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19,786 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessPsychology

How reliable are gray matter disruptions in specific reading disability across multiple countries and languages? insights from a large‐scale voxel‐based morphometry study

Katarzyna Jednoróg, Artur Marchewka, Irène Altarelli et al. · 2015 · Human Brain Mapping

The neural basis of specific reading disability (SRD) remains only partly understood. A dozen studies have used voxel-based morphometry (VBM) to investigate gray matter volume (GMV) differences between SRD and control children, however,…

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Negative / Null Result ReportBusiness, Management and Accounting

Do Digital Video Recorders Influence Sales?

Bart J. Bronnenberg, Jean‐Pierre Dubé, Carl F. Mela · 2010 · Journal of Marketing Research

The authors analyze a multimillion dollar, three-year field study sponsored by five firms to assess whether enabling skipping of advertisements using digital video recorders (DVRs) affects consumers’ shopping behavior for advertised and…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of ovarian cancer biomarkers HE4 and CA-125 in women presenting with a suspicious cystic ovarian mass

Karolina Partheen, Björg Kristjánsdóttir, Karin Sundfeldt · 2011 · Journal of Gynecologic Oncology

OBJECTIVE: Women presenting with a large or complex ovarian cyst are referred to extensive surgical staging to ensure the correct diagnosis and treatment of a possible epithelial ovarian cancer. We hypothesized that measurement of the…

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Negative / Null Result ReportOpen accessMedicine

7 tesla MRI of microbleeds and white matter lesions as seen in vascular dementia

Jens Theysohn, Oliver Kraff, Stefan Maderwald et al. · 2011 · Journal of Magnetic Resonance Imaging

PURPOSE: To evaluate 7T MRI in the assessment of cerebrovascular alterations as seen in vascular dementia by means of detection of cerebral microbleeds (CMB) and depiction of white matter lesions (WML). 7T imaging was evaluated with…

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Negative / Null Result ReportOpen accessMedicine

Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study

Elisa V. Bandera, Melony King, Urmila Chandran et al. · 2011 · BMC Women s Health

BACKGROUND: While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. METHODS: We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial ovarian cancer risk. Cases were identified in six counties in New Jersey through the New Jersey State Cancer Registry. Controls were identified by random digit dialing, CMS (Centers for Medicare and Medicaid Service) lists, and area sampling. A total of 205 cases and 390 controls were

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Negative / Null Result ReportOpen accessMedicine

Effect of Alirocumab on Coronary Atheroma Volume in Japanese Patients With Acute Coronary Syndrome ― The ODYSSEY J-IVUS Trial ―

Junya Ako, Kiyoshi Hibi, Kenichi Tsujita et al. · 2019 · Circulation Journal

BACKGROUND: In patients with acute coronary syndrome (ACS), alirocumab reduced the risk of recurring ischemic events. ODYSSEY J-IVUS assessed the effect of alirocumab on coronary atheroma volume in Japanese patients recently hospitalized…

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Negative / Null Result ReportOpen accessMathematics

Paired-Samples Tests of Equivalence

Constance A. Mara, Robert A. Cribbie · 2012 · Communications in Statistics - Simulation and Computation

Equivalence tests are used when the objective is to find that two or more groups are nearly equivalent on some outcome, such that any difference is inconsequential. Equivalence tests are available for several research designs, however,…

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Negative / Null Result ReportOpen accessNursing

Antioxidants and Reactive Oxygen Species: Shaping Human Health and Disease Outcomes

Charles F. Manful, Eric Fordjour, Dasinaa Subramaniam et al. · 2025 · International Journal of Molecular Sciences

Reactive molecules, including oxygen and nitrogen species, serve dual roles in human physiology. While they function as essential signaling molecules under normal physiological conditions, they contribute to cellular dysfunction and damage when produced in excess by normal metabolism or in response to stressors. Oxidative/nitrosative stress is a pathological state, resulting from the overproduction of reactive species exceeding the antioxidant capacity of the body, which is implicated in several chronic human diseases. Antioxidant therapies aimed at restoring redox balance and preventing oxida

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Negative / Null Result ReportOpen accessComputer Science

BenSignNet: Bengali Sign Language Alphabet Recognition Using Concatenated Segmentation and Convolutional Neural Network

Abu Saleh Musa Miah, Jungpil Shin, Md. Al Mehedi Hasan et al. · 2022 · Applied Sciences

Sign language recognition is one of the most challenging applications in machine learning and human-computer interaction. Many researchers have developed classification models for different sign languages such as English, Arabic, Japanese, and Bengali; however, no significant research has been done on the general-shape performance for different datasets. Most research work has achieved satisfactory performance with a small dataset. These models may fail to replicate the same performance for evaluating different and larger datasets. In this context, this paper proposes a novel method for recogn

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Negative / Null Result ReportOpen accessEngineering

Fixed Effects Estimation of the Intensive and Extensive Margins of Irrigation Water Demand

Nathan Hendricks, Jeffrey M. Peterson, Hendricks, Nathan P. et al. · 2012 · AgEcon Search (University of Minnesota, USA)

Irrigation water demand is estimated using field-level panel data from Kansas over 16 years. The cost of pumping varies over time due to changes in energy prices and across space due to differences in the depth to water. Exploiting this…

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Negative / Null Result ReportOpen accessDentistry

Enamel Bond Strength of New Universal Adhesive Bonding Agents

DE McLean, EJ Meyers, VL Guillory et al. · 2015 · Operative Dentistry

PURPOSE: Universal bonding agents have been introduced for use as self-etch or etch-and-rinse adhesives depending on the dental substrate and clinician's preference. The purpose of this study was to evaluate the shear bond strength (SBS)…

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Negative / Null Result ReportOpen accessMedicine

