Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Christian Borel, Caroline Even, Christophe Le Tourneau et al. · 2023 · BMJ Oncology
Objective Salivary gland cancers (SGC) are rare cancers with currently no standard treatment for recurrent/metastatic disease. Based on checkpoint inhibitors benefit in a broad range of tumours, NIvolumab in Salivary gland CArcinoma of the Head and Neck (NISCAHN) evaluated nivolumab efficacy in SGC.Methods and analysis In this phase II single-stage Fleming design, patients with SGC with a progressive disease progression within 6 months prior to entering the study, were divided into ACC (adenoid cytic carcinoma) and non-ACC. All received nivolumab for a maximum of 12 months. The primary endpoin
View details →Negative / Null Result ReportOpen accessMicrobiology
José C. Segovia, Juan C. Ramírez, Paula Río et al. · 2025 · Microbiology Spectrum
ABSTRACT Two strains of the minute virus of mice (MVM) parvovirus (of the species Protoparvovirus rodent1), named i (immunosuppressive) and p (prototype), show disparate tropism and pathogenicity in mice. Unlike the virulent MVMi, the MVMp is attenuated and infection-restricted in primary mouse hematopoietic cells; however, it does infect human transformed, established, and stem cells. We thus seek here a putative MVMp natural tropism to humans compared to MVMi. Infectious purified MVMp virions suppress in vitro the clonogenic potential of human committed (erythroid and myeloid) and primitive
View details →Negative / Null Result ReportOpen accessMedicine
Lei Huang, Tong Li, Lei Xu et al. · 2016 · Chinese Medical Journal
Background: There has been no external validation of survival prediction models for severe adult respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO) therapy in China. The aim of study was to compare the performance of multiple models recently developed for patients with ARDS undergoing ECMO based on Chinese single-center data. Methods: A retrospective case study was performed, including twenty-three severe ARDS patients who received ECMO from January 2009 to July 2015. The PRESERVE (Predicting death for severe ARDS on VV-ECMO), ECMOnet, Respiratory Extracorpore
View details →Negative / Null Result ReportOpen access
Dwi Gemina, Tini Kartini, Pra Gemini · 2021 · JURNAL AKUNIDA
Cooperatives are directed as a collective community effort to increase the level of economic prosperity together. The research objective was to analyze the effect of external capital, business volume and total assets on the residual…
View details →Negative / Null Result ReportOpen accessSports medicine
Max K Dummar, Michael S Crowell, Will Pitt et al. · 2024 · International Journal of Sports Physical Therapy
# Background Concussions are often accompanied by balance disturbances. Clinically accurate evaluation systems are often expensive, large, and inaccessible to most clinicians. The Sway Balance Mobile Application (SWAY) is an accessible method to quantify balance changes. # Purpose To determine the known groups and convergent validity of the SWAY to assess balance after a concussion. # Study Design Case-Control Study. # Methods Twenty participants with acute concussion and twenty controls were recruited. At initial, one-week, and final return to activity (RTA) evaluations, all participants comp
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Yiding XIAO, Zhujun LI, Bozhi HU et al. · 2025 · Neurologia Medico-Chirurgica
For resectable malignant peripheral nerve sheath tumors, the additional benefits of radiotherapy remain controversial. This study aims to investigate whether there is an additional benefit of radiotherapy for resectable malignant peripheral nerve sheath tumors. We retrospectively collected data on malignant peripheral nerve sheath tumor cases from the Surveillance, Epidemiology, and End Results database. Overall, 926 malignant peripheral nerve sheath tumor cases occurred in soft tissues, with surgical resection performed in 783 cases. After excluding cases with distant metastasis, incomplete f
View details →Negative / Null Result ReportOpen accessMedicine
H. Pinnock, J. Hanley, L. McCloughan et al. · 2013 · British medical journal
Objective To test the effectiveness of telemonitoring integrated into existing clinical services such that intervention and control groups have access to the same clinical care. Design Researcher blind, multicentre, randomised controlled…
View details →Negative / Null Result ReportOpen accessMedicine
Sungha Park, Sang-Hyun Ihm, In-Jeong Cho et al. · 2023 · Clinical Hypertension
