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Browse the failure-mode index

20,253 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Variations in transcranial doppler among pediatric patients with sickle cell disease in the Brazilian Northeast: a cross-sectional study.

de Oliveira Castro Marques TR, Vidal SA, da Costa HA et al. · 2026 · Hematology, transfusion and cell therapy

Background Stroke, the most severe neurological complication of sickle cell disease, can result in irreversible sequelae and death. Transcranial Doppler combined with periodic blood transfusions reduces the chances of stroke by 90 %. In…

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Negative / Null Result ReportMedicine

The impact of a second embryo biopsy for preimplantation genetic testing for monogenic diseases (PGT-M) with inconclusive results on pregnancy potential: results from a matched case-control study.

Guarneri C, Reschini M, Pinna M et al. · 2024 · Journal of assisted reproduction and genetics

Purpose To evaluate whether a second biopsy, following a first diagnostic failure on blastocysts tested for preimplantation genetic testing for monogenic diseases (PGT-M), allows to obtain genetic diagnosis and to what extent this…

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Negative / Null Result ReportOpen accessMedicine

Pre-Analytical and Analytical Challenges in Whole-Exome Sequencing of Formalin-Fixed Paraffin-Embedded Breast and Prostate Cancer Tissue: A Real-World Multicenter Study.

Rosa ML, Bordignon C, Schuch JB et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Formalin-fixed paraffin-embedded tissue is widely used in pathology and molecular diagnostics, yet its variable quality can critically influence the accuracy of sequencing-based analyses. This study investigated…

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Negative / Null Result ReportOpen accessMedicine

Comprehensive assessment of invalid and indeterminate results in Truenat MTB-RIF testing across sites under the national TB elimination program of India.

Gopalaswamy R, Kumar N, Vashistha H et al. · 2023 · Frontiers in public health

Introduction Truenat MTB-RIF assay (Truenat), a nucleic acid amplification test (NAAT), is a real-time polymerase chain reaction (RT-PCR) chip-based assay that can detect Mycobacterium tuberculosis ( Mtb ) and rifampicin (RIF) drug…

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Negative / Null Result ReportMedicine

Dietary Iron Intake and Risk of Gastric Cancer.

Pham YT, Nguyen BN, Nguyen TG et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Iron is one of the essential elements for human life. Prior studies provided inconclusive results about the association between dietary iron intake and gastric cancer risk. We determined the association between dietary iron…

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Negative / Null Result ReportOpen accessMedicine

Rare Occurrence of Myxoma in Heart Transplant Recipient: A Case Report.

Gutowska A, Bohdan M, Radtke-Łysek A et al. · 2026 · The American journal of case reports

BACKGROUND Cardiac myxomas are the most common primary cardiac tumors in the general population but are exceedingly rare in orthotopic heart transplant recipients. Fewer than 5 cases have been reported. Their pathogenesis in the setting of…

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Negative / Null Result ReportMedicine

The effect of an intervention to reduce aflatoxin consumption from 6 to 18 mo of age on length-for-age z-scores in rural Tanzania: a cluster-randomized trial.

Phillips E, Ngure FM, Kassim N et al. · 2025 · The American journal of clinical nutrition

Background Linear growth faltering continues to negatively affect children in low- and middle-income countries and is associated with poor cognitive, developmental, and educational outcomes. Laboratory and observational data suggest that…

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Negative / Null Result ReportOpen accessMedicine

Prior Use of Renin-Angiotensin System Inhibitors and Risk of Renal Replacement Therapy in Critically Ill Elderly Patients With Sepsis: A Population-Based Cohort Study.

Otero Castro V, Scales DC, Angriman F · 2025 · Critical care explorations

Objectives We sought to estimate the association between chronic use of renin-angiotensin system inhibitors and acute kidney injury requiring renal replacement therapy in critically ill adult patients with sepsis. Design Population-based…

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Negative / Null Result ReportOpen accessMedicine

No evidence of BoHV-1 exposure and low levels of pestivirus exposure in sera from 116 opportunistically sampled wild deer in Northern Ireland.

Lyons M, Lahuerta-Marin A, Clarke J et al. · 2025 · Irish veterinary journal

Bovine Viral Diarrhoea Virus (BVDV), Border Disease Virus (BDV), and Bovine Herpesvirus-1 (BoHV-1, the cause of Infectious Bovine Rhinotracheitis, IBR), are economically important endemic viruses in ruminant livestock in the United Kingdom…

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Negative / Null Result ReportMedicine

Efficacy and safety of esketamine versus propofol in electroconvulsive therapy for treatment-resistant depression: A randomized, double-blind, controlled, non-inferiority trial.

Zeng QB, Zou DC, Huang XB et al. · 2025 · Journal of affective disorders

Background Electroconvulsive therapy (ECT) is a commonly used alternative for treatment-resistant depression (TRD). Although esketamine has a rapid pharmacological antidepressant action, it has not been studied as an ECT anesthetic. The…

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Negative / Null Result ReportOpen accessMedicine

Preoperative Lateralization and Diagnostic Value of Selective Bilateral Internal Jugular Venous Sampling in Primary Hyperparathyroidism: Single-Center Experience.

Solodjankina A, Kratovska A, Ponomarjova S et al. · 2024 · Medicina (Kaunas, Lithuania)

Background and Objectives : Primary hyperparathyroidism (pHPT) is a common endocrine disorder caused by excessive production of parathyroid hormone (PTH) leading to elevated calcium levels. Diagnosis is primarily based on biochemical…

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Negative / Null Result ReportMedicine

The utility of disc space and vertebral body specimens cell count differential for the diagnosis of native vertebral osteomyelitis: a prospective cohort study.

Zein SE, Tande AJ, Carr CM et al. · 2024 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Background Diagnostic methods for native vertebral osteomyelitis (NVO) often yield inconclusive results. Image-guided spine biopsies for culture are specific but diagnose NVO in only 50% of cases. Pre-exposure to antimicrobials further…

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Negative / Null Result ReportMedicine

Sharpening the lens to evaluate interprofessional education and interprofessional collaboration by improving the conceptual framework: a critical discussion.

Neubauer FB, Wagner FL, Lörwald A et al. · 2024 · BMC medical education

It has been difficult to demonstrate that interprofessional education (IPE) and interprofessional collaboration (IPC) have positive effects on patient care quality, cost effectiveness of patient care, and healthcare provider satisfaction.…

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