20,201 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Cecilia Elam, Per Aagaard, Frode Slinde et al. · 2021 · Journal of Physical Therapy Science
[Purpose] To examine the effects of age and gender in an ageing population with respect to functional decline and the relationship between muscle power and functional capacity. [Participants and Methods] The cohort (N=154) was subdivided…
View details →Tong He, Ru Kong, Avram J. Holmes et al. · 2018
In recent years, deep learning has transformed the field of machine learning. In the field of neuroimaging, there are increasing interests in adopting deep learning techniques. However, deep neural networks (DNNs) usually need large…
View details →Wouter M. IJgosse, Harry van Goor, Camiel Rosman et al. · 2020 · JMIR Serious Games
Background Surgical residents underutilize opportunities for traditional laparoscopic simulation training. Serious gaming may increase residents’ motivation to practice laparoscopic skills. However, little is known about the effectiveness of serious gaming for laparoscopic skills training. Objective The aim of this study was to establish construct validity for the laparoscopic serious game Underground. Methods All study participants completed 2 levels of Underground. Performance for 2 novel variables (time and error) was compared between novices (n=65, prior experience <10 laparoscopic proc
View details →Nour El Din El Sheikh, Esteban Paz, Juan Pinto et al. · 2021
The blocking performance of a heuristic and a deep reinforcement learning approach for resource provisioning in a dynamic multi-band elastic optical network is evaluated. The heuristic is based on a previous proposal that prioritises the…
View details →Shahar Shelly, Pritikanta Paul, Hong‐Yan Bi et al. · 2020 · Neurology
OBJECTIVE: To improve myasthenia gravis (MG) autoantibody testing. METHODS: MG serologic tests with confirmatory or refuting clinical-electrodiagnostic (EDX) testing and cancer evaluations were reviewed over 4 years (2012-2015). All…
View details →D. Beaujean, Fedor Gassner, A Wong et al. · 2016 · BMC Public Health
BACKGROUND: Lyme disease or Lyme borreliosis (LB) is the most common tick-borne disease both in the United States and Europe. Children, in particular, are at high risk of contracting LB. Since child-specific educational tools on ticks, tick bites and LB are lacking, we developed an online educational video game. In this study, we compared the effectiveness of an online educational video game versus a newly developed leaflet aimed to improve prevention of tick bites and LB among Dutch schoolchildren. METHODS: A total of 887 children, aged 9-13 years and attending the two final years of primary
View details →Natalie L. Wilver, Jesse R. Cougle · 2018 · Journal of Consulting and Clinical Psychology
OBJECTIVE: The current study extended upon previous research efforts by evaluating the utility and feasibility of an 8-session Internet-based interpretation bias modification (IBM) training protocol targeting evaluation- and…
View details →Patrick J. McIntyre, Sharon Y. Strauss · 2017 · Evolution
The geographic distributions of polyploids suggest they can have distinct and sometimes broader niches compared to diploids. However, relatively few field experiments have investigated whether range differences are associated with local…
View details →Troels Yndigegn, Bertil Lindahl, Joakim Alfredsson et al. · 2022 · European Heart Journal - Cardiovascular Pharmacotherapy
AIMS: Most trials showing benefit of beta-blocker treatment after myocardial infarction (MI) included patients with large MIs and are from an era before modern biomarker-based MI diagnosis and reperfusion treatment. The aim of the…
View details →Maria L.V. Dizon, Rakesh Rao, Shannon E. G. Hamrick et al. · 2019 · BMC Pediatrics
BACKGROUND: While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systematically evaluated. This is important as these centers typically have multidisciplinary neonatal neurocritical care teams and protocolized approaches to treating conditions such as hypoxic ischemic encephalopathy (HIE), a population at high risk for neonatal seizures. To identify opportunities for quality improvement (QI), we evaluated ICV in AED utilization for neonates with H
View details →Bisakha Sen, Justin Blackburn, Michael A. Morrisey et al. · 2012 · Health Services Research
Objective To explore whether health care utilization changed among enrollees in Alabama's CHIP program, ALL Kids, following copayment increases at the beginning of fiscal year 2004. Data Sources Data on all ALL Kids enrollees over…
View details →Andreas Carus, Howard Gurney, Val Gebski et al. · 2013 · Journal of Translational Medicine
