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WASTE Journal

Browse the failure-mode index

19,918 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

PcrV in an intranasal adjuvanted tobacco mosaic virus conjugate vaccine mediates protection from Pseudomonas aeruginosa via an early Th1/Th17 skewed localized and systemic immune response.

Katseff AS, Toumanios C, Barahim E et al. · 2025 · Vaccine

Multi-drug-resistant Pseudomonas aeruginosa (PA) infections are a growing problem for at-risk populations, causing thousands of deaths per year, and novel therapies to treat or prevent severe PA infection are desperately needed. We…

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Negative / Null Result ReportMedicine

Preimplantation genetic testing for aneuploidy mosaicism reporting lacks clinical predictive value for live birth in a multisite, double-blinded study with independent validation.

Gill P, Tao X, Zhan Y et al. · 2026 · American journal of obstetrics and gynecology

Background Preimplantation genetic testing for aneuploidy is used to improve in vitro fertilization outcomes by identifying embryos with lethal chromosomal abnormalities that impair development or lead to pregnancy loss. The adoption of…

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Negative / Null Result ReportMedicine

Perceptual, Thermoregulatory, and Performance Effects of Menthol Gel Application in Trained Triathletes Exercising in Hot Conditions.

Barwood M, Barwood H, Davis D et al. · 2025 · International journal of sports physiology and performance

Purpose Topical menthol application improves thermal perception and enhances performance but reduces sweat production in hot environments. In the aquatic environment, where sweat evaporation is of limited thermoregulatory benefit (ie,…

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Negative / Null Result ReportMedicine

Reduction of Enteric Pathogens in Bottled Water Using Residual Ozone.

Schwaner WR, Kumar S, Thippareddi H · 2025 · Journal of food protection

Ozone is an effective and safe disinfectant used globally in the bottled water industry. Ozone infusion at a high level helps maintain a residual level (0.1-0.4 mg/L) at the time of bottling, thus can ensure 4 log microbial reductions.…

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Negative / Null Result ReportOpen accessMedicine

Evaluating Dermal Bioactivity of Metal Additive Manufacturing Powders Using Human <i>In Vitro</i> and <i>Ex Vivo</i> Skin Models.

Persson A, Łyczyńska Z, Shahata M et al. · 2026 · Chemical research in toxicology

Metal additive manufacturing (AM) relies on alloy feedstock powders that may come into contact with the workers' skin during handling, yet skin-relevant data on metal release and biological reactivity remain limited. Here, we assessed the…

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Negative / Null Result ReportMedicine

Design and optimization of an automatic deep learning-based cerebral reperfusion scoring (TICI) using thrombus localization.

Folcher A, Piters J, Wallach D et al. · 2025 · Journal of neuroradiology = Journal de neuroradiologie

Background The Thrombolysis in Cerebral Infarction (TICI) scale is widely used to assess angiographic outcomes of mechanical thrombectomy despite significant variability. Our objective was to create and optimize an artificial intelligence…

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Negative / Null Result ReportMedicine

A single session of whole-body vibration did not affect cardiovascular autonomic recovery after a high intensity exercise in horses

Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science

Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic reactivity during…

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Negative / Null Result ReportOpen accessMedicine

Trained immunity agonists given to neonatal mice fail to protect against leptospiral infection in adulthood and may cause adverse effects.

Fernandez M, Vernel-Pauillac F, Pezier T et al. · 2026 · Innate immunity

Background and ObjectivesTrained immunity (TI) refers to a non-specific, long-lasting protective immune response that occurs following initial stimulation of the immune system and thought to be largely mediated by functional reprogramming…

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Negative / Null Result ReportMedicine

Will a co-created program enhance implementation of injury prevention training in youth handball in Sweden? A cluster-randomized controlled trial.

Ageberg E, Donaldson A, Lucander K et al. · 2025 · Journal of science and medicine in sport

Objectives To compare the implementation of a co-created evidence-based injury prevention intervention with an existing program in youth team handball. Design Pragmatic two-armed cluster-randomized controlled trial, conducted…

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Negative / Null Result ReportMedicine

The metal-organic framework MIL-100(Fe) and ferric citrate as potential counteracting biomaterials against osteoarthritis-induced articular inflammation and fibrosis.

Tsai PS, Wu KC, Wu CH · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Osteoarthritis (OA) is a degenerative and deteriorating disease. The accompanying pain, stiffness, inflammation of the synovial joint, and the loss of articular function compromise the mobility, stability, and routine of patients' lives.…

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Negative / Null Result ReportMedicine

Added value of a balloon-based mucosal exposure device in computer-aided detection-assisted colonoscopy: a randomized controlled trial (COMBAT study).

