Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Joyce O’Shaughnessy, Hartmut Koeppen, Yuanyuan Xiao et al. · 2015 · Clinical Cancer Research
PURPOSE: We conducted a randomized phase III study to determine whether patients with early breast cancer would benefit from the addition of capecitabine (X) to a standard regimen of doxorubicin (A) plus cyclophosphamide (C) followed by…
View details →Negative / Null Result ReportOpen accessMedicine
Shannon Rhodes, Janet S. Sinsheimer, Yvette Bordelon et al. · 2010 · Annals of Human Genetics
In the investigation of disease aetiology, the genome-wide association study (GWAS) provides a hypothesis-free investigation of the broader human genome and, as with all scientific investigations, replication is essential to validate any…
View details →Negative / Null Result ReportOpen accessEngineering
Adrian S. Sabau, Adrian Bejan, D.L. Brownell et al. · 2020 · Applied Thermal Engineering
A novel heat exchanger architecture was investigated, in which each fluid pathway transitions through the heat exchanger from tube-flow to shell-flow, or from shell-flow to tube-flow. The heat exchangers (HX) consisted of two plenums…
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Shuming Jiao, Yang Gao, Jun Feng et al. · 2020 · Optics Express
Deep learning has been extensively applied in many optical imaging problems in recent years. Despite the success, the limitations and drawbacks of deep learning in optical imaging have been seldom investigated. In this work, we show that…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Arshad Husain Rahmani, Mohammad A. Alzohairy, Ali Yousif Babiker et al. · 2012 · PubMed
A high frequency of mutations at the PTEN locus has been noticed in carcinoma of oral. However, the role of PTEN alternations and its association with outcome variables in the genesis of oral carcinoma is not understood fully. The purpose…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Charles R. Dunlop, Yann Wallez, Timothy Isaac Johnson et al. · 2020 · British Journal of Cancer
BACKGROUND: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR inhibitor, AZD6738, in combination with gemcitabine (ATRi/gem), we investigated ATM loss as a predictive biomarker of response to ATRi/gem in PDAC. METHODS: Through kinase inhibition, siRNA depletion and CRISPR knockout of ATM, we assessed how ATM targeting affected the sensitivity of PDAC cells to ATRi/gem. Using flow cytometry, immunofluorescence and immunoblotting, we investigate
View details →Negative / Null Result ReportOpen accessMedicine
Ira J. Dunkel, François Doz, Nicholas K. Foreman et al. · 2023 · Neuro-Oncology
BACKGROUND: Therapeutic options are limited in pediatric CNS malignancies. CheckMate 908 (NCT03130959) is an open-label, sequential-arm, phase 1b/2 study investigating nivolumab (NIVO) and NIVO + ipilimumab (IPI) in pediatric patients with…
View details →Negative / Null Result ReportOpen accessMedicine
Yoshiyuki Suzuki, Katsuyuki Shirai, Kuniyuki Oka et al. · 2010 · Journal of Radiation Research
phosphorylated-Akt (pAkt) plays an important role in tumorigenesis through promotion of cell survival by inhibiting apoptosis and mediating cell proliferation. Higher expression of pAkt has been reported to be associated with an…
View details →Negative / Null Result ReportMedicine
Paul B. Perrin, Andrew J. Johnston, Bruce Vogel et al. · 2010 · The Journal of Rehabilitation Research and Development
This study developed and implemented the Transition Assistance Program (TAP) for stroke caregivers. The program is composed of (1) skill development, (2) education, and (3) supportive problem solving. Sixty-one dyads (n = 122)…
View details →Negative / Null Result ReportOpen accessMedicine
Jorming Goh, Elizabeth A. Kirk, Shu Xian Lee et al. · 2026 · PubMed
Regular exercise and physical activity provide many health benefits and are encouraged by medical professionals for the primary prevention of and adjuvant treatment of breast cancer Current consensus in the discipline of exercise oncology…
View details →Negative / Null Result ReportOpen accessNeuroscience
Paul Dagum, Donald Leo Elbert, Laurent Giovangrandi et al. · 2026 · Nature Communications
ABSTRACT Poor sleep is implicated in the development of Alzheimer’s disease (AD) pathology and cognitive impairment. Dysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and AD, and in…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Adrian Abac, I. Abouelfettouh, F. Acernese et al. · 2026 · The Astrophysical Journal Letters
