Negative / Null Result ReportOpen accessMedicine
Tao Li, Xiaodong Zhou, Zhi Wang et al. · 2016 · PLoS ONE
To evaluate retinal thickness (RT), retinal volume (RV) and choroidal thickness (ChT) in Chinese children using Cirrus-HD optical coherence tomography (OCT), and assess their associations with spherical equivalent (SE), age and gender.This was a prospective study that recruited 193 healthy Chinese children (193 eyes) with no ophthalmic disease history between December 2012 and December 2013. RT and RV were acquired using OCT. Subfoveal ChT (SFCT) and ChT1-mm and 2-mm temporal, nasal, superior and inferior to the fovea were measured manually.RT in the inner temporal and nasal regionsdiffered si
View details →Negative / Null Result ReportOpen accessMicrobiology
Mamta Soni, Supraja Sundaram, Sindhuja Kesavan · 2021 · National Journal of Laboratory Medicine
Introduction: Haemophagocytic Lymphohistiocytosis (HLH) is a rapidly progressive life threatening condition in which activated macrophages engulf haematopoietic cells. HLH is often overlooked because of its rarity and lack of awareness of this prevailing condition. Though previously attempts have been made to quantify hemophagocytes in marrow aspirates, to the best of present knowledge, none of the studies have correlated the number of hemophagocytes with the clinical outcomes of the patients. Aim: To study the role of laboratory parameters and number of hemophagocytes detected in bone marrow
View details →Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Paula Melariri, Chioma Ihemanma, Udoka Chigbo et al. · 2024 · Journal of Parasitology Research
Malaria presents a huge threat to pregnant women, their foetus, and children below five years. This study is aimed at assessing malaria prevalence, associated clinical symptoms, and urine abnormalities among pregnant women in Aba metropolis, Abia State, Nigeria. A cross-sectional study involving 450 pregnant women purposively selected from nine health care centres was conducted. Data were analysed using SPSS version 26. The overall malaria prevalence rate was 68.4% (n=308). Age group of 21-25 years had the highest prevalence rate of 20.4% (n=92) while the least was recorded among the age group
View details →Negative / Null Result ReportOpen accessOphthalmology
Neoh Yee Ling, Tan Ee Ling, Syed Mudassar Imran Bukhari et al. · 2015 · Journal of Clinical Ophthalmology and Research
Introduction: Systemic diseases such as hypertension and diabetes mellitus (DM) have been identified as the risk factor for glaucoma. However, there is minimal knowledge on the impact of systemic diseases on severity of glaucoma. This study aimed to determine the association between systemic disease and systemic treatment and severity of glaucoma. Materials and Methods: A cross-sectional study was conducted involving 298 primary open-angle glaucoma (POAG; 169 high tension glaucoma (HTG) and 129 normal tension glaucoma (NTG)) patients presented at the eye clinic of two tertiary hospitals in Mal
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Jian Sun, Zhiyong Shi, Lebao Yu et al. · 2022 · BMC Neurology
Abstract Objective To explore potential risk factors of preoperative cognitive dysfunction in adult patients with moyamoya disease (MMD) and discuss significance of moyamoya vessels. Methods The author reviewed adult MMD patients harboring no parenchymal infarction or hemorrhage underwent a standardized neuropsychological assessment test battery from December 2018 to May 2019. The authors defined patients with cognitive dysfunction as cognitive impairment shown on 3 or more neuropsychological tests. According to the presence of cerebral angiography, arterial stenosis, moyamoya vessels, and com
View details →Negative / Null Result ReportOpen accessNursing
Parul Sharma, Bindu Shaiju, Jahanara Rahman et al. · 2024 · Indian Journal of Psychiatric Nursing
Introduction: Nurses make up the largest group of health-care workers, so it is important to rule out compassion fatigue (CF) and compassion satisfaction among nursing officers. Methodology: A descriptive study was adopted, and purposive sampling technique was used. The present study’s sample included 134 nursing officers. The data were gathered in January 2022 using the Structured CF Scale and the Structured Compassion Satisfaction Scale. The data were analyzed using descriptive and inferential statistics. Results: The findings of the research revealed that the majority of the nursing officer