Biomarker signatures for progressive idiopathic pulmonary fibrosis

Britt Clynick, Tamera J. Corte, Helen E. Jo et al. · 2021 · European Respiratory Journal

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease in which circulatory biomarkers have the potential for guiding management in clinical practice. We assessed the prognostic role of serum biomarkers in three…

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Negative / Null Result ReportOpen accessMedicine

Telepractice Versus In-Person Delivery of Voice Therapy for Primary Muscle Tension Dysphonia

Balaji Rangarathnam, Gary H. McCullough, Hylan Pickett et al. · 2015 · American Journal of Speech-Language Pathology

PURPOSE: The purpose of this study was to investigate the utility of telepractice for delivering flow phonation exercises to persons with primary muscle tension dysphonia (MTD). METHOD: Fourteen participants with a diagnosis of primary MTD…

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Negative / Null Result ReportOpen accessEnvironmental Science

Inferred Paternity and Male Reproductive Success in a Killer Whale (Orcinus orca) Population

Michael J. Ford, M. Bradley Hanson, Jennifer A. Hempelmann et al. · 2011 · Journal of Heredity

We used data from 78 individuals at 26 microsatellite loci to infer parental and sibling relationships within a community of fish-eating ("resident") eastern North Pacific killer whales (Orcinus orca). Paternity analysis involving 15…

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Negative / Null Result ReportNeuroscience

A Pilot Study on the Combination of Applied Behavior Analysis and Bumetanide Treatment for Children with Autism

Lin Du, Ling Shan, Bing Wang et al. · 2015 · Journal of Child and Adolescent Psychopharmacology

OBJECTIVE: The purpose of this study was to investigate the therapeutic effects of combined bumetanide and applied behavior analysis (ABA) treatment in children with autism. METHODS: Sixty children diagnosed with autism according to the…

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Negative / Null Result ReportMedicine

Benralizumab effect on severe chronic rhinosinusitis with nasal polyps (CRSwNP): A randomized double‐blind placebo‐controlled trial

Jody Tversky, Andrew P. Lane, Antoine Azar · 2021 · Clinical & Experimental Allergy

BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) can be a severe and debilitating disease associated with significant morbidity, loss of smell, sinus pressure and asthma exacerbations. Eosinophils play a role in the majority…

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Negative / Null Result ReportOpen accessPhysics and Astronomy

What's in Your Tweets? I Know Who You Supported in the UK 2010 General Election

Antoine Boutet, Hyoungshick Kim, Eiko Yoneki · 2021 · Proceedings of the International AAAI Conference on Web and Social Media

Nowadays, the use of social media such as Twitter is necessary to monitor trends of people on political issues. As a case study, we collected the main stream of Twitter related to the 2010 UK general election during the associated period.…

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Negative / Null Result ReportMedicine

Hemorrhage after Transoral Robotic‐Assisted Surgery

Scott A. Asher, Hilliary N. White, Alexandra E. Kejner et al. · 2013 · Otolaryngology

OBJECTIVE: An increasing number of head and neck surgeons have begun using transoral robotic-assisted surgery. Our objective was to examine the postoperative bleeding complications we have encountered to determine risk factors and to…

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Negative / Null Result ReportOpen accessMedicine

Patterns of distant metastases in 215 Merkel cell carcinoma patients: Implications for prognosis and surveillance

Christopher W. Lewis, Jamiluddin Qazi, Daniel S. Hippe et al. · 2019 · Cancer Medicine

Approximately one-third of Merkel cell carcinoma (MCC) patients eventually develop distant metastatic disease. Little is known about whether the location of the primary lesion is predictive of initial distant metastatic site, or if survival likelihood differs depending on the metastatic site. Such data could inform imaging/surveillance practices and improve prognostic accuracy. Multivariate and competing-risk analyses were performed on a cohort of 215 MCC patients with distant metastases, 31% of whom had two or more initial sites of distant metastasis. At time of initial distant metastasis in

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Negative / Null Result ReportOpen accessMedicine

Survival effect of first- and second-line treatments for patients with primary glioblastoma: a cohort study from a prospective registry, 1997-2010

Felice Nava, Irene Tramacere, Veronica Andrea Fittipaldo et al. · 2014 · Neuro-Oncology

BACKGROUND: Prospective follow-up studies of large cohorts of patients with glioblastoma (GBM) are needed to assess the effectiveness of conventional treatments in clinical practice. We report GBM survival data from the Brain Cancer…

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Negative / Null Result ReportEnvironmental Science

Heterocyclic Aromatic Hydrocarbons Show Estrogenic Activity upon Metabolization in a Recombinant Transactivation Assay

Markus Brinkmann, Sibylle Maletz, Martin Krauß et al. · 2014 · Environmental Science & Technology

Heterocyclic aromatic hydrocarbons (hetero-PAHs) are increasingly studied at contaminated sites; especially at former industrial facilities where coal tar-oil was handled, e.g., wood treatment plants, high concentrations of hetero-PAHs are…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Copy Number Variation in Familial Parkinson Disease

Nathan Pankratz, Alexandra Dumitriu, Kurt N. Hetrick et al. · 2011 · PLoS ONE

Copy number variants (CNVs) are known to cause Mendelian forms of Parkinson disease (PD), most notably in SNCA and PARK2. PARK2 has a recessive mode of inheritance; however, recent evidence demonstrates that a single CNV in PARK2 (but not a single missense mutation) may increase risk for PD. We recently performed a genome-wide association study for PD that excluded individuals known to have either a LRRK2 mutation or two PARK2 mutations. Data from the Illumina370Duo arrays were re-clustered using only white individuals with high quality intensity data, and CNV calls were made using two algorit

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