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Browse the failure-mode index

19,906 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Efficacy of a multiple-component and multifactorial personalized fall prevention program in community-dwelling older adults at moderate-to-high fall risk: The PRE.C.I.S.A. Randomized Controlled Trial

Fabio La Porta, S. Caselli, G. Lullini et al. · 2022 · medRxiv

Background: The fall risk in the elderly is a major public health issue due to the immediate injury-related consequences and the risk of associated long-term disability. However, the delivery of effective interventions for fall prevention…

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Negative / Null Result ReportMedicine

Low-intensity versus high-intensity home-based treadmill training and walking attainment in young children with spastic diplegic cerebral palsy.

K. Mattern-Baxter, J. Looper, Chuan Zhou et al. · 2020 · Archives of Physical Medicine and Rehabilitation

OBJECTIVE To compare the effect of low-intensity (LI) versus high-intensity (HI) TT on walking attainment and overall walking activity in children with cerebral palsy (CP). DESIGN Prospective, multi-site, randomized controlled trial…

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Negative / Null Result ReportOpen accessMedicine

Hypoparathyroidism: what is the best calcium carbonate supplementation intake form?

Loraine Gollino, M. Biagioni, Nathalia Regina Sabatini et al. · 2017 · Brazilian Journal of Otorhinolaryngology

Introduction In hypoparathyroidism, calcium supplementation using calcium carbonate is necessary for the hypocalcemia control. The best calcium carbonate intake form is unknown, be it associated with feeding, juice or in fasting. Objective…

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Negative / Null Result ReportMedicine

How does variation of the bag volume in inert gas rebreathing cardiac output measurements influence the reproducibility in patients with pulmonary diseases?

F. Trinkmann, F. Kraus, M. Borggrefe et al. · 2011 · European Respiratory Journal

Background: Cardiac output (CO) is an important hemodynamic parameter, however its determination is difficult in daily clinical routine. Non-invasive inert gas rebreathing (IGR) showed promising results in recent investigations with the…

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Negative / Null Result ReportOpen accessMedicine

Assessment of proprioceptive exercises in the treatment of rotator cuff disorders in nursing professionals: a randomized controlled clinical trial.

L. V. Martins, M. Marziale · 2012 · Brazilian Journal of Physical Therapy

BACKGROUND Shoulder pain in nursing professionals may lead to limitations in occupational and daily activities and consequently interfere with quality of life. OBJECTIVE To compare the effects of two physical therapy programs which…

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Negative / Null Result Report

СООТНОШЕНИЕ МЕЖДУ ГЕНДЕРНЫМИ ПСИХОЭМОЦИОНАЛЬНЫМИ ХАРАКТЕРИСТИКАМИ И ШКОЛЬНОЙ УСПЕВАЕМОСТЬЮ В РАННЕМ ПОДРОСТКОВОМ ВОЗРАСТЕ

А.И. Боравова · 2024 · Асимметрия

В работе проведен сравнительный анализ психоэмоциональных особенностей учащихся средней школы. Установлены достоверно значимые различия эмоциональных личностных характеристик между мальчиками и девочками подросткового возраста в…

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Negative / Null Result ReportOpen access

Correlation of Problem Based Learning Model and Discovery Learning Model with the Development of Creativity and Motivation of Students

Jaka Sayidina Ali, A. Pambudi, Stefanus Prasetyo Yudi Susanto · 2024 · International journal of multidisciplinary research and analysis

This study aims to determine the correlation of Problem-Based Learning Model and Discovery Learning Model with students' creativity and learning motivation. This research uses a quantitative approach of correlation type. . The sample in…

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Negative / Null Result ReportOpen accessMedicine

Влияние экзогенных сурфактантов на показатели газового состава крови у новорождённых с респираторным дистресс-синдромом

A. A. Перепелица, Array М Голубев, Array В. Мороз · 2007

Objective: to study the effects of the surfactants Surfactant-BL and Curosurf on pulmonary oxygenizing properties in preterm neonatal infants with respiratory distress syndrome (RDS). The studies were performed in 81 preterm neonates with…

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Negative / Null Result ReportMedicine

Concepts of care for people with dementia

N. Rieckmann, C. Schwarzbach, M. Nocon et al. · 2009 · GMS Health Technology Assessment

Introduction Today there are approximately one million people with dementia in Germany. If current demographic trends continue, this number is likely to rise substantially in the coming years. In the older population, dementia is the most…

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Negative / Null Result ReportOpen accessMedicine

Ivermectin treatment of demodicosis in 56 hamsters.

