20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Clarke JG, Dutta N, Nickel MS et al. · 2026 · ACS medicinal chemistry letters
Semisynthetic modification of mycothiazole ( 1 ) with Meerwein's salt to generate a more stable and/or potent analog than 8- O -acetylmycothiazole ( 2 ) unexpectedly yielded diastereomers devoid of the diene. Analysis of NMR, HR-LCMS, and…
View details →Zhang Z, van Lieshout L, Bekkering H · 2024 · Preprint
When people are offered the opportunity to choose, they tend to learn better. To investigate cognitive mechanisms of this beneficial effect of choice on learning, a learning task was designed in which we independently manipulated choice…
View details →Doneddu PE, Collet-Vidiella R, Gallo C et al. · 2026 · Journal of the peripheral nervous system : JPNS
Background and aims Rituximab has been proposed as a potential treatment in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but formal evidence regarding its clinical effectiveness is weak. The CIDPRIT trial found no…
View details →Cavazza M, Carità G, Pizzuto S et al. · 2025 · Preprint
Abstract Background Acute occlusions of the anterior circulation with an underlying intracranial atheromatous disease (ICAD) represent a diagnostic and therapeutic challenge. The aim of this study was to compare the results of the…
View details →Tajika A, Toyomoto R, Sakata M et al. · 2026 · BMJ mental health
Background Depression is a leading cause of global disability, and subthreshold cases contribute substantially to the burden. Cognitive behavioural therapy (CBT) is effective for depressive symptoms, but its impact on social functioning in…
View details →Miletić M, Kovač V, Barišić L et al. · 2025 · Pharmaceutics
Background/Objectives : Resveratrol (RSV) and curcumin (CRC) have antioxidant, anti-inflammatory, photoprotective, and cell-repairing properties. We selected them to investigate the potential role involved in human keratinocyte protection.…
View details →Charles AL, Tetsi L, Quiring G et al. · 2026 · Muscles (Basel, Switzerland)
Peripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia-reperfusion (IR) settings, but whether PDE 4 inhibition protects…
View details →Li J, Yang C, Li K · 2026 · BMC pregnancy and childbirth
BACKGROUND: Restricted gestational weight gain (GWG) following lifestyle interventions for gestational diabetes mellitus (GDM) has been observed in clinical trials but not been explicitly confirmed in real-world clinical settings.…
View details →Geertsma RC, Polinder J, Groen D et al. · 2025 · Preprint
Abstract Recent reports suggest that reef-building corals can shift from autotrophic to heterotrophic feeding during episodic heatwaves, which may have mitigating effects on thermal stress. It is yet unclear to what extent this could occur…
View details →Stanley M, Huang K, Garlich J et al. · 2025 · Journal of orthopaedic trauma
Objectives To compare time, fluoroscopic utilization, and number of misses for placement of far interlocking screws in tibial and femoral nails using a targeting arm (Targeter) versus perfect circle technique (Control). Methods . Design…
View details →Gewiss C, Gehrdau K, Hischke S et al. · 2025 · Journal of wound care
Objective The application of cold atmospheric plasma (CAP) has been described as a promising therapeutic approach for wound healing. Its use in immunologically mediated wounds such as pyoderma gangrenosum (PG) has not yet been sufficiently…
View details →Avetisian H, Mathew K, Myers A et al. · 2026 · Global spine journal
Study DesignCross-sectional.ObjectivesLaminoplasty (LP) and laminectomy with fusion (LF) are surgical approaches for degenerative cervical myelopathy (DCM), but their comparative effectiveness remains controversial. Systematic reviews and…
View details →Lee J, Sun J, Lee HW · 2025 · Annals of the American Thoracic Society
Rationale: In patients with lung cancer, the impact of chronic obstructive pulmonary disease (COPD) diagnosis and subsequent management on mortality remains uncertain, because evidence supporting the efficacy of inhaled therapies in…
View details →Tamber MS, Jensen H, Reeder R et al. · 2025 · Journal of neurosurgery. Pediatrics
Objective The Hydrocephalus Clinical Research Network-Quality (HCRNq) was established to encourage adoption of evidence-based best practices for the care of children with hydrocephalus. A shunt infection prevention initiative is ongoing…
View details →Pearson AC, Yampolsky LY · 2025 · Biogerontology
NAD + homeostasis is an important determinant of lifespan and may be a key mechanism of caloric restriction (CR) expansion of lifespan. Ketone bodies such as beta-hydroxybutyrate (BHB) that regulate NAD + abundance and NAD + precursors…
View details →Valiensi SM, Vera VA, Folgueira AL et al. · 2025 · Brain sciences
