19,918 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Tian Y, Kim H, Ratcliffe PJ et al. · 2026 · Preprint
Oxidative post-translational modifications on the sulfhydryl group of cysteines can occur spontaneously or enzymatically. The dioxygenation of N-terminal cysteines has emerged as a new oxygen sensing paradigm, catalysed by…
View details →Franco Vega I · 2026 · Journal of sex research
This study assessed the effects of condom types and brands on use in a free condom distribution intervention in hostales (love hotels). New policies are needed to overcome the low levels of contraceptive use in Perú. Hostales could serve…
View details →Hodder RK, O'Brien KM, Wolfenden L et al. · 2026 · Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals
Issue addressed Tobacco, alcohol and other drug use contribute significantly to the global burden of disease, with initiation typically occurring during childhood and adolescence. School-based substance use prevention interventions are…
View details →Sundarakrishnan A, Siek B, Clarke PBS · 2026 · Behavioural brain research
The sucrose preference test is the primary measure of anhedonia in rat models of depression, but it does not specifically assess anticipatory anhedonia, a deficit commonly observed in patients. Anticipatory 50-kHz ultrasonic vocalizations…
View details →Getman-Pickering Z, Thaler J, Davis J et al. · 2026 · Preprint
During domestication, selection has typically decreased plant resistance to herbivores and reduced beneficial relationships with microbial mutualists such as mycorrhizae. These two processes raise the question of whether reductions in…
View details →S Krishnan V, Hodgetts SI, Harvey AR et al. · 2025 · Biogerontology
This two part study on the afferent connectivity of lumbar spinal motor neurons in normal ageing mice investigates; Study 1: time course analysis of age-related changes in the synaptic coverage of lumbar spinal cords of male C57BL/BJ mice…
View details →Gonotkov MA, Safiulina VF · 2026 · Preprint
Whole-cell patch-clamp studies often fail to observe the expected effect of melatonin on the IK1 current in cardiomyocytes, which may be due to cytoplasmic dialysis and the loss of key components of the intracellular signaling system. The…
View details →Borghero G, Pierri V, Pili F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Objective To analyze disease-modifying effects of percutaneous endoscopic gastrostomy (PEG) insertion for supporting nutrition, noninvasive ventilation (NIV), and tracheostomy-assisted ('invasive') ventilation (TIV) in amyotrophic lateral…
View details →Maiden MJ, Torpy DJ, Ludbrook GL et al. · 2024 · Experimental and therapeutic medicine
Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is…
View details →Nygaard B, Jensen CZ, Jorsal M et al. · 2025 · European thyroid journal
Objective Patients are increasingly using and requesting LT4/LT3 combination treatment for persistent hypothyroid symptoms, but the efficacy and side effects of long-term therapy remain largely unexplored. This study aimed to describe the…
View details →Cioe PA, Stang GS, Azam D et al. · 2025 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Introduction Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of…
View details →Parales-Girón JE, Dos Santos Neto JM, Lock AL · 2026 · Journal of dairy science
We evaluated the effects of whole cottonseed (WCS) and fatty acid (FA) supplementation on the production responses of early-lactation cows. Fifty-two multiparous cows were used in a randomized complete block design with a 2 × 2 factorial…
View details →Martin EL, Adarve-Rengifo I, Siddons SR et al. · 2026 · Ecology and evolution
Terrestrial leaf litter can release chemical compounds into the water, creating a solution called "leachate" that can have direct and indirect impacts on freshwater organisms. In this study, we investigated the direct effects of leaf…
View details →Forde G, Ifantides KB, Mayadev A et al. · 2026 · Toxicon : official journal of the International Society on Toxinology
OnabotulinumtoxinA (onabotA) is approved for the treatment of various therapeutic indications, which require retreatment. In clinical practice, many patients receive onabotA for multiple therapeutic indications concomitantly over extended…
View details →Anderbrant O, Huynh H, Isaksson A et al. · 2025 · Journal of Applied Entomology
Currant, and in particular blackcurrant, Ribes nigrum, is widely grown in Europe. It is the host of a number of pest insects, but their occurrence and the damage they cause vary geographically. In northern Europe, three lepidopteran…
View details →Xicota L, Cheng R, Barral S et al. · 2025 · Preprint
