20,192 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Megan Best, Phyllis Butow, Ian Olver · 2016 · Journal of Clinical Medicine
Background: Despite known health benefits of spiritual care and high patient interest in discussing spirituality with their physicians, the frequency of spiritual discussions in the medical consultation is low. We investigated spiritual…
View details →Florian Thibord, Melissa V. Chan, Ming‐Huei Chen et al. · 2022 · Human Genetics and Genomics Advances
Host genetic variants influence the susceptibility and severity of several infectious diseases, and the discovery of genetic associations with coronavirus disease 2019 (COVID-19) phenotypes could help to develop new therapeutic strategies…
View details →Zahra Yazdanpour, Omid Tadjrobehkar, Motahareh Shahkhah · 2020 · BMC Microbiology
BACKGROUND: Antibiotic resistance is an increasing phenomenon in many bacterial pathogens including uropathogenic Escherichia coli. Hypothetical anti-virulent agents could be a solution, but first clear virulence associated gene-pool of antibiotic resistant isolates have to be determined. The aim of this study is to investigate the significant associations between genes encoding VFs with antibiotic resistance and phylogenetic groups in UPEC isolates. RESULTS: The majority of 248 UPEC isolates belonged to phylogenetic group B2 (67.3%). The maximum and minimum resistance was attributed to amoxic
View details →Juan Pablo Nani, Fernanda Marcondes de Rezende, Francisco Peñagaricano · 2019 · BMC Genomics
BACKGROUND: Fertility is among the most important economic traits in dairy cattle. Genomic prediction for cow fertility has received much attention in the last decade, while bull fertility has been largely overlooked. The goal of this study was to assess genomic prediction of dairy bull fertility using markers with large effect and functional annotation data. Sire conception rate (SCR) was used as a measure of service sire fertility. Dataset consisted of 11.5 k U.S. Holstein bulls with SCR records and about 300 k single nucleotide polymorphism (SNP) markers. The analyses included the use of bo
View details →Xi Yang, Xing He, Hansi Zhang et al. · 2020 · JMIR Medical Informatics
BACKGROUND: Semantic textual similarity (STS) is one of the fundamental tasks in natural language processing (NLP). Many shared tasks and corpora for STS have been organized and curated in the general English domain; however, such resources are limited in the biomedical domain. In 2019, the National NLP Clinical Challenges (n2c2) challenge developed a comprehensive clinical STS dataset and organized a community effort to solicit state-of-the-art solutions for clinical STS. OBJECTIVE: This study presents our transformer-based clinical STS models developed during this challenge as well as new mo
View details →Matthew R. Masters, Amr H. Mahmoud, Markus A. Lill · 2025 · Nature Communications
Co-folding models represent a major innovation in deep-learning-based protein-ligand structure prediction. The recent publications of RoseTTAFold All-Atom, AlphaFold3, and others have shown high-quality results on predicting the structures of proteins interacting with small-molecules, nucleic-acids, and other proteins. Despite these advanced capabilities and broad potential, the current study presents critical findings that question the adherence of these models to fundamental physical principles. Through adversarial examples based on established physical, chemical, and biological principles,
View details →Nienke M. Siebelink, Susan M. Bögels, Anne Speckens et al. · 2021 · Journal of Child Psychology and Psychiatry
BACKGROUND: Family mindfulness-based intervention (MBI) for child attention-deficit/hyperactivity disorder (ADHD) targets child self-control, parenting and parental mental health, but its effectiveness is still unclear. METHODS: MindChamp…
View details →Xiao Fan, Wentao Han, Linhong Teng et al. · 2019 · New Phytologist
Brown algae have convergently evolved plant-like body plans and reproductive cycles, which in plants are controlled by differential DNA methylation. This contribution provides the first single-base methylome profiles of haploid gametophytes and diploid sporophytes of a multicellular alga. Although only c. 1.4% of cytosines in Saccharina japonica were methylated mainly at CHH sites and characterized by 5-methylcytosine (5mC), there were significant differences between life-cycle stages. DNA methyltransferase 2 (DNMT2), known to efficiently catalyze tRNA methylation, is assumed to methylate the
View details →Cristiano Xavier Lima, Danielle G. Souza, Flávio A. Amaral et al. · 2015 · PLoS ONE
INTRODUCTION: Toll-like receptors (TLRs) play an important role in the recognition of microbial products and in host defense against infection. However, the massive release of inflammatory mediators into the bloodstream following TLR activation following sepsis is thought to contribute to disease pathogenesis. METHODS: Here, we evaluated the effects of preventive or therapeutic administration of monoclonal antibodies (mAbs) targeting either TLR2 or TLR4 in a model of severe polymicrobial sepsis induced by cecal ligation and puncture in mice. RESULTS: Pre-treatment with anti-TLR2 or anti-TLR4 m
