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Browse the failure-mode index

19,902 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Efficacy of Watercress (<i>Nasturtium officinale</i> R.Br.) Consumption on Blood Pressure, Oxidative Stress Biomarkers, and Estimated Cardiovascular Risk in Thai Middle-Aged Adults: A Randomized Placebo-Controlled Pilot Study.

Kijkuokool P, Rerkasem K, Fakfum P et al. · 2026 · Antioxidants (Basel, Switzerland)

Watercress ( Nasturtium officinale R.Br.) is a cruciferous vegetable rich in bioactive compounds that may improve cardiovascular disease (CVD) risk factors. However, clinical evidence regarding its direct impact on CVD risk remains…

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Negative / Null Result ReportMedicine

Serum ceramides predict all-cause and cardiovascular mortality in Chinese incident hemodialysis patients: a retrospective cohort study.

Zhang S, Wu YL, Li ZY et al. · 2026 · Kidney research and clinical practice

Background This study explored serum ceramide (Cer) levels' association with all-cause and cardiovascular disease (CVD) mortality in Chinese incident hemodialysis (HD) patients. Methods This retrospective cohort study included 253 adults…

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Negative / Null Result ReportMedicine

Unilateral posterior vertebral column resection versus bilateral approach for post-traumatic thoracic angular kyphosis: a propensity-matched non-inferiority study.

Ghobashy MK, AbdelFatah MA, Youssef ME et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose Posterior vertebral column resection (PVCR) for severe post-traumatic thoracic angular kyphosis is effective but carries high morbidity. This study compares unilateral PVCR (UPVCR) with traditional bilateral PVCR (BPVCR),…

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Negative / Null Result Report

Theta Dual-Brain Stimulation of rTPJ Shapes Joint Agency

Kurihara Y, Tsuchiya A, Dumas G et al. · 2026 · Preprint

Summary Joint agency, the shared feeling of “we are doing this together”, has been linked to inter-brain synchrony, but its causal role in shaping this experience remains unclear. We applied dual transcranial alternating current…

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Negative / Null Result ReportMedicine

Face-to-face vs. telerehabilitation for thoracic hyperkyphosis in children- A randomized controlled pilot study.

Gözener Canbülbül S, Canbülbül B, Özcan Şİ et al. · 2026 · Journal of pediatric rehabilitation medicine

PurposeThis pilot study aimed to compare the effects of face-to-face and telerehabilitation approaches on thoracic hyperkyphosis, back extensor muscle strength, and discomfort in children.MethodsA randomized clinical trial was conducted in…

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Negative / Null Result ReportMedicine

The John Charnley Award: A Randomized Controlled Trial of Dual Mobility and Single Bearings for Patients at High Risk of Dislocation Following Primary Total Hip Arthroplasty.

Potluri AS, Yadav AS, Weintraub MT et al. · 2026 · The Journal of arthroplasty

Introduction This multicenter randomized controlled trial (RCT) sought to determine if dual-mobility bearings (DM) reduce dislocations in patients at high-risk for instability undergoing primary total hip arthroplasty (THA) compared to…

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Negative / Null Result ReportMedicine

Nocturnal Hypoxemia and Incident Coronary Artery Disease in Obstructive Sleep Apnea: Results from the Sleep Apnea Patients in Skaraborg Study.

Peker Y, Hjälm HH, Glantz H et al. · 2026 · Balkan medical journal

Background The relationship between obstructive sleep apnea (OSA) and coronary artery disease (CAD) remains controversial. Although observational studies have suggested that OSA is associated with an increased risk of coronary events,…

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Negative / Null Result Report

Association of Driver Oncogenic Alterations with SUVmax, Preoperative Serum Calcium, and Smoking Status in Surgically Resected Non-Small Cell Lung Cancer: A Retrospective Single-Center Study

Korodimos N, Wojtyś ME, Kostopanagiotou K et al. · 2026 · Preprint

Background: Non-small cell lung cancer (NSCLC) is driven by distinct oncogenic al-terations with important therapeutic and prognostic implications. Noninvasive bi-omarkers that predict molecular status in surgically resectable disease may…

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Negative / Null Result ReportOpen accessMedicine

Investigation of Contrast-Induced Neurotoxicity and the Effects of Sildenafil and <i>N</i>-Acetylcysteine on HIF-1α Levels in Wistar Rats.