Abstract Version 4.0 of the Gravitational-Wave Transient Catalog (GWTC-4.0) adds new candidates detected by the LIGO, Virgo, and KAGRA observatories through the first part of the fourth observing run (O4a: 2023 May 24 15:00:00 to 2024 January 16 16:00:00 UTC) and a preceding engineering run. In these new data, we find 128 compact binary coalescence candidates that are identified by at least one of our search algorithms with a probability of astrophysical origin p astro ≥ 0.5 and that are not vetoed during event validation. We also provide detailed source property measurements for 86 of these t
View details →Negative / Null Result ReportOpen accessMedicine
Nagla Abdel Karim, James Schuster, Ihab Eldessouki et al. · 2017 · Oncotarget
// Nagla Abdel Karim 1 , James Schuster 2 , Ihab Eldessouki 1 , Ola Gaber 1 , Tariq Namad 3 , Jiang Wang 4 , Changchun Xie 5 and John C. Morris 1 1 Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45219, USA 2 University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA 3 Military Hospital of Mohammed V, Department of Medical Oncology, Quartier Irfane, Rabat 10080, Morocco 4 UC Health University Hospital, Department of Pathology and Laboratory Medicine, Cincinnati, OH 45219, USA 5 Division of Biostatistics and Bioinformatics, Department of Environmental H
View details →Negative / Null Result ReportOpen accessMedicine
Carolyn Tam, Deborah L. O’Connor, Gideon Koren · 2012 · Obstetrics and Gynecology International
There are increasing concerns that exposure to unmetabolized folic acid, which results from folic acid intakes that overwhelm the liver's metabolic capacity, may be associated with adverse effects. In this paper, we examined the folic acid status of women of reproductive age in relation to dietary intake and the effect of folic acid supplementation (1.1 mg or 5 mg). Plasma unmetabolized folic acid was not significantly correlated with folate intake estimated by food frequency questionnaire or biomarkers. The proportion of women with detectable levels of unmetabolized folic acid increased from
View details →Negative / Null Result ReportOpen accessMedicine
Mazen Hanna, W.H. Wilson Tang, Boon Wee Teo et al. · 2011 · Congestive Heart Failure
Compared with conventional diuretic (CD) therapy, ultrafiltration (UF) is associated with greater weight loss and fewer re-hospitalizations in patients admitted with decompensated heart failure (HF). Concerns have been raised regarding its…
View details →Negative / Null Result ReportOpen accessMedicine
J. Michael Jumper, Pravin U. Dugel, Sanford Chen et al. · 2018 · Clinical ophthalmology
PURPOSE: To evaluate the efficacy, safety, and injection frequency of vascular endothelial growth factor (VEGF) antagonists in the treatment of macular edema secondary to retinal vein occlusion (RVO) in clinical practice. PATIENTS AND…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Catherine E. Cottrell, Natalie Bir, Liz Varga et al. · 2011 · Autism Research
Structural and sequence variation have been described in several members of the contactin (CNTN) and contactin-associated protein (CNTNAP) gene families in association with neurodevelopmental disorders, including autism. Using array…
View details →Negative / Null Result Report
Irene Blanken, Niels van de Ven, Marcel Zeelenberg et al. · 2014 · Social Psychology
The present work includes three attempts to replicate the moral licensing effect by Sachdeva, Iliev, and Medin (2009) . The original authors found that writing about positive traits led to lower donations to charity and decreased…
View details →Negative / Null Result ReportOpen accessMedicine
C. Lennartz, John W. Pickering, Sarah Seiler-Mußler et al. · 2016 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Progression of CKD toward ESRD is heterogeneous. The Kidney Failure Risk Equation (KFRE) was developed to identify CKD patients at high risk of ESRD. We aimed to externally validate KFRE and to test whether the…
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Rosendo Estrada, Guruprasad A. Giridharan, Mai-Dung Nguyen et al. · 2011 · Biomicrofluidics
Atherosclerotic lesions occur non-randomly at vascular niches in bends and bifurcations where fluid flow can be characterized as “disturbed” (low shear stress with both forward and retrograde flow). Endothelial cells (ECs) at these…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Caroline Cormier, Bruno Voisard · 2018 · Frontiers in ICT
The flipped classroom as a form of active pedagogy in post-secondary chemistry has been developed during the last 10 years and has been gaining popularity with instructors and students ever since. In the current paradigm in STEM (science, technology, engineering and mathematics) education, it is widely recognized that active learning has significant positive effects on students’ grades. Post-secondary organic chemistry is a difficult course for students and the traditional way of teaching does not foster students’ active involvement. Implementation of active pedagogy could increase students’ a
