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20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Biological soil amendments can support survival of pathogenic and non-pathogenic Escherichia coli in soils and sporadic transfer to Romaine lettuce.

Xiong ZR, Gabriel E, Gutierrez A et al. · 2025 · International journal of food microbiology

Biological soil amendments (BSAs) are essential agricultural inputs that provide critical nutrients in organic leafy green production. Heat-treated poultry pellets (HTPP) and seabird guano (SBG), which have been treated to reduce microbial…

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Negative / Null Result ReportMedicine

A single session of whole-body vibration did not affect cardiovascular autonomic recovery after a high intensity exercise in horses.

Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science

Background Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic…

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Negative / Null Result ReportOpen accessMedicine

Topical betulinic acid for treatment of equine melanoma and sarcoid.

Moreno C, Mudge M, Horne R et al. · 2026 · Frontiers in veterinary science

Introduction Betulinic acid, a natural pentacyclic triterpenoid, has demonstrated anti-inflammatory and anti-tumor properties in vitro, including activity against equine melanoma and sarcoid. However, there is limited in vivo evidence…

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Negative / Null Result ReportMedicine

Cryoprotective effects of cholesterol-loaded cyclodextrin and iodixanol on ram sperm: assessment of post-thaw quality and in vitro fertilization outcomes.

Arıcı R, Eser A, Yağcıoğlu S et al. · 2026 · BMC veterinary research

Background This study aimed to investigate the effects of cholesterol-loaded cyclodextrin (CLC) and iodixanol, added individually or in combination to a ram semen extender, on post-thaw sperm quality, in vitro fertilization outcomes, and…

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Negative / Null Result ReportOpen accessMedicine

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

Stanfield B, Leroux B, Kaeberlein M et al. · 2026 · Journal of cachexia, sarcopenia and muscle

Background Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise ('cycling hypothesis'). Whether this concept translates to older adults…

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Negative / Null Result ReportMedicine

Comparisons of the amylolytic enzymes and malt starch hydrolysates of two barley cultivars, Hokudai 1 (the first cultivar developed in Japan) and Kitanohoshi (currently used cultivar for beer production).

Saburi W, Mori H · 2024 · Bioscience, biotechnology, and biochemistry

Starch degradation in malted barley produces yeast-fermentable sugars. In this study, we compared the amylolytic enzymes and composition of the malt starch hydrolysates of two barley cultivars, Hokudai 1 (the first cultivar established in…

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Negative / Null Result ReportMedicine

Acute Effects of Taurine Supplementation on Maximal Fat Oxidation and FATmax in Recreational Endurance Runners: A Randomized, Placebo-Controlled, Crossover, and Triple-Blinded Study.

Ghazzagh A, Naderi A, Agha-Alinejad H et al. · 2025 · International journal of sport nutrition and exercise metabolism

Taurine (TAU) has been shown to improve time to exhaustion (TTE) and fat oxidation during exercise; however, no studies have examined the effect of acute TAU supplementation on maximal fat oxidation (MFO) and related intensity to MFO…

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Negative / Null Result ReportMedicine

Evaluating the Effectiveness of Assisted Oocyte Activation in ICSI: Pairwise Meta-Analyses and Systematic Evidence Evaluation.

Fawzy M, Elsuity MA, Magdi Y et al. · 2025 · BJOG : an international journal of obstetrics and gynaecology

Background Artificial oocyte activation (AOA) is used to improve fertilisation rates in intracytoplasmic sperm injection (ICSI) cycles. Objectives To assess the effectiveness of AOA on fertilisation, embryo development, and clinical…

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Negative / Null Result ReportOpen accessMedicine

Effect of final irrigation protocols on the bond strength and dentinal tubule penetration of root canal sealers: an ex vivo laboratory study.

Örs SA, Yılmaz GA, Şengül N et al. · 2026 · BMC oral health

BACKGROUND: Effective disinfection and sealing of the root canal system are essential for the long-term success of endodontic treatment. Final irrigation solutions can influence the interactivity between dentin and sealers. This study…

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Negative / Null Result ReportMedicine

Matrigel-encapsulated articular cartilage derived fibronectin adhesion assay derived chondroprogenitors for enhanced chondrogenic differentiation: An in vitro evaluation.

Parasuraman G, Rani J MS, Zachariah MM et al. · 2025 · Tissue & cell

Purpose In cartilage research, three-dimensional (3D) culture models are pivotal for assessing chondrogenic differentiation potential. Standard pellet cultures, despite their utility, pose challenges like uneven differentiation and…

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Negative / Null Result ReportMedicine

Arthroscopic Microdrilling for Full-Thickness Trochlear Cartilage Defects in Patients Undergoing High Tibial Osteotomy Confers Improved Cartilage Status at 1 Year and Rate of Minimal Clinically Important Difference at Short-Term Follow-Up.

