19,885 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Pasupuleti R · 2026 · Preprint
Abstract We propose the Multi-Timescale Delay-Embedded Echo State Network (MT-DE-ESN). The architecture combines three established mechanisms — slow leaky reservoir dynamics, adaptive delay features, and state normalisation — with a useful…
View details →Dawson ZP, Curtis A, Cross S et al. · 2026 · Cureus
To report a rare presentation of endogenous methicillin-resistant Staphylococcus aureus (MRSA) endophthalmitis with necrotizing scleritis manifesting as an anterior chamber (AC) abscess, and to highlight the diagnostic value of repeating…
View details →Li X, Peng Y, Liu W et al. · 2025 · Taiwanese journal of obstetrics & gynecology
Objective To investigate the cause of a false-negative result in prenatal amniotic fluid karyotype analysis for a fetus with mosaic trisomy 15, and to propose a cytomolecular genetic strategy for detecting mosaicism in amniotic fluid. Case…
View details →Hogg JP 3rd · 2026 · AJP reports
Background Prenatal cell-free DNA (cfDNA) screening has revolutionized the prenatal detection of fetal aneuploidy and other conditions. Originally designed to identify risk for trisomy 21, cfDNA screening has expanded to other fetal…
View details →Sachner L, Flynn JS, Hsu CW et al. · 2026 · Journal of pediatric psychology
Objective Children with cancer increasingly undergo germline genetic testing to identify genetic predispositions and inform clinical care options. Parents of children with pathogenic/likely pathogenic (P/LP) germline results have reported…
View details →Lee S, Lee J, Park D et al. · 2026 · NPJ digital medicine
Gastroesophageal reflux disease (GERD) diagnosis traditionally relies on acid exposure time (AET) obtained from 24-h multichannel intraluminal impedance-pH (MII-pH) monitoring, the gold standard for GERD diagnosis. However, a negative…
View details →Galloway NL, Sargeant GA, Powers JG et al. · 2026 · Journal of wildlife diseases
Effective wildlife disease management and research rely on trustworthy disease diagnostics. For chronic wasting disease (CWD), immunohistochemistry (IHC) is recognized as the gold standard, and ELISA is a reliable high-throughput screening…
View details →Rincón-González AM, Galeano-Tamayo DC, Zuluaga LSD · 2025 · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
Objective To explore the factors associated with the use of the antibiotic implicated in an adverse reaction following a negative challenge test in pediatric patients in a clinical allergology service of a health institution in Medellin.…
View details →Kilic A, Celiktas B · 2026 · Preprint
Abstract As Large Language Models (LLMs) are integrated into critical infrastructure, externally auditing their safety mechanism activation without internal access becomes essential. This paper investigates whether LLM safety refusals…
View details →Warintaksa P, Youkhong C, Trikasemmart M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Introduction True labor is characterized by regular uterine contractions and cervical changes. However, the precise diagnosis of the "onset" of true labor is challenging, as the examination of cervical changes requires multiple timepoints,…
View details →Dincer M, Aydin O, Karakus V et al. · 2026 · Laboratory medicine
Introduction Electrophoresis tests are reported as negative, positive, or-rarely-as suspicious for monoclonal band (SfMB). This study aimed to determine the fate of patients with SfMB findings in long-term follow-up. Methods Patients with…
View details →Slade T · 2026 · Preprint
Large language models (LLMs) are increasingly deployed in academic and professional contexts where epistemic restraint, boundary recognition, and instruction adherence are as important as raw capability. However, existing evaluations…
View details →Hidalgo CM, Yin LX, Bogan AW et al. · 2026 · Head and neck pathology
Purpose The uses for circulating tumor high risk human papillomavirus DNA (ctHPVDNA) in the diagnostic work-up and treatment of HPV-associated oropharyngeal squamous cell carcinoma (HPV( +)OPSCC) patients are actively being investigated.…
View details →Omari Y, Nohomovich B, Sallam D et al. · 2026 · Cureus
Multitarget stool DNA-fecal immunochemical testing (mt-sDNA-FIT) is validated for colorectal cancer (CRC) screening in asymptomatic, average-risk adults. However, its application in symptomatic patients represents a misuse of a screening…
View details →Bhangu G, Greutert S, Robert-Ebadi H et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Background Pregnancy and the postpartum period increase the risk of venous thromboembolism including pulmonary embolism (PE), which is an important cause of maternal morbidity and mortality. While diagnostic strategies for suspected PE in…