Abstract Nocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime BP. As efficacy of BP medications wanes during nighttime and early morning, control of nocturnal hypertension and morning hypertension can be difficult. As such, chronotherapy, the dosing of BP medication in the evening, has been an ongoing topic of interest in the field of hypertension. Some studies have shown that chronotherapy is effective in reducing nocturnal BP, improving
View details →Negative / Null Result ReportOpen accessDentistry
Ahmed Hassan Kamil Mustafa, Ahmed Mohammed Suleiman · 2020 · International Journal of Dentistry
Background. Bell’s palsy is an acute idiopathic facial nerve paralysis of sudden onset. It is the most common cause of lower motor neuron facial nerve paralysis with an annual incidence of 15–30 per 100,000 population. The objective of this work is to study the grade of the attack and the associated symptoms of Bell’s palsy in a group of Sudanese patients. The study type is an analytical prospective-based study. The study was carried out at Khartoum Teaching Dental Hospital, Khartoum General Teaching Hospital. In this prospective of the study, 48 patients with Bell’s palsy were evaluated using
View details →Negative / Null Result ReportOpen accessMedicine
Vera Dias, Eunsung Junn, M. Maral Mouradian · 2013 · Journal of Parkinson’s Disease
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential in neurons interfere with several biological processes, ultimately leading to cell death. Evidence has been developed for oxidative and nitrative damage to key cellular components in the PD substantia nigra. A number of sources and mechanisms for the generation of reactive oxygen species (ROS) are recognized including the metabolism of dopamine itself, mitochondrial dysfunction, iron, neuroinflammatory cells, calcium
View details →Negative / Null Result ReportOpen accessMedicine
Lisa Baquet, Helge Hasselmann, Stefan Patra et al. · 2018 · PeerJ
Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist
View details →Negative / Null Result ReportOpen access
Nelly Masnila, R. Mayasari, Firmansyah Firmansyah et al. · 2021 · International Journal of Business, Management and Economics
This study aimed to determine the relationship and effect of the GGG variable on the quality of the financial reports in municipal governments in Indonesia by implementing the IIAG (The Ibrahim Index of African Governance) indicator. The…
View details →Negative / Null Result Report
Yoga Wahyu Pratama, Fransiska Prihatini, Orissa Octaria et al. · 2025 · Mars : Jurnal Teknik Mesin, Industri, Elektro Dan Ilmu Komputer
The use of technology in data management has become the key to improving the efficiency and effectiveness of company performance. PT Indofood CBP Sukses Makmur Tbk has implemented a computerized employee attendance system through the…
View details →Negative / Null Result ReportOpen access
Okunlola D. O, Otinwa G.O · 2024 · African Journal of Social Issues
The purpose of this research was to investigate effects of two massage therapy techniques on the rate of perceived exertion and performance recovery among adolescent footballers in Lagos state. Pre-test post-test experimental research…
View details →Negative / Null Result Report
Angga Kurniawan, Nelson Lajuni, Tasrim Tasrim et al. · 2026 · EKUITAS (Jurnal Ekonomi dan Keuangan)
This study aims to analyze the effects of Electronic Word of Mouth Effect, Brand Image, and Email Marketing on Purchase Intention in the context of purchasing official MotoGP merchandise. It was conducted among respondents who are members…
View details →Negative / Null Result ReportMedicine
de-la-Llave-Rincón, Ambite-Quesada, Pacho-Hernández et al. · 2026 · Pain research & management
To determine the influence of sensitization-associated and neuropathic-like symptoms and clinical features in conditioned pain modulation (CPM) activity in women with episodic or chronic migraine. A cross-sectional study including 70 women…
View details →Negative / Null Result ReportMedicine
Yersel, Ucan, Tekce · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists
This in vitro study aimed to evaluate the effect of layer thickness, printing orientation angle, and resin type on the radiopacity of 3D-printed dental resins. Three dental 3D-printed resins (VarseoSmile TriniQ, Crowntec, and Primeprint…
View details →Negative / Null Result ReportMedicine
Na Z, Guo X, DuMei Y · 2026 · Medicine
Osteoporosis is a systemic skeletal disease characterized by decreased bone mass and microstructural destruction of bone tissue, leading to fragile bones and susceptibility to fractures, significantly affecting the quality of life of…
