e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Refining the role of presurgical PET/4D-CT in a large series of patients with primary hyperparathyroidism undergoing [ 18 F]Fluorocholine PET/CT.

Kaseb A, Benider H, Treglia G et al. · 2025 · European journal of clinical investigation

Background 4D-CT has garnered attention as complementary imaging for patients with primary hyperparathyroidism (pHPT). Herein we evaluated a diagnostic strategy using [ 18 F]Fluorocholine Positron Emission Tomography/Computed Tomography…

View details →
Negative / Null Result ReportOpen accessMedicine

Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar.

Ramasindrazana B, Rahalison ZA, Gauthier P et al. · 2025 · PLoS neglected tropical diseases

Background The plague, caused by Yersinia pestis, remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid and accurate detection of this pathogen is essential for effective outbreak management and…

View details →
Negative / Null Result ReportMedicine

Genetic counselling in the era of next generation sequencing.

Espada-Musitu D, Manero-Azua Á, Vado Y et al. · 2025 · Anales de pediatria

Advances in next-generation sequencing (NGS) technologies have made the detection of the molecular causes of paediatric diseases increasingly affordable, accessible and rapid. While exome sequencing and genome sequencing were until…

View details →
Negative / Null Result ReportOpen accessMedicine

Baseline radiological parameters associated with good neurological outcome following ventriculoperitoneal shunt in normal pressure hydrocephalus: A single-center study on 82 patients.

Paracino R, De Domenico P, Ricciuti RA et al. · 2025 · Surgical neurology international

Background Idiopathic normal pressure hydrocephalus (iNPH) is a benign neurologic condition with treatment response rates ranging only between 30 and 50%. Several studies have attempted to identify clinical or radiological predictive…

View details →
Negative / Null Result ReportMedicine

Cancer genetic profile and risk of thrombosis.

Pelegrín-Mateo FJ, Zambrano CB, Vázquez EB et al. · 2025 · European journal of internal medicine

Cancer-associated thrombosis (CAT) remains a leading cause of morbidity and mortality among oncology patients, with an incidence influenced by tumor type, stage, treatment, and molecular characteristics. This review explores the molecular…

View details →
Negative / Null Result ReportMedicine

Intraoperative electrophysiological balloon test occlusion (BTO): A novel Solution to an inconclusive conventional BTO.

Datta A, Katyayan I, Das KK et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Parent Artery Occlusion (PAO) is a valid treatment choice in giant internal carotid artery (ICA) aneurysms of the cavernous segment when the preoperative balloon test occlusion (BTO) demonstrates an adequate cross circulation from the…

View details →
Negative / Null Result ReportMedicine

Incidental Ovarian Uptake in Bone Scintigraphy.

Saber Tanha A, Hosseini S, Soltani E et al. · 2025 · Clinical nuclear medicine

Abstract A 47-year-old woman, recently diagnosed with breast cancer, underwent staging. A whole-body bone scan revealed an unexpected focal 99m Tc-MDP uptake in her right ovary. Extensive literature review suggested various malignant…

View details →
Negative / Null Result ReportOpen accessMedicine

A new multiplex molecular assay based on padlock probes and rolling circle amplification for MDR-TB detection in clinical specimens: a prospective diagnostic accuracy study.

Dudnyk A, Tytarenko N, Lytvyniuk O et al. · 2026 · Therapeutic advances in infectious disease

Background Patients with multidrug-resistant tuberculosis (MDR-TB) receive treatment that is at least 20% less effective than drug-susceptible cases globally. Objectives The study evaluated the diagnostic accuracy of mfloDx MDR-TB assay…

View details →
Negative / Null Result ReportMedicine

Assessment of blood serum stability with Raman spectroscopy and explanatory AI.

Mieites V, Fernández-Manteca MG, Santiuste Torcida I et al. · 2025 · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

This study explores the potential of conventional Raman spectroscopy and commonly used spectral analysis pipelines for rapid and straightforward assessment of degradation in serum samples resulting from storage delays. Serum samples from…

View details →
Negative / Null Result Report

Discovery of a novel bandavirus using metagenomic sequencing in a retrospective analysis of an unresolved 2020 mortality event involving black vultures in the northeastern United States

Mwakibete L, Hoarau AOG, Ahyong V et al. · 2024 · Preprint

Investigations of wildlife diseases and mortality events can sometimes lead to inconclusive results due to limitations in diagnostics combined with an ever-increasing number of emerging viruses. The use of tools such as unbiased…

View details →
Negative / Null Result ReportOpen accessMedicine

The Role of Inflammasomes in LPS and Gram-Negative Bacterial Sepsis.

