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20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Evaluating Food and Drug Administration approved gastrointestinal cancer drugs: clinical benefit and trial endpoints over the past two decades.

Jamal F, Sahvan O, Junior PLSU et al. · 2025 · The oncologist

Background The increasing reliance on accelerated approvals and surrogate endpoints for Food and Drug Administration (FDA) approvals of gastrointestinal (GI) cancer therapies raises concerns about their clinical benefit and long-term…

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Negative / Null Result ReportMedicine

Patient-reported outcomes with paclitaxel and ramucirumab switch maintenance in advanced gastroesophageal cancer: A secondary endpoint of the ARMANI phase 3 trial.

Cristarella E, Ambrosini M, Di Maio M et al. · 2025 · European journal of cancer (Oxford, England : 1990)

Background In the ARMANI trial, switch maintenance with paclitaxel plus ramucirumab improved progression-free survival and overall survival versus continuation of oxaliplatin-based chemotherapy in patients with HER2-negative advanced…

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Negative / Null Result ReportMedicine

Evaluating patients on immune checkpoint inhibitors for cardiac adverse events: The EPICC study.

Vang K, Panich J, Folz C et al. · 2025 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

IntroductionImmune checkpoint inhibitors (CPIs) work by engaging the patient's immune system against tumor cells and have demonstrated a significant benefit in the treatment of cancers. Activation of the patient's immune system can lead to…

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Negative / Null Result ReportMedicine

Real-time qPCR evaluation of amino acids buffered sodium hypochlorite gel as an adjunct to non-surgical periodontal treatment: a randomized clinical trial.

Dolińska E, Starosz A, Grubczak K et al. · 2026 · Scientific reports

This study aimed to evaluate the effects of non-surgical periodontal therapy (SRP) and SRP with an amino acid-buffered hypochlorite solution (NaOCl/AA + SRP) on subgingival plaque bacteria. Quantitative changes in Porphyromonas gingivalis,…

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Negative / Null Result ReportMedicine

Mandibular Response in Class II Division 1 Growing Subjects: Clear Aligners vs. Rapid Maxillary Expansion Therapy. A Controlled Pilot Study.

Chiara RF, Letizia L, Francesca G et al. · 2026 · Orthodontics & craniofacial research

Objectives The present study aimed to evaluate the skeletal and dental changes in two different groups of mixed dentition Class II division 1 patients treated with Clear Aligners and with Rapid Maxillary Expansion and to assess the…

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Negative / Null Result ReportOpen accessMedicine

Randomized Controlled Pilot Study of Transcutaneous Electrical Nerve Stimulation for Acute Back Pain in Emergency Department Patients.

Moor-Smith M, Kozak N, McCue M et al. · 2026 · The western journal of emergency medicine

Background Musculoskeletal back pain is a common presenting complaint to emergency departments (ED) worldwide. In this study we aimed to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) as an adjunct to…

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Negative / Null Result ReportMedicine

Comparative effects of metformin and lifestyle therapy on bone metabolism markers: A 6-month pilot, open-label randomized-clinical trial.

Almosfer M, Sabico S, Wani K et al. · 2026 · Aging clinical and experimental research

Background The metabolic effects of Metformin (Met) and lifestyle modification in early type 2 diabetes mellitus (T2DM) management are well established, but their influence on bone remodeling remains uncertain in under-investigated…

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Negative / Null Result ReportMedicine

Twelve-month outcomes after open bleb revision for Preserflo<sup>®</sup> microshunt bleb failure in refractory glaucoma patients.

Darmon J, Bastelica P, Huard M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Purpose To evaluate the 12-month efficacy and safety of open bleb revision (OBR) for Preserflo ® MicroShunt (PMS) (Santen, Osaka, Japan) bleb failure. Patients and methods All consecutive patients who underwent PMS OBR for primary bleb…

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Negative / Null Result ReportOpen accessMedicine

Use of vericiguat in the VICTOR trial: a study that is difficult to interpret.

Orso F, Basile C · 2026 · European heart journal supplements : journal of the European Society of Cardiology

Vericiguat is a soluble guanylate cyclase stimulator that acts by restoring the nitric oxide-cyclic guanosine monophosphate pathway, which is markedly impaired in heart failure with reduced ejection fraction (HFrEF). The VICTORIA trial…

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Negative / Null Result ReportOpen accessMedicine

Impact of red propolis addition on the color stability and surface roughness of glass ionomer cements.

Sampaio GKML, Sette-de-Souza PH, Vieira BR et al. · 2026 · Biomaterial investigations in dentistry

Objective The present study aimed to evaluate the surface roughness (SR) and color stability of conventional restorative glass ionomer cements (GICs) modified with the addition of red propolis ethanolic extract (RPEE) as an antimicrobial…

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Negative / Null Result ReportMedicine

Phthalocyanine-based mouth gel as an adjunct to non-surgical periodontal treatment: a randomized controlled trial.

Neto SOP, Rosalen PL, da Cruz Pegoraro JV et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology

This study aimed to evaluate the effect of topical application of a mouth gel formulation containing iron tetracarboxyphthalocyanine (FeTcPc) during non-surgical periodontal treatment. Forty-seven individuals with periodontitis underwent a…

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Negative / Null Result ReportOpen accessMedicine

Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations.

Camargo A, Kaya I, Sturchio A et al. · 2026 · Translational psychiatry

Lipid systems play a substantial role in the pathophysiological mechanisms underlying several brain disorders. However, the mechanisms underlying the lipid profile in stress-induced maladaptations and how these changes can impact distinct…

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Negative / Null Result ReportMedicine

Impact of aromatherapy neck massage on resting cardiovascular parameters in patients with chronic kidney disease and secondary hypertension: A self-controlled study.

Deepa Y, Vijay A, Padmavathi K et al. · 2026 · Journal of bodywork and movement therapies

Objective Chronic kidney disease (CKD) is characterized by kidney damage persisting for 3 months or more. Hypertension (HTN) is a common cause of CKD progression. Previous studies had shown that aroma massage can effectively reduce…

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Negative / Null Result ReportMedicine

Transitions to old age: a multidimensional poverty approach for Chile.

Amarante V, Colacce M · 2026 · Longitudinal and life course studies : international journal

Evaluating deprivation among individuals transitioning to older ages requires a multidimensional approach to evaluate their diverse needs. Despite its importance, research on this topic remains limited in the developing world, particularly…

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