19,906 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Li X, Li Y, Wang T et al. · 2025 · Stroke
Background Previous trials have failed to demonstrate the benefits of extracranial-intracranial (EC-IC) bypass surgery for patients with carotid or middle cerebral artery occlusion. However, little evidence has focused on the effect of age…
View details →Tojo K, Yazawa T · 2024 · Preprint
Abstract Background Although alveolar hyperoxia exacerbates lung injury, clinical studies have failed to demonstrate the beneficial effects of lowering the fraction of inspired oxygen (F I O 2 ) in patients with acute respiratory distress…
View details →Woittiez AJ, Postma CT, de Leeuw PW · 2026 · Kidney medicine
Atherosclerotic renal artery stenosis (ARAS) remains a complex contributor to hypertension and kidney disease. Although randomized trials failed to show benefit of revascularization on top of medical therapy over medical therapy alone,…
View details →Perdue MV, Geeraert BL, Manning KY et al. · 2024 · Preprint
Numerous studies have linked reading ability to white matter microstructure using diffusion tensor imaging, but recent large studies have failed to show consistency. Fiber-specific diffusion-weighted magnetic resonance imaging (dMRI)…
View details →Wang X, Men C, Shan S et al. · 2025 · Gene
Chemoresistance is a considerable challenge for gastric cancer (GC), and the combination of cisplatin (DDP) and anti-EGFR therapy failed to show remarkable benefit. So other targets in EGFR-overexpressed and DDP-resistant GC need to be…
View details →Drieghe B, De Buyzere M, Bové T et al. · 2024 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Randomized clinical trials failed to show additional benefit of renal artery stenting on top of medical therapy. Instead of writing an obituary on renal artery stenting, we try to explain these disappointing results. A transstenotic…
View details →Davani SZ, Pazooki D, Kamalzadeh N · 2024 · Preprint
41-year-old male with no significant past medical history presented as an outpatient with atypical chest pain and had positive nuclear stress test. The patient subsequently underwent left heart catheterization, which revealed a fistula…
View details →Morimoto J, Satogami K, Naraoka T et al. · 2024 · International heart journal
Deficiency of vitamin B 1 (VB1), an essential micronutrient, causes heart failure (HF). A recent randomized controlled trial failed to show any improvement in HF prognosis after short-term VB1 supplementation. In the current study, we…
View details →Canning C, McCormack T, Clifford E et al. · 2024 · The British journal of developmental psychology
Previous studies have failed to show an effect of episodic future thinking (EFT) on children's delay of gratification (DoG), contrasting strikingly with adult findings. Recent findings from a sample of 8-11-year-old children by Canning et…
View details →Danahay H, McCarthy C, Schofield T et al. · 2025 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Inhibiting ENaC in the airways of people with cystic fibrosis (pwCF) is hypothesized to enhance mucociliary clearance (MCC) and provide clinical benefit. Historically, inhaled ENaC blockers have failed to show benefit in pwCF…
View details →Cornell CA, Norman KA, Griffiths TL et al. · 2024 · Psychological science
We often use cues from our environment when we get stuck searching our memories, but prior research has failed to show benefits of cuing with other, randomly selected list items during memory search. What accounts for this discrepancy? We…
View details →Legendre M, Sabourin S, Bégin C · 2022 · Eating and weight disorders : EWD
Purpose A higher risk of food addiction (FA) in individuals reporting childhood sexual abuse (CSA) has been well demonstrated with community samples, but studies including clinical samples failed to replicate this relation. This study…
View details →Zhang J, Whitehurst LN, Mednick SC · 2022 · Neurobiology of learning and memory
Prior studies suggest a role for sleep in memory consolidation, with specific contributions from slow oscillations and sleep spindles (Rasch & Born, 2013). However, recent studies failed to replicate sleep's superiority over wake in…
View details →Aitken-Buck HM, Moore MK, Bingham KT et al. · 2024 · Forensic science, medicine, and pathology
Epicardial adipose tissue (EAT) deposition has been long associated with heart weight. However, recent research has failed to replicate this association. We aimed to determine the association of EAT volume with heart weight in post-mortem…
View details →Forestier C, de Chanaleilles M, Boisgontier MP et al. · 2021 · Preprint
The replication crisis in psychology has led to question popular phenomena such as ego depletion, which has been criticized after studies failed to replicate. Here, we describe limitations in the literature that contributed to these…