Jung SH, Jung M, Chung K et al. · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purpose To compare the patient-reported outcome (PRO) improvements and cartilage status of trochlear cartilage defects (TCDs) after additional arthroscopic microdrilling versus no treatment for TCDs during medial open-wedge high tibial…

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Negative / Null Result ReportMedicine

Assessment of coated orthodontic miniscrews with chlorhexidine hexametaphosphate antimicrobial nanoparticles: A randomized clinical trial.

Al-Hilaly AA, Alhuwaizi AF · 2025 · Journal of the World federation of orthodontists

Background Using miniscrews to control anchorage made the application of force for various orthodontic treatment approaches easier and increased their effectiveness. Some problems may occur during the use of miniscrews, such as…

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Negative / Null Result ReportMedicine

Training Effects of Traditional versus Cluster Set Configuration with and without Blood Flow Restriction.

Cornejo-Daza PJ, Sánchez-Valdepeñas J, Rodiles-Guerrero L et al. · 2025 · Medicine and science in sports and exercise

Purpose This study compared the effects of four different resistance training (RT) programs that differed in the set configuration (cluster vs traditional) and the blood flow condition (free-flow [FF] vs blood flow restriction [BFR]) on…

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Negative / Null Result ReportMedicine

Chelating agents desorb soil acid-soluble and iron‑manganese oxide-bound Cd into dissolved Cd-chelate complexes yet with low phytoavailability.

Dong Q, Tang W, Wang X et al. · 2025 · Journal of hazardous materials

The use of chelating agents in remediation of cadmium (Cd)-contaminated soils by leaching has gained popularity. However, the environmental risks associated with this practice, particularly its impact on soil Cd phytoavailability, remain…

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Negative / Null Result ReportOpen accessMedicine

Should Microhematuria Be Incorporated into the 2023 Duke-International Society for Cardiovascular Infectious Diseases Minor Immunological Criteria?

Regina J, Stavart L, Guery B et al. · 2025 · Antibiotics (Basel, Switzerland)

Background/Objectives : Microhematuria is common in patients with infective endocarditis (IE). The present study aims to assess whether the addition of microhematuria in the 2023 Duke-International Society for Cardiovascular Infectious…

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Negative / Null Result ReportMedicine

Comparing letters written by humans and ChatGPT: A preliminary study.

Matsubara S · 2025 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective There are no criteria for what type of manuscript and to what extent ChatGPT use is permissible in writing manuscripts. I aimed to determine which, human or ChatGPT, writes more readable letters to the editor and whether ChatGPT…

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Negative / Null Result ReportMedicine

Malate or Not? Acute Effects of L-Citrulline Versus Citrulline Malate on Neuromuscular Performance in Young, Trained Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.

Martín-Olmedo JJ, Miras-Moreno S, Cuadra-Montes K et al. · 2025 · International journal of sport nutrition and exercise metabolism

L-citrulline (CIT) supplementation seems to improve resistance training performance; yet, whether malate has additive ergogenic effects when combined with CIT is unknown. This randomized, double-blind, placebo-controlled crossover trial…

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Negative / Null Result ReportMedicine

Effect of Cold Stress on Field Performance, Chlorophyll Fluorescence, Electrolyte Leakage and Leaf Gas Exchange Parameters of Potato (Solanum tuberosum L.) Genotypes

Angmo D, Sharma SP, Kalia A et al. · 2024 · Potato Res..

North-western parts of the Indo-Gangetic Plains are prone to occasional frost incidences which may result in 40–60% loss of tuber yield in potato. The overall aim of this study was to identify the morpho-physiological responses of two…

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Negative / Null Result ReportMedicine

Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency.

Xu Y, Sawamoto T, Sun R et al. · 2024 · Bioscience, biotechnology, and biochemistry

Protective effect of quercetin against acetaldehyde was evaluated using the cultured hepatocyte models with aldehyde dehydrogenase (ALDH) isozyme deficiency (aldh2-kd and aldh1a1-kd). The quercetin-induced cytoprotection against…

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Negative / Null Result Report

Evaluating Synergistic Effects of Hyaluronic Acid, Human Umbilical Cord-Derived Mesenchymal Stem Cells, and Growth Hormones in Knee Osteoarthritis: A Multi-Arm Randomized Trials

Dilogo IH, Canintika AF, Hartanto BR et al. · 2024 · Preprint

Background: Knee osteoarthritis (OA) significantly affects quality of life and imposes economic burdens due to its prevalence and the disability it causes. The efficacy of current treatments is limited to alleviate the symptoms and not for…

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