ABSTRACT Introduction Polygenic risk scores (PRS) have been used to assess an individual’s risk for various diseases, including Alzheimer’s disease (AD). This study applied the PRS approach to a cohort of families ascertained for healthy…
View details →Quévreux P, Zou K, Barot S et al. · 2025 · Freshwater Biology
The classical concepts of top‐down and bottom‐up cascading effects in ecosystems are challenged by the interactions between green and brown food webs. The green food web relies on photosynthesis and the brown food web relies on the…
View details →Amindarolzarbi A, Satcowitz K, Khalil A et al. · 2025 · Nuclear medicine communications
Objective The appropriate clinical management of indeterminate small renal masses can be improved based on accurate risk stratification. This study aimed to investigate the impact of renal function on the uptake of technetium-99m ( 99m…
View details →Prieto ML, Madison DV, Maduke M · 2025 · Biophysical journal
Ultrasound neuromodulation is a rapidly developing tool for noninvasive control of brain activity. An in vitro model recapitulating the effects of ultrasound on neural tissue in vivo would be extremely valuable in guiding the development…
View details →Medina Poeliniz C, Hoban R, Janes J et al. · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
Objective: To determine if cumulative measures of pumping behaviors over the first 5 days postpartum predicted lactation outcomes by postpartum days 7 (achievement of secretory activation [SA] and pumped milk volume) and 14 (achievement of…
View details →Prasifka JR, Fugate KK, Hulke BS · 2025 · Crop Science.
Variation in the quality, quantity, or accessibility of nectar and pollen within plant species is a potential target for plant breeding, both to enhance pollination and to support nutritional needs of pollinators. A biparental population…
View details →Shi J, Chen M, Zhang Y et al. · 2026 · Psychopharmacology
Rationale Autism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B -/- ) mouse model displays ASD-related…
View details →Park SJ, Manson JE, Kim E et al. · 2026 · Thrombosis and haemostasis
Epidemiological and experimental studies suggest cocoa flavanols and multivitamin-multimineral (MVM) supplements may confer arterial vascular benefits. However, their effects on clinical venous thromboembolic events have been infrequently…
View details →McGregor D, Shynkaruk T, Adler CAB et al. · 2026 · Poultry science
Commercial transport of newly hatched poultry species typically occurs under darkness. The impact of providing light during chick transportation has not been investigated and previous research suggests blue light may have a calming effect…
View details →Prandin G, Naccarato M, Furlanis G et al. · 2025 · Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Background Sympathetic activation, inflammation, and neuro-endocrine response after an ischemic stroke contribute to the development of the stroke heart syndrome (SHS). One marker of SHS is a troponin "rise and fall pattern" > 30%. Among…
View details →Dinleyici EC, Indrio F, Szajewska H et al. · 2026 · Journal of pediatric gastroenterology and nutrition
For many years, biotics (including probiotics, prebiotics, human identical milk oligosaccharides, synbiotics, and postbiotics) have been added to infant formula to influence the gut microbiota of formula-fed infants, aiming to bring it…
View details →Brizuela M, Bony AR, Garcia-Caraballo S et al. · 2026 · Experimental physiology
Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage-gated calcium and potassium channels by G protein-coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the…
View details →Lemper M, Luetjens CM, Fuchs A et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
To further understand the safety profile of zilucoplan, reproductive toxicology studies in non-human primates (NHPs) were performed, including a male fertility study and a combined embryo-foetal development (EFD) and enhanced pre- and…
View details →Alshuweishi Y, Binzomah Alghamdi F, Patrick K et al. · 2025 · Cells
AMP-activated protein kinase (AMPK) is activated by reduced cellular energy charge and mimics the action of insulin in muscle by stimulating increased trafficking of GLUT4 to the plasma membrane. In contrast, we have previously reported…
View details →Kishinevsky M, Ferrer-Suay M, Ives AR · 2024 · Preprint
The enemy release hypothesis, that the success of invading species is due to release from natural enemies that occur in their home range but not in the new range, can be an important explanation for successful invasions. Testing this…
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