e-ISSN: Pending

Browse the failure-mode index

19,918 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Immediate effects of extracorporeal shockwave, ultrasound, and shortwave diathermy in non-specific low back pain: A single-session randomized trial.

Arovah NI, Kushartanti W, Ambardini RL · 2026 · Rehabilitacion

Background and objective Nonspecific low back pain (NSLBP) is a prevalent musculoskeletal condition. This study examined the immediate effects of extracorporeal shockwave therapy (ESWT), ultrasound therapy (UST), and shortwave diathermy…

View details →
Negative / Null Result ReportMedicine

Longitudinal associations between depression, substance use, and immune activation and inflammation: A secondary analysis of men who have sex with men living with HIV in Brazil (HPTN 063).

Cherenack EM, Larson ME, Roach ME et al. · 2026 · Brain, behavior, and immunity

Background Limited research has examined the longitudinal interplay of depression, substance use, and immune dysregulation among men with HIV. Methods We analyzed longitudinal data from 100 men who have sex with men (MSM) living with HIV…

View details →
Negative / Null Result ReportOpen accessMedicine

Educational Impact of a 30-Minute Ultrasound Training Lecture on Medial Meniscus Extrusion Measurements: A Pilot Study of Intra- and Inter-rater Reliability Among Novice Students.

Tozawa R, Ishii N, Minamoto Y · 2026 · Cureus

Background Medial meniscus extrusion (MME) is a pivotal biomarker for knee osteoarthritis progression. Although ultrasonography offers a dynamic and cost-effective MME assessment, its clinical utility is often limited by the perceived high…

View details →
Negative / Null Result ReportOpen accessMedicine

Evaluation of the validity and reliability of the Meloq EasyBase force platform for assessing jump performance and balance parameters.

Arslan SG, Gultekinler BD · 2026 · BMC sports science, medicine & rehabilitation

Background Force platforms are widely used to assess postural stability and vertical jump performance, yet their cost and limited portability restrict routine clinical and field-based use. The Meloq EasyBase force platform offers a…

View details →
Negative / Null Result ReportOpen accessMedicine

Baseline Procalcitonin and C-Reactive Protein Levels in Asymptomatic Individuals From West Africa With and Without <i>P. falciparum</i> Parasitemia.

Strauss R, Wafula ST, Kobbe R et al. · 2026 · Open forum infectious diseases

We assessed baseline C-reactive protein (CRP) and procalcitonin levels in asymptomatic individuals from malaria-endemic West Africa. C-reactive protein remained unaffected by Plasmodium falciparum parasitemia, while procalcitonin (PCT) was…

View details →
Negative / Null Result Report

CD44-Hyaluronan-Dependent Monocyte Rolling

Hubbe M, Eibl RH · 2026 · Preprint

Leukocyte recruitment from blood into tissues involves sequential adhesive steps, including rolling and integrin-dependent arrest. VLA-4 can support firm adhesion and, in some settings, rolling interactions, whereas CD44–hyaluronan…

View details →
Negative / Null Result Report

Emergent primordial heritability in short random RNA pools

Kakizaki J, Widada AA, Ichihashi N et al. · 2026 · Preprint

The emergence of heritable molecular information is a fundamental step in the origins of life. Prior to the evolution of defined self-reproducing RNAs in the RNA world hypothesis, mixtures of primordial oligonucleotides may have supported…

View details →
Negative / Null Result ReportMedicine

Intrinsically nonlocal metamaterials.

Ware A, LaMountain J, White RC et al. · 2026 · Nature communications

The electromagnetic response of materials serves as the foundation for a broad range of vital applications, from imaging, to sensing, to classical and quantum communications. Here we demonstrate, theoretically and experimentally, a…

View details →
Negative / Null Result ReportOpen accessMedicine

Long-Term Clinical, Immunologic, and Viral Reservoir Outcomes in Children Treated With VRC01LS and 10-1074 Monoclonal Antibodies in the Tatelo Study.

Ajibola G, Nelson BS, Niesar A et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Broadly neutralizing antibodies (bNAbs) are a promising treatment option for children with HIV-1, but their long-term impact on virologic, immunologic, and clinical outcomes is unknown. Methods The Tatelo Study investigated dual…

View details →
Negative / Null Result ReportOpen accessMedicine

Metformin

· 2006

Data from well-conducted studies indicate that metformin levels in milk are low and infants would receive less than 0.5% of their mother's weight-adjusted dosage. Milk metformin levels are relatively constant during maternal metformin use,…

View details →
Negative / Null Result ReportOpen accessMedicine

Combustion and Heated Tobacco Cigarettes, but Not E-Cigarettes, Impair Aquaporin-Dependent H<sub>2</sub>O<sub>2</sub> Permeability in ATII-Like Cells.

Senise G, Bodega F, Porta C et al. · 2026 · Cells

Cigarette smoke is a major inducer of oxidative stress, promoting reactive oxygen species (ROS) accumulation and contributing to the pathogenesis of chronic obstructive pulmonary disease (COPD) and lung cancer. Heated tobacco products…

View details →
Negative / Null Result ReportOpen accessMedicine

Citalopram

· 2006

Infants receive citalopram in breastmilk, and it is detectable in low levels in the serum of some. The dosage that the infant receives and serum level achieved are probably related to the genetic metabolic capacity of the mother and…

View details →
Negative / Null Result Report

Particle Structure from Codimension-Two Carrier Closure

Li B · 2026 · Preprint

The Standard Model describes particle phenomena through continuous gauge structures, chiral assignments, color, generations, and Yukawa masses, but it does not derive these labels from a deeper structural principle. This paper proposes a…

View details →
Negative / Null Result ReportOpen accessMedicine

Biomarker analysis of circulating tumor DNA in clinical stage III melanoma patients treated with neoadjuvant immunotherapy combined with targeted therapy.

Stoff R, Routman DM, Yalon M et al. · 2026 · Therapeutic advances in medical oncology

Background Circulating tumor DNA (ctDNA) is predictive of recurrence in resected stage III melanoma, yet its role in the neoadjuvant setting for clinical stage III (cSIII) is unclear. Objective Assess the association between ctDNA and…

View details →
Negative / Null Result ReportMedicine

CRISPR/Cas9-Mediated Knockout of the NAD-Dependent Lactate Dehydrogenases for Altered Stereospecific Lactic Acid Production in Lacticaseibacillus paracasei NC4.

Chu NH, Le HD, Quach NT et al. · 2026 · Biochemical genetics

The optical purity of lactic acid is a critical parameter for producing high-performance polylactic acid (PLA). To investigate the genetic basis of stereospecific lactic acid biosynthesis, the present study aimed to functionally…

View details →