View details →Negative / Null Result ReportOpen accessMedicine (General)
Katarzyna Budzynska, Daniel Passerman, Denise White-Perkins et al. · 2018 · BMC Family Practice
Abstract Background Colorectal cancer (CRC) develops from colorectal adenomatous polyps. This study is to determine if diabetes mellitus (DM), its treatment, and hemoglobin A1c (HbA1c) level are associated with increased risk of colorectal adenomatous polyps. Methods This was a retrospective cohort study that included patients who had at least one colonoscopy and were continuously enrolled in a single managed care organization during a 10-year period (2002–2012). Of these patients (N = 11,933), 1800 were randomly selected for chart review to examine the details of colonoscopy and pathology fin
View details →Negative / Null Result ReportOpen accessPsychiatry
U. Raja, A. Misra, N. Kar · 2024 · European Psychiatry
Introduction The Crisis and Home Treatment Teams (CRHT) in psychiatry manages patients with risk to self and others in the community. The number of patents under CRHT who attempt or die of suicide is high in the UK (Hunt et al BJPsych Bull. 2016;40:172-4). The CRHT is an option to help support patients in managing their risk using various interventions and also aim to prevent admission to acute psychiatric wards where possible. Objectives We intended to study the change in risk to self and others and the factors associated with it during the intervention from a CRHT taking care of adult patien
View details →Negative / Null Result ReportOpen accessMedicine
Hoda Shamsaddin, Fatemeh Jahanimoghadam, Hamidreza Poureslami et al. · 2017 · Journal of Oral Health and Oral Epidemiology
BACKGROUND AND AIM: Early childhood caries (ECC) is a specific form of rampant dental caries affecting infants and young children. ECC is still a problem that threatens the health of the community and its management is important. It is believed that the majorities of children with ECC also suffer from malnutrition, anemia, low weight and altered physical growth patterns. This study was undertaken to compare blood indices [mean corpuscular volume (MCV), hemoglobin and serum ferritin] in a population of children in Kerman, Iran, and the association between growth factors, blood parameters, and E
View details →Negative / Null Result ReportOpen accessMedicine
Yousef Roosta, Ahmad Nazarpour, Farhad Behzadi et al. · 2025 · Disease and Diagnosis
Background: The number of individuals undergoing dialysis is rising. Impaired renal function has been linked to a heightened risk of cancer. This study aimed to examine cancer incidence among hemodialysis (HD) patients. Materials and Methods: This retrospective cross-sectional study analyzed the medical records of individuals with newly diagnosed end-stage renal disease (ESRD) who initiated HD sessions between July 2018 and December 2023 at Urmia Imam Khomeini hospital. The data collected for this study included patient demographics, underlying diseases, malignancy status, and duration of mali
View details →Negative / Null Result ReportOpen accessOrthopedic surgery
Koichiro Yanai, MD, Tsuyoshi Tajika, MD, PhD, Yuhei Hatori, MD et al. · 2025 · JSES International
Background: An increase in carrying angle (CA) on the throwing side has been reported in professional baseball pitchers. However, no reports have investigated high school baseball pitchers, and the associated factors remain unknown. This study aimed to examine the difference in the CA between the throwing and nonthrowing sides in high school baseball pitchers and to investigate the association between the CA and medial instability of the elbow and general joint laxity (GJL). Methods: We surveyed 216 high school baseball pitchers who underwent medical checkups during the 2023-24 off-season. All
View details →Negative / Null Result ReportOpen accessMedicine (General)
Shichong Jia, Xuyang Wen, Min Zhou et al. · 2021 · Frontiers in Medicine