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Muhammad Shahbaz, Mehmet Balcılar, Mantu Kumar Mahalik et al. · 2021 · International Journal of Finance & Economics
Abstract By using quarterly data over the period 1970Q1‐2017Q4, this paper examines the dynamic causal relationship between globalization and energy consumption by using rolling and recursive rolling Granger causality methods. This study…
View details →Negative / Null Result ReportOpen accessNeuroscience
Alexander C. Wilson, Dorothy Bishop · 2018 · PeerJ
BACKGROUND: It has been suggested that failure to establish cerebral lateralisation may be related to developmental language disorder (DLD). There has been weak support for any link with handedness, but more consistent reports of associations with functional brain lateralisation for language. The consistency of lateralisation across different functions may also be important. We aimed to replicate previous findings of an association between DLD and reduced laterality on a quantitative measure of hand preference (reaching across the midline) and on language laterality assessed using functional t
View details →Negative / Null Result ReportOpen accessComputer Science
David Rozado · 2024 · PLoS ONE
I report here a comprehensive analysis about the political preferences embedded in Large Language Models (LLMs). Namely, I administer 11 political orientation tests, designed to identify the political preferences of the test taker, to 24 state-of-the-art conversational LLMs, both closed and open source. When probed with questions/statements with political connotations, most conversational LLMs tend to generate responses that are diagnosed by most political test instruments as manifesting preferences for left-of-center viewpoints. This does not appear to be the case for five additional base (i.
View details →Negative / Null Result ReportOpen accessMedicine
John P Grogan, Demitra Tsivos, Laura Smith et al. · 2017 · eLife
Emerging evidence suggests that dopamine may modulate learning and memory with important implications for understanding the neurobiology of memory and future therapeutic targeting. An influential hypothesis posits that dopamine biases reinforcement learning. More recent data also suggest an influence during both consolidation and retrieval. Eighteen Parkinson's disease patients learned through feedback ON or OFF medication, with memory tested 24 hr later ON or OFF medication (4 conditions, within-subjects design with matched healthy control group). Patients OFF medication during learning decre
View details →Negative / Null Result ReportSocial Sciences
Céline Teney, Perrine Devleeshouwer, Laurie Hanquinet · 2013 · Ethnicities
Ethnic disparities in educational aspirations and choices are important to comprehend ethnic education inequality. Based on a mixed-method approach (3121 questionnaires and 40 interviews of pupils), this article investigates ethnic…
View details →Negative / Null Result ReportSocial Sciences
Haeseung Seo, Aiping Xiong, Dongwon Lee · 2019
Despite increased interests in the study of fake news, how to aid users' decision in handling suspicious or false information has not been well understood. To obtain a better understanding on the impact of warnings on individuals' fake…
View details →Negative / Null Result ReportPsychology
Kasia Müldner, Rachel Lam, T. H. Michelene · 2013 · Journal of Educational Psychology
A promising instructional approach corresponds to learning by observing others learn (i.e., by watching tutorial dialogue between a tutor and tutee). However, more work is needed to understand this approach’s pedagogical utility. Thus, in…
View details →Negative / Null Result ReportOpen accessMedicine
Yi-Chieh Perng, Zhikang Qian, Anthony R. Fehr et al. · 2011 · Journal of Virology
In this study, we adopted a conditional protein genetic approach to characterize the role of the human cytomegalovirus (HCMV) gene UL79 during virus infection. We constructed ADddUL79, a recombinant HCMV in which the annotated UL79 open…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Laoise Renwick, Mary Lavelle, G. BRENNAN et al. · 2016 · International Journal of Mental Health Nursing
Workplace violence is a significant problem for health service personnel, with National Health Service (NHS) workers subject to 68 683 physical assaults between 2013 and 2014. Almost 70% of assaults occur in the mental health sector, and…
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