Background . Although melatonin is widely used in Sleep Medicine for its chronobiological action, its potent antioxidant and mitochondrial regulatory effects, as well as its immunomodulatory and anti-inflammatory functions, make it of…
View details →El Hajjaji A, Akasbi N, El Mezouar I et al. · 2025 · Cureus
Introduction Knee osteoarthritis (KO) is a major public health issue, that significantly affects patients' quality of life. Metabolic comorbidities, particularly dyslipidemia, have been shown to influence the incidence and progression of…
View details →de Souza EDF, E Silva LO, Vieira LM et al. · 2026 · Theriogenology
The aim was to evaluate the effects of administering long-acting injectable progesterone (iP4) and/or hCG 3 days after timed artificial insemination (TAI) on luteal dynamics, circulating progesterone (P4) concentrations, and fertility…
View details →Lindhard K, Hansen HP, Gliese K et al. · 2026 · The journal of vascular access
Introduction Improved arteriovenous fistula (AVF) maturation is crucial for reducing the dependency on central venous catheters in patients undergoing hemodialysis (HD). Far-infrared radiation (FIR) is a treatment modality that may enhance…
View details →Conteduca J, Longo D, Casto A et al. · 2025 · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
Purpose The objective of this study was to assess the benefits of utilizing a silicone ring tourniquet in relation to traditional pneumatic cuff tourniquets and scenarios without any tourniquet intervention. The tested hypothesis…
View details →Ricigliano VA, Szejko N, Camera V et al. · 2026 · Multiple sclerosis and related disorders
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neuronal loss, with significant public health impact. Despite important therapeutic advances, major unmet needs remain, mainly in…
View details →Terakawa H, Kawata C, Kurokawa Y et al. · 2025 · Gan to kagaku ryoho. Cancer & chemotherapy
Oncotype DX is performed to predict prognosis and the added benefit of chemotherapy in hormone receptor-positive, HER2-negative breast cancer, with the goal of individualizing chemotherapy decisions. Here, we report 2 cases of early- stage…
View details →Singh A · 2026 · Preprint
Abstract Three decades of national-level ICDS evaluation have produced largely inconclusive results at the anthropometric growth parameters of children. This paper argues that this inconclusiveness reflects an aggregation problem:…
View details →Dravigney L, Chartier C, Grelaud P et al. · 2026 · Journal of helminthology
Anthelmintic resistance (AR) in gastrointestinal nematodes is insufficiently studied in cattle in many European regions, including France, where only three studies have been conducted in the north-west. This study evaluated the efficacy of…
View details →Granda D, Szmidt MK, Jarmuzek-Orska P et al. · 2026 · Scientific reports
To date, only a few studies have examined the relationship between dietary patterns and premenstrual syndrome (PMS), and these have been limited to Asian populations with inconclusive results, while studies in European populations are…
View details →De Silva DTN, Hamilton AJ, Strunk T et al. · 2026 · European journal of hospital pharmacy : science and practice
Objective To investigate the chemical and visual compatibility of dexmedetomidine injection with 44 secondary intravenous (IV) drugs and six 2-in-1 parenteral nutrition (PN) solutions used in neonatal intensive care unit settings. Methods…
View details →Giulia C, Simona M, Monia M et al. · 2026 · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Background and aims The current diagnostic approach to inherited cardiac conditions (ICCs) is primarily focused on the analysis of single-nucleotide variants (SNVs) and small insertions/deletions (InDels). However, as recommended for other…
View details →Wu H, Wang H, Liang Y et al. · 2025 · Journal of assisted reproduction and genetics
Purpose To investigate whether re-biopsy and re-vitrification affect embryo developmental potential and clinical outcomes. Methods Embryos that underwent preimplantation genetic testing for aneuploidy (PGT-A) and single embryo transfer…
View details →Mohn C, Haga E, Nilsson HSW et al. · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research
Background In a recent Norwegian regional suicide prevention media campaign, we found small and inconclusive results regarding changes in attitudes to suicide and help-seeking. In this exploratory study we add the data from two other…
View details →GONDA K, Ozaki A, Ito S et al. · 2026 · Preprint
Abstract In the setting of blood group chimerism/mosaicism, conventional BRCA1/2 genetic testing may yield inconclusive results. Multigene panel testing (MGPT) may overcome this limitation. We report a case in which BRCA2 pathogenic…
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