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Browse the failure-mode index

20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Immune dysregulation in gestational diabetes mellitus: placental downregulation of CXCL9 and IL1RL1 and altered immune cell infiltration.

Zhou Z, Huang L, Sheng L et al. · 2026 · Frontiers in cell and developmental biology

Background Immune dysregulation is implicated in pregnancy complications, particularly gestational diabetes mellitus (GDM). This study aimed to identify immune-related genes and characterize immune cell infiltration in GDM placentas.…

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Negative / Null Result ReportMedicine

Comparative Phylogenetic Study on Host Newts (Caudata: Salamandridae) and Parasitic Mites (Acariformes: Hydrachnidia: Hygrobatidae) in East and Southeast Asia.

Shen Y, Nishikawa K, Hiruta SF et al. · 2025 · Zoological science

The water mite genus Hygrobates and the newt family Salamandridae are distributed widely in the northern hemisphere. However, only in Eastern and Southeastern Asia a host-parasite association developed, with several Hygrobates species,…

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Negative / Null Result ReportMedicine

Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, Placebo-Controlled Trial.

Ala-Jaakkola R, Forssten SD, Cheng J et al. · 2025 · Molecular nutrition & food research

Functional constipation (FC) is characterized by difficult, infrequent, or incomplete bowel movements without clear physiological cause. Daily intake of Bifidobacterium lactis HN019 has been shown to reduce colonic transit time or…

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Negative / Null Result ReportMedicine

Supportive Environmental Features at Home as Proactive/Reactive Associates of Disability and Mortality Status in Older Adults.

Barbakoff D, Glennie K, Yan M et al. · 2026 · Journal of applied gerontology : the official journal of the Southern Gerontological Society

Supportive environmental features (SEFs) are attributes of homes that help people overcome activity limitations. Evidence suggests that SEFs may facilitate aging in place. However, real-life SEF implementation patterns are not fully…

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Negative / Null Result ReportMedicine

Sensorimotor dysfunction does not predict pain-related cognition, but proprioception is associated with pain catastrophizing and pain self-efficacy in people with lower limb tendinopathy: A cross-sectional study.

Mest J, Flood A, Preston P et al. · 2026 · Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

Objectives To investigate if sensorimotor function predicts pain-related cognition in people with lower limb tendinopathy. Design Single-cohort, cross-sectional study. Setting Sports and exercise research laboratory. Participants…

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Negative / Null Result ReportOpen accessMedicine

Adolescent binge drinking causes sex-specific deficits in behavioral reactivity, endocrine recovery from stress and altered expression of hypothalamic KCC2 in males.

Büyükdemirtaş B, Benn M, Kwon HB et al. · 2026 · Psychopharmacology

Rationale Binge drinking during adolescence is associated with a higher risk of developing Alcohol Use Disorders and impaired stress reactivity in adulthood. The hypothalamic-pituitary-adrenal axis matures during adolescence and is under…

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Negative / Null Result ReportMedicine

Linking overstory relative density to light availability and understory plant community composition in disturbance-dependent, Pinus rigida -dominated forests of the mid-Atlantic coastal plain, USA

Isaacson BN, Serbin SP, Grabosky JC · 2025 · Forest Ecology and Management.

There is a vigorous debate around whether and how to manage forests for climate mitigation or for other goals such as biodiversity. To achieve any of these goals it is necessary to define the parameters within which they can exist;…

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Negative / Null Result ReportOpen accessMedicine

Subclinical peripheral nerve demyelination without overt symptoms in a family with neuronal intranuclear inclusion disease harboring biallelic repeat expansions.

Zhang H, Zhao T, Zheng H et al. · 2026 · BMC neurology

Neuronal intranuclear inclusion disease (NIID) is a rare, progressive neurodegenerative disorder caused by abnormal GGC repeat expansions in the NOTCH2NLC gene, leading to multisystem involvement. Electrophysiological abnormalities in NIID…

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Negative / Null Result Report

Evaluating Working Memory as a Buffer for Visual Search

Su Z, Wyble B, Fu Y · 2024 · Preprint

This study explores the relationship between working memory and attention during visual search tasks, focusing on how time constraints affect the encoding of visual information into working memory. The research is based on the premise that…

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Negative / Null Result ReportMedicine

Insufficient Evidence for Load as the Primary Cause of Nonspecific (Chronic) Low Back Pain. A Scoping Review.

de Bruin LJE, Hoegh M, Greve C et al. · 2024 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To assess the causal role of the relationship between loading and the onset of nonspecific low back pain (NSLBP) and persistence of NSLBP (chronic low back pain [CLBP]). DESIGN : Scoping review. LITERATURE SEARCH : We searched…

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Negative / Null Result Report

Multiple mating predicts queen reproductive output in the polygynous Neotropical trap-jaw ant, Odontomachus chelifer (Formicidae: Ponerinae)

Florindo HS, Azevedo-Silva M, Pereira-Romeiro MP et al. · 2025 · Preprint

The factors that influence the organisms’ ability to reproduce are diverse. In ants, social structure may contribute to queens’ Reproductive Output (RO), alongside environmental conditions and genetic attributes. Polygynous species like…

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Negative / Null Result ReportOpen accessMedicine

C-reactive protein and prospective cardiometabolic risk: observational and Mendelian randomization study of ischemic stroke and all-cause death.

Rolver MG, Emanuelsson F, Nordestgaard BG et al. · 2025 · Cardiovascular diabetology

Background and objectives Elevated C-reactive protein (CRP) is a well-established marker of low-grade systemic inflammation often accompanying cardiometabolic diseases like type 2 diabetes. We sought to determine if plasma CRP…

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Negative / Null Result ReportMedicine

Goal framing of health promotion messages in contact lens wear.

Wagner H, Lam D, Nguyen AL · 2025 · Contact lens & anterior eye : the journal of the British Contact Lens Association

Purpose Appropriate framing of health information influences the adoption of health behaviors. This study explored whether (1) gain- or loss-framed health promotion messages, emphasizing positive or negative consequences, respectively,…

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Negative / Null Result ReportMedicine

Exposure to Acetaminophen (Paracetamol) during Pregnancy and Childhood Cancer: A Population-Based Cohort Study in Taiwan.

Sirirungreung A, Lee PC, Hu YH et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background The safety of using acetaminophen (paracetamol) during pregnancy has been questioned because of concerns about its potential negative impact on fetal development and the risk of adverse pediatric outcomes. We aimed to…

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