19,906 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Martínez-Salmerón MDM, Amaya-Pascasio L, Martínez-Sánchez P et al. · 2026 · Revista de neurologia
Background There is considerable interest in the underlying mechanisms of cryptogenic stroke, with hypercoagulable states being widely studied. An elevated level of Factor VIII has been proposed as a potential prothrombotic marker…
View details →Wallam S, Park J, Wu LW et al. · 2025 · Journal of gastrointestinal oncology
Background Claudin18.2 (CLDN18.2), a tight junction molecule, is a novel therapeutic target for patients with advanced gastroesophageal adenocarcinoma. Recent phase III trials demonstrated improved survival with the addition of an…
View details →Cigarán-Méndez M, de-la-Llave-Rincón AI, Pacho-Hernández JC et al. · 2026 · International journal of molecular sciences
The role of the catechol-O-methyltransferase (COMT) Val158Met rs4680 polymorphism in altered pain processing in headaches is controversial. The aim of this study was to investigate the influence of the Val158Met rs4680 polymorphism in…
View details →Campos A, Tuomainen J, Tuomainen O · 2023 · Preprint
This study compared cortical responses to speech in preschoolers with typical language development (TLD) and Developmental Language Disorder (DLD), and in adults. We investigated whether top-down language effects modulate speech perception…
View details →Thapa M, Courville J, Leonhard R et al. · 2025 · Frontiers in stroke
Introduction Whole blood viscosity (WBV), reflecting the intrinsic resistance of blood flow, is an established predictor of stroke events in individuals. This study aims to correlate the WBV at different shear rates with the outcome of…
View details →Indraccolo S, Signoriello S, Piga I et al. · 2024 · The International journal of biological markers
Introduction In ovarian cancer, expression of metabolism-related markers has been investigated in several studies focusing on individual markers; however, a parallel quantitative evaluation of markers mapping to distinct metabolic…
View details →Wentworth BJ, Shwetar M, Mallawaarachchi I et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology
Background and aims Spontaneous bacterial peritonitis (SBP) is common in decompensated cirrhosis and often accompanied by large volume ascites. However, the safety of early therapeutic paracentesis is unknown and may lead to unnecessary…
View details →Sanchez JA, de Pedro L, López-Gallego E et al. · 2024 · Scientific reports
Many agricultural landscapes offer few resources for maintaining natural enemy populations and floral plantings have frequently been adopted to enhance biological pest control in crops. However, restored margins may harbour both pests and…
View details →Patsiou D, Digka N, Galli M et al. · 2024 · Marine environmental research
Monitoring microplastics (MPs) in the marine environment is an ongoing process, and our understanding of their impact on marine organisms is limited. The present study evaluates the effects of ingested MPs on the marine MP pollution…
View details →Wattacheril J, Kleinstein SE, Shea PR et al. · 2024 · Preprint
Background and Aims Nonalcoholic Fatty Liver Disease (NAFLD) is a complex human disease. Common genetic variation in the patatin-like phospholipase domain containing 3 ( PNPLA3 ) and transmembrane 6 superfamily member 2 ( TM6SF2 ) genes…
View details →Curtis A, Skvarc D, Brittain N et al. · 2025 · Drug and alcohol review
Introduction Substance use has been associated with child-to-parent violence (CPV), yet little is known about the contributing factors. This study investigated the association between parental substance use and substance involved child to…
View details →D'Marco L, Checa-Ros A, Locascio A et al. · 2025 · Frontiers in medicine
Background Several studies suggest that C-peptide (CP) is involved in regulating lipolysis, adipokine release, and other functions in the adipose tissue. On the other hand, organ-specific adipose tissues, such as the epicardial adipose…
View details →Nguyen TT, Pineda R, Reynolds S et al. · 2026 · Physical & occupational therapy in pediatrics
Aim To examine the relationship between feeding therapy and the timing of independent oral feeding (IOF) in preterm infants in the neonatal intensive care unit (NICU). Study design A retrospective analysis of 536 preterm infants ( Results…
View details →Stankovic M, Weber C, Koser M et al. · 2025 · Journal of frailty, sarcopenia and falls
Objectives While chronological aging does not necessarily impair oncological outcomes after radical prostatectomy, the role of frailty remains less clear. This study aimed to evaluate whether frailty significantly affects early continence…
View details →Keser CS, Erdemir M, Yilmaz M et al. · 2025 · BMC nephrology
Background Hemodynamic instability related to renal replacement therapy (HIRRT) is a serious complication of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), significantly increasing…
