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Browse the failure-mode index

20,261 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Effect of a community-based intervention for cardiovascular risk factor control on stroke mortality in rural Gadchiroli, India: a cluster-randomised controlled trial

Kalkonde Y, Jadhao S, Bhusari V et al. · 2026 · Preprint

Background: Stroke is the second leading cause of death globally. We tested whether it was feasible to deliver a community-based intervention package for prevention of stroke and, whether such an intervention would reduce stroke mortality…

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Negative / Null Result ReportOpen accessMedicine

Combined effects of mesenchymal stromal cells and antibiotic therapy on Enterobacter ventilator-associated pneumonia in rabbits.

Jacquier M, Laroye C, Bensoussan D et al. · 2026 · Respiratory research

Background Although mesenchymal stromal cells (MSCs) have shown promising effects in preclinical pneumonia models, their ability to improve outcomes in ventilator-associated pneumonia (VAP) remains poorly explored, despite VAP being a…

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Negative / Null Result ReportMedicine

Systemic Administration of an Anti-CD18 Antibody Prevents the Accumulation of Peripheral Leukocytes in Pericontusional Tissue, but Does Not Improve Outcome after Traumatic Brain Injury in Mice.

Guo Y, Hu S, Wang Z et al. · 2026 · Journal of neurotrauma

The formation of brain edema is one of the key factors that determine patient outcomes following traumatic brain injury (TBI). Despite decades of research, no causal treatment is available to date. Among the many factors discussed,…

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Negative / Null Result ReportMedicine

Early recurrence after primary TURBT for non-muscle-invasive bladder cancer in Iceland: the critical role of surgical quality.

Björnsson O, Geirsson G, Leifsson ÁS et al. · 2026 · Scandinavian journal of urology

Introduction Transurethral resection of bladder tumor (TURBT) is the standard treatment for non-muscle-invasive bladder cancer (NMIBC), but early recurrences remain frequent. The objective of this study was to standardize TURBT management…

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Negative / Null Result ReportMedicine

Levan-derived oligosaccharides (LOS) confer selective resistance against Phytophthora capsici but not Botrytis cinerea in melon and watermelon.

Yang M, Chen Y, Yang L et al. · 2026 · International journal of biological macromolecules

Plants face significant threats from pathogens while chemical pesticides remain the primary method for disease control. However, excessive use of chemical pesticides has led to increased pathogen resistance and environmental hazards,…

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Negative / Null Result ReportMedicine

The defense-inducing compound N-hydroxy pipecolic acid is a major substrate for the methyltransferase PbBSMT of Plasmodiophora brassicae.

Benade F, Jülke S, Schwelm A et al. · 2026 · Journal of experimental botany

The clubroot pathogen Plasmodiophora brassicae has an effector protein that can methylate the plant defense compound salicylic acid (SA), and the protein sequence is highly conserved in different isolates worldwide. Sequencing the…

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Negative / Null Result ReportMedicine

Early risk assessment and aspirin prophylaxis did not reduce preterm preeclampsia in Sweden: a population-based study.

Mans-Gallart N, Carlhäll S, Hildebrand E et al. · 2026 · American journal of obstetrics and gynecology

Background Preeclampsia is a substantial cause of maternal and perinatal morbimortality, with complications becoming more severe the earlier it manifests during pregnancy. The Fetal Medicine Foundation has developed a method that combines…

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Negative / Null Result ReportMedicine

Randomized field trial on the effects of on-arrival intranasal vaccination against bovine coronavirus on pneumonia and average daily gain in beef-on-dairy calves.

Jourquin S, Lowie T, Clinquart J et al. · 2026 · Journal of dairy science

This randomized clinical trial evaluated the effect of upon-arrival intranasal vaccination against bovine coronavirus (BCoV) on pneumonia risk in a beef-on-dairy veal production system. Secondary objectives were to assess the effect…

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Negative / Null Result ReportMedicine

Closed incisional negative-pressure wound therapy vs standard surgical dressing for groin incisions following arterial vascular surgery: A prospective multicenter randomized clinical trial.

