19,885 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Li S, Mahr C, Kataria R et al. · 2026 · JACC. Advances
Background Landmark randomized controlled trials like DanGer Shock, IABP-SHOCK II, and ECLS-SHOCK guide infarct-related cardiogenic shock (CS) management with temporary mechanical circulatory support (tMCS), but strict enrollment criteria…
View details →Albers GW, Bernstein R, Brachmann J et al. · 2021 · Stroke
Occult atrial fibrillation (AF) is a leading cause of stroke of unclear cause. The optimal approach to secondary stroke prevention for these patients remains elusive. The term embolic stroke of undetermined source (ESUS) was coined to…
View details →Ishizuka K, Ono S · 2025 · Journal of clinical pharmacology
Despite the tremendous effort in the oncology community, the success rate of anticancer development remained low at 30% to 40% from the Phase 3 study to the regulatory approval. The factors associated with the regulatory approval for…
View details →Chen H, Colasurdo M, Matsukawa H et al. · 2026 · European stroke journal
Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…
View details →Cerbone L, Orecchia S, Bertino P et al. · 2023 · Cancers
Mesothelioma comprises a group of rare cancers arising from the mesothelium of the pleura, peritoneum, tunica vaginalis testis and pericardium. Mesothelioma is generally associated with asbestos exposure and has a dismal prognosis, with…
View details →Pellesi L, Onan D, Martelletti P · 2024 · Toxins
Post-traumatic headache (PTH) is a common and debilitating consequence of traumatic brain injury (TBI), often resembling migraine and tension-type headaches. Despite its prevalence, the optimal treatment for PTH remains unclear, with…
View details →Zhou Q, Gao B, Hu J et al. · 2026 · BMJ oncology
Background Many patients with non-small cell lung cancer (NSCLC) have tumours that are either refractory or develop resistance following an initial response to anti-programmed cell death protein (ligand)-1 (PD-(L)1)-based treatment,…
View details →Kasperkiewicz M, van Beek N, Schmidt E · 2026 · Drugs
Autoimmune blistering diseases (AIBDs) are a heterogeneous group of at least a dozen disorders characterized by autoantibodies against structural proteins of desmosomes in the skin and surface-close epithelia in pemphigus and of the…
View details →Baugher B, Walter E, Hennigs E et al. · 2025 · Cureus
Freezing of gait (FoG) is a disabling symptom of Parkinson's disease (PD) characterized by involuntary cessation/reduction. While deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) effectively treats common PD symptoms…
View details →Park L, Furey M, Nugent A et al. · 2018 · Biological psychiatry
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This conference abstract has been retracted at the request of author Maura Furey,…
View details →Autler AS, Darling AM, Skow RJ et al. · 2025 · Autonomic neuroscience : basic & clinical
Young women, who suffer from major depressive disorder (MDD) at twice the rate as young men, are particularly vulnerable to cardiovascular events triggered by emotional stress, an association that may be partially explained by excessive…
View details →Molto A, López-Medina C, Van den Bosch FE et al. · 2021 · Annals of the rheumatic diseases
Objectives To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis (axSpA) with those of usual care (UC). Methods Pragmatic, prospective, cluster-randomised, controlled, open, 1-year trial…
View details →Denton CP, Del Galdo F, Khanna D et al. · 2022 · Rheumatology (Oxford, England)
Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc has the potential to slow or stop the disease process.…
View details →Lahiri JB, Panwar S · 2026 · Preprint
Abstract Covariance matrices underpin multivariate signal classifiers in brain-computer interfaces, clinical neurophysiology, and condition monitoring. Characteristic Response Analysis (CRA) and its Positive-Orthant Characteristic Response…
View details →Ferguson I, George G, Wu C et al. · 2025 · Cognitive therapy and research
Background The tendency to negatively interpret ambiguous situations (i.e., interpretation bias) is associated with the development and maintenance of emotional disorders. Reliable measures of this transdiagnostic construct are critical…
View details →van der Meulen C, van de Stadt LA, Kroon FPB et al. · 2025 · Rheumatology (Oxford, England)
Objective Pain in hand osteoarthritis (OA) is evaluated with repeated pain questionnaires. It is unclear whether these questionnaires adequately capture changes in pain recalled by patients. This study investigated whether changes on pain…
View details →Laviolle B, Locher C, Allain JS et al. · 2025 · Clinical pharmacology and therapeutics
Studies with negative results are less likely to be published than others, potentially leading to publication bias. Introduced in 2000, trial registration could have participated in decreasing the proportion of unpublished studies. We…
View details →Ter Bruggen FFJA, Redekop WK, Stronks DL et al. · 2021 · Journal of pain research
Objective The success of neurostimulation depends partly on the amount of coverage of the neurostimulation-induced paresthesia of the painful area. This is often achieved by asking feedback from patients intraoperatively. If sedation…
View details →Agostinho M, Shani A, Canaipa R et al. · 2024 · Pain reports
Introduction Within-subject variability (WSV) of pain intensity reports has been shown to predict the placebo response. The focused analgesia selection test (FAST), which allows to experimentally assess WSV of pain reports, has been used…
View details →Dijk SW, Wollny C, Barkhausen J et al. · 2025 · JAMA
Importance Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective To assess the effects of…
View details →Correll CU, Durgam S, Kozauer SG et al. · 2026 · International clinical psychopharmacology
This Phase 3, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of lumateperone to treat bipolar depression. Patients (18-75 years) with bipolar I or bipolar II disorder experiencing a major depressive…
View details →Seybold U · 2018 · Deutsche medizinische Wochenschrift (1946)
Vaccination practices in Germany are driven by scientific developments and a complex regulatory environment. Some important developments in 2018 are described here: Starting in 2018 only quadrivalent influenza vaccines will be used for the…
View details →Bremhorst A, Mills DS, Stolzlechner L et al. · 2021 · Frontiers in psychology
The inner brow raiser is a muscle movement that increases the size of the orbital cavity, leading to the appearance of so-called 'puppy dog