Chronic inflammation has been recognized to foster tumour development. Whether chemotherapy can be used to neutralize chronic inflammation is unclear. We evaluated baseline and nadir neutrophils in 111 patients (pts.) with non-small cell lung cancer (NSCLC) and 118 pts. with ovarian cancer (OC) treated with chemotherapy administered with dose-individualization to achieve nadir neutropenia of 1.5. We used predefined baseline neutrophil cut-offs 4.5 × 109/L (NSCLC) and 3.9 × 109/L (OC). Absence of chemotherapy-induced nadir neutropenia (CTCAE grade 0, neutrophils ≥ LLN) was seen in 23% of OC and
View details →Irene Mosca, Bláithín Ní Bhuachalla, Rose Anne Kenny · 2013 · BMC Cardiovascular Disorders
BACKGROUND: To assess prevalence rates of subjective and objective reports of two cardiovascular disorders (hypertension and hypercholesterolemia) for the same subset of respondents in a large-scale study. To determine whether and the extent to which the socioeconomic health gradient differed in the subjective and objective reports of the two cardiovascular disorders. METHODS: Data from the first wave (2009/2011) of The Irish Longitudinal Study on Ageing were used (n = 4,179). This is a nationally representative study of community-dwelling adults aged 50+ residing in Ireland. Subjective measur
View details →Natalie Kashefi, Jonathan I. Nathan, Sharmila Dissanaike · 2014 · Plastic & Reconstructive Surgery Global Open
BACKGROUND: Smoke inhalation is a major source of morbidity and mortality. Heparin and N-acetylcysteine treatment has potential efficacy in inhalation injury. We investigated the impact of a heparin/N-acetylcysteine/albuterol nebulization…
View details →Fang He, Huai‐Qiang Ju, Yi Ding et al. · 2020 · British Journal of Cancer
BACKGROUND: For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS: The pCR individuals who received different ACT cycles were paired by propensity score matching. Overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were calculated by Kaplan-Meier and log-rank test. RESULTS: In total, 1041 pCR individuals were identified from 5567 LARC cases.
View details →Weikun Li, Murat Yalçın, Dhruba J. Bharali et al. · 2019 · Scientific Reports
Abstract The anti-angiogenic agent, diamino propane tetraiodothyroacetic acid (DAT), is a thyro-integrin (integrin αvβ3) antagonist anticancer agent that works via genetic and nongenetic actions. Tetraiodothyroacetic acid (tetrac) and DAT as thyroid hormone derivatives influence gene expression after they transport across cellular membranes. To restrict the action of DAT to the integrin αvβ3 receptors on the cell surface, we used DAT-conjugated PLGA nanoparticles (NDAT) in an active targeting mode to bind to these receptors. Preparation and characterization of NDAT is described, and both in vi
View details →Nilgün Mendil, Şahin Temel, Recep Civan Yüksel et al. · 2021 · TURKISH JOURNAL OF MEDICAL SCIENCES
Background/aim: High flow nasal cannula (HFNC) was mostly used in intensive care units (ICUs) with few studies in other departments. We hypothesized that HFNC applied at wards is beneficial for acute respiratory failure in hematological malignancy patients. Materials and methods: The study is a single center, randomized controlled study. Inclusion criteria were hypoxemic respiratory failure and hematological malignancy. Patients were randomized to either venturi mask/nasal cannula oxygen treatment or HFNC. Results: One hundred patients were included in the study. Median age was 58.5 (18–86) ye
View details →Leon Deutsch, Damjan Osredkar, Janez Plavec et al. · 2021 · Metabolites
Spinal muscular atrophy (SMA) is a genetically heterogeneous group of rare neuromuscular diseases and was until recently the most common genetic cause of death in children. The effects of 2-month nusinersen therapy on urine, serum, and…
View details →Rune Strand Ødegård, Atle Nesje, Ketil Isaksen et al. · 2017 · The Cryosphere
Abstract. Despite numerous spectacular archaeological discoveries worldwide related to melting ice patches and the emerging field of glacial archaeology, governing processes related to ice patch development during the Holocene and their…
View details →Austin Clyde, Xuefeng Liu, Thomas Brettin et al. · 2023 · Scientific Reports
Abstract Protein-ligand docking is a computational method for identifying drug leads. The method is capable of narrowing a vast library of compounds down to a tractable size for downstream simulation or experimental testing and is widely…
View details →Verônica Belchior, Bruno G. Botelho, Adriana S. Franca · 2022 · Foods
