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19,885 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Paucibacillary Pleural Tuberculosis Presenting as Subpleural Nodules: A Diagnostic Challenge With Negative PCR and Smear Tests.

Al Ayoubi O, Aldakak MA, Ibrahim B et al. · 2026 · Clinical case reports

Pleural tuberculosis is a common manifestation of extrapulmonary tuberculosis; however, its diagnosis remains challenging in paucibacillary disease, where clinical presentation may be atypical and microbiological tests frequently yield…

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Negative / Null Result ReportMedicine

Utilization of Cancer Screening, Prevention, and Treatment in Women With Variants of Uncertain Significance in Breast Cancer Susceptibility Genes.

Nielsen SM, Russell EM, Ellsworth RE et al. · 2025 · Journal of the National Comprehensive Cancer Network : JNCCN

Background The presence of variants of uncertain significance (VUS) should not influence clinical management; however, prior studies on breast cancer-related health care utilization in women with VUS versus negative germline genetic test…

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Negative / Null Result ReportOpen accessMedicine

Preliminary Validation of a Colorimetric Loop-Mediated Isothermal Amplification (c-LAMP) Assay for Detection of <i>Pythium insidiosum</i> in Clinical Specimens.

Sridapan T, Jaturapaktrarak C, Rujirawat T et al. · 2026 · Journal of fungi (Basel, Switzerland)

Pythiosis is an emerging infectious disease caused by the oomycete Pythium insidiosum , affecting humans and animals primarily in subtropical and tropical regions. The pathogen is commonly found in swampy environments, and exposure can…

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Negative / Null Result ReportOpen accessMedicine

Efficacy and Safety of Azacitidine Combined With Lisaftoclax in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome With Increased Blasts.

Meng S, Zhao W, Zhang H et al. · 2026 · EJHaem

Objective To retrospectively analyze the early efficacy and safety of azacitidine plus lisaftoclax in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome with increased blasts (MDS-IB), providing a reliable clinical…

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Negative / Null Result ReportMedicine

Impact of repeatedly screening negative on cervical cancer risk.

Castle PE, Befano B, Hyer M et al. · 2026 · Journal of the National Cancer Institute

Background We demonstrated that cervical cancer risk following any screening result is lower if there is a known prior negative screening history vs an unknown screening history. We extended these findings to look at how screening performs…

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Negative / Null Result ReportMedicine

Diagnostic utility of urinalysis parameters in predicting urine culture positivity: A gender-stratified evaluation.

Çubuk F, Öksüz C, Öz M · 2026 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Objective A substantial proportion of urine cultures in patients with suspected urinary tract infections (UTIs) yield negative results. This study aimed to evaluate whether parameters from automated urinalysis could predict the likelihood…

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Negative / Null Result ReportOpen accessMedicine

Association between the extent of intrapulmonary spread on chest CT and false-negative results of T-SPOT.TB in pulmonary tuberculosis: a retrospective study.

Sato R, Takasaka N, Hosaka Y et al. · 2025 · BMC infectious diseases

Background The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative T-SPOT.TB results. The extent of TB spread may influence host immune functions, which can…

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Negative / Null Result ReportOpen accessMedicine

Enhanced serodiagnosis of opisthorchiasis using a multi-epitope dot-ELISA: comparative evaluation of visual and imageJ-assisted analysis of IgG and IgM responses.

Sripa J, Suebsamran P, Pangjit K · 2026 · BMC infectious diseases

Background Opisthorchiasis remains an important public health problem in Southeast Asia and is strongly associated with cholangiocarcinoma. Although stool-based diagnosis is widely used, its sensitivity is limited in light infections,…

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Negative / Null Result ReportOpen accessMedicine

Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma: A Phase II Study.

Mukherjee S, Fujiwara Y, Fountzilas C et al. · 2025 · Cancer medicine

Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel…

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Negative / Null Result ReportMedicine

Phase 2 Single-arm Trial of Primary Retroperitoneal Lymph Node Dissection in Patients with Seminomatous Testicular Germ Cell Tumors with Clinical Stage IIA/B (PRIMETEST).