Altintop I, Tatli M, Sarica ZS et al. · 2026 · Brain sciences

Background Contrast-induced encephalopathy (CIE) is an uncommon yet clinically significant complication associated with iodinated contrast media, with its mechanisms remaining unclear. Objective The aims of this study are to examine the…

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Negative / Null Result ReportMedicine

Comparison of esketamine combined with dexmedetomidine versus propofol combined with midazolam on drug-induced sleep endoscopy: a randomized controlled trial.

Jiang Y, Wang Z, Wen H et al. · 2026 · BMC anesthesiology

Background Drug-induced sleep endoscopy (DISE) is widely used to evaluate upper airway obstruction in patients with obstructive sleep apnea syndrome (OSAS). We aimed to compare the sedative efficacy and safety of esketamine combined with…

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Negative / Null Result ReportMedicine

Prognostic Value of BUN-Based Ratios for Mortality and Prolonged Hospitalization in Acute Upper Gastrointestinal Bleeding: Comparison with Established Risk Scores.

İnan B, Erdoğan Ç, Keskin ET et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : This study investigated the prognostic value of two simple blood urea nitrogen (BUN)-based ratios, BUN/hemoglobin (Hb) and BUN/Albumin, for predicting in-hospital mortality and prolonged hospitalization in…

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Negative / Null Result ReportMedicine

Direct Maxillary Sinus Tissue Analysis for <i>TAS2R38</i> Polymorphisms: Establishing a Tissue-Based Translational Framework in Odontogenic Rhinosinusitis.

Greța-Oanță AL, Roman A, Berindan-Neagoe I et al. · 2026 · Journal of clinical medicine

Background/Objectives: Bitter taste receptors (T2Rs), specifically T2R38, are present in the respiratory epithelium and react with bacterial quorum-sensing molecules to induce an innate immunity response. Although TAS2R38 polymorphisms…

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Negative / Null Result ReportMedicine

Inhibitory Control and Creativity in Children With Mild Intellectual Disabilities.

Japundža-Milisavljević M, Buha N, Milanović-Dobrota B · 2026 · Journal of applied research in intellectual disabilities : JARID

Background The study is based on the Dual Pathway to Creativity Model and explores the relationship between inhibitory control and creativity in children with mild intellectual disabilities. Method The sample consisted of 58 children with…

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Negative / Null Result ReportMedicine

Tasting beer based on the tactile thickness of the glass lip

Ariga A, Kubo N, Koizumi T et al. · 2026 · Food Quality and Preference.

Multisensory research has demonstrated that the perceptual characteristics of a receptacle can influence how beverages are experienced, a phenomenon known as sensation transference. Previous studies have shown that the lip thickness of a…

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Negative / Null Result Report

Do drugs with biliary toxicity cause cholangiocarcinoma?

Zong C, Lim K, Walker SA et al. · 2026 · Preprint

A bstract Many commonly used therapeutic drugs cause biliary toxicity, but it is unclear if they are directly responsible for the increasing incidence of cholangiocarcinoma (CCA). We tested experimentally and analyzed through a cohort…

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Negative / Null Result ReportMedicine

Incidence and associated factors of metachronous contralateral cryptorchidism after unilateral cryptorchidism: a retrospective cohort study.

Grande-Moreillo C, Pérez-López C, Vicente-Sánchez N et al. · 2026 · European journal of pediatrics

Acquired cryptorchidism is an increasingly recognized condition and may present bilaterally with a metachronous pattern. The objective of this study was to evaluate the incidence of acquired contralateral metachronous cryptorchidism and to…

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Negative / Null Result ReportMedicine

Frequent Ambulatory Care Visits Predict Harmful Diagnostic Errors in High-Risk Hospitalized Patients: a Retrospective Cohort Study.

Goyal A, Konieczny K, Plombon S et al. · 2026 · Journal of general internal medicine

Background Diagnostic errors (DEs) are a major threat to hospital patient safety. Identifying admission-based predictors associated with harmful DEs may help improve diagnostic safety in high-risk populations. Objective To assess the…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of Hyaluronic Acid Gel in Preventing Postoperative Intrauterine Adhesion Formation Following Operative Hysteroscopy.

Ciftci B, Karadag B · 2026 · International journal of women's health

Objective To evaluate the effectiveness of intrauterine hyaluronic acid (HA) gel application in preventing postoperative intrauterine adhesion formation following operative hysteroscopy. Methods This retrospective comparative study was…

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