Hernández-Cuellar E, Tsuchiya K, Medina-Contreras O et al. · 2025 · Journal of clinical medicine

Background/Objectives : Sepsis is a life-threatening condition characterized by an uncontrolled immune response due to systemic infections. It is responsible for millions of deaths worldwide. Although inflammasomes play an important role…

View details →
Negative / Null Result ReportMedicine

Ivermectin performance against equine strongylids: Efficacy, egg reappearance periods, and fecal egg counting method comparison.

Nielsen MK, Bartholdy ID, Kristensen KS et al. · 2025 · Veterinary parasitology

Equine strongylids are ubiquitous and can cause severe health issues. Anthelmintic resistance is widely common in cyathostomin parasites, and recent studies have documented increasing incidence of resistance to the macrocyclic lactone drug…

View details →
Negative / Null Result ReportMedicine

Clinical utility of comprehensive gene panel testing for common and rare causes of skeletal dysplasia and other skeletal disorders: Results from the largest cohort to date.

MacCarrick G, Aradhya S, Bailey M et al. · 2024 · American journal of medical genetics. Part A

Molecular genetics enables more precise diagnoses of skeletal dysplasia and other skeletal disorders (SDs). We investigated the clinical utility of multigene panel testing for 5011 unrelated individuals with SD in the United States…

View details →
Negative / Null Result ReportOpen accessMedicine

T174M-M235T <i>AGT</i> Gene Haplotypes in Women with Pre-Eclampsia from Northwest Mexico: A Pilot Case-Control Study.

Portillo-Gallo JH, Sánchez-González JM, Saldaña-Cruz AM et al. · 2026 · Current issues in molecular biology

Pre-eclampsia is a Hypertensive Disorder of Pregnancy (HDP) characterized by hypertension and proteinuria, affecting 2-8% of pregnancies worldwide and constituting a major public health concern. Genes of the renin-angiotensin system have…

View details →
Negative / Null Result ReportOpen accessMedicine

Infectious potential and circulation of SARS-CoV-2 in wild rats.

Beissat K, Lattard V, Picard-Meyer E et al. · 2025 · PloS one

Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, a wide range of animal species (pets, mink…) have been naturally infected with this betacoronavirus. The emergence of new variants has…

View details →
Negative / Null Result ReportOpen accessMedicine

Hierarchical Classification of Factors Associated With Noninvasive Prenatal Testing Failures and Its Impact on Pregnancy Outcomes.

Xie J, Jiang Y, Zhou Y et al. · 2024 · Maternal-fetal medicine (Wolters Kluwer Health, Inc.)

Objective To conduct a hierarchical classification analysis of the nonreportable results of noninvasive prenatal testing in an attempt to reduce failure rates and provide pregnant women with accurate information to alleviate their anxiety.…

View details →
Negative / Null Result ReportMedicine

Frailty, Physical Function Impairment, and Pulmonary Function in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.

Abdo M, Kunisaki KM, Morris A et al. · 2026 · AIDS research and human retroviruses

People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments.…

View details →
Negative / Null Result ReportOpen accessMedicine

Challenges in Results Robustness of Trials with Missing Data for the Primary Endpoint: Insights from Coronary Balloon/Stent Trials.

Lang X, Zhao Y, Zhu Y et al. · 2025 · Risk management and healthcare policy

Background To assess the consequence of different degrees of missing primary endpoint data for randomized controlled trials and to find the influence factors. Methods PubMed, Cochrane Library, EMBASE and ClinicalTrials.gov were searched up…

View details →
Negative / Null Result ReportMedicine

Polygene by environment interactions predicting depressive outcomes.

Grillo AR · 2025 · American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Depression is a major public health problem with a continued need to uncover its etiology. Current models of depression contend that gene-by-environment (G × E) interactions influence depression risk, and further, that depression is…

View details →
Negative / Null Result ReportMedicine

Performance of SARS-CoV-2 nucleic acid amplification testing in Austria as measured by external quality assessment schemes during 3 years of the COVID-19 pandemic: an observational retrospective study.

Buchta C, Aberle SW, Allerberger F et al. · 2023 · The Lancet. Microbe

Background The aim of external quality assessment (EQA) schemes is to evaluate the analytical performance of laboratories and test systems in a near-to-real-life setting. This monitoring service provides feedback to participant…

View details →