View details →Byeongsoo · 2026 · Preprint
Abstract Background. Flux balance analysis (FBA) is widely used to simulate gene essentiality in genome-scale metabolic models (GEMs), and several studies have proposed using FBA-based combination simulations to predict antibiotic synergy.…
View details →Ten Have L, Buil JB, van Dijk K · 2026 · Medical mycology
In this article, we evaluate a possible postzone effect for the Histoplasma antigen lateral flow assay (LFA). We re-tested urine samples that were Histoplasma-positive with the LFA, both for an undiluted and diluted sample. Of the 12…
View details →Safiejko K, Juchimiuk M, Pierko J et al. · 2026 · Cancers
Background: Liquid biopsy using circulating tumor DNA (ctDNA) is rapidly reshaping gastrointestinal (GI) oncology. The highest-impact applications are molecular residual disease (mRD) detection after curative-intent therapy and early…
View details →Knasmüller S, Nersesyan A, Mišík M et al. · 2026 · Mutagenesis
We describe the impact of lifestyle related factors on the formation of micronuclei (MN) in buccal cells. It is known that consumption of alcohol and of other drugs including tobacco and other plants cause damage of the genetic material…
View details →Vardanega MJ, Longo T, Aceino A et al. · 2026 · Journal of veterinary internal medicine
Vulvovaginal squamous cell carcinoma (SCC) is an uncommon neoplasm in dogs. An 11-year-old female spayed German Shepherd dog presented with a history of excessive peri-vulvar grooming and a 3 cm × 3 cm irregular mass involving the vagina…
View details →Goubeau L, Curis E, Delavenne X et al. · 2026 · Blood advances
Phase 3 trials evaluating inhibitors of coagulation factor (F) XI and/or its activated form (FXIa) as novel anticoagulant drugs are ongoing. These agents include parenteral monoclonal antibody (abelacimab) and oral small molecules…
View details →Limbu N, Lamsal RR, Shrestha A · 2025 · Preprint
Abstract Citrus Decline, a complex and devastating disorder caused by various biotic and abiotic factors has emerged as a significant challenge for citrus cultivation in Nepal. This study on “Prevalence and severity of citrus decline and…
View details →Yin J, Wang Q, Lan T et al. · 2026 · Frontiers in pediatrics
Background Copy number variants of uncertain significance (VUS-CNVs) pose significant challenges in prenatal counseling for congenital heart malformations (CHMs). Their clinical relevance remains poorly defined, particularly in the absence…
View details →Kazanskii M, Golikova M, Kasianov A et al. · 2025 · Preprint
We investigated the possibility of estimating the age of ancient biological samples directly from their DNA damage profiles using supervised machine learning. Traditional dating methods such as radiocarbon dating, dendrochronology rely on…
View details →Iwata K, Mori N, Ogasawara K · 2025 · Cureus
Introduction Noninvasive methods for assessing liver fibrosis are increasingly important for early detection of advanced liver fibrosis (ALF), particularly in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).…
View details →Zych-Krekora K, Sylwestrzak O, Krekora M · 2026 · Journal of clinical medicine
Background/Objectives : Maternal rectovaginal carriage of Group B Streptococcus (GBS, Streptococcus agalactiae ) is a major risk factor for vertical transmission and early-onset neonatal infection. Intrapartum antibiotic prophylaxis…
View details →Galván CA, Durán R, Larco JI et al. · 2026 · Immunity, inflammation and disease
Background Accurate identification of respiratory allergen sensitization is essential for managing asthma and allergic rhinitis (AR). While Skin Prick Test (SPT) and ImmunoCAP are standard diagnostic tools, exploratory comparative data for…
View details →Nakai Y, Onishi K, Asakawa I et al. · 2026 · The Prostate
Background Long-term clinical data evaluating oncological outcomes and patient-reported quality of life (QOL) after combining celecoxib with radiotherapy are lacking. Therefore, we aimed to assess oncological outcomes and QOL with extended…
View details →Oshiro Y, Kawashima A, Akashi M et al. · 2026 · Tropical medicine and health
Background Giardiasis and cryptosporidiosis are often misdiagnosed by stool ova and parasite test (classical O&P). Multiplex PCR and rapid antigen immunochromatography (rapid-IC) could offer high diagnostic accuracy; however, their cost…
View details →Espigares LF, Panadero AF, Sánchez MD et al. · 2026 · Multiple sclerosis and related disorders
Objective Accurate anti-JC virus (JCV) antibody testing is essential for progressive multifocal leukoencephalopathy (PML) risk stratification in natalizumab-treated patients. This study assessed evaluated inter-assay concordance between…
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