Purpose: To evaluate the efficacy of an external carotid artery (ECA) alternative route in intra-arterial chemotherapy (IAC) for treatment of retinoblastoma.Methods: In this retrospective, single-centre, case-control study, 98 retinoblastoma patients who received successful IAC were included. The drug delivery routes were the primary ophthalmic artery (OA) route and the ECA route when OA catheterization was not feasible.Results: A total of 337 successful IAC procedures were performed in our study, of which 32 (9.5%) procedures were performed through the ECA route. Eighteen eyes (18.4%) accepte
View details →Negative / Null Result ReportOpen accessMedicine
Arno C Hessels, Abraham Rutgers, Jan Stephan F Sanders et al. · 2018 · PLoS ONE
Azathioprine is a widely used immunosuppressive drug. Genetic polymorphisms and activity of the enzyme thiopurine methyltransferase (TPMT) have been associated with azathioprine efficacy and toxicity in several populations. We investigated whether these associations also exist for ANCA associated vasculitis (AAV) patients, who receive azathioprine maintenance therapy after remission induction with cyclophosphamide.207 AAV patients treated with cyclophosphamide induction and azathioprine maintenance therapy were included and followed for 60 months. TPMT genotype and tertiles of TPMT activity we
View details →Negative / Null Result ReportOpen accessMedicine (General)
Almansour A, Alagil J, Alamoudi NB et al. · 2022 · Journal of Multidisciplinary Healthcare
Abdulelah Almansour,1 Jumana Alagil,2 Naela B Alamoudi,3 Rahmah M Alamrie,3 Sundus Alarifi,4 Sarah AlUrifan,4 Abdullatif Althunyan,1 Abdullah Alghumlas,1 Abdullah Alreedy,1 Adam Aldhawyan,1 Shaher Alshehri,1 Arwa Alumran5 1Family and Community Medicine Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 3College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 4General Dentist, Ministry of Health, Dammam, Saudi Arabia; 5Health Information Man
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Ulrike Stentzel, Jeanette Bahr, Daniel Fredrich et al. · 2018 · BMC Health Services Research
Abstract Background In rural regions with a low population density, distances to health care providers as well as insufficient public transport may be barriers for the accessibility of health care. In this analysis it was examined whether the accessibility of gynecologists and GPs, measured as travel time both by car and public transport has an influence on the utilization of health care in the rural region of Western Pomerania in Northern Germany. Methods Utilization data was obtained from the population based Study of Health in Pomerania (SHIP). Utilization was operationalized by the paramet
View details →Negative / Null Result ReportOpen accessMedicine
Shanshan Shi, Xiuchun Zhang, M Alejandra Mandel et al. · 2017 · PLoS ONE
Cassava (Manihot esculenta) is an important tropical subsistence crop that is severely affected by cassava brown streak disease (CBSD) in East Africa. The disease is caused by Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV). Both have a (+)-sense single-stranded RNA genome with a 5' covalently-linked viral protein, which functionally resembles the cap structure of mRNA, binds to eukaryotic translation initiation factor 4E (eIF4E) or its analogues, and then enable the translation of viral genomic RNA in host cells. To characterize cassava eIF4Es and their potent
View details →Negative / Null Result ReportOpen accessDentistry
Ramtin Azar, Hassan Semyari, Mohamad Javad Kharazifard · 2020 · Frontiers in Dentistry
Objectives: This study aimed to compare the oral health related quality of life (OHRQoL) of patients using conventional dentures versus implant-supported overdentures. Materials and Methods: This study evaluated the OHRQoL of 90 patients between 35 to 75 years who were selected from several public and private dental clinics in Tehran in 2018. Of all, 45 had conventional dentures of both jaws, and 45 had a mandibular overdenture supported by two implants at the site of mandibular canine teeth and a conventional maxillary denture. The OHRQoL of patients was determined using the Oral Health Impac
View details →Negative / Null Result ReportOpen accessMedicine
Linh Tran, Jeah Jung, Roger Feldman et al. · 2022 · PLoS ONE