Rocchetto S, Rondonotti E, Alicante S et al. · 2025 · Endoscopy

Both computer-aided detection (CADe) systems and mucosal exposure devices can enhance adenoma detection during colonoscopy. This research investigates whether combining a CADe system with a balloon-based mucosal exposure device increases…

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Negative / Null Result ReportMedicine

The role of social and emotional experience in representing abstract words.

Goriachun D, Strijkers K, Gala N et al. · 2025 · Journal of experimental psychology. General

words challenge embodied cognition theories due to their lack of direct connections to the sensory and bodily world. To address this, some theories propose that abstract words are represented through emotional and social information. We…

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Negative / Null Result ReportMedicine

PcrV in an intranasal adjuvanted tobacco mosaic virus conjugate vaccine mediates protection from Pseudomonas aeruginosa via an early Th1/Th17 skewed localized and systemic immune response.

Katseff AS, Toumanios C, Barahim E et al. · 2025 · Vaccine

Multi-drug-resistant Pseudomonas aeruginosa (PA) infections are a growing problem for at-risk populations, causing thousands of deaths per year, and novel therapies to treat or prevent severe PA infection are desperately needed. We…

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Negative / Null Result ReportMedicine

Cost does not prevent pigeons from investing in the future.

Cowie S, Davison M · 2025 · Behavioural processes

One of the simplest forms of behavior, operant behavior, appears fundamentally prospective, implying potential similarity to 'sophisticated' prospective behaviors like planning in terms of underlying mechanisms. But differences between…

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Negative / Null Result ReportOpen accessMedicine

Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial.

Ratajczak M, Bilska A, Musialik K et al. · 2026 · Frontiers in endocrinology

Background Metformin is widely used as a first-line therapy for type 2 diabetes and increasingly prescribed off-label in women with elevated HOMA-IR indices, including those at risk of metabolic disorders. However, its clinical use is…

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Negative / Null Result ReportMedicine

Mesenchymal Stem Cell Therapy Fails to Improve Fat Graft Retention: Cryopreserved and Cultured Syngeneic and Allogeneic Mesenchymal Stem Cells in a Rat Model.

Alstrup T, Pedersen JO, Kjær EM et al. · 2025 · Plastic and reconstructive surgery

Background Fat grafting is a gentle technique used to correct soft-tissue defects, but it is challenged by low graft survival rates. To enhance retention, mesenchymal stromal cells (MSCs) have been explored. Autologous MSC therapy has…

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Negative / Null Result ReportOpen accessMedicine

Evidence that SmTetX is not a tetracycline resistance determinant.

Beech MJ, Trush MM, Toma EC et al. · 2026 · Microbiology spectrum

SmTetX, a flavin-dependent monooxygenase from the opportunistic pathogen Stenotrophomonas maltophilia , is structurally related to the tetracycline-degrading Tet(X) resistance enzymes, though displays substantial divergence in active site…

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Negative / Null Result ReportOpen accessMedicine

Non-visualization of the fetal gallbladder with ultrasound in the second trimester in a Chinese cohort: prognosis and clinical consultation.

Ding H, Wang Y, He F et al. · 2026 · BMC pregnancy and childbirth

BACKGROUND: To investigate the prenatal characteristics and clinical outcomes of fetuses with non-visualization of the fetal gallbladder (NVFGB) with ultrasound during the second trimester and to promote prenatal consultations based on…

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Negative / Null Result ReportOpen accessMedicine

Acute beetroot juice ingestion fails to improve sprint performance and neuromuscular function in trained male sprinters: a randomized, double-blind, placebo-controlled study.

López-Samanes Á, Moreno-Pérez D, Aguilar-Navarro M et al. · 2026 · Journal of the International Society of Sports Nutrition

Introduction The aim of this study was to evaluate the acute effect of beetroot juice ingestion on sprint performance and neuromuscular properties of male trained sprinters. Methods Twelve male sprinters (24.3 ± 4.8 years) participated in…

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Negative / Null Result ReportMedicine

Criteria for knee flexion range of motion and quadriceps strength to ascend and descend stairs 1 year after bilateral total knee arthroplasty: A cross-sectional study.

Nanjo K, Ikeda T, Kaneyama R et al. · 2025 · Journal of back and musculoskeletal rehabilitation

BackgroundStair ascent/descent pose significant challenges after total knee arthroplasty (TKA); however, the exact knee flexion range of motion (ROM) and quadriceps strength requirements remain unclear.ObjectiveTo establish criteria for…

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