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Browse the failure-mode index

19,915 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of Chitosan Modification and Support Type on the Catalytic Properties of Supported Palladium Catalysts in Hydrogenation of 2-Propen-1-ol.

Naizabayev, Talgatov, Auyezkhanova et al. · 2026 · Molecules (Basel, Switzerland)

Palladium catalysts modified with chitosan (CS) and supported on MgO, SiO 2 , TiO 2 , and Al 2 O 3 were prepared by a precipitation method and evaluated in the low-temperature hydrogenation of 2-propen-1-ol. Chitosan was first deposited…

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Negative / Null Result ReportMedicine

Optimized Extraction of Medicinal Mushroom Polysaccharides and Their Protective Effects Against 5-Fluorouracil-Induced Gastrointestinal Mucositis.

Dos Santos, Sauruk da Silva, Iacomini et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Background : Ganoderma lucidum is a medicinal mushroom widely recognized for its high content of bioactive polysaccharides, particularly β-glucans with immunomodulatory properties. This study aimed to optimize polysaccharide…

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Negative / Null Result ReportMedicine

A Randomized Study Evaluating the Effect of Ossein-Hydroxyapatite Complex on the Functional Outcomes of Patients After Conservative Treatment of Distal Radius Fracture.

Zaborska, Sobczak, Kubas et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Background: Distal radius fractures (DRFs) are the most common upper limb fractures worldwide. The main goal of DRF treatment is to achieve optimal functional outcomes with the lowest complication rate as rapidly as possible. Achieving…

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Negative / Null Result ReportMedicine

Phytochemicals from Agro-Industrial By-Products for Breast Cancer Prevention and Therapy: Molecular Mechanisms and Circular Bioeconomy Perspective.

Maffia, Marra, Battaglia et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Breast cancer remains one of the most frequently diagnosed malignancies and a leading cause of cancer-related mortality among women worldwide. The growing interest in natural bioactive compounds has highlighted plant-derived phytochemicals…

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Negative / Null Result ReportMedicine

Residual biological surrogate aerosol risk reduction during disrobing litter-bound manikin patients using two dry air treatments for cold regions.

Garner C, Sleeth D, Slagley J et al. · 2026 · American journal of disaster medicine

Objective Determine relative effectiveness of two dry air decontamination methods to reduce residual airborne surrogate biological agent on litter-bound manikin patients during disrobing. Design Fluorescent 1 µm polystyrene latex (PSL)…

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Negative / Null Result ReportMedicine

[Comparison of CNV-seq and chromosomal microarray analyses of abortive tissues].

Fu Y, Liu J, Sun H et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To compare the performance of copy number variation sequencing (CNV-seq) and chromosomal microarray analysis (CMA) for the analysis of abortive tissues. Methods Tissue samples were collected from 396 patients with missed abortion…

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Negative / Null Result ReportOpen accessMedicine

Perception of the patient safety culture among healthcare workers.

Ibrahim MG, Hassan MH, Lotfy AMM · 2026 · BMC health services research

Background Patient safety culture (PSC) is a key determinant of care quality, influencing clinical outcomes, staff functioning, and the resiliency of organizations. While PSC has evolved globally, it remains established in developing…

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Negative / Null Result ReportMedicine

Comparison of Super Mini Percutaneous Nephrolithotomy (smPCNL) and Extracorporeal Shock Wave Lithotripsy (ESWL) in Pediatric 1-2 cm Kidney Stones: A Single-Center Retrospective Controlled Study.

Sevim M, Demir M, Eryılmaz R et al. · 2026 · Urology journal

Purpose To compare outcomes of super mini percutaneous nephrolithotomy (smPCNL) with extracorporeal shock wave lithotripsy (ESWL) for stones 1-2 cm. Materials and methods After receiving ethics committee approval for this study (Date:…

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Negative / Null Result ReportOpen accessMedicine

Effects of Different Carbohydrate Level Diets on Growth Performance and Glycometabolism in Mandarin Fish (<i>Siniperca chuatsi</i>) Under Saline-Alkali Stresses.