View details →Dora J, Van Lissa CJ, Shinn M et al. · 2026 · Preprint
Laboratory studies consistently support the hypothesis that people drink alcohol to regulate stress and negative affect, yet ecological momentary assessment (EMA) studies have repeatedly failed to detect the predicted within-person…
View details →Taheri F, Tanha AS, Aboutorabi RB et al. · 2026 · Clinical nuclear medicine
A 78-year-old woman with medullary thyroid carcinoma (MTC) demonstrated persistently elevated serum calcitonin despite prior surgery and radiotherapy. 99mTc-octreotide imaging failed to detect skeletal metastases, while 68Ga-FAPI PET/CT…
View details →Huang Y, Huang X, Ling L et al. · 2024 · Kardiologiia
Aim Elevated levels of pro-inflammatory factors in plasma have been linked to worse prognosis after on-pump cardiac surgery, yet interventions that reduce the levels in patients have failed to improve prognosis. Therefore, we explored…
View details →Hanazawa R, Sato H, Hirakawa A · 2025 · Therapeutic innovation & regulatory science
Background Alzheimer's disease (AD) is a neurodegenerative disease for which many clinical trials failed to detect treatment effects, possibly due to the heterogeneity of disease progression among the patients. Predicting and clustering a…
View details →Knappich C, Bohmann B, Kirchhoff F et al. · 2025 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Objective Various studies have failed to detect a difference in outcomes between carotid endarterectomy (CEA) with patch angioplasty and eversion CEA. This study aimed to assess whether surgical technique and related department policy are…
View details →Treeratanapun N, Lerttiendamrong B, Vacharathit V et al. · 2026 · Preprint
Abstract Background The implementation of sentinel lymph node biopsy (SLNB) with permanent section (PS) analysis alone in patients who satisfied the ACOSOG Z0011 criteria did not alter the standard of care offered by the additional frozen…
View details →Lee N, Yang Y, Tian D et al. · 2026 · Journal of ginseng research
We determined whether Korean Red Ginseng (KRG) extract and ginsenosides (Rb1, Rg1, or Rg3) have estrogen receptor-mediated or androgen receptor-mediated activities using OECD TG455/458 assays with S9 metabolic activation. They did not…
View details →Adams MS, Mensink RP, Plat J et al. · 2026 · European journal of clinical nutrition
Background Previous almond intervention studies involving relatively healthy populations did not demonstrate improvements in cognitive performance. However, a long-term study with participants at risk of cognitive decline, such as those…
View details →Kant N, Garssen SH, Vernooij CA et al. · 2024 · Studies in health technology and informatics
Adding continuous monitoring to usual care at an acute admission ward did not have an effect on the proportion of patients safely discharged. Implementation challenges of continuous monitoring may have contributed to the lack of effect…
View details →Sanders JF, de Boer SE, Jonker J et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points Low-dose tacrolimus, everolimus, and prednisolone did not result in a higher rate of successful transplantation in older kidney transplant recipients. Low-dose tacrolimus, everolimus, and prednisolone did not result in better…
View details →Hüther A, Sherman CL, Sumaroka A et al. · 2026 · Ophthalmic genetics
Purpose To describe the phenotype of a patient with bi-allelic pathogenic variants in NR2E3 that did not result in an overt enhanced S-cone syndrome (ESCS) phenotype. Methods The patient underwent a comprehensive ophthalmic exam, imaging…
View details →Wu C, Zhu X, Dai Q et al. · 2026 · Chest
Case presentation A 74-year-old woman sought treatment with a 4-day history of high fever and rapidly progressive dyspnea. A 2-day course of ceftriaxone and betamethasone administered in an outpatient setting did not result in any clinical…
View details →Stewart D, Greenberg M, Heppell S et al. · 2025 · Emergency medicine Australasia : EMA
Objective To determine the proportion of patients who are admitted to hospital following a 'did not wait' (DNW) encounter that are related to the initial episode of care, and to assess the frequency of clinical deterioration in this…
View details →Furne Gouveia G · 2026 · Preprint
The Michelson–Morley experiment yielded a null result, indicating equal light travel times in the longitudinal and transverse arms of an interferometer, traditionally interpreted as evidence against a light-propagating medium. This paper…
View details →Furne Gouveia G · 2026 · Preprint
The Michelson–Morley experiment yielded a null result, indicating equal light travel times in the longitudinal and transverse arms of an interferometer, traditionally interpreted as evidence against a light-propagating medium. This paper…
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