K. Tani, T. Iwanaga, K. Sonoda et al. · 2001 · Journal of Veterinary Medical Science

Fifty-six hamsters with demodicosis were treated with daily oral administration of ivermectin (0.3 mg/kg). Thirty-three cases (58.9%) were cured and 6 cases (10.7%) had improved clinically but needed to continue treatment. Of 5 cases…

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Negative / Null Result ReportOpen accessMedicine

Vaccination counseling with and without excipient skin testing in patients with suspected allergic reactions to mRNA COVID-19 vaccines and patients with atopy

Dilawar Khokhar, K. O’Shea, C. Akin et al. · 2022 · Journal of Allergy and Clinical Immunology: Global

Background Allergic reactions have been reported with mRNA vaccines for COVID-19 prevention. Patients perceived to be at higher risk for a reaction may be referred to an allergist, although evaluation strategies may differ between…

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Negative / Null Result ReportMedicine

Exploratory safety investigations in normal, freely moving Göttingen minipigs using telemetry: Pharmacological validation.

Julie Jacobsen, Berit Ø. Christoffersen · 2025 · Journal of pharmacological and toxicological methods

INTRODUCTION Adverse cardiovascular (CV) effects is a major cause of drug attrition. Early assessment of CV risk for new drug candidates may be warranted for early de-risking of the further development. Predictive animal models and a…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of Health Literacy and Associated Factors Among Adults Living in Saudi Arabia: A Cross-Sectional Study

Yaser M. Alahmadi · 2023 · Inquiry : a journal of medical care organization, provision and financing

In this westernized culture, maintaining a healthy lifestyle has become a major health concern internationally. Health literacy is an emerging concept and requires effective measures and reform to improve the health status and health of…

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Negative / Null Result ReportMedicine

PP27 Pre-hospital lactate monitoring: a worthy adjunct to systolic blood pressure and shock index in triggering blood product administration in patients with suspected traumatic haemorrhage?

J. Griggs, M. Sherriff, J. Leung et al. · 2019 · Emergency Medicine Journal

Introduction Pre-hospital identification of patients with suspected occult traumatic haemorrhage is problematic. Physiological parameters and clinical gestalt are inadequate surrogates for ongoing haemorrhage. Lactate monitoring may hold…

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Negative / Null Result ReportMedicine

AAV2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial.

T. Aleman, Rachel M. Huckfeldt, Leona W. Serrano et al. · 2022 · Ophthalmology (Rochester, Minn.)

PURPOSE To assess the safety of the subretinal delivery of a recombinant adeno-associated virus serotype 2 (AAV2) vector carrying a human CHM-encoding cDNA in choroideremia (CHM). DESIGN Prospective, open-label, non-randomized,…

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Negative / Null Result Report

Production of recombinant pepsin, pancreatic lipase and colipase from Pichia pastoris as feed additive

F. Liu · 2014 · Recent progress in swine breeding and raising technologies and cutting-edge reproductive technologies and perspectives for their usage in swine

Enzyme feed additives are always added in animal nutrition to improve the quality of feeds, or to improve the animals’ growth performance and health through intensifying digestibility of the feed ingredients. This study investigated the…

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Negative / Null Result Report

MODERASI KEBIJAKSANAAN DALAM HUBUNGAN IDENTITAS DIGITAL DAN PERBANDINGAN SOSIAL PADA GENERASI Z PENGGUNA LINKEDIN

Riana Sahrani, Cherry Delfina Setiawan, Callista Chandra et al. · 2026 · CENDEKIA: Jurnal Ilmu Pengetahuan

ABSTRACT Digital identity is a self-representation built through online activities and has become a crucial aspect for Generation Z, who grew up amidst technological advancements. One widely used platform is LinkedIn, which functions not…

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Negative / Null Result ReportOpen accessMedicine

Assessing the Safety of Craniotomy for Resection of Primary Central Nervous System Lymphoma: A Nationwide Inpatient Sample Analysis

Jonathan Yun, Jingyan Yang, Michael Cloney et al. · 2017 · Frontiers in Neurology

Background Unlike many other central nervous system (CNS) tumors, the surgical management of primary central nervous system lymphomas (PCNSL) is traditionally limited by diagnostic biopsy. Studies that predate the use of modern…

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Negative / Null Result ReportOpen accessMedicine

Is the use of BITA vs SITA grafting safe and beneficial in octogenarians?

D. Pevni, T. Ziv-Baran, A. Kramer et al. · 2020 · Annals of Thoracic Surgery

BACKGROUND Bilateral internal thoracic artery grafts (BITA) is questionable in octogenarians because of shorter life expectancy and increased risk of perioperative complications. The aim of this study was to examine the safety and…

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Negative / Null Result ReportOpen accessMedicine

Atlantooccipital overlapping and its effect on outcomes after ventral fixation in dogs with atlantoaxial instability

F. Takahashi, Takaharu Hakozaki, Shigenori Kouno et al. · 2018 · Journal of Veterinary Medical Science

We compared clinical outcomes after ventral fixation in dogs with atlantoaxial instability (AAI) on the basis of the presence or absence of atlantooccipital overlapping (AOO). Of 41 dogs diagnosed with AAI and treated ventral fixation, 12…

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