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Browse the failure-mode index

19,902 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Potential usefulness of [123I]I-MIBG SPECT/CT with AC Quant protocols in diagnostics and treatment monitoring of children with neuroblastoma.

Śliwińska A, Świtaj K, Durma AD · 2026 · Nuclear medicine review. Central & Eastern Europe

Background Neuroblastoma (NB) is the most common extracranial solid tumor in children. Metaiodobenzylguanidine (MIBG) selectively accumulates in adrenergic tissue, enabling its use for diagnostic imaging of NB. The implementation of new…

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Negative / Null Result ReportMedicine

Driving Cerebellar Theta Oscillations Interferes With Voluntary Neck Movements in Cervical Dystonia.

Costa D, Guerra A, Birreci D et al. · 2026 · Movement disorders : official journal of the Movement Disorder Society

Background Cervical dystonia (CD) is a movement disorder with a complex pathophysiology, including cerebellar abnormalities. Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique capable of entraining…

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Negative / Null Result ReportMedicine

Maxillary Advancement and Impaction Increase the Size of the Nasal Airway Anterior to the Piriform Aperture, but Not Posterior to it.

Giotakis AI, Steinbichler TB, Heppt H et al. · 2026 · The Journal of craniofacial surgery

The exact nasal changes caused by several types of maxillofacial surgery are not yet thoroughly understood. The aim of the present study was to determine the exact nasal airway changes caused by maxillary advancement and impaction. In a…

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Negative / Null Result ReportOpen accessMedicine

Lean Mass Gains, Cardiac Remodeling, and Muscle Oxidative Changes With High-Dose Salbutamol During Resistance Training: A Randomized Controlled Trial.

Hostrup M, Jessen S, Tischer SG et al. · 2026 · Scandinavian journal of medicine & science in sports

Misuse of beta 2 -agonists to promote leanness is increasingly reported among young men undertaking resistance training. However, preclinical models demonstrate adverse cardiac remodeling with high-dose beta 2 -agonist. We investigated…

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Negative / Null Result ReportMedicine

Change in modified star excursion balance test performance between 6 and 12 months after anterior cruciate ligament reconstruction.

Rostron ZPJ, Feller JA, McClelland JA et al. · 2026 · Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

Objectives To determine the change in modified star excursion balance test scores in patients between 6 and 12 months following anterior cruciate ligament (ACL) reconstruction and the change in the proportion of patients who met…

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Negative / Null Result ReportMedicine

The impact of hormonal contraceptives containing estradiol, estradiol valerate, and estetrol on liver proteins, lipids, glucose, blood pressure, and bone. A literature review.

Cagnacci A, Xholli A, Gabbi L et al. · 2026 · The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

Objective We investigated the metabolic profile induced by contraceptives containing body-identical oestrogens. Methods A literature search was made for articles on contraceptives with oestradiol/nomegestrol acetate (E2/NOMAc), oestradiol…

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Negative / Null Result ReportMedicine

Quantification of Changes in Bifidobacteria and Lactobacilli Colony-forming Units During Rifaximin Treatment and Synbiotic Gel in Healthy Volunteers.

Cassís-Nosthas ML, Vorácková FV, Dzib FT et al. · 2026 · Journal of visualized experiments : JoVE

Although the gut microbiota is generally stable, it can be influenced by antibiotic treatment. Rifaximin, which is used to treat gastrointestinal disorders, is frequently administered with probiotics to reduce the risk of dysbiosis.…

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Negative / Null Result ReportMedicine

Cerebral physiology following general anaesthesia with sevoflurane or propofol in healthy volunteers - a randomised, single-blind cross-over trial.

Madsen SS, Asghar MS, Lindberg U et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Although general anaesthesia is a very common medical procedure, knowledge of how the brain physiologically recovers remains limited. In this randomized cross-over trial, we investigated brain physiology during recovery from general…

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Negative / Null Result ReportMedicine

Long-term risk of major adverse cardiovascular events after carotid endarterectomy-a 9-year prospective cohort study of the Athero-Express biobank.

Mol BM, de Bresser CJM, de Kleijn PV et al. · 2026 · European stroke journal

Carotid endarterectomy (CEA) is performed to lower the long-term risk of stroke in patients with carotid stenosis. Data evaluating long-term outcomes after CEA are scarce, but crucial for accurately determining long-term benefits. We aimed…

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Negative / Null Result ReportMedicine

Efficacy of Aerobic Exercise on Brain MRI Measures in Parkinson's Disease.

Langeskov-Christensen M, Nygaard MKE, Eskildsen SF et al. · 2026 · Neurorehabilitation and neural repair

Objectives Medical disease-modifying treatments are lacking in Parkinson's disease (PD). Physical exercise is potentially an inexpensive and easily accessible disease-modifying therapy, but this remains to be studied using recent promising…

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Negative / Null Result ReportMedicine

Auditory mismatch-negativity predicts response to dorsomedial prefrontal intermittent theta-burst stimulation in major depressive disorder.

Anderson M, Bodén R, Wass CE et al. · 2026 · Journal of affective disorders

Background Impaired plasticity has been implicated in major depressive disorder (MDD), which is reflected in impaired automatic sensory detection as measured using mismatch negativity (MMN). Intermittent theta-burst stimulation (iTBS) is…

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Negative / Null Result ReportOpen accessMedicine

Increased cytokine production capacity and persistent inflammation after achieving remission of Cushing's syndrome.

van Houten P, van de Ven AC, van Herwaarden AE et al. · 2026 · Journal of clinical & translational endocrinology

Endogenous Cushing's syndrome (CS) is characterized by chronic hypercortisolism. After achieving remission, morbidity remains increased and quality of life remains impaired. Moreover, the incidence of inflammatory disorders increases after…

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Negative / Null Result ReportMedicine

Chronic atorvastatin treatment weakens procontractile influence of NADPH oxidase derived ROS in systemic murine arteries.

Shvetsova AA, Zakirjanova GF, Ostapchuk KP et al. · 2026 · Pflugers Archiv : European journal of physiology

The beneficial effects of statins for cardiovascular system were widely described in various pathologies. However, much less is known about the effects of statins in healthy organism, especially in systemic resistance arteries. We aimed to…

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Negative / Null Result Report

The Utility of MRI for spinal clearance in blunt trauma. A retrospective cohort study of 539 blunt trauma patients in a level one trauma center in Singapore

Cayden L, Chandrasagran RA, Adam C et al. · 2026 · Preprint

Abstract Introduction: The majority of spinal injuries occur secondary to blunt trauma and patients with significant blunt trauma must be assumed to have an unstable spinal injury until complete radiological and clinical assessment. MRI…

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Negative / Null Result ReportMedicine

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury - a pilot study.

Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology

Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…

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