Lenselink E, Ruig M, Grootendorst DC et al. · 2026 · Journal of vascular surgery

Objective Groin wound complications-including surgical site infections, hematomas, seroma leakage, necrosis, and wound dehiscence-are frequently reported after arterial vascular surgery and significantly impact patient morbidity and…

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Negative / Null Result ReportMedicine

Effects of tumour necrosis factor and interleukin-6 inhibitor therapy on exercise-related visceral adipose tissue reduction in rheumatoid arthritis.

Jønck S, Adamsen ML, Rasmussen IE et al. · 2026 · Experimental physiology

Excess visceral adipose tissue (VAT) mass increases cardiovascular disease risk. Exercise supports overall health and VAT mass reduction in rheumatoid arthritis (RA). Unlike tumour necrosis factor (TNF), interleukin-6 (IL-6) is upregulated…

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Negative / Null Result ReportMedicine

Primary Prophylaxis for Clostridioides difficile Infection in Lung Transplant Recipients: A Retrospective Study.

Irwin M, Leedy N, Nandavaram S et al. · 2026 · Transplant infectious disease : an official journal of the Transplantation Society

Background Clostridioides difficile infection (CDI) is a common complication in patients receiving broad-spectrum antibiotics and causes significant morbidity, especially in solid organ transplant recipients. Oral vancomycin has shown…

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Negative / Null Result ReportMedicine

Comparison of international league of associations for rheumatology and pediatric rheumatology international trials organization classification criteria for juvenile idiopathic arthritis: insights from an African multicenter cohort.

Hamdi W, Ben Nessib D, Hashad S et al. · 2025 · European journal of pediatrics

The International League of Associations for Rheumatology (ILAR) classification criteria for juvenile idiopathic arthritis (JIA) are currently widely used in clinical practice. However, new criteria have recently been proposed by the…

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Negative / Null Result ReportMedicine

Biodegradable patch based on chitosan-collagen with glycerol plasticizer as scaffold for tympanic membrane perforation.

Widiyanti P, Putra AF, Rudyardjo DI · 2026 · The International journal of artificial organs

Perforation on tympanic membrane could decrease the hearing ability. In some cases, myringoplasty should be performed. Myringoplasty requires material as patch to cover tympanic membrane's hole. This study is aimed to create innovation…

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Negative / Null Result ReportMedicine

Effect of neuromuscular blockade on opioid consumption in high-risk children undergoing adenotonsillectomy: A randomized-controlled trial.

Efune PN, Nakonezny PA, Pinales P et al. · 2026 · Journal of clinical anesthesia

Background Protective reflexes like coughing occur frequently during pediatric adenotonsillectomy (AT) and are difficult to blunt with anesthetics, potentially leading to higher than necessary opioid administration. Our objective was to…

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Negative / Null Result ReportMedicine

Comparing the Antimicrobial Resistance Crisis to the Coronavirus Disease 2019 Pandemic: A Randomized Public Health Messaging Experiment.

Thorpe A, Lee RA, Szymczak JE et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Antimicrobial resistance (AMR) is an urgent health threat. Effective communication about AMR and avoiding antibiotics for viral infections is a public health priority. Here, we evaluated whether comparing the AMR crisis to the…

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Negative / Null Result Report

Virtual embodiment of civic heroes preserves the conflict associated with anti-mafia intentions and enhances physiological discomfort in response to mafia-related crime

Placidi V, Lisi MP, Vabba A et al. · 2025 · Preprint

Although Mafia-type criminal organizations (MCOs) exert severe societal harm, evidence-based interventions fostering anti-mafia motives remain scarce. We investigated whether embodying virtual heroic characters enhances opposition to MCOs.…

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Negative / Null Result ReportMedicine

Effect of two-session remote ischaemic preconditioning on myocardial injury after noncardiac surgery in patients undergoing abdominal surgery: a randomised clinical trial.

Zheng Z, Wang F, Wang X et al. · 2026 · British journal of anaesthesia

Background Myocardial injury after noncardiac surgery is associated with both short-term and long-term mortality. However, effective preventive strategies remain limited. Remote ischaemic preconditioning (RIPC) confers distinct early and…

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