19,918 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Struja T, Hansen LH, Matos J et al. · 2026 · BMJ open
Importance Clinical trials have produced inconclusive results regarding the optimal glucose range for a patient with sepsis in the intensive care unit (ICU) receiving insulin treatment. Objective To investigate the optimal glucose range in…
View details →Droste MJ, Remeijer M, Planqué R et al. · 2024 · Preprint
A bstract In isothermal chemical reaction networks, reaction rates depend solely on the reactant concentrations setting their thermodynamic driving force. Living cells can, in addition, alter reaction rates in their enzyme-catalysed…
View details →Klim L, Michalik M, Cichocka-Jarosz E et al. · 2025 · Nutrients
Background: Diagnosing food allergy (FA) typically involves a detailed clinical history and confirmation of allergen-specific IgE. Oral food challenges (OFCs) remain the gold standard in FA diagnosis. This study aimed to present our…
View details →Jain M, Pal DK, Narayan Sahu R et al. · 2025 · World journal of orthopedics
Background Sagittal spinopelvic alignment (SSA) is essential for preserving a stable and effective upright posture and locomotion. Although alterations in the SSA are recognised to induce compensatory modifications in the pelvis, hips, and…
View details →Buchta C, Aberle SW, Görzer I et al. · 2024 · Wiener klinische Wochenschrift
Background External quality assessment (EQA) schemes provide objective feedback to participating laboratories about the performance of their analytical systems and information about overall regional analytical performance. The EQAs are…
View details →Katz A, Kreiner M, Korain Blank P et al. · 2025 · Journal of pediatric orthopedics
Background Clubfoot is a congenital condition affecting 1 to 2 per 1000 live births, with treatment primarily involving the Ponseti method and/or surgical intervention. It is important to ascertain whether children affected by clubfoot are…
View details →Zeinhom MG, Elsayed Khalil MF, Omar Youssif TY et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Although topiramate and valproate are antiseizure medications that have many contraindications and could produce many side effects, they are still used as migraine preventive therapy in middle- and low-income countries. Several trials…
View details →La Jeon Y, Lee SG, Lee EH et al. · 2023 · Diagnostic microbiology and infectious disease
We investigated whether inconclusive results could be interpreted differently depending on the situation. First, data from retesting of the initial samples from subjects without a confirmed COVID-19 history were analyzed. And by analyzing…
View details →Palomino-Padilla S, Caceres-Cardenas G, Calderon R et al. · 2024 · Frontiers in public health
Objectives The COVID-19 pandemic caused a global shortage of nasopharyngeal (NP) swabs, required for RT-PCR testing. Canadian manufacturers were contacted to share NP swab innovations. The primary objective was to determine whether novel…
View details →Wang L, Xue C, Zhu B et al. · 2025 · Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
Background/objective Data in terms of how dynamic changes of muscle mass and function affect mortality in end-stage kidney disease (ESKD) patients undergoing dialysis have led to inconclusive results. The main goal of this research was to…
View details →Bevilacqua C, Boscarato V, Pieroni G et al. · 2024 · Preprint
Background: developmental dysplasia of the hip (DDH) is a condition characterized by abnormal hip development in infancy. Early diagnosis allows for effective treatment, while late presentation often necessitates complex surgical…
View details →Rajamanickam SK, Prades Morera E, Agarwal A et al. · 2025 · Cureus
Background Fine needle aspiration cytology (FNAC) is widely used to evaluate head and neck masses, with both ultrasound (US)-guided and freehand techniques being employed. While US-guided FNAC is thought to enhance accuracy, freehand FNAC…
View details →Reiner M, Drobińska H, Miciak M et al. · 2026 · Cancer management and research
Background Thyroid cancer (TC) is the most commonly diagnosed endocrine malignancy, with rising global incidence. Current diagnostic techniques, including ultrasound and fine-needle aspiration biopsy (FNAB), often yield inconclusive…
View details →Wasmuth HH, Færden AE · 2024 · Updates in surgery
The paucity of prospective data on the subject of Watch and Wait for rectal cancer prompted the implementation of Norwait, a population-based study including rectal cancer patients after neoadjuvant therapy. The aim of the study was to…
View details →Phillips E, Ngure FM, Kassim N et al. · 2025 · The American journal of clinical nutrition
Background Linear growth faltering continues to negatively affect children in low- and middle-income countries and is associated with poor cognitive, developmental, and educational outcomes. Laboratory and observational data suggest that…
