20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Patoglu OR, Horne RSC, Mann DL et al. · 2026 · European journal of pediatrics
A hallmark of Prader-Willi syndrome (PWS) is hypothalamic-pituitary axis dysfunction, which can result in reduced growth hormone (GH) production. While GH replacement therapy is common in children with PWS, it has also been implicated in…
View details →Eser M, Yazıcı C, Kandemir Ü et al. · 2026 · Research in veterinary science
Ivermectin (IVR) is a semi-synthetic macrocyclic lactone widely used against nematodes. Under physiological conditions, its central nervous system (CNS) penetration is limited by P-glycoprotein-mediated efflux at the blood-brain barrier…
View details →Targhetta VP, Vieira RdS, Ranfley H et al. · 2025 · Preprint
Inflammasomes are multiprotein complexes that activate pro-caspase-1, leading to the maturation of the pro-inflammatory cytokines IL-1β and IL-18. Nlrp1 , the first receptor identified with inflammasome-forming capacity, is highly…
View details →Wooliver R, Neupane A, DeBruyn JM et al. · 2026 · Journal of environmental quality
Microplastics derived from agricultural plastic films accumulate in soils, potentially impacting ecosystem functions such as soil organic carbon (SOC) storage. Microbial degradation of biodegradable plastics, which are intentionally tilled…
View details →Inoue H · 2025 · Preprint
Abstract The novel coronavirus SARS-CoV-2, commonly referred to as COVID-19, triggered a global pandemic. Although understanding the nature of international infection spread is critically important, extracting diffusion networks from…
View details →Zhao X, Tian Q, Michelsen A et al. · 2025 · Applied Soil Ecology.
Roots and extraradical mycelium (EMM) influence the soil carbon (C) cycle, but it remains unclear how warming alters their effects on soil organic carbon (SOC) and its composition in alpine swamp meadows. A three-year ingrowth core…
View details →Bertrand-Ndoye M, Girard H, Hakim F et al. · 2026 · Forensic science international
In forensic thanatology, post-mortem blood is often stored for long periods, leading to in vitro variations in drug concentrations. This study evaluated the use of dried blood microsampling supports dried (Dried Blood Spot - DBS and…
View details →Fukunaga N, Takanishi T, Wakami T et al. · 2026 · Circulation reports
Background The impact of emergency surgery for acute type A aortic dissection (ATAAD) on renal function in patients with autosomal dominant polycystic kidney disease (ADPKD) remains unclear. Methods and results The renal function of 4…
View details →Li T, Jiang X, Tian X et al. · 2026 · The Journal of endocrinology
Postmenopausal osteoporosis, characterized by estrogen deficiency-induced bone loss and elevated fracture risk, is commonly managed with hormone replacement therapy (HRT). This study aimed to evaluate whether passive exercise via…
View details →Chen W, Zhang C, Guo W et al. · 2026 · Journal of experimental botany
Apple is an important economic species, but it suffers from biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apple. Members of the leucine-rich…
View details →Fischer J, Seguel JM, Drole K et al. · 2026 · BMC sports science, medicine & rehabilitation
Background This study investigated the comparative acute effects of 3 × 30 s of vibration foam rolling (VFR) or percussive massage (PM) on the hamstring muscles, specifically range of motion (ROM), maximum voluntary isometric contraction…
View details →Fujii N, Katagiri A, Nakagome K et al. · 2026 · Scandinavian journal of medicine & science in sports
Continuous monitoring of core temperature is crucial for optimizing exercise performance, promoting health, and ensuring safety. Here, we evaluated the validity of a machine learning-based earbud-type core temperature sensor during…
View details →Lamekina Y, Panela R, Kortje C et al. · 2026 · Preprint
Event segmentation – the division of continuous experience into meaningful units – is essential for understanding narratives. Although event segmentation has been widely studied in visual contexts, little is known about how listeners…
View details →Lamekina Y, Panela R, Kortje C et al. · 2026 · Preprint
Event segmentation – the division of continuous experience into meaningful units – is essential for understanding narratives. Although event segmentation has been widely studied in visual contexts, little is known about how listeners…
View details →Selimović-Pašić A, Haglund L, Bensberg M et al. · 2026 · Preprint
The BCL-2 inhibitor venetoclax (VEN) in combination with hypomethylating agents (HMAs) has improved treatment responses in acute myeloid leukaemia (AML), but the mechanisms underlying their synergy remain unclear. We investigated the role…
View details →Maksymowych WP, Weiss PF, Francavilla ML et al. · 2026 · Seminars in arthritis and rheumatism
