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Browse the failure-mode index

20,253 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

CRISPR/Cas9-Mediated Knockout of the NAD-Dependent Lactate Dehydrogenases for Altered Stereospecific Lactic Acid Production in Lacticaseibacillus paracasei NC4.

Chu NH, Le HD, Quach NT et al. · 2026 · Biochemical genetics

The optical purity of lactic acid is a critical parameter for producing high-performance polylactic acid (PLA). To investigate the genetic basis of stereospecific lactic acid biosynthesis, the present study aimed to functionally…

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Negative / Null Result ReportMedicine

Liquid Chromatography-High-Resolution Mass Spectrometric Determination of Nitrite Ion Concentration in the Natural Water Resources.

Ganji SK, Talari K, Maloth RK et al. · 2026 · Rapid communications in mass spectrometry : RCM

Rationale Nitrite anion is among the highly reactive anions and converts the secondary amines to their corresponding carcinogenic N-nitroso metabolites in the human body. Nitrite ion is highly abundant in natural waters and enters the body…

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Negative / Null Result ReportMedicine

Exploratory comparative analysis of automated morphologic and perfusion features derived from one-stop computed tomography angiography and computed tomography perfusion in large unruptured intracranial aneurysms.

Niu J, Huang W, Zou J · 2026 · Clinical neurology and neurosurgery

Purpose To compare rupture-related signals captured by automatically extracted computed tomography angiography (CTA) morphologic features and threshold-based computed tomography perfusion (CTP) metrics in large unruptured intracranial…

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Negative / Null Result ReportOpen accessMedicine

Non-Essential Element-Based Nanoparticles in Rice: Unraveling the Impacts of Yttrium Oxide and Zirconium Oxide Nanoparticles on Root Accumulation and Antioxidant Responses.

Xie B, Rui Y · 2026 · Plants (Basel, Switzerland)

Nanotechnology has attracted increasing attention in agricultural and environmental research, but the biological effects and potential risks of nanoparticles based on non-essential elements remain insufficiently understood. This study…

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Negative / Null Result ReportMedicine

Current comorbid psychiatric symptoms in the statistical indirect association between childhood attention-deficit/hyperactivity disorder symptoms and functional impairment among university students.

Koyuncu Z, Evcil FY, Kilimci ÖS et al. · 2026 · BMC psychiatry

Objective This study investigated whether current comorbid psychiatric symptoms were involved in statistical indirect associations between childhood attention-deficit/hyperactivity disorder (ADHD) symptoms (CAS) and functional impairment…

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Negative / Null Result Report

High Concordance in Molecular Profiles Between Primary Tumors and Matched Lymph Node Metastases in Differentiated Thyroid Carcinoma: Implications for Clinical Sample Selection

Pan Y, Sun Y, Shi C et al. · 2026 · Preprint

Abstract Genetic testing guides personalized management of differentiated thyroid carcinoma (DTC). However, tumor heterogeneity, including spatial and temporal heterogeneity, has created an unresolved clinical problem. It remains unclear…

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Negative / Null Result ReportMedicine

Influence of inhalation exposure to biogenic volatile organic compounds from Syringa oblata flowers on behavior, spatial working memory, and hematological parameters in mice.

Tuo Y, Yang S, Dai X et al. · 2026 · Journal of ethnopharmacology

Ethnopharmacological relevance Syringa oblata Lindl. emits a variety of biogenic volatile organic compounds (BVOCs) during full bloom, which forms the key chemical basis for its characteristic floral scent. Species of the genus Syringa…

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Negative / Null Result ReportMedicine

Plasma protein biomarkers for early risk prediction of colorectal cancer.

Chen W, Ge X, Hu C et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Prospective studies are necessary to determine the association between circulating proteins and colorectal cancer (CRC) risk, offering non-invasive biomarkers for early CRC risk prediction and interventions. The Olink Explore-3072 platform…

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Negative / Null Result ReportMedicine

Preliminary investigation of T-wave peak-end interval and its ratio to QT interval in dogs with an echocardiographic phenotype of dilated cardiomyopathy and its possible correlation with left ventricular diameter and volume.

Kurogochi K, Stern JA, DeFrancesco TC et al. · 2026 · Journal of the American Veterinary Medical Association

Objective The T-wave peak-end (TpTe) interval and its ratio to the QT interval (TpTe:QT) are ECG markers of myocardial repolarization dispersion. We hypothesized that these markers are associated with echocardiographic indices reflecting…

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