View details →Otero Castro V, Scales DC, Angriman F · 2025 · Critical care explorations
Objectives We sought to estimate the association between chronic use of renin-angiotensin system inhibitors and acute kidney injury requiring renal replacement therapy in critically ill adult patients with sepsis. Design Population-based…
View details →Lyons M, Lahuerta-Marin A, Clarke J et al. · 2025 · Irish veterinary journal
Bovine Viral Diarrhoea Virus (BVDV), Border Disease Virus (BDV), and Bovine Herpesvirus-1 (BoHV-1, the cause of Infectious Bovine Rhinotracheitis, IBR), are economically important endemic viruses in ruminant livestock in the United Kingdom…
View details →Zeng QB, Zou DC, Huang XB et al. · 2025 · Journal of affective disorders
Background Electroconvulsive therapy (ECT) is a commonly used alternative for treatment-resistant depression (TRD). Although esketamine has a rapid pharmacological antidepressant action, it has not been studied as an ECT anesthetic. The…
View details →Solodjankina A, Kratovska A, Ponomarjova S et al. · 2024 · Medicina (Kaunas, Lithuania)
Background and Objectives : Primary hyperparathyroidism (pHPT) is a common endocrine disorder caused by excessive production of parathyroid hormone (PTH) leading to elevated calcium levels. Diagnosis is primarily based on biochemical…
View details →Zein SE, Tande AJ, Carr CM et al. · 2024 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Background Diagnostic methods for native vertebral osteomyelitis (NVO) often yield inconclusive results. Image-guided spine biopsies for culture are specific but diagnose NVO in only 50% of cases. Pre-exposure to antimicrobials further…
View details →Neubauer FB, Wagner FL, Lörwald A et al. · 2024 · BMC medical education
It has been difficult to demonstrate that interprofessional education (IPE) and interprofessional collaboration (IPC) have positive effects on patient care quality, cost effectiveness of patient care, and healthcare provider satisfaction.…
View details →Huish S, Sinha S · 2024 · Current opinion in nephrology and hypertension
Purpose of review Vascular and valvular calcification are associated with cardiovascular morbidity and mortality in people with chronic kidney disease (CKD). Uncertainty exists regarding therapeutic strategies to attenuate calcification.…
View details →Fortier A, Zouaoui I, Dumais A et al. · 2024 · Psychiatric services (Washington, D.C.)
Objective Recreational cannabis legalization (RCL) is expanding rapidly. RCL's effects on mental health issues are of particular concern because cannabis use is more frequent among people receiving psychiatric care and is associated with…
View details →Rodrigo C, Gnanathasan A · 2024 · Transactions of the Royal Society of Tropical Medicine and Hygiene
Globally, snakebites cause an estimated 80 000-140 000 deaths annually. While there are evidence-based recommendations for managing snakebite victims, recommendations on the prevention of snakebites are limited to expert opinions. We…
View details →Paisant A, Faroche E, Fouche A et al. · 2024 · Abdominal radiology (New York)
Purpose Preoperative imaging is now recommended in patients with suspected acute appendicitis (AA) by the World Society of Emergency Surgery. Our aims were (i) to describe our local practice and (ii) to evaluate the efficiency of…
View details →Hinney B, Wiedermann S, Vaneev X et al. · 2024 · Parasites & vectors
The population of South American camelids (SAC) has been steadily growing in Europe, where they are confronted with the regional endoparasite population of ruminants. As there are no anthelmintic drugs registered for use against nematode…
View details →Shen C, Zhu Z, Zhang X et al. · 2024 · Preprint
Purpose: Numerous epidemiological studies have explored the association between the components of metabolic syndrome (MetS) and risk of prostate cancer (PCa). However, to date, the findings have yielded inconclusive results. This study…
View details →Mildner FO, Sykora MM, Hackl H et al. · 2024 · Lung cancer (Amsterdam, Netherlands)
Background Cancer immune evasion is critical in non-small cell lung cancer (NSCLC) and has been targeted by immunotherapy. High soluble (s)PD-L1 is associated with reduced survival and treatment failure in advanced stages. Here we…
View details →Johnson MS, Adams VM, Byrne J · 2024 · Preprint
Abstract Effective adaptation to climate risks requires identifying and realizing community beliefs about which locations require management attention. Environmental planners and asset managers, especially those in rural and regional…
View details →Le NT, Nguyen TG, Huynh NYN et al. · 2025 · Scientific reports
Dietary calcium's role in human health and disease prevention is inconclusive. We examined the associations between dietary calcium intake and the risk of overall and specific causes of mortality. A prospective cohort study was performed…
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