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Browse the failure-mode index

19,923 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Early stage adrenocortical carcinoma—what contributes to poor prognosis after adrenalectomy? A retrospective cohort study

Douk Kwon, C. Rah, Byung-Chang Kim et al. · 2024 · Annals of Surgical Treatment and Research

Purpose Adrenocortical carcinoma (ACC) is a rare primary carcinoma originating in the adrenal gland with a poor prognosis and a high recurrence rate. This study evaluated the risk factors associated with recurrence in patients with early…

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Negative / Null Result ReportMedicine

Dehorning Does Not Alter the Stress Response in Southern White Rhinoceroses (Ceratotherium simum simum) during Transport: A Preliminary Investigation

Anita Metzinger, Leith C. R. Meyer, P. Buss et al. · 2024 · Journal of Wildlife Diseases

Abstract: Translocation and dehorning are common and important practices for rhinoceros management and conservation. It is not known if dehorning causes a stress response or negatively affects rhinoceroses during transport. Twenty-three…

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Negative / Null Result ReportOpen accessMedicine

Ventilation during continuous compressions or at 30:2 compression-to-ventilation ratio results in similar arterial oxygen and carbon dioxide levels in an experimental model of prolonged cardiac arrest

Jukka Kopra, E. Litonius, P. Pekkarinen et al. · 2023 · Intensive Care Medicine Experimental

Background In refractory out-of-hospital cardiac arrest, transportation to hospital with continuous chest compressions (CCC) from a chest compression device and ventilation with 100% oxygen through an advanced airway is common practice.…

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Negative / Null Result ReportMedicine

Effect of Volume on Postoperative Outcomes After Left Pancreatectomy: A Multicenter Prospective Snapshot Study (SPANDISPAN Project)

D. Aparicio-López, J. Ramia, C. Villodre et al. · 2025 · Journal of Clinical Medicine

Background/Objectives: Like many other countries, the management of pancreatic cancer in Spain has developed in a fragmented manner. This study analyzes clinical outcomes related to patient volume at different centers after left…

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Negative / Null Result ReportOpen accessMedicine

The Effect of Two Calcium Silicate Materials on the Fracture Strength of Simulated Immature Teeth during Regenerative Endodontic Treatment

H. Edrees, A. Y. Siddiqui, M. M. Almousa et al. · 2021 · Journal of Evolution of Medical and Dental Sciences

BACKGROUND Necrotic immature permanent teeth undergoing Regenerative Endodontic Treatment (RET) are subjected to functional forces that might lead to their fracture before achieving apical closure. This study compared the fracture strength…

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Negative / Null Result ReportMedicine

A Half-Century Review of Male and Female Resident Outcomes in Oral and Maxillofacial Surgery: A Single-Institution Report.

Susan Keefe, Carrie Baldwin, Elda Fisher et al. · 2025 · Journal of oral and maxillofacial surgery

BACKGROUND Limited comprehensive historical data exist comparing male and female residents in oral and maxillofacial surgery (OMS) residency programs. This gap underscores the need to examine sex-based differences to guide equitable…

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Negative / Null Result ReportOpen access

Entry Requirements as Predictors of the Academic Performance of Postgraduate Students in Universities in Zimbabwe

Norman Rudhumbu, Patience Kelebogile Mudau · 2022 · International Journal of Learning, Teaching and Educational Research

One of the major strategies that universities use to ensure quality in education is the use of entry requirements as a screening procedure to ensure that only those considered to be the ‘best’ students are admitted. Whether these so-called…

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Negative / Null Result ReportMedicine

The Effect of the Lateral First Metatarsal Head Shape on Hallux Valgus in Forced Turnout in Pre-Pointe Female Ballet Dancers: A Pilot Study.

Paul H Doan, David M Handojo, Shivani Parihar et al. · 2024 · Journal of the American Podiatric Medical Association (Print)

BACKGROUND A rounded lateral first metatarsal head shape is associated with higher rates of hallux abducto valgus recurrence following corrective surgery; however, the effect of the lateral first metatarsal head shape on the hallux…

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Negative / Null Result ReportOpen accessMedicine

A Benchmark Side-by-Side Comparison of Two Well-Established Protocols for in vitro Hematopoietic Differentiation From Human Pluripotent Stem Cells

F. Gutiérrez-Agüera, Virginia C. Rodríguez-Cortez, P. Petazzi et al. · 2021 · Frontiers in Cell and Developmental Biology

The generation of transplantable hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) remains challenging. Current differentiation protocols from hPSCs generate mostly hematopoietic progenitors of the primitive…

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Negative / Null Result ReportMedicine

Which clinical factors and biochemical parameters differentiate major depressive disorder with versus without lifetime psychotic symptoms?

C. M. Esposito, F. Legnani, J. Barkin et al. · 2026 · International journal of psychiatry in clinical practice

OBJECTIVE Major depressive disorder (MDD) is a prevalent disabling condition, with psychotic features complicating its course and management. Purpose of the study is to identify clinical and biochemical factors differentiating psychotic…

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Negative / Null Result ReportOpen accessPsychology

The Effects of a Structured and Unstructured Kindergarten Program on the Readiness Scores of Children in Selected Public Schools in Lafayette Parish, Louisiana.