Hiester A, Che Y, Lusch A et al. · 2023 · European urology

Background Primary retroperitoneal lymph node dissection (RPLND) for clinical stage (CS) IIA/B seminoma without adjuvant treatment is an experimental treatment to avoid radiotherapy- or chemotherapy-related toxicity from standard…

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Negative / Null Result ReportMedicine

No evidence of influenza A virus infection in marine mammals stranded in Basque Country coast (Northern Spain) in the context of H5N1 clade 2.3.4.4b expansion.

López-Morales A, Benito D, Gerrikagoitia X et al. · 2026 · Canadian journal of microbiology

Influenza A infection is frequently detected in marine mammals causing mortality events of different magnitude. In recent years, the highly pathogenic avian influenza (HPAI) H5N1 virus (clade 2.3.4.4b) has been rapidly expanding and…

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Negative / Null Result ReportMedicine

Unmet HIV and STI Prevention Needs and Limited Linkage to Care Among Gay, Bisexual, and Other Men Who Have Sex with Men in Southern Spain: A Community-Based Intervention Study.

Corma-Gómez A, Santos M, Martín-Carmona J et al. · 2026 · AIDS patient care and STDs

To evaluate the proportion of gay, bisexual, and other men who have sex with men (GBMSM) with ongoing high-risk sexual practices not engaged in care, and to assess linkage to and retention in care following a community-based intervention.…

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Negative / Null Result ReportOpen accessMedicine

Machine says go, doctor says no: an ecological momentary assessment analysis examining clinicians' perceptions of, and their antibiotic prescribing behaviour when using rapid molecular diagnostic tests in intensive care.

Stewart SF, Enne VI, Pandolfo AM et al. · 2026 · Antimicrobial resistance and infection control

Background Rapid molecular diagnostics such as the BioFire FilmArray Pneumonia Panel (the Pneumonia Panel) can improve antibiotic stewardship by supporting doctors to make more targeted antibiotic prescribing decisions faster compared to…

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Negative / Null Result ReportMedicine

Evaluating causal links between retinal thickness, Alzheimer's disease, and circulating total-tau: evidence from Mendelian randomization and colocalization analysis.

Sheng D, Wang S, Xiao Z et al. · 2026 · European archives of psychiatry and clinical neuroscience

BACKGROUND: Observational studies have reported associations between retinal thickness and Alzheimer’s disease (AD); however, the causal relationship remains uncertain. OBJECTIVE: To investigate the potential causal relationships between…

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Negative / Null Result ReportMedicine

Innovation in Personal Protective Equipment Decontamination During the COVID-19 Pandemic: The Powered-Air Purifying Respirator Hood Optimal Decontaminant Distribution System.

Schwartz A, Mikati S, Knipper F et al. · 2025 · Applied biosafety : journal of the American Biological Safety Association

Background The COVID-19 pandemic highlighted critical shortages in personal protective equipment (PPE), particularly respirators, which limited healthcare workers' safety worldwide. Decontamination and reuse of PPE, including powered-air…

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Negative / Null Result ReportOpen accessMedicine

The accuracy of recording malaria rapid diagnostic test (RDT) results in public health facilities in Benin; results from the MaCRA project.

Ahogni I, Avanon H, Hueha C et al. · 2026 · Malaria journal

Background Accurate interpretation and recording of malaria rapid diagnostic tests (RDTs) are critical for case management and surveillance in malaria-endemic settings. In Benin, where over 90% of malaria diagnoses rely on RDTs, concerns…

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Negative / Null Result ReportMedicine

Performance of five mpox antigen-based rapid diagnostic tests tested on lesion swabs from patients with suspected mpox from the Kinshasa province of DR Congo: a diagnostic accuracy study.

Kavunga-Membo H, Chi HF, Emperador DM et al. · 2026 · The Lancet. Infectious diseases

Background Mpox has spread to 36 countries in Africa, yet many face challenges achieving nationwide PCR-based testing due to cost and limited access in remote and rural areas. Point-of-care antigen-based rapid diagnostic tests (RDTs) might…

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Negative / Null Result ReportOpen accessMedicine

Hit-and-run hypothesis: revisiting the impact of EBV in malignancies.

Mangiaterra T, Chabay P, Bellan C et al. · 2026 · Frontiers in immunology

Epstein-Barr virus (EBV) infects more than 90% of the global population and is etiologically linked to a wide spectrum of lymphoid and epithelial malignancies. Although its role as an oncogenic virus is well established, the mechanisms…

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