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20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Lack of association between SLFN11 expression and treatment efficacy or survival outcomes in patients with pancreatic ductal adenocarcinoma.

Nakamura T, Hatanaka KC, Kawamoto Y et al. · 2025 · Journal of cancer research and clinical oncology

Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Despite the use of aggressive combination chemotherapy regimens, outcomes remain unsatisfactory. Schlafen family member 11 (SLFN11) has been reported to regulate the DNA…

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Negative / Null Result ReportMedicine

Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study.

Tabara Y, Shoji-Asahina A, Ogawa A et al. · 2024 · International journal of obesity (2005)

Background Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy…

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Negative / Null Result ReportOpen accessMedicine

Association of Hormone Replacement Therapy with Inflammatory Bowel Disease Risk in Women with Menopausal Disorders: A Population-Based Retrospective Cohort Study.

Tseng YT, Chen II, Wang CH · 2025 · Healthcare (Basel, Switzerland)

Background : The long-term effects of hormone replacement therapy (HRT) on inflammatory bowel disease (IBD) remain unclear, necessitating further investigations of the association between HRT and the development of ulcerative colitis and…

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Negative / Null Result ReportMedicine

Association between pregnancy intention and postpartum contraceptive interest among pregnant people with opioid use disorder.

Schiff DM, Wheeler A, Lewis D et al. · 2026 · Journal of substance use and addiction treatment

Objective Identify sociodemographic and substance use characteristics associated with pregnancy intention and explore the relationship between pregnancy intent and postpartum contraception interest among pregnant individuals with opioid…

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Negative / Null Result ReportOpen accessMedicine

Long-Term Impact of Orthodontic Treatment on Oral Behaviours, Temporomandibular Disorder-Related Pain, and Anxiety: An 18-Month Prospective Study.

Reda B, Zanon G, Contardo L et al. · 2025 · Orthodontics & craniofacial research

Objective Orthodontic treatment is a common approach for correcting malocclusion but is often associated with discomfort. The aim of this study was to assess the longitudinal changes in oral behaviours, temporomandibular disorder…

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Negative / Null Result ReportOpen accessMedicine

Blood omega-3 fatty acids and coronary artery stenosis: a postmortem study.

Randall B, Leković A, Nikolić S et al. · 2025 · Lipids in health and disease

The role of omega-3 fatty acids in the atherosclerotic process remains unclear. Early studies demonstrated a profound anti-atherogenic effect of cod liver oil in a pig model, and autopsy reports from Alaska Natives consuming omega-3 rich…

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Negative / Null Result ReportMedicine

Lack of Association of Initial Vasopressor Dosing with Survival and Cardiac Re-Arrest Likelihood After Return of Spontaneous Circulation.

Sharpe AR, Richardson K, Stanton M et al. · 2023 · The Journal of emergency medicine

Background Cardiac arrest occurs in approximately 350,000 patients outside the hospital and approximately 30,000 patients in the emergency department (ED) annually in the United States. When return of spontaneous circulation (ROSC) is…

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Negative / Null Result ReportMedicine

Coagulation factor XI in cirrhosis does not predict thrombo-hemorrhagic complications and hepatic decompensation.

Zanetto A, Campello E, Spiezia L et al. · 2024 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Introduction Factor XI (FXI) is associated with thrombosis in patients without liver disease, but it alterations and prognostic value in cirrhosis are uncertain. Patients and methods We studied a prospective cohort of cirrhosis patients…

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Negative / Null Result ReportOpen accessMedicine

Dietary Diversity Score and Its Sociodemographic Determinants in School-Aged Children: Cross-Sectional Baseline Findings From a Quasi-experimental Study.

Singh T, Kumar S, Sinha S et al. · 2025 · Cureus

Background Dietary diversity is an essential component of nutritional adequacy, particularly for school-aged children who are undergoing rapid physical and cognitive development. Inadequate dietary diversity can lead to micronutrient…

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Negative / Null Result ReportMedicine

Place of Death, Care Intensity, Symptom Prevalence, and Symptom Management for Patients With Stroke at End-of-Life.

Ramsburg H, Hinkle JL, MacKenzie Greenle M · 2026 · The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses

Background Each year in the United States, 795,000 people are diagnosed with a new or recurrent stroke, resulting in 165,393 deaths. However, little is known about the quality of end-of-life (EOL) care in this population, including the…

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Negative / Null Result ReportMedicine

Intrapartum Glycemic Control and Clinical Outcomes.