The Specialty Coffee Association (SCA) sensory analysis protocol is the methodology that is used to classify specialty coffees. However, because the sensory analysis is sensitive to the taster’s training, cognitive psychology, and…
View details →Þórunn Rafnar, Patrick Sulem, Søren Besenbacher et al. · 2011 · Cancer Research
Genome-wide association studies (GWAS) have identified 3 genomic regions, at 15q24-25.1, 5p15.33, and 6p21.33, which associate with the risk of lung cancer. Large meta-analyses of GWA data have failed to find additional associations of…
View details →Jan G. Voelkel, Mark J. Brandt, Matteo Colombo · 2018 · Comprehensive Results in Social Psychology
People are prejudiced toward groups they perceive as having a worldview dissimilar from their own. This link between perceived attitudinal dissimilarity and prejudice is so stable that it has been described as a psychological law. The current research tests whether reducing people’s (over-)confidence in their own understanding of policies by puncturing their illusion of explanatory depth in the political domain will reduce the link between perceived attitudinal dissimilarity and prejudice. In an initial pre-registered experiment (N = 296), we did not find support for our hypothesis, but explor
View details →Amy Armstrong, Fleur Coburn, Yanyamba Nsereko et al. · 2025 · Journal of Peptide Science
Peptide-drug conjugates (PDCs) are advancing as targeted cancer therapies, leveraging lessons from antibody-drug conjugates (ADCs) to improve tumour specificity. These molecules combine a homing peptide with a cytotoxic payload via a linker, enabling precise drug delivery while sparing healthy tissue. Despite their potential, PDCs face challenges including metabolic instability, premature payload release and rapid clearance, limiting clinical success. Only Lutathera remains FDA-approved after Pepaxto's withdrawal, though Pepaxto retains EMA and MHRA approval-highlighting regulatory and technic
View details →Hilmar Zech, Philip A. Gable, W. van Dijk et al. · 2022 · Behavior Research Methods
The approach-avoidance task (AAT) is an implicit task that measures people's behavioral tendencies to approach or avoid stimuli in the environment. In recent years, it has been used successfully to help explain a variety of health problems (e.g., addictions and phobias). Unfortunately, more recent AAT studies have failed to replicate earlier promising findings. One explanation for these replication failures could be that the AAT does not reliably measure approach-avoidance tendencies. Here, we first review existing literature on the reliability of various versions of the AAT. Next, we examine
View details →Dae-Sang Lee, Mi Yeon Lee, Chi-Min Park et al. · 2018 · PLoS ONE
Delirium is a common complication of vascular surgery. The protective effect of preoperative statins on delirium after vascular surgery is controversial. The authors hypothesized that preoperative statin administration would decrease the incidence of delirium after vascular surgery. From May 2010 to May 2015, 1,132 patients underwent vascular surgery. Postoperative delirium was diagnosed from patients' medical records. The incidence of delirium was 11.5%. The preoperative statin exposure was not associated with reduced delirium in the univariate analysis. After adjusting for covariates, preope
View details →Markus Orsi, Jean-Louis Reymond · 2024 · Journal of Cheminformatics
Abstract Molecular fingerprints are indispensable tools in cheminformatics. However, stereochemistry is generally not considered, which is problematic for large molecules which are almost all chiral. Herein we report MAP4C, a chiral…
View details →Jacob Guinot, Sandra Miralles, Alma Rodríguez-Sánchez et al. · 2020 · Employee Relations: The International Journal
Purpose Based on a new management paradigm rooted on care and compassion, this study explores the consequences of compassion at work on organizational learning and firm performance. Design/methodology/approach Structural equation modeling…
View details →Takudzwa C. Madzivanzira, Josie South, Olaf L. F. Weyl · 2021 · Freshwater Biology
Abstract Data on ecological impacts of freshwater crayfish invasions in Africa are scarce but invasion history suggests the likelihood of negative implications for biodiversity. To evaluate the potential for ecological impacts we describe…
View details →Talia Gonda, Frank P Deane, Ganapathi Murugesan · 2012 · Australian & New Zealand Journal of Psychiatry
Objective: The first aim of this study was to assess the proportion of patients who achieved reliable and clinically significant change over the course of treatment in an inpatient psychosocial rehabilitation program. The second aim was to…
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