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20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Association Between Patient Sex and Familial Hypercholesterolemia and Long-Term Cardiovascular Risk Factor Management 5 Years After Acute Coronary Syndrome.

Krasieva K, Gencer B, Locatelli I et al. · 2024 · Circulation. Cardiovascular quality and outcomes

Background Long-term control of cardiovascular risk factors after acute coronary syndrome (ACS) is the cornerstone for preventing recurrence. We investigated the extent of cardiovascular risk factor management in males and females with and…

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Negative / Null Result ReportMedicine

Vitamin D lowers the number of intestinal tumours in adult intestine-specific Apc-mutant mice only during early tumour initiation in gestation and juvenility.

Rebel HG, de Gruijl FR · 2026 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

We reported earlier that adult FabplCre;Apc 15lox/+ mice with either daily UV exposure or vitamin D supplementation developed not significantly fewer intestinal tumours but less tumour bulk (reduced outgrowth) than control mice that…

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Negative / Null Result ReportMedicine

Omega-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Did Not Reduce Inflammation to Improve Iron Absorption in South African Women Living with Overweight or Obesity.

Uyoga MA, Baumgartner J, Malan L et al. · 2026 · The Journal of nutrition

Background Young South African women face a double-burden of overweight or obesity and iron deficiency, with the former predicting the latter. Omega-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation can reduce inflammation.…

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Negative / Null Result ReportMedicine

Ultrasound-Guided Superficial Parasternal Intercostal Plane Block for Early Pain Management in Patients Undergoing Cardiac Surgery-A Randomized Controlled Trial.

Kalli AJ, Mäkelä P, Huhtala H et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Sternotomy causes substantial postoperative pain. Recently, several less invasive nerve blocks have been described that are safer to use even on anticoagulated patients. This study aims to evaluate early pain management using…

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Negative / Null Result ReportMedicine

Thoracic duct ligation during esophagectomy fails to prevent chylothorax or improve survival: a propensity score matched cohort study.

Quan S, Xie H, Zhang D et al. · 2026 · Esophagus : official journal of the Japan Esophageal Society

Background Postoperative chylothorax is a serious complication following esophagectomy. The efficacy of thoracic duct ligation (TDL) for chylothorax prevention is controversial. This study aimed to evaluate the impact of TDL on chylothorax…

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Negative / Null Result ReportMedicine

The Effect of Bariatric Surgery on Complication Risk Following Total Hip Arthroplasty in Patients with Morbid Obesity.

Lex JR, Ekhtiari S, Entezari B et al. · 2026 · The Journal of bone and joint surgery. American volume

Background Obesity is an independent risk factor for complications following total hip arthroplasty (THA). Preoperative bariatric surgery to facilitate weight loss has been used to reduce complication risk, but its effectiveness remains…

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Negative / Null Result ReportMedicine

Intraoperative PEEP Strategy and Postoperative Pulmonary Complications in Obese Patients: A Randomized Trial with Exploratory Analysis of Smoking Status.

Giaccari LG, Brunetti S, Coppolino F et al. · 2026 · Medical sciences (Basel, Switzerland)

Background : Obesity increases the risk of postoperative pulmonary complications (PPCs), and active smoking may further amplify this risk. Whether smoking status identifies a subgroup of obese surgical patients with differential PPC risk…

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Negative / Null Result ReportMedicine

Is emotion regulation a mechanism of change in virtual reality-assisted therapy for auditory hallucinations? Secondary analyses of the CHALLENGE randomized clinical trial.

Glenthøj LB, Vernal DL, Mariegaard LS et al. · 2026 · Schizophrenia (Heidelberg, Germany)

Virtual reality (VR)-assisted avatar therapy has shown promising effects for reducing voice-related distress and overall severity of persistent auditory verbal hallucinations (AVH) in psychosis, yet the mechanisms underlying these…

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Negative / Null Result ReportOpen accessMedicine

Fertility and mode of delivery after ileal pouch-anal anastomosis for ulcerative colitis: A population-based study.

Brar MS, Park JJ, de Buck van Overstraeten A · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Background and aims Fertility and mode of delivery are major concerns for women with ulcerative colitis (UC) undergoing ileal pouch-anal anastomosis (IPAA). Although infertility after IPAA has been attributed to pelvic adhesions, the…

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Negative / Null Result ReportMedicine

Evaluation of microleakage and remineralization potential of a fissure sealant containing microcapsules on artificial enamel lesions: with and without adhesive application.

Parlak Insel B, Guven Y, Sepet E et al. · 2026 · BMC oral health

Within the concept of minimal invasive dentistry, the progression of initial caries lesions can be inhibited with preventive measures. This study evaluated the microleakage and remineralization potential of a bioactive fissure sealant (FS)…

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Negative / Null Result ReportMedicine

Effects of the ABCDEF Bundle on Delirium, Function, and Quality of Life in Australian ICU Patients: A Pragmatic Randomized Controlled Trial.

Sosnowski KJ, Ranse KL, Mitchell ML et al. · 2026 · Critical care medicine

Objectives To test whether the ABCDEF bundle, compared with usual care, decreases delirium incidence and duration, improves functional status in the ICU, and enhances 90-day post-ICU discharge quality of life in critically ill Australian…

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Negative / Null Result ReportMedicine

Pre-Endoscopic Retrograde Cholangiopancreatography Cholangitis and Stent Outcomes in Malignant Distal Biliary Obstruction: A Multicenter Propensity Score-Matched Analysis.

Niiya F, Satoh T, Kobayashi Y et al. · 2026 · Digestive diseases and sciences

Background Clinical evidence on whether acute cholangitis accelerates early stent failure via rapid bacterial adhesion and biofilm formation remains limited. We assessed the influence of pre-endoscopic retrograde cholangiopancreatography…

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Negative / Null Result ReportMedicine

Mechanisms reducing parasympathetic activity in chronic hypoxia.

Maier LE, Douglas A, Foster K et al. · 2026 · The Journal of physiology

Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. We investigated whether (i) arterial chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii) pulmonary stretch, (iv)…

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Negative / Null Result ReportMedicine

[Efficacy and safety of ticagrelor versus clopidogrel after percutaneous coronary intervention in patients with acute coronary syndrome without standard modifiable cardiovascular risk factors].

Na K, Qiu MH, Wang ZH et al. · 2026 · Zhonghua xin xue guan bing za zhi

Objective: To evaluate the efficacy and safety of ticagrelor versus clopidogrel in real-world patients with acute coronary syndrome (ACS) without standard modifiable cardiovascular risk factors (SMuRF-less) following percutaneous coronary…

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Negative / Null Result ReportMedicine

Do coexistent overactive bladder symptoms affect the outcome of single-incision sling in women with urodynamic stress incontinence?

Hsieh TH, Liang CC, Liang CY et al. · 2026 · Taiwanese journal of obstetrics & gynecology

Objective To explore whether preoperative overactive bladder (OAB) symptoms affect the outcome of single-incision slings (SIS) for urodynamic stress incontinence (USI). Materials and methods This retrospective study involved 106 patients…

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