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Browse the failure-mode index

19,915 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The effect of serum lipase levels on clinical severity scores and mortality in acute pancreatitis: a retrospective cohort study.

Kilicaslan MB, Dikme O, Girgin MC et al. · 2026 · BMC gastroenterology

Aims This study aimed to investigate the relationship between admission serum lipase levels, prognostic clinical scoring systems, and in-hospital mortality in patients presenting to the emergency department with acute pancreatitis. Methods…

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Negative / Null Result ReportOpen accessMedicine

A Comprehensive Analysis of Predictors of Marginal Ulcers After Roux-en-Y Gastric Bypass: A Cohort Review of 2106 Patients.

Abedalqader T, Migliorini A, Cerecedo LG et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives: Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed metabolic and bariatric surgeries worldwide. Marginal ulcers (MU) are a common complication following RYGB, yet their pathophysiology and the…

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Negative / Null Result ReportOpen accessMedicine

Lack of Association of Serum MMP-9 Concentration and rs17576 Single Nucleotide Variant <i>MMP-9</i> Gene With the Degree of Coronary Atherosclerosis and Other Risk Factors in Ukrainian Patients With Coronary Artery Disease.

Pogorielova OS, Korniienko VV, Chumachenko YD et al. · 2025 · Cardiology research and practice

This study probes the relationship between serum matrix metalloproteinase-9 (MMP-9) levels, the genetic variant rs17576 in the MMP-9 gene, and the extent of coronary atherosclerosis among Ukrainian patients diagnosed with coronary artery…

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Negative / Null Result ReportMedicine

The acute effects of vaporized cannabis on drivers' hazard perception and risk-taking behaviors in medicinal patients: A within-subjects experiment.

Schiemer C, Horswill MS, Hill A et al. · 2025 · Journal of safety research

Introduction As the medically prescribed use of cannabis flower continues to increase, there is a need to understand how vaporized cannabis can acutely affect driving-related skills and risk-taking behaviors in medicinal populations.…

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Negative / Null Result ReportOpen accessMedicine

Lack of association between the -2549 insertion/deletion variant of vascular endothelial growth factor and coronary artery disease in the Turkish population.

Yigit S, Nursal AF, Celik A et al. · 2024 · Revista da Associacao Medica Brasileira (1992)

Objective Coronary artery disease is the leading cause of death worldwide. Vascular endothelial growth factor is known to induce endothelial cell migration and proliferation, increase vascular permeability, and modulate thrombogenicity.…

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Negative / Null Result ReportOpen accessMedicine

Cord blood DNA methylation and cell-type composition are not significantly associated with severe preeclampsia after cell-type and clinical covariate adjustment.

Yang X, Liu W, Mao Z et al. · 2026 · GigaScience

Background Preeclampsia is a severe pregnancy complication that threatens maternal and neonatal health and well-being. Previous studies on epigenome-wide association studies (EWAS) of preeclampsia produced inconsistent results in cord…

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Negative / Null Result ReportOpen accessMedicine

Relationships in anesthesia work areas between contamination measured as colony-forming units, <i>Staphylococcus aureus</i> detection<i>, and S. aureus</i> transmission.

Bhushan A, Dexter F, Brindeiro C et al. · 2026 · Anesthesiology and perioperative science

Purpose Earlier, patients developed surgical site infection for 2.0% of cases without Staphylococcus aureus transmission through anesthesia work areas, 11% with S. aureus transmitted susceptible to prophylactic antibiotic, and 18% with…

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Negative / Null Result ReportOpen accessMedicine

Are high residual chlorhexidine skin concentrations associated with improved clinical outcomes? Lessons from the CLEAR trial.

Khoja R, Catuna TD, Gussin GM et al. · 2026 · Infection control and hospital epidemiology

Residual chlorhexidine gluconate (CHG) skin concentrations are thought to improve disease prevention. In the Changing Lives by Eradicating Antibiotic Resistance (CLEAR) trial, posthospitalization decolonization of MRSA carriers reduced…

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Negative / Null Result ReportOpen accessMedicine

Cognitive Impairment and Quality of Life in AQP4-IgG Seropositive Neuromyelitis Optica Spectrum Disorder: A Cross-Sectional Study in Iranian Patients.

