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Browse the failure-mode index

20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Breaking the PROMISE: poor association between brain volume loss and clinical disability worsening over 2 years of follow-up in primary progressive multiple sclerosis.

Koch M, Mostert J, Strijbis EM et al. · 2026 · Journal of neurology, neurosurgery, and psychiatry

Background Phase 2 clinical trials in primary progressive multiple sclerosis (PPMS) often use MRI brain volume measures as their primary endpoint. Here, we investigate the longitudinal association between change in MRI outcomes and change…

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Negative / Null Result ReportMedicine

High-frequency Ultrasound Evaluation of Midline Crossing-over Vessel: Correlation with Perfusion of Deep Inferior Epigastric Perforator Flap.

Lee SJ, Han HH, Eom JS et al. · 2026 · Plastic and reconstructive surgery

Background The deep inferior epigastric perforator (DIEP) flap is widely used in autologous breast reconstruction, with its success heavily reliant on the vascular anatomy, particularly midline crossing-over vessels that facilitate…

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Negative / Null Result ReportMedicine

Investigating the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Executive Errors Scale in Adults With Schizophrenia Spectrum Disorders.

Raudeberg R, Iverson GL · 2026 · Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Objective The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a brief neuropsychological screening battery that measures aspects of attention, immediate and delayed memory, and verbal and…

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Negative / Null Result ReportMedicine

Prospective evaluation of recombinant Herpes zoster vaccine in SSc: immunogenicity, safety and disease outcomes.

Luppino-Assad AP, Mello RP, Medeiros-Ribeiro AC et al. · 2026 · Rheumatology (Oxford, England)

Objectives To evaluate humoral immune response to recombinant zoster vaccine (RZV) in immunosuppressed patients with SSc compared with healthy controls, to identify factors influencing vaccine response and to assess RZV safety and impact…

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Negative / Null Result ReportMedicine

Pain, respiratory symptoms, interpretation bias and death anxiety are associated with fear of disease progression in people with asthma.

Sharpe L, Shaw J, Boyse JB et al. · 2026 · British journal of health psychology

Aims Asthma is a chronic condition characterized by episodes of breathlessness. Although common, asthma is known to be associated with higher rates of depression and anxiety, but there are few studies that have attempted to document the…

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Negative / Null Result Report

Psychology at the screen: The flaws of the current VAR protocol

Walker D, Staniforth CE, Thomas J et al. · 2025 · Preprint

The English Premier League claim that the introduction of the Video Assistant Referee (VAR) has led to more correct decisions. However, the psychological mechanisms of the current protocol have yet to be explored, and the current study…

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Negative / Null Result ReportMedicine

Examining links between somatosensation and cognition in children with hemiplegic cerebral palsy.

Hewitt KM, Bayliss DM, McLean BA et al. · 2026 · Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

Children with cerebral palsy (CP) are at increased risk of impaired somatosensation and cognition. Among children with hemiplegia, approximately three-quarters have impaired somatosensation and one-third have intellectual impairment. While…

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Negative / Null Result ReportMedicine

Patient-reported levels of pain and itch in hypertrophic scar before and after fractional ablative laser treatment.

Carreras JP, Carney BC, Lee D et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association

Skin fibrosis, especially hypertrophic scars (HTS), remains understudied with few effective treatments. Studying HTS is challenging due to its natural tendency to improve over time, making it hard to separate intervention effects. This…

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Negative / Null Result ReportMedicine

Associations of spirituality and craving among individuals in substance use disorder treatment: A latent change score modeling approach.

Rabinowitz JA, Masyn K, Thomas N et al. · 2026 · Drug and alcohol dependence

Objective Using a latent change score modeling approach, we tested the bidirectional relationships between spirituality and craving during the first month of substance use disorder (SUD) treatment. Specifically, we examined whether higher…

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Negative / Null Result ReportMedicine

Evaluating day +90 donor chimerism as a prognostic marker of clinical outcomes among allogeneic hematopoietic cell transplant recipients who received myeloablative conditioning.

Jubas S, Collins K, Obara K et al. · 2026 · Transplantation and cellular therapy

Background Allogeneic hematopoietic cell transplantation (allo-HCT) is potentially curative for hematologic malignancies. However, relationships between donor chimerism and clinical outcomes remain poorly characterized. Objective The…

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Negative / Null Result ReportMedicine

Eating Behavior Traits and Success in Dietary Changes in Men with Prediabetes - the T2D-GENE Intervention.

Koivu N, Lankinen M, Schwab U · 2026 · Health education & behavior : the official publication of the Society for Public Health Education

Sustained dietary change is essential for type 2 diabetes prevention, yet most Finnish men do not follow dietary recommendations. Eating behavior traits such as cognitive restraint, uncontrolled eating, and emotional eating may influence…

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Negative / Null Result ReportMedicine

Longitudinal Association Between Sprint and Jump Performance in Youth Male Soccer Players: Implications for Talent Development.

Laas MM, Wright M, Enright K et al. · 2026 · Research quarterly for exercise and sport

This study analyzed the longitudinal relationship between short sprints and counter movement jump (CMJ) in youth male soccer players. Players ( n = 304, age 13.0 ± 1.9 years) from a Scottish soccer academy completed sprints (10 m, 20 m…

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Negative / Null Result ReportMedicine

The effect of childhood trauma on the severity of depressive symptoms and drug resistance in major depressive disorder - results from the international PROMPT study.

Ferensztajn-Rochowiak E, Rybakowski F, Michalak M et al. · 2026 · Journal of affective disorders

Objectives Treatment resistance in major depressive disorder (MDD) affects nearly 30% of patients, and early childhood trauma (CT) may play a significant role in its development. The international PROMPT project investigates the…

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Negative / Null Result ReportMedicine

Prolonged Mismatch Negativity Latencies in Intensive Care Unit Patients With Active Delirium.

Chen YC, Chang HJ, Chang CW et al. · 2026 · Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

Introduction Delirium is a common and serious complication in critically ill patients, associated with higher mortality, prolonged intensive care unit (ICU) stays, and cognitive impairments. Furthermore, renal dysfunction is a…

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