View details →Katarzyna A. Cieslik, George E. Taffet, Jeffrey R. Crawford et al. · 2013 · Journal of Molecular and Cellular Cardiology
We have demonstrated that scar formation after myocardial infarction (MI) is associated with an endogenous pool of CD44(pos)CD45(neg) multipotential mesenchymal stem cells (MSC). MSC differentiate into fibroblasts secreting collagen that forms a scar and mature into myofibroblasts that express alpha smooth muscle actin (α-SMA) that stabilizes the scar. In the aging mouse, cardiac repair after MI is associated with impaired differentiation of MSC; MSC derived from the aged hearts form dysfunctional fibroblasts that deposit less collagen in response to transforming growth factor beta-1 (TGF-β1)
View details →David Casadevall, Javier Gimeno, Sergi Clavé et al. · 2015 · Oncotarget
// David Casadevall 1, 6, * , Javier Gimeno 2, * , Sergi Clavé 3, 4, * , Álvaro Taus 1 , Lara Pijuan 2 , Miriam Arumí 1 , Marta Lorenzo 4 , Silvia Menéndez 4 , Israel Cañadas 4 , Joan Albanell 1, 4, 5 , Sergio Serrano 2 , Blanca Espinet 3, 4 , Marta Salido 3, 4 , Edurne Arriola 1, 4, # 1 Servei d’Oncologia Mèdica, Hospital del Mar, Barcelona, Spain 2 Servei de Patologia, Hospital del Mar, Barcelona, Spain 3 Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain 4 Cancer Research Program, IMIM (Hospita
View details →Wenji Piao, Lisa W. Ru, Kurt H. Piepenbrink et al. · 2013 · Proceedings of the National Academy of Sciences
Toll/IL-1R resistance (TIR) domain-containing adapter-inducing IFN-β (TRIF) is a Toll-like receptor (TLR) adapter that mediates MyD88-independent induction of type I interferons through activation of IFN regulatory factor 3 and NFκB. We…
View details →Yongbo Wang, Xiang Gao, Pardis Pedram et al. · 2016 · Nutrients
Selenium (Se) is a trace element which plays an important role in adipocyte hypertrophy and adipogenesis. Some studies suggest that variations in serum Se may be associated with obesity. However, there are few studies examining the…
View details →Rong Zhang, Yize Li, Timothy J. Cowley et al. · 2015 · Journal of Virology
UNLABELLED: Mouse hepatitis virus (MHV) isolates JHM.WU and JHM.SD promote severe central nervous system disease. However, while JHM.WU replicates robustly and induces hepatitis, JHM.SD fails to replicate or induce pathology in the liver.…
View details →Claudio Toma, Amaia Hervás, Bàrbara Torrico et al. · 2012 · Psychiatric Genetics
Impairment of language abilities is a common feature in autistic individuals. Heterozygous mutations in the Forkhead Box P2 (FOXP2) gene lead to a severe spoken language disorder. Recently, several studies have pinpointed the involvement…
View details →Jonna Nilsson, Alexander V. Lebedev, Martin Lövdén · 2015 · Frontiers in Aging Neuroscience
Transcranial direct current stimulation (tDCS) has been put forward as a non-pharmacological alternative for alleviating cognitive decline in old age. Although results have shown some promise, little is known about the optimal stimulation parameters for modulation in the cognitive domain. In this study, the effects of tDCS over the dorsolateral prefrontal cortex (dlPFC) on working memory performance were investigated in thirty older adults. An N-back task assessed working memory before, during and after anodal tDCS at a current strength of 1 mA and 2 mA, in addition to sham stimulation. The st
View details →Timothy P. LaBranche, Alison M. Bendele, Brian C Omura et al. · 2016 · Annals of the Rheumatic Diseases
OBJECTIVE: To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. METHODS:…
View details →Batsirai Winmore Mazviona, T Sakahuhwa, M Dube · 2017 · RePEc: Research Papers in Economics
The study sought to examine factors affecting the performance of insurance companies in Zimbabwe. We utilized secondary data from twenty short-term insurance companies. The data was for the period from 2010 to 2014. We used factor analysis and multiple linear regression models to determine the factors affecting performance and identifying their impact. Our findings revealed that expense ratio, claims ratio and the size of a company significantly affect insurance companies’ performance negatively. Whilst leverage and liquidity affect performance positively. We recommend that insurance companies
View details →Anna Elisabet Olafsdottir, Daniel D. Reidpath, Subhash Pokhrel et al. · 2011 · BMC Public Health
BACKGROUND: The literature on health systems focuses largely on the performance of healthcare systems operationalised around indicators such as hospital beds, maternity care and immunisation coverage. A broader definition of health systems however, needs to include the wider determinants of health including, possibly, governance and its relationship to health and health equity. The aim of this study was to examine the relationship between health systems outcomes and equity, and governance as a part of a process to extend the range of indicators used to assess health systems performance. METHOD
