of computer-aided detection (CADe) have not been replicated in multiple pragmatic CADe…
Zevallos-Morales A, Romani-Huacani E, Psoter KJ et al. · 2025 · Frontiers in public health
Background Peru has one of the highest burdens of asthma in the world, as well as large gaps in access to evidence-based treatments. Studies often overlook the ways in which the research context and data collection activities interact and…
Kracht CL, Falkenhain K, Flanagan EW et al. · 2026 · JMIR mental health
Background Household chaos is an emerging risk factor for childhood obesity development, especially in families with lower socioeconomic status (SES). It is unclear if changes in household chaos, especially in pregnancy, may mediate the…
Lee GJ, Morrell HER, Adams M et al. · 2026 · The journal of nutrition, health & aging
Background With the rising incidence of neurodegenerative diseases and aging of the global population, it is important to investigate foods that may preserve cognitive function with advancing years. Avocados are rich in fiber, carotenoids,…
Nicolaou L, Reuland CJ, Yang M et al. · 2026 · Lancet regional health. Americas
Background Household air pollution (HAP) is a major global health risk. Observational studies link HAP exposure to impaired child growth, but randomized controlled trial (RCT) evidence is inconsistent. Methods We followed children born…
Li S, Mahr C, Kataria R et al. · 2026 · JACC. Advances
Background Landmark randomized controlled trials like DanGer Shock, IABP-SHOCK II, and ECLS-SHOCK guide infarct-related cardiogenic shock (CS) management with temporary mechanical circulatory support (tMCS), but strict enrollment criteria…
Terpstra JA, van Beugen S, van der Vaart R et al. · 2026 · Internet interventions
Background Rheumatic and musculoskeletal diseases have a high burden. We aimed to evaluate the effectiveness of a therapist-guided internet-based cognitive-behavioral therapy (iCBT) on pain coping and secondary physical, psychological, and…
Wilkie DJ, Yao Y, Ezenwa MO et al. · 2020 · Journal of pain and symptom management
Context Unrelieved cancer pain at the end of life interferes with achieving patient-centered goals. Objective To compare effects of usual hospice care and PAINRelieveIt® on pain outcomes in patients and their lay caregivers. Methods In a…
Witzel S, Statland JM, Steinacker P et al. · 2024 · European journal of neurology
Background and purpose Rasagiline might be disease modifying in patients with amyotrophic lateral sclerosis (ALS). The aim was to evaluate the effect of rasagiline 2 mg/day on neurofilament light chain (NfL), a prognostic biomarker in ALS.…
Shepard S, Anderson JM, Heigle B et al. · 2023 · Journal of orthopaedic surgery and research
Purpose To our knowledge, no study has quantified the rate of discontinuation and nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity fractures. Methods We searched ClinicalTrials.gov on September 9th,…
Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine
Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…
Sanderson C, Hardy J, Spruyt O et al. · 2013 · Journal of pain and symptom management
Placebo and nocebo effects are known to contribute significantly to the response to symptom control, including analgesia. Clinical trial methodologies using placebo controls are designed to identify the magnitude of these effects in the…
Kleckner AS, Zhou Y, Diaz-Mercado Y et al. · 2026 · Chronobiology international
Circadian rest-activity rhythms, or a person's consistency in their daily activity and rest patterns, can be quantified using various parametric and non-parametric methods. However, these methods are seldom applied to understand symptoms…
Bhattacharjee B, Ghosh S, Basu N et al. · 2026 · Journal of integrative and complementary medicine
Objectives To assess the feasibility of conducting a randomized controlled trial and to explore preliminary effects of individualized homoeopathic medicines (IHMs) compared with placebo in patients with temporomandibular joint dysfunction…
Kultanaruangnonth M, Chatrung L, Tansawet A et al. · 2026 · World journal of emergency surgery : WJES
Background Surgical site infections (SSIs) remain a major concern after abdominal surgery, with incidences of 15-22%. Intraoperative wound irrigation (IOWI) before closure is routinely performed to reduce bacterial contamination, but the…
Arslan Çarpar K, Yılmaz T · 2026 · BMC oral health
BACKGROUND: This study aimed to compare the plaque removal efficacy of manual and powered toothbrushes around attachments in patients undergoing clear aligner therapy under standardized, single-brushing conditions. METHODS: This…
Agarwal P, Kumar P, Chugh VK et al. · 2026 · Cureus
Background and aim Postoperative pain following root canal treatment (RCT) can be influenced by the obturation technique, as variations in apical sealing and material extrusion may affect periapical tissue response. The aim of this study…
Soenarti S, Sitorus S, Nugroho MB et al. · 2026 · Rehabilitacion
Sarcopenia represents a leading cause of functional decline in older adults. This randomized controlled trial examined whether the addition of ankle weights to a Nordic walking protocol yields superior outcomes compared with standard…
Lewis MN, Feola N, Watson K et al. · 2025 · PRiMER (Leawood, Kan.)
Introduction Poster displays are commonly used to present scholarly activity. Most current research evaluates posters' visual appeal. Isolated studies looking at knowledge transfer have evaluated standalone posters. The innovation of…
McKay NJ, Horvatits EJ, Jean M et al. · 2024 · Physiology & behavior
It is well known that a large portion of the population elevates their intake of high energy-dense foods during times of stress; however, it is understudied whether stress affects the reinforcing value of a food reward. Further knowledge…
Kazemipour S, Yamin JB, Moore D et al. · 2026 · Pain reports
Introduction More than three-fourths of people with fibromyalgia complain of cognitive difficulties, including memory and attention problems, which result in impaired job performance and disability. Cognitive behavioral therapy (CBT) is…
Siengsukon CF, Hand LK, Nelson E et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction Insomnia is associated with increased risk for Alzheimer's disease (AD). It is unknown how cognitive behavioral therapy for insomnia (CBT-I) impacts two hallmarks of AD progression, cognitive performance and beta-amyloid (Aβ)…
Renwick JRM, Preobrazenski N, Giudice MD et al. · 2024 · International journal of exercise science
The purpose of the current study was to test the hypothesis that individual response classification for surrogate markers of cardiorespiratory fitness (CRF) will agree with response classification for VO 2peak . Surrogate markers of CRF…