Purpose Chronic hepatitis C virus (HCV) infection is an important public health concern. Limited information exists on disparities in the quality of HCV care. We examine disparities in genotype or quantitative HCV ribonucleic acid testing before and after starting HCV treatment, and screening for hepatocellular carcinoma (HCC) in HCV patients with cirrhosis. Methods This national study included Medicare beneficiaries with HCV between 2014 and 2017. We used bivariate probit to estimate the probability of receiving recommended tests before and after HCV treatment by patient race/ethnicity, urban
View details →Negative / Null Result ReportOpen accessMedicine
F. E. Kocak, M. Yöntem, Ö. Yücel et al. · 2013 · Biochemia Medica
Introduction: Today, the pneumatic tube transport system (PTS) is used frequently because of its advantages related to timing and speed. However, the impact of various types of PTS on blood components is unknown. The aim of this study was…
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Priyadharshini Mohan, Karthika Priyadharshini Udayakumar, Hiramath PB · 2020 · National Journal of Physiology, Pharmacy and Pharmacology
Back ground: In addition to the imbalance in the cardiac autonomic function, deficiency of micronutrients such as zinc (Zn), magnesium, and copper (Cu) was also found to be one of the cause of hypertensive disorders of pregnancy. Although there are number of studies done to know the autonomic balance and serum trace elements among preeclamptic women, none of the studies were done among the gestational hypertensives, hence, we have chosen this study on association between the level of micronutrients and frequency domain parameters of heart rate variability (HRV) among newly diagnosed gestationa
View details →Negative / Null Result ReportOpen accessEnvironmental sciences
Bouziani Amina, Benkirane Hasnae, Idrissi Mohamed et al. · 2021 · E3S Web of Conferences
In addition to age, gender, body weight, hormonal status as well as certain physiological and pathological states, other factors exert considerable effects on calcium (Ca) retention and therefore on its urinary excretion. Among these other factors, many dietary nutrients have all been discussed as factors affecting urinary Ca through different studies. Thus, our study aims to evaluate the impact of various nutritional factors on urinary Ca excretion among a sample of Moroccan children and adolescents aged from 6 to 18 years old. A total of 133 Moroccan children and adolescents aged between 6 a
View details →Negative / Null Result ReportOpen accessDentistry
Ziyao Han, Cui Wang, Yiping Wei et al. · 2022 · BMC Oral Health
Abstract Background Assessment of the keratinized mucosa width (KMW) at edentulous sites is important for the subsequent implant treatment design. This pilot study aimed to evaluate the characteristics of the KMW at edentulous molar sites and explore the associated factors. Methods A total of 150 patients with 222 edentulous molar sites were included. The buccal KMW of the edentulous molar sites was measured during implant treatment planning. Potentially associated factors, including age, sex, smoking status, location, reasons for tooth loss/extraction, gingival phenotype (GP) and keratinized
View details →Negative / Null Result ReportOpen accessMedicine
Rajalakshmi R., Chinnappa A. Uthaiah, Ramya C. M. et al. · 2022 · PLoS ONE
Background Disorders of mental health are known to affect cognitive functions, hence called as cognitive disorders. Impaired glucose metabolism, insulin resistance, vitamin-D deficiency and oxidative stress are some of the key early events reported to be involved in the pathogenesis of most common cognitive disorders, which include Alzheimer’s disease. Type-2 diabetes mellitus (T2DM) is one of the known contributing factors of cognitive impairment and dementia. Methods A cross sectional study was carried out in 145 subjects, who were assessed for cognitive function by modified mini mental stat
View details →Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Bertrand Pavlovsky, Christophe Desprez, Jean-Christophe Richard et al. · 2024 · Annals of Intensive Care
