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Browse the failure-mode index

19,915 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Pumping Behaviors of Breast Pump-Dependent Mothers of Preterm Infants in the Neonatal Intensive Care Unit (NICU): Importance of the First Five Postpartum Days.

Medina Poeliniz C, Hoban R, Janes J et al. · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

Objective: To determine if cumulative measures of pumping behaviors over the first 5 days postpartum predicted lactation outcomes by postpartum days 7 (achievement of secretory activation [SA] and pumped milk volume) and 14 (achievement of…

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Negative / Null Result ReportMedicine

Targeting synaptic plasticity and acetylcholine dysregulation in the medial prefrontal cortex: Rosmarinic acid attenuates Autism-like phenotypes in Shank3B<sup>-/-</sup> mice via the CREB/BDNF pathway.

Shi J, Chen M, Zhang Y et al. · 2026 · Psychopharmacology

Rationale Autism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B -/- ) mouse model displays ASD-related…

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Negative / Null Result ReportOpen accessMedicine

No light, no problem: provision of light during simulated transport does not alter broiler chick performance or welfare outcomes.

McGregor D, Shynkaruk T, Adler CAB et al. · 2026 · Poultry science

Commercial transport of newly hatched poultry species typically occurs under darkness. The impact of providing light during chick transportation has not been investigated and previous research suggests blue light may have a calming effect…

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Negative / Null Result ReportMedicine

Role of beta-blocker therapy on the sympathetic effects in stroke heart syndrome.

Prandin G, Naccarato M, Furlanis G et al. · 2025 · Clinical autonomic research : official journal of the Clinical Autonomic Research Society

Background Sympathetic activation, inflammation, and neuro-endocrine response after an ischemic stroke contribute to the development of the stroke heart syndrome (SHS). One marker of SHS is a troponin "rise and fall pattern" > 30%. Among…

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Negative / Null Result ReportMedicine

Recommendations on the health outcomes of infant formula supplemented with biotics by the ESPGHAN Special Interest Group on Gut Microbiota and Modifications.

Dinleyici EC, Indrio F, Szajewska H et al. · 2026 · Journal of pediatric gastroenterology and nutrition

For many years, biotics (including probiotics, prebiotics, human identical milk oligosaccharides, synbiotics, and postbiotics) have been added to infant formula to influence the gut microbiota of formula-fed infants, aiming to bring it…

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Negative / Null Result ReportOpen accessMedicine

GABA<sub>B</sub> receptor-mediated modulation of sensory neuron excitability: Roles of Ca<sub>V</sub>2.2, G-protein-coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels in human and mouse nociception.

Brizuela M, Bony AR, Garcia-Caraballo S et al. · 2026 · Experimental physiology

Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage-gated calcium and potassium channels by G protein-coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the…

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Negative / Null Result ReportMedicine

Subcutaneous zilucoplan: Evaluation of reproductive toxicology.

Lemper M, Luetjens CM, Fuchs A et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)

To further understand the safety profile of zilucoplan, reproductive toxicology studies in non-human primates (NHPs) were performed, including a male fertility study and a combined embryo-foetal development (EFD) and enhanced pre- and…

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Negative / Null Result ReportOpen accessMedicine

Connexin-43-Mediated Gap Junction Coupling Between Adipocytes Regulates Norepinephrine-Induced Ca<sup>2+</sup> Responses in Perivascular Adipose Tissue.

Kim AR, Jamka J, Jackson WF et al. · 2026 · Cells

Anticontractile factors secreted by perivascular adipose tissue (PVAT) play an important role in regulating vascular tone. This process is driven by the neurotransmitter norepinephrine (NE), but recent data show that adrenergic innervation…

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Negative / Null Result ReportMedicine

Alpha-secretase inhibition impairs Group I metabotropic glutamate receptor-mediated protein synthesis, long-term potentiation and long-term depression.

Mockett BG, Davies JWT, Mills ZB et al. · 2024 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Group I metabotropic glutamate receptors (Gp1-mGluRs) exert a host of effects on cellular functions, including enhancement of protein synthesis and the associated facilitation of long-term potentiation (LTP) and induction of long-term…

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Negative / Null Result ReportOpen accessMedicine

Pin1 promotes human Ca V 2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2.

Fu SJ, Cheng KM, Hsiao CT et al. · 2024 · Cell communication and signaling : CCS

Loss-of-function mutations in the human gene encoding the neuron-specific Ca 2+ channel Ca V 2.1 are linked to the neurological disease episodic ataxia type 2 (EA2), as well as neurodevelopmental disorders such as developmental delay and…

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Negative / Null Result ReportOpen accessMedicine

Viniferin-Rich Phytocomplex from <i>Vitis vinifera</i> L. Plant Cell Culture Mitigates Neuroinflammation in BV2 Microglia Cells.

Videtta G, Sasia C, Quadrino S et al. · 2026 · Molecules (Basel, Switzerland)

Activation of microglia and resulting neuroinflammation are central processes that significantly contribute to neurodegenerative disease progression. Treatments capable of attenuating neuroinflammation are therefore an urgent medical need.…

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Negative / Null Result ReportOpen accessMedicine

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio.

Nguyen AP, Hadi DL, Todd DA et al. · 2026 · Clinical pharmacology and therapeutics

Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5-fold…

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Negative / Null Result ReportOpen accessMedicine

SYNCHRONIZE: Real-World Retrospective Safety Analysis of Patients Treated with OnabotulinumtoxinA for More than One Therapeutic Indication.

Forde G, Brucker BM, Becker Ifantides K et al. · 2024 · Toxins

OnabotulinumtoxinA (onabotA) is approved in the US for 12 therapeutic indications. Real-world data on onabotA multi-indication use are limited, often leading to delayed or reduced treatment. This study provides real-world evidence on the…

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Negative / Null Result ReportMedicine

Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance.

Goettel M, Werner C, Honarvar N et al. · 2024 · Toxicology

The fungicide fluxapyroxad (BAS 700 F) has been shown to significantly increase the incidence of liver tumours in male Wistar rats at dietary levels of 1500 and 3000 ppm and in female rats at a dietary level of 3000 ppm via a non-genotoxic…

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Negative / Null Result ReportOpen accessMedicine

Body composition and muscle health changes after providing vascular imaging results in older adults: secondary analysis of a randomised controlled trial.

Dalla Via J, Radavelli-Bagatini S, Sim M et al. · 2026 · Aging clinical and experimental research

Background Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim This secondary analysis of a 12-week…

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Negative / Null Result ReportMedicine

Theory-guided process evaluation of a multicomponent, technology-based 'SMART Eating' trial among Indian adults: an embedded mixed-methods study.

Kaur J, Kaur M, Chakrapani V et al. · 2023 · Health education research

We report process evaluation findings from the 'SMART Eating' intervention trial, which significantly improved fat, sugar and salt (FSS), and fruits and vegetables (FVs) intake among adults. Intervention used information technology [short…

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Negative / Null Result ReportOpen accessMedicine

The impact of CYP2D6 on donepezil concentration and its lack of effect on the treatment response and adverse effect in Korean patients with Alzheimer's disease.

Kim TE, Bae JW, Hong S et al. · 2025 · The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Donepezil, an acetylcholinesterase inhibitor, is widely used for managing the symptoms of Alzheimer's disease (AD), yet its clinical response varies widely among individuals. This study aims to investigate the influence of CYP2D6 genetic…

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