Ramazanzadeh S, Ashtari F · 2026 · Neurology research international

Background Cognitive impairment (CI) has been reported with wide variability in neuromyelitis optica spectrum disorder (NMOSD), but its impact on patients' quality of life (QoL) is not well understood. The aim of this study was to describe…

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Negative / Null Result ReportOpen accessMedicine

Plasmid diversity, antibiotic resistance and virulence genes associated with Staphylococcus aureus isolates from private hospitals in Gauteng, South Africa.

Ngoie K, Kingsburgh C, Hamiwe T et al. · 2026 · World journal of microbiology & biotechnology

This study investigated the association between plasmid diversity, antibiotic resistance and virulence genes of Staphylococcus aureus (S. aureus) isolates from private hospitals in Gauteng, South Africa. Automated antibiotic susceptibility…

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Negative / Null Result ReportMedicine

Understanding Platelet Activation in the Aeson Bioprosthetic Total Artificial Heart: Insights From Aspirin Treatment and Outcomes.

Smadja DM, Roux de Bezieux J, Peronino C et al. · 2025 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

This study aimed to assess platelet activation following implantation of the Aeson bioprosthetic total artificial heart (A-TAH). We monitored plasma levels of platelet activation markers in patients receiving A-TAH support (n = 16)…

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Negative / Null Result ReportMedicine

Lack of association between Lp(a) and retinal vein occlusion in a single institution and US national database.

Russell MW, Maatouk CM, Kim S et al. · 2024 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Objective This study examines associations between lipoprotein(a) (Lp[a]), a low-density-like lipoprotein, and renal vein occlusion (RVO) in US cohorts to characterize its prognostic role in the setting of RVO. Design A two-phase…

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Negative / Null Result ReportOpen accessMedicine

Single-arm Cohort Study on the Effects of the COVID-19 Pandemic on the Radiation Treatment of Cancer Patients Referred to the Radiation Oncology Division of a Tertiary Hospital.

de Guzman SPC, Chavez LL, Abrilla AA · 2024 · Acta medica Philippina

Objective This study aimed to identify the effects of COVID-19 pandemic on radiation treatment delays, interruptions, and cancer outcomes if any, in a Philippine tertiary hospital. Methods A retrospective observational cohort study was…

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Negative / Null Result ReportOpen accessMedicine

Rurality and Long-Term Outcomes after Critical Illness.

Mart MF, Jones MT, Raman R et al. · 2026 · Annals of the American Thoracic Society

Rationale How rurality may influence recovery after critical illness is unknown. Objectives To examine the association between rurality and disability, cognitive function, and health-related quality of life in ICU survivors and whether it…

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Negative / Null Result ReportOpen accessMedicine

A brief research report of suicide rates in the Brazilian elderly over a 12-year period: the lack of association of the " Setembro Amarelo " campaign for suicide prevention.

Corrêa Matias Pereira C, Najafi Moghaddam Gilani V, Nazif-Munoz JI · 2024 · Frontiers in psychiatry

Objectives Aiming to disseminate information related to suicide prevention in Brazil, the " Setembro Amarelo " campaign has been conducted since 2015. The objective of this study is to assess the association between this campaign and…

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Negative / Null Result ReportOpen accessMedicine

Descriptive Epidemiology and Prognostic Significance of Diaphragm Thickness in the General Population: The Nagahama Study.

Tabara Y, Matsumoto T, Murase K et al. · 2025 · Journal of cachexia, sarcopenia and muscle

Background Diaphragm thickness is a potential marker of sarcopenia in addition to muscle mass and strength at extremities. We aimed to clarify the descriptive epidemiology and prognostic significance of diaphragm thickness in the general…

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Negative / Null Result ReportOpen accessMedicine

Outcomes of ACL Reconstruction with Quadriceps Tendon Graft Based on Graft Diameter Relative to Notch Width.

Dadoo S, Vieider RP, Grandberg C et al. · 2026 · Orthopaedic journal of sports medicine

Background While quadriceps tendon (QT) autograft is being increasingly utilized for primary anterior cruciate ligament reconstruction (ACLR), there remains limited evaluation of how QT autograft diameter and the ratio of graft diameter to…

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