Bitar G, Fishel Bartal M · 2025 · Diabetes spectrum : a publication of the American Diabetes Association

Current recommendations encourage strict intrapartum glycemic control for individuals with diabetes in pregnancy to optimize maternal and neonatal outcomes. However, established evidence is limited in providing a strong association between…

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Negative / Null Result ReportOpen accessMedicine

The effect of centralized care on the management of postoperative fluctuations in plasma sodium concentration after pediatric suprasellar brain tumor surgery.

Hulsmann SC, Zaal DC, van Gestel JPJ et al. · 2026 · Pituitary

PURPOSE: Children undergoing neurosurgery for (supra)sellar tumors are at risk of developing arginine vasopressin-deficiency (AVP-D), which can cause severe sodium fluctuations and associated neurological complications, prolonged…

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Negative / Null Result ReportOpen accessMedicine

Parent substance use and child-to-parent violence: A brief report.

Curtis A, Skvarc D, Brittain N et al. · 2025 · Drug and alcohol review

Introduction Substance use has been associated with child-to-parent violence (CPV), yet little is known about the contributing factors. This study investigated the association between parental substance use and substance involved child to…

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Negative / Null Result ReportOpen accessMedicine

Feeding Therapy and its Relationship to Timing of Independent Oral Feeding for Preterm Infants in the Neonatal Intensive Care Unit.

Nguyen TT, Pineda R, Reynolds S et al. · 2026 · Physical & occupational therapy in pediatrics

Aim To examine the relationship between feeding therapy and the timing of independent oral feeding (IOF) in preterm infants in the neonatal intensive care unit (NICU). Study design A retrospective analysis of 536 preterm infants ( Results…

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Negative / Null Result ReportOpen accessMedicine

The value of transpulmonary thermodilution parameters in predicting hemodynamic instability in intensive care patients undergoing continuous renal replacement therapy.

Keser CS, Erdemir M, Yilmaz M et al. · 2025 · BMC nephrology

Background Hemodynamic instability related to renal replacement therapy (HIRRT) is a serious complication of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), significantly increasing…

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Negative / Null Result ReportOpen accessMedicine

Neighborhood Physical Disinvestment and Incident Diabetes between visits 1 and 2 of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Smith CM, Spalt EW, Gallo LC et al. · 2026 · Journal of urban health : bulletin of the New York Academy of Medicine

Neighborhood-scale environmental factors, including disinvestment in infrastructure, may impact cardiometabolic disease risk. To our knowledge, no prior studies have investigated the association between neighborhood disinvestment and…

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Negative / Null Result ReportOpen accessMedicine

Burden of atherosclerosis, cardiovascular risk factors and atrial fibrillation in individuals with covert brain infarcts in late midlife: the Akershus Cardiac Examination 1950 Study.

Ihle-Hansen H, Walle-Hansen MM, Berge T et al. · 2026 · BMJ open

Background Current expert consensus statements generally suggest cardiovascular risk assessment, including atrial fibrillation (AF) screening, on detection of covert brain infarctions (CBIs). However, evidence to guide management of CBI…

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Negative / Null Result ReportMedicine

Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.

O'Brien EA, Wypij D, Rofeberg V et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective Investigate the association between placental vascular abnormalities and regional brain volumes in congenital heart disease (CHD) fetuses with and without genetic abnormalities. Study design Secondary analysis of brain magnetic…

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Negative / Null Result ReportOpen accessMedicine

Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?

Girişgen İ, Altıncık SA, Avcı E et al. · 2025 · Journal of clinical research in pediatric endocrinology

Objective To compare serum mitochondrial open reading frame of 12S rRNA-c (MOTS-c) levels, a new potential biomarker for oxidative stress, in children with type 1 diabetes mellitus (T1DM) and healthy children. A further aim was to…

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Negative / Null Result ReportOpen accessMedicine

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study.

Tristani-Firouzi B, Pappas L, Joseph M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology

Objective Maternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight…

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Negative / Null Result ReportMedicine

Lack of association between periodontitis and rheumatoid arthritis.

Posada-López A, Duque JD, Pineda-Tamayo RA et al. · 2023 · Reumatologia clinica

Background and objective Periodontitis and rheumatoid arthritis (RA) have been associated in a bidirectional way. The objective of this study was to determine the association between clinical parameters of periodontitis and RA. Materials…

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