Mary Coletta mcdonough Newkome · 1974

The major purpose of this study was to determine if there was a significant difference in readiness test scores between students who participated in a structured kindergarten program and those who participated in an unstructured program.…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of the Effectiveness and Safety of a Multifaceted Computerized Antimicrobial Stewardship Intervention in Surgical Settings: A Single-center Cluster-randomized Controlled Trial.

Xin Yuan, Kai Chen, Jing Yuan et al. · 2023 · International Journal of Antimicrobial Agents

BACKGROUND Inappropriate antimicrobial use is common for patients undergoing surgery. Whether a multifaceted computerized antimicrobial stewardship program is effective and safe in reducing inappropriate antimicrobial use in surgical…

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Negative / Null Result ReportOpen accessBiology

Effects of new polymorphisms in the bovine myocyte enhancer factor 2D (MEF2D) gene on the expression rates of the longissimus dorsi muscle

E. Juszczuk-Kubiak, R. Starzyński, T. Sakowski et al. · 2012 · Molecular Biology Reports

Myocyte enhancer factor 2D (MEF2D), a product of the MEF2D gene, belongs to the myocyte enhancer factor 2 (MEF2) protein family which is involved in vertebrate skeletal muscle development and differentiation during myogenesis. The aim of…

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Negative / Null Result ReportOpen accessChemistry

Trehalose may prevent postsurgical adhesions in a rabbit model of hysterotomy.

H. Fujino, Soojung Lee, Shigeki Suzuki et al. · 2011 · Journal of Veterinary Medical Science

The adhesion-preventing effect of trehalose in visceral organs was evaluated in a rabbit model. All rabbits underwent a hysterotomy, during which mild abrasion and desiccation was induced on the surfaces of visceral organs. In the control…

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Negative / Null Result ReportOpen accessMedicine

Medical management in locally advanced and metastatic prostate cancer: Does changes in treatment policy have any specific effect on PSA levels?

M. Bağcıoğlu, C. Surcel, S. Ozcan et al. · 2017 · Archivio Italiano di Urologia e Andrologia

OBJECTIVE Androgen deprivation therapy (ADT) is commonly used as a first-line treatment for locally advanced and metastatic prostatic cancer (Pca). There is no consensus about which alternative treatment should be used after the failure of…

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Negative / Null Result ReportOpen accessMedicine

No difference in anti-spike antibody and surrogate viral neutralization following SARS-CoV-2 booster vaccination in persons with HIV compared to controls (CO-HIV Study)

Kendall Kling, Patrick Janulis, A. Demonbreun et al. · 2023 · Frontiers in Immunology

Background Understanding the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination will enable accurate counseling and inform evolving vaccination strategies. Little is known about antibody response…

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Negative / Null Result Report

Performance and Carass Potential of Pantaneiro Lambs Supplemented with Saccharomyces cerevisiae

Rafaela Machado dos Santos, Simone Fernanda Nedel Pértile, Marcos Barbosa Ferreira et al. · 2024 · Ensaios e Ciência: Ciências Biológicas, Agrárias e da Saúde

Abstract The aim of this study was to evaluate the effect of a feed additive for feedlot Pantaneiro lambs on weight gain, dry matter intake, carcass and meat characteristics, in addition to the comparison between males and females. Eleven…

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Negative / Null Result ReportOpen access

Association of β-Globin Gene Haplotypes with Haematological Parameters and Foetal Haemoglobin among Patients with Sickle Cell Disorder in Raipur, Chhattisgarh, India

S. Bhagat, A. Thakur · 2023 · Journal of Clinical and Diagnostic Research

Introduction: Sickle cell disease is caused by a single nucleotide substitution in the β-globin gene. The variations in Foetal Haemoglobin (HbF) levels, β-globin gene cluster haplotype have been used as predictors of disease severity in…

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Negative / Null Result ReportOpen accessMedicine

The Neonatal Congenital Anomalies: Incidence and Risk Factors Before and After the war at Al-Thawrah Hospital- Sana'a,Yemen.

F. M. Abol-Gaith, N. Ismail, A. Al-Mutawakel · 2019 · Assiut Scientific Nursing Journal

Background: Congenital anomalies (CAs) are structural or functional abnormalities that occur during intrauterine life and can be identified prenatally, at birth or may be detected in infancy later. Aim: To compare the incidence and risk…

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Negative / Null Result ReportOpen access

Pertumbuhan Transplan Karang Lunak Sinularia polydactyla dan S. asterolobata Berdasarkan Metode Tebar Dasar dan Penempelan Substrat Pada Lokasi yang Berbeda

I. G. A. B. K. Jayantika, I. Dharma, W. Widiastuti · 2021

Soft coral transplantations are widely used for rehabilitation of coral reef ecosystems and commercial needs with common method are substrated-attached and placed on the metal table frame. These methods are considered as costly. This study…

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Negative / Null Result ReportOpen accessMedicine

“Customized Titanium Mesh versus Titanium Reinforced Membrane in localized Alveolar Ridge Augmentation with Simultaneously delayed implant placement” A randomized clinical study

Maha Shaikh, A. Gamal, Ahmed Amr · 2020

Aim: To compare two different alveolar ridge augmentation (ARA) approaches applied in conjunction with delayed dental implants regarding the enhancement of the buccolingual alveolar ridge width and the changes in alveolar crestal level…

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