Objective The OMERACT JAMRIS working group has defined a spectrum of MRI lesions in the sacroiliac joint (SIJ) in pediatric cases with spondyloarthritis (SpA) that match domains for inflammation and structural damage. We aimed to assess…
View details →Gama de Matos D, de Santana JL, Aidar FJ et al. · 2025 · Preprint
Background: Frailty is a multifactorial condition that significantly impacts older adults health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
View details →Yang Y, Lan C, Jiang Z · 2026 · Tissue engineering and regenerative medicine
Background This study evaluates the impact of Bacillus subtilis dual-strain enteric-coated capsules combined with vonoprazan-amoxicillin (VA) therapy on Helicobacter pylori (Hp) eradication rates, gastrointestinal symptoms, adverse events…
View details →Pinheiro-Machado E, Kuiper T, Huurman RH et al. · 2026 · Journal of biomedical materials research. Part B, Applied biomaterials
Polymer scaffolds are a promising platform for the transplantation of insulin-producing cells in Type 1 Diabetes. While vascularization has been a primary focus due to its role in oxygen and nutrient delivery, the interplay between blood…
View details →Ten Berg S, Beske RP, Grand J et al. · 2026 · European heart journal. Acute cardiovascular care
Background Noradrenaline is frequently used to increase mean arterial pressure (MAP) in patients with cardiogenic shock caused by infarction-related out-of-hospital cardiac arrest (OHCA-AMICS). This Blood pressure and Oxygenation-Targets…
View details →Dong M, Niimi T, Maturana AD · 2026 · Journal of cellular physiology
Intracellular calcium (Ca 2+ ) signaling controls myoblast proliferation, fusion, and myofiber formation. In myoblasts, Transient Receptor Potential Canonical (TRPC) channels, with TRPC1 as a predominant isoform, mediate store-operated…
View details →Hirlemann M, Garmon M, Ribeiro-Parenti L et al. · 2026 · Preprint
ABSTRACT This study investigates the individual and combined effects of Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and metformin on glucose regulation in a non-obese, insulin-deficient model of type 2 diabetes. Female…
View details →Wongwachira C, Suwajanakorn D, Kongwattananon W et al. · 2026 · Eye (London, England)
Purpose To compare the SITA Standard 24-2 and SITA Faster 24-2 C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk. Methods A prospective, cross-sectional study of 75 participants who…
View details →Shober A, Qin Z, Pokhrel S et al. · 2026 · Preprint
Abstract Background and Aims Historical manure applications on the Delmarva Peninsula have created legacy soil phosphorus (P) accumulation, yet winter wheat ( Triticum aestivum L.) often faces early-season P deficiency due to fixation in…
View details →Morales Ruiz S, Wang Z, Miura T et al. · 2026 · Virology
We constructed two novel LC16-derived vaccinia viruses as candidate mpox vaccines to clarify the contribution of B5 to vaccine-induced protection. LC16m8Δ2 is a B5R-null mutant derived from LC16mO that contains no artificial sequences.…
View details →Beffara B, Hadj-Bouziane F, Ben Hamed S et al. · 2026 · Preprint
The control of selective visuo-spatial attention is known to rely on multiple signals, including reward. While most attention control signals are well acknowledged to interact with each other, the case of reward has led to mixed findings…
View details →Sinha P, Chatterjee P, Kathiresan P et al. · 2026 · Journal of the American Geriatrics Society
Objective To evaluate the efficacy of adjunct probiotic supplementation (Lactobacillus helveticus and Bifidobacterium longum) alongside standard care compared to placebo in older adults with moderate unipolar depression. Methods A…
View details →Pontet Y, Aguirrezábal P, Pintos J et al. · 2026 · Journal of clinical gastroenterology
Background In adults, the diagnosis of celiac disease (CeD) relies on the presence of disease-specific antibodies and the confirmation of duodenal atrophy. This study aimed to develop a diagnostic model to predict duodenal atrophy in…
View details →Tanabe H, Watanabe D, Agawa M et al. · 2026 · Biochemical and biophysical research communications
Objectives Intestinal fibrosis is a severe complication of Crohn's disease (CD). While ADAMDEC1 has been identified as a marker for specific fibroblast subsets, its functional role in fibrogenesis remains unclear. This study aimed to…
View details →Souza AF, Fraga MAA, Correr AB et al. · 2026 · Dental materials : official publication of the Academy of Dental Materials
Objectives To evaluate the effects of incorporating the antibacterial monomer dimethylaminohexadecyl methacrylate (DMAHDM; 2.5% and 5% wt%) and amorphous calcium phosphate nanoparticles (NACP; 2 wt%) on the antibacterial activity,…
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