View details →Smith CM, Spalt EW, Gallo LC et al. · 2026 · Journal of urban health : bulletin of the New York Academy of Medicine
Neighborhood-scale environmental factors, including disinvestment in infrastructure, may impact cardiometabolic disease risk. To our knowledge, no prior studies have investigated the association between neighborhood disinvestment and…
View details →Ihle-Hansen H, Walle-Hansen MM, Berge T et al. · 2026 · BMJ open
Background Current expert consensus statements generally suggest cardiovascular risk assessment, including atrial fibrillation (AF) screening, on detection of covert brain infarctions (CBIs). However, evidence to guide management of CBI…
View details →Abdalla M · 2026 · Frontiers in medicine
Background Hormone replacement therapy (HRT) is widely prescribed for managing menopausal symptoms, yet its effects on the endometrium remain clinically important. While large-scale studies have established that estrogen-only HRT increases…
View details →O'Brien EA, Wypij D, Rofeberg V et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association
Objective Investigate the association between placental vascular abnormalities and regional brain volumes in congenital heart disease (CHD) fetuses with and without genetic abnormalities. Study design Secondary analysis of brain magnetic…
View details →Rosa R, Rosello G, Manzanillo K et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE
Following the implementation of in-house Candidozyma auris ( C. auris ) polymerase chain reaction as part of our surveillance strategy, we observed increasing incidence rates of colonization with C. auris already present at hospital…
View details →Carabas BA, Țǎpoi DA, Costache M · 2026 · Diagnostics (Basel, Switzerland)
Background: Neoadjuvant chemotherapy (NAC) is widely used in the management of stage I-III breast cancer, with tumor regression serving as an important surrogate for long-term outcome. Identifying reliable pathological biomarkers…
View details →Lee CC, Miller AA, Tallman PS et al. · 2025 · American journal of human biology : the official journal of the Human Biology Council
Helicobacter pylori (H. pylori) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological…
View details →Kozłowski K, Konończuk K, Muszyńska-Rosłan K et al. · 2024 · Journal of clinical medicine
Background/Objectives: The survival rate among pediatric cancer patients has reached 80%; however, these childhood cancer survivors (CCSs) are at a heightened risk of developing chronic conditions in adulthood, particularly kidney and…
View details →Ji S, Park SJ, Lee JY et al. · 2023 · Experimental gerontology
Myonectin is a muscle-secreted factor that helps maintain homeostasis in the body by regulating several functions, including lipid metabolism. Previous studies suggested that myonectin may play a role in muscle health in an autocrine…
View details →Agarwal Y, Metgudmath A, Metgudmath V · 2026 · Cureus
Aim To evaluate the association of mean platelet volume (MPV) and immature platelet fraction (IPF) with coronary angiographic severity, categorised by the number of significantly diseased epicardial vessels (single, double or triple vessel…
View details →Akbar Z, Fituri S, Shi Z et al. · 2025 · Diseases (Basel, Switzerland)
Background Evidence linking dietary fiber intake with cancer risk and mortality is equivocal. Objective We investigated the relationship between dietary fiber intake and all-cause, cancer, and cardiovascular disease (CVD) mortalities in US…
View details →Djordjevic N, Todorovic A, Sazdanovic P et al. · 2025 · Biomedicines
Objectives : Chlamydia trachomatis (CT) infection affects female fertility. The purpose of our study was to assess the association between serological and follicular fluid markers of CT infection and in vitro fertilization (IVF) success.…
View details →Kyriakidis I, Pelagiadis I, Martimianaki G et al. · 2026 · Cureus
Background Neuroblastoma (NB) is the most common extracranial solid tumor in children, but the inherited factors influencing susceptibility are not fully understood. Given the link between defective microRNA biogenesis and aggressive NB,…
View details →Bonardi CM, Nosadini M, Lorenzoni G et al. · 2024 · Clinical pediatrics
Appropriate status epilepticus (SE) management is key to minimize admission to the pediatric intensive care unit (PICU). We retrospectively describe 115 children admitted to the PICU of the tertiary-care referral hospital of Padova for…
View details →Errigo A, Dore MP, Mocci G et al. · 2024 · Scientific reports
More than two decades ago, in the central-eastern region of the Mediterranean island of Sardinia, a mountain area was identified where the population displays exceptional longevity, especially among men (the Longevity Blue Zone, LBZ). This…
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