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Browse the failure-mode index

19,902 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of a Self-Management Program for Temporomandibular Myalgia in Patients With Fibromyalgia: A Single-Arm Study.

Ferrández-Gómez JE, Baño-Alcaraz A, Gacto-Sanchez M · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Purpose Myogenic temporomandibular disorder frequently co-occurs with fibromyalgia and is associated with pain, disability, and maladaptive pain cognitions. This study evaluated the short- and long-term effects of an online Pain…

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Negative / Null Result ReportMedicine

Thrombotic Outcomes Associated With Factor Eight Inhibitor Bypassing Activity Use in Neonatal and Infant Cardiac Surgery Including the Norwood Procedure: A Propensity Score‒Matched Analysis.

Houska N, McCaw N, Meneses EC et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives To describe thrombotic outcomes associated with Factor Eight Inhibitor Bypassing Activity (FEIBA) exposure in neonates and infants undergoing cardiac surgery with cardiopulmonary bypass (CPB), including the Norwood procedure.…

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Negative / Null Result ReportMedicine

Comparison of pain perception and heart rate between Dentapen and Vibraject during local anesthesia administration in adult patients: a randomized clinical study.

Almuashi H, AbuMostafa A · 2026 · Quintessence international (Berlin, Germany : 1985)

Objective The management of pain in dental procedures is crucial, as local anesthetic injections may induce patient anxiety and discomfort. Various techniques including Vibraject and Dentapen have been devised to alleviate injection…

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Negative / Null Result ReportMedicine

Trends and regional inequalities in cerebrovascular disease mortality in Peru: An ecological time-series analysis, 2017-2025.

Veli-Quispe D, Urquizo-Prado S, Cesare-Ariza E et al. · 2026 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Background Cerebrovascular disease remains a leading cause of mortality worldwide. In Peru, evidence on recent mortality trends and regional disparities is limited. Objective To evaluate temporal trends and regional disparities in…

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Negative / Null Result ReportMedicine

Impact of Aflibercept Dosing Frequency on Retinal Nonperfusion Progression Assessed by Ultra-Widefield Angiography After Endolaserless Vitrectomy for Proliferative Diabetic Retinopathy-Related Vitreous Hemorrhage.

Qin LG, Camarda ND, Kasetty VM et al. · 2026 · Journal of vitreoretinal diseases

Purpose: To investigate the effect of intravitreal (IVT) aflibercept injection monotherapy on retinal ischemia in eyes with severe proliferative diabetic retinopathy (PDR) that underwent pars plana vitrectomy (PPV) without panretinal…

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Negative / Null Result ReportMedicine

Effect of dietary carrageenan supplementation on growth performance, digestive enzyme and antioxidant enzyme activity, immune gene expression, and capacity against S. agalactiae of Nile tilapia (Oreochromis niloticus).

Ramachandran I, Rajesh AT, Elumalai P · 2026 · Fish physiology and biochemistry

The current study aimed to ascertain the growth, antioxidant capacity, intestinal architecture, digestive enzyme activity, and disease resistance of S. agalactiae of Nile tilapia (Oreochromis niloticus) fed a diet enriched with…

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Negative / Null Result ReportOpen accessMedicine

Comparison of root coverage by injectable-platelet rich fibrin in thick and thin phenotypes: a parallel-armed, prospective, preliminary clinical study with up to 48 months of follow-up.

Ayyildiz BG, Terzioglu B, Eken S · 2026 · Journal of applied oral science : revista FOB

Objective This study aimed to compare the effectiveness of injectable platelet-rich fibrin (I-PRF) using a submucosal injection technique for creeping attachment in thin and thick phenotypes with gingival recession. Methodology The study…

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Negative / Null Result ReportMedicine

Female reproductive toxicity induced by nitrate in drinking water and the comparative ameliorative effects of ascorbic acid, curcumin and their combination.