Kong Y, Fan J, Li Y et al. · 2026 · Aquaculture nutrition

Saline-alkali cultivation is a crucial approach to alleviate the fresh water crisis. However, prolonged saline-alkali stresses might bring adverse effects on fish growth, health, and even death. This study evaluated the effects of…

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Negative / Null Result ReportMedicine

Consistency and Objectivity in Assignment Evaluation in Dental Education: A Comparison of Different Assessment Methods.

Yiğit E, Atsü S · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Objective This study examines differences in scores assigned to dental students' assignments when evaluated by two instructors and compares assessments conducted with a structured preclinical assessment form versus those without one.…

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Negative / Null Result Report

Is protrusive occlusal interference a risk factor for anterior disc displacement of the temporomandibular joint: A retrospective analysis based on the superior head of the lateral pterygoid muscle

Lin J, Chen J, Wang D et al. · 2026 · Preprint

Abstract Objective :‌ To investigate whether protrusive occlusal interference is related to anterior displacement of the temporomandibular joint disc based on clinical data, and to explore the relationship between the two and the superior…

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Negative / Null Result ReportOpen accessMedicine

Effects of water and fertilizer coupling on growth and development of Chinese dwarf cherry (<i>Cerasus humilis</i>) and evaluation of water and fertilizer use efficiency.

Liu S, Li Z, Chen S et al. · 2026 · Frontiers in plant science

Introduction In recent years, the demand for high-nutrition fruits has increased. As a unique fruit tree in China, Cerasus humilis has both ecological and nutritional value. Water and fertilizer nutrition is closely related to plant growth…

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Negative / Null Result ReportOpen accessMedicine

Mechanical Tuning of the Cell Microenvironment Using a Biomimetic Hydrogel System for Articular Cartilage Tissue Engineering.

van Mourik M, Spierings J, Koca P et al. · 2026 · Journal of tissue engineering and regenerative medicine

Providing a functional pericellular matrix (PCM) by fine-tuning the microenvironment of the articular chondrocytes (ACs) can greatly improve the outcomes of articular cartilage tissue engineering. While harvesting ACs with their PCM…

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Negative / Null Result ReportOpen accessMedicine

Long-Term Outcomes of Combined Phacoemulsification and Non-Penetrating Deep Sclerectomy versus Standalone Non-Penetrating Deep Sclerectomy.

Safadi K, Gutierrez Vargas GA, Cnaany Y et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose To compare the efficacy and safety of combined phacoemulsification and non-penetrating deep sclerectomy (Phaco-NPDS) with standalone NPDS in a large glaucoma cohort with long-term follow-up. Methods This retrospective cohort study…

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Negative / Null Result Report

Clinical Characteristics and Disease Severity Analysis of Mycoplasma pneumoniae Pneumonia in Guangxi ChildrenCarrying Drug-Resistant Genes: A Retrospective Clinical Study

Mo R, Chen J, Liu G et al. · 2026 · Preprint

Abstract ‌ Objective: ‌ To investigate the clinical characteristics of Mycoplasma pneumoniae pneumonia (MPP) in children from Guangxi carrying drug-resistant genes and to identify risk factors for predicting severe cases. ‌ Methods: ‌ A…

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Negative / Null Result ReportOpen accessMedicine

Vonoprazan as an adjuvant to cisplatin: enhancing antitumor efficacy while mitigating nephrotoxicity and gastrointestinal adverse effects.

Alenezi FN, Abdelmageed ME, Nader MA et al. · 2026 · Frontiers in pharmacology

Background/objective Cisplatin is a popular platinum-containing chemotherapeutic agent that has been used clinically since the 1970s to manage a wide range of hematologic and solid tumors. However, its therapeutic purpose is restricted by…

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Negative / Null Result ReportOpen accessMedicine

Effects of 3',4'-dihydroxyflavonol treatment on Neu N and BDNF and ICAM levels in the striatum of rats subjected to transient bilateral carotid occlusion-induced ischemia-reperfusion.

Hoşgör M, Uzdil EK, Aladag T et al. · 2026 · Journal of bioenergetics and biomembranes

Cerebral infarction is a leading cause of severe long-term disability and functional and cognitive impairment. With the advancement of acute stroke treatment, more patients are now experiencing stroke with varying degrees of impairment.…

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