View details →Negative / Null Result ReportMedicine
Pennings VHM, Verwijk E, de Bie RMA et al. · 2026 · Journal of Parkinson's disease
BackgroundDespite the frequent decline in verbal fluency after STN-DBS surgery, the cause of decline remains unclear.ObjectiveThis study investigates whether mental speed and executive dysfunctions are underlying mechanisms of the phonemic…
View details →Negative / Null Result ReportOpen accessMedicine
Chen CD, Aguero C, Melloni A et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction Alzheimer's disease (AD) biomarkers are assessed on their ability to detect AD pathophysiology in vivo, with confirmation of AD neuropathology only at autopsy. Methods Positron emission tomography (PET), plasma, and cognitive…
View details →Negative / Null Result ReportMedicine
Karunakaran KB, Purushottam M, Balakrishnan N et al. · 2026 · Translational psychiatry
Depressive disorder (DD), Alzheimer's disease (AD), and schizophrenia (SZ) are evolutionarily relevant traits that disrupt neural networks supporting affect and cognition. While genome-wide association studies have identified risk-related…
View details →Negative / Null Result ReportOpen accessMedicine
Thapa M, Adhikari GP, Saroj GC et al. · 2026 · BMC ophthalmology
BACKGROUND: To evaluate reliability and agreement of non-contact tonometry (NCT) and trans-palpebral tonometry (TPT) compared with Goldmann-applanation tonometry (GAT). METHODS: A total of 224 eyes from 112 patients were included between…
View details →Negative / Null Result Report
Wang F, Chen L, Xu X et al. · 2026 · Preprint
Abstract Background This study aimed to apply a 3D vertical cephalometric analysis to evaluate vertical skeletal relationships in adult patients. Methods The CBCT data of ninety-seven first-visit adult patients were retrospectively…
View details →Negative / Null Result ReportMedicine
Khalid H, Tsai WS, Lamanna F et al. · 2026 · The British journal of ophthalmology
Background/aims To characterise the distribution of retinal non-perfusion and its relationship with neovascularisation elsewhere (NVE) and visual acuity (VA) in referable diabetic retinopathy (DR) using ultra-widefield fluorescein…
View details →Negative / Null Result Report
Sun C, Zhang B, Tong C et al. · 2026 · Preprint
Abstract Objective: This study investigated post-SMILE changes in corneal refractive power, axial length, and anterior chamber depth, and examined the relationship between anterior chamber depth change and corneal ablation depth. Biometric…
View details →Negative / Null Result ReportMedicine
Yan Z, Chen T, Ma X et al. · 2026 · Psychology research and behavior management
Purpose Impaired cognitive flexibility is a core feature of obsessive-compulsive disorder (OCD) and may contribute to symptom persistence and variabe therapeutic outcomes. However, traditional measures may adequately capture how cognitive…
View details →Negative / Null Result ReportMedicine
Pérez-Bellido A, Duato D, Giannelli F et al. · 2026 · Journal of experimental psychology. Learning, memory, and cognition
Statistical learning is the process of extracting regularities from the environment. Although sequential cross-modal regularities are ubiquitous (e.g., the sight of a falling ball followed by the sound of impact), previous research has…
View details →Negative / Null Result ReportMedicine
Cuccia F, Cracchiolo AN, Piras A et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Background Radiotherapy (RT) is a cornerstone in cancer management, but late radiation tissue injury (LRTI) remains a relevant clinical issue, affecting approximately 5% of patients and significantly impacting quality of life. Hyperbaric…
View details →Negative / Null Result ReportMedicine
Samuels S, Seaton M, Abdel-Rahman SM et al. · 2026 · Therapeutic innovation & regulatory science
Background Legislative initiatives have spurred an increase in pediatric drug development programs. However, some drug products studied in the pediatric population have not received an approved pediatric indication, and efforts have been…
View details →Negative / Null Result ReportMedicine
Koncz S, Pothorszki D, Papp N et al. · 2026 · British journal of pharmacology
Background and purpose Ketamine consists of two enantiomers, (R)-ketamine and (S)-ketamine, which exhibit distinct pharmacological properties. Currently, only the (S)-enantiomer has been approved for the treatment of major depressive…
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