Sharma M, Kaur N · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

The reproductive toxicity of nitrate in juvenile and adult female rats, and its amelioration with ascorbic acid, curcumin or their combination, was studied. Rats were classified into five groups: control, nitrate, nitrate + ascorbic acid,…

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Negative / Null Result Report

Emotions and bodily sensations evoked by cardiac adenosine stress

Egorova K, Maaniitty T, Kärpijoki H et al. · 2026 · Preprint

Peripheral physiological processes contribute to emotions; however, the extent of the influence of internal signals on subjective emotional experiences remains a subject of debate. Methods Here we investigated the bodily sensations induced…

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Negative / Null Result ReportOpen accessMedicine

National Football League (NFL) "Dynamic Kickoff" Rule Change: A Comparative Analysis of Concussion and Musculoskeletal Injury Incidence.

Puga T, Haechten T, Cush C et al. · 2025 · Orthopaedic journal of sports medicine

Background Kickoffs in the National Football League (NFL) are historically one of the most dangerous plays during an NFL game, with high levels of injuries. In 2024, the NFL introduced new rules aimed at reducing injuries during kickoffs,…

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Negative / Null Result Report

The Effect of Screening Training for Diseases Caused by Environmental and Industrial Pollutants on the Evaluation Scores of Medical Clerkship and Internship

Javaheri J, Asgari M, Mohaghegh P et al. · 2026 · Preprint

Abstract Background: Routine monitoring, identification, early diagnosis and screening of diseases caused by environmental and industrial pollutants by all physicians who will practice in large and polluted cities or areas affected, must…

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Negative / Null Result ReportMedicine

Haemoglobin threshold-based blood transfusion practices in patients following hip fracture surgery: a multicentre retrospective study.

Berube M, Bortman JM, Law AC et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy

Background The optimal threshold to blood transfusion in patients after hip fracture surgery is unclear. This study leveraged regression discontinuity to quantify blood transfusion practices across haemoglobin thresholds of 7.0, 8.0, and…

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Negative / Null Result ReportMedicine

Expression of tardigrade extremotolerance-associated proteins improves recovery but not acute stress response of human microvascular endothelial cells.

Darch W, Soliman J, Higgins NC et al. · 2026 · Scientific reports

Vascular endothelial cells (VECs) play a critical role in tissue and organ homeostasis, wound healing, and immune function. VECs are commonly utilized for in vitro cell culture and in vivo tissue engineering applications which experience…

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Negative / Null Result ReportMedicine

Microsurgical Denervation of the Penis for Lifelong Premature Ejaculation: A Prospective Multicenter Study Evaluating Technique Modification and Early Clinical Outcomes.

Almekaty K, Alhefnawy M, Ismael A et al. · 2026 · Urology

Objective To prospectively assess the clinical outcomes and safety of microsurgical denervation of the penis (MSDP) for treatment of lifelong premature ejaculation (LPE); and to examine the impact of transitioning from partial to more…

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Negative / Null Result ReportMedicine

Dento-facial changes and oral health-related quality of life assessment in management of anterior crossbite in mixed dentition: a randomized clinical trial.

Salem AS, Albelasy NF, El-Bialy AA · 2026 · The Angle orthodontist

Objectives To compare the effectiveness of clear aligner (CA) vs removable inclined plane (RP) in improving the dentofacial changes and oral health-related quality of life (OHRQoL) in children with anterior crossbite in the mixed…

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Negative / Null Result ReportMedicine

Size Dependent Effects of Aluminum Oxide Particles on Tissue Accumulation and Antioxidant Enzyme Activities of Oreochromis niloticus.

Tuncsoy M, Tuncsoy B · 2026 · Bulletin of environmental contamination and toxicology

Aluminum (Al) is a widely occurring element in nature and is the most abundant element in the earth's crust after oxygen and silicon. In this study, metal accumulation levels in the gills, liver and muscle tissues and liver SOD, CAT and…

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