View details →Kin Sibanda, Progress Hove-Sibanda, Herring Shava · 2018 · Acta Commercii
Orientation: Globally, the majority of Small and Medium-sized entities (SMEs) are resource constrained. As a result, not all SMEs are able to fully exploit the benefits associated with international trade as they face challenges when exporting their produce.Research purpose: This article presents an investigation into the impact of access to finance on firm performance and exporting behaviour of SMEs in Harare, Zimbabwe.Motivation for the study: The article stems from the observation that although there is a growing importance and contribution of SMEs worldwide, research has shown that only a
View details →Lincoln Colling, Dénes Szűcs, Damiano De Marco et al. · 2020 · Advances in Methods and Practices in Psychological Science
The attentional spatial-numerical association of response codes (Att-SNARC) effect (Fischer, Castel, Dodd, & Pratt, 2003)—the finding that participants are quicker to detect left-side targets when the targets are preceded by small numbers and quicker to detect right-side targets when they are preceded by large numbers—has been used as evidence for embodied number representations and to support strong claims about the link between number and space (e.g., a mental number line). We attempted to replicate Experiment 2 of Fischer et al. by collecting data from 1,105 participants at 17 labs. Acr
View details →Karin Welén, Ebba Rosendal, Magnus Gisslén et al. · 2021 · European Urology
BACKGROUND: Men are more severely affected by COVID-19. Testosterone may influence SARS-CoV-2 infection and the immune response. OBJECTIVE: To clinically, epidemiologically, and experimentally evaluate the effect of antiandrogens on…
View details →Ashley L. Ruba, Andrew N. Meltzoff, Betty M. Repacholi · 2019 · Developmental Psychology
There is extensive disagreement as to whether preverbal infants have conceptual categories for different emotions (e.g., anger vs. disgust). In addition, few studies have examined whether infants have conceptual categories of emotions…
View details →Tomris Özben · 2014 · Current Topics in Medicinal Chemistry
Radiation and some chemotherapeutic agents used in conventional cancer treatment generate reactive oxygen species (ROS), and a high ROS level diminishes cellular antioxidant capacity and leads to apoptosis and cancer cell death.…
View details →Brett M. Kroncke, Amanda M. Duran, Jeffrey Mendenhall et al. · 2016 · Biochemistry
There is a compelling and growing need to accurately predict the impact of amino acid mutations on protein stability for problems in personalized medicine and other applications. Here the ability of 10 computational tools to accurately…
View details →Chia‐Hsuin Chang, Jou‐Wei Lin, Fu‐Chun Chiu et al. · 2014 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: This study examined the effect of radiofrequency catheter ablation (RFA) on reducing morbidity and mortality among patients with atrial fibrillation (AF). METHODS AND RESULTS: A retrospective cohort of patients with AF without…
View details →Daniel M. Mazzaferro, Ari M. Wes, Sanjay Naran et al. · 2017 · Plastic & Reconstructive Surgery
BACKGROUND: The effects of orthognathic surgery go beyond objective cephalometric correction of facial and dental disproportion and malocclusion, respectively. The authors hypothesized that there is tangible improvement following surgery…
View details →Charles Honoré, V. Atallah, Olivier Mir et al. · 2017 · PLoS ONE
BACKGROUND: Desmoplastic Small Round Cell Tumor (DSRCT) is a rare disease affecting predominantly children and young adults and for which the benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery (CCRS) remains unknown. METHODS: To identify patients with DSRCT without extraperitoneal metastases (EPM) who underwent CCRS between 1991 and 2015, a retrospective nation-wide survey was conducted by crossing the prospective and retrospective databases of the French Network for Rare Peritoneal Malignancies, French Reference Network in Sarcoma Pathology, Fren
View details →Josep Tabernero, Paulo M. Hoff, Lin Shen et al. · 2022 · Gastric Cancer
BACKGROUND: Dual-targeted anti-HER2 therapy significantly improves outcomes in HER2-positive breast cancer and could be beneficial in other HER2-positive cancers. JACOB's end-of study analyses aimed to evaluate the long-term efficacy and safety of pertuzumab plus trastuzumab and chemotherapy for previously untreated HER2-positive metastatic gastric or gastroesophageal junction cancer. METHODS: Eligible patients were randomized 1:1 to pertuzumab/placebo plus trastuzumab and chemotherapy every 3 weeks. PRIMARY ENDPOINT: overall survival (OS). Secondary endpoints included progression-free surviva
View details →Clark DuMontier, Hajime Uno, Tammy T. Hshieh et al. · 2021 · Haematologica
We conducted a randomized controlled trial in older adults with hematologic malignancies to determine the impact of geriatrician consultation embedded in our oncology clinic alongside standard care. From February 2015 to May 2018,…
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