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19,902 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The impact of total laparoscopic excision of deep endometriosis (DE) on bladder and bowel dysfunction: a prospective longitudinal study.

Morris JS, Rajshekhar S, Gremmo G et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Deep endometriosis (DE) is established to cause chronic pelvic pain (CPP), lower urinary tract symptoms (LUTS) and altered bowel function. Although the aim of surgical excision is often to relieve CPP, evidence suggests it could also…

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Negative / Null Result ReportOpen accessMedicine

Molecular imaging of lymphatic organs provides prognostic value after acute myocardial infarction.

Reiter T, Dörrler AL, Hasenauer N et al. · 2026 · European journal of nuclear medicine and molecular imaging

Introduction Acute myocardial infarction (AMI) triggers local inflammation in the injured myocardium, followed by a systemic inflammatory response of lymphatic organs. This prospective trial (NCT05519735) focused on molecular imaging of…

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Negative / Null Result ReportMedicine

Effects of heat stress on human health and physio-biochemical attributes of quinoa growing in arsenic contaminated soil.

Shabbir A, Abbas G, Alharby HF et al. · 2026 · International journal of phytoremediation

Heat stress and soil arsenic (As) contamination are resulting in severe decline in crop production around the world. The present experiment aimed to assess physiological and biochemical changes induced by the combination of As and heat…

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Negative / Null Result ReportMedicine

Evaluation of incisional negative pressure wound therapy with anterior approach total ankle arthroplasty.

Cottom JM, Verdoni TJ · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

Background Total ankle replacement continues to find significantly increased utilization as the technology advances. While there are different systems on the market, most are implanted through an anterior incisional approach just lateral…

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Negative / Null Result ReportMedicine

Exposure levels and target attainment of meropenem in adult patients admitted to the intensive care unit: a prospective observational study.

El-Haffaf I, Marsot A, Paillault A et al. · 2025 · Canadian journal of physiology and pharmacology

In this study, we evaluate the exposure and pharmacokinetic/pharmacodynamic target attainment of meropenem in critically ill patients. We conducted a prospective observational study in two Canadian intensive care units (ICUs) from January…

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Negative / Null Result ReportOpen accessMedicine

Comparing a Conceptual Framework and Factor Analysis to Achieve Survey Item Reduction in Predicting Medication Non-Persistence.

Umeaghadi CF, Taylor JG, Yao S et al. · 2026 · Patient preference and adherence

Adherence surveys can be lengthy due to the high number of potential risk factors to be analyzed. As a result, researchers often reduce items into conceptual domains (eg, beliefs, economic factors) to overcome power constraints or focus…

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Negative / Null Result ReportMedicine

Acceptability of Adolescent Portal Access Policies to Parents and Adolescents: A Delphi Study.

Sisk BA, Antes AL, Bereitschaft C et al. · 2025 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Purpose United States healthcare systems have enacted varied adolescent online patient portal policies. No prior work has established whether these policies are acceptable to adolescents and parents. Methods Mixed-method Delphi approach…

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Negative / Null Result ReportOpen accessMedicine

Safety Audit of a Large Language Model for Lay Self-Triage Using Japanese Symptom Vignettes: Persistent Red-Flag Under-Triage Despite Improved Reproducibility Under Near-Deterministic Decoding.

Harada Y · 2026 · Cureus

Introduction Large language models are increasingly discussed as tools for patient-facing symptom assessment, but safe self-triage depends on the concrete next action recommended to the user rather than on generic urgency language alone.…

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Negative / Null Result ReportMedicine

The State of Surgery in Botswana, 2018 to 2022.

Romeo DJ, Wagner CS, Ahluwalia V et al. · 2025 · The Journal of craniofacial surgery

Many people living in low-income and middle-income countries (LMICs) lack access to safe surgical and anesthetic care. The Lancet Commission on Global Surgery (LCGS) recommended that all countries track surgical volume and target 5,000…

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Negative / Null Result ReportMedicine

Factors associated with failure to achieve Scoliosis Research Society-22r minimal clinically important difference despite achieving optimal global alignment in adult spinal deformity surgery.

Park SJ, Park JS, Kang DH et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose To identify factors associated with failure to achieve the minimal clinically important difference (MCID) in the Scoliosis Research Society-22r (SRS-22r) despite achieving optimal global alignment in adult spinal deformity (ASD)…

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Negative / Null Result ReportMedicine

Operative Management of Perianal Crohn's Disease.

Wilkinson T, Booth K · 2025 · The Surgical clinics of North America

The management of perianal Crohn's disease is challenging and complex and requires a multidisciplinary approach as a favorable working relationship between gastroenterologists and colorectal surgeons is necessary to provide excellent care…

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Negative / Null Result ReportOpen accessMedicine

Evaluating oral ketamine's adverse side effects in chronic pain patients.

Hom B, McIntee D, Zhang YP et al. · 2025 · Saudi journal of anaesthesia

Background Ketamine has been shown to be an effective treatment at sub-anesthetic doses for various chronic pain conditions. This study assesses the relationship between oral ketamine and the incidence of adverse side effects in patients…

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Negative / Null Result ReportMedicine

Standardization of Lesion Classification and Assessment by Investigators in Clinical Trials for Hidradenitis Suppurativa: A Consensus Exercise Using a Modified Delphi Approach.

Garg A, Strunk A, Midgette B et al. · 2026 · JAMA dermatology

Importance Accurate classification and reliability in assessment for lesions of hidradenitis suppurativa (HS) by investigators is critical to the determination of responder status and to overall data quality in clinical trials. Objective…

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Negative / Null Result ReportOpen accessMedicine

The use of cellphone based automated pupillometry to quantify opioid withdrawal in patients receiving treatment for opioid use disorder.

Evonko CJ, Vigilante KC, Leli NB et al. · 2026 · Journal of substance use and addiction treatment

Introduction Overdose deaths attributed to opioid misuse resulted in over 50,000 deaths in 2024. Opioid agonist therapies such as methadone and buprenorphine are effective for the treatment of opioid use disorder (OUD). Yet, patient…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of dilution ventilation in mitigating occupational exposure to volatile organic compounds (VOCs) at the breathing zone of nail technicians: a simulation study.

Salari S, Fazeli-Tabar S, Karimi A et al. · 2026 · Scientific reports

Volatile Organic Compounds (VOCs) from nail products pose potential health risks to technicians and clients. The present study investigates the exposure of nail technicians to VOC and assesses the effectiveness of dilution ventilation in…

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