Abstract Background Various Positive End-Expiratory Pressure (PEEP) titration strategies have been proposed to optimize ventilation in patients with acute respiratory distress syndrome (ARDS). We aimed to compare PEEP titration strategies based on electrical impedance tomography (EIT) to methods derived from respiratory system mechanics with or without esophageal pressure measurements, in terms of PEEP levels and association with recruitability. Methods Nineteen patients with ARDS were enrolled. Recruitability was assessed by the estimated Recruitment-to-Inflation ratio (R/Iest) between PEEP 1
View details →Negative / Null Result ReportOpen accessGenetics
Yun-Hsuan Chang, Yun-Hsuan Chang, Yun-Hsuan Chang et al. · 2018 · Frontiers in Genetics
Studies suggest that a functional polymorphism of brain-derived neurotrophic factor (BDNF), polymorphism BDNF Val66Met affects cognitive functions, however, the effect is unclear in bipolar II (BD-II) disorder. We used the Wechsler Memory Scale-third edition (WMS-III), the presence of the BDNF Val66Met polymorphism, and plasma concentrations of BDNF to investigate the association between memory impairment and BDNF in BD-II disorder. We assessed the memory functions of 228 BD-II patients and 135 healthy controls (HCs). BD-II patients had significantly lower scores on five of the eight WMS-III s
View details →Negative / Null Result Report
Yucel Kilic, Müzeyyen Aslaner Ak · 2025 · Ağrı Tıp Fakültesi Dergisi
Aim: The studies show that dyslipidemia may pose a risk factor for the emergence of malignancies. The study evaluates the lipid parameters of patients diagnosed with hematologic malignancy during diagnosis, investigating their relationship…
View details →Negative / Null Result ReportOpen accessMedicine
Sigrid Børte, Bendik S Winsvold, Synne Øien Stensland et al. · 2017 · PLoS ONE
Background There is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults. Methods The population-based Nord-Trøndelag Health Study (HUNT 3) contained a validated headache questionnaire, which differentiated between migraine and tension-type headache. These data were linked to information on weight and gestational age at birth from the Norwegian Medical Birth Registry. In total 4557 females and 2
View details →Negative / Null Result ReportOpen accessInternal medicine
Katherine Rieke, Ramon Durazo-Arvizu, Kiang Liu et al. · 2014 · Journal of Obesity
Objective. To examine the association between anxiety and weight change in a multiethnic cohort followed for approximately 10 years. Methods. The study population consisted of participants of the multiethnic study of atherosclerosis who met specified inclusion criteria (n = 5,799). Weight was measured at baseline and four subsequent follow-up exams. Anxiety was analyzed as sex-specific anxiety quartiles (QANX). The relationship between anxiety level and weight change was examined using a mixed-effect model with weight as the dependent variable, anxiety and time as the independent variables, an
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Ganeshgouda Majigoudra, Ashish K Duggal, Debashish Chowdhury et al. · 2023 · Annals of Indian Academy of Neurology
Background: Myasthenia Gravis (MG) is a chronic fluctuating illness, due to the dysfunction of neuromuscular junction which is autoimmune in nature. The disease severely affects the Quality Of Life (QOL). Objective: The primary objective of our study was to assess the QOL in patients with MG using Short Form 36 (SF 36) and MGQOL 15 R (Hindi translated).The secondary objective was to assess the correlation of age, sex, illness duration, clinical characteristics, severity, and treatment with the QOL in MG patients. Methodology: A cross sectional study of 55 MG patients was done to analyse and ev
View details →Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
adel abd elhaleim hagag · 2015 · Mediterranean Journal of Hematology and Infectious Diseases
Abstract Background: Acute myeloid leukemia (AML) accounts for 25%-35% of the acute leukemia in children. BAALC (Brain and Acute Leukemia, Cytoplasmic gene) is a recently identified gene on chromosome 8q22.3 that has prognostic significance in AML. The aim of this work was to study the impact of BAALC gene expression on prognosis of AML in Egyptian children. Patients and methods: This study was conducted on 40 patients of newly diagnosed AML who were subjected to the following: Full history taking, clinical examination, laboratory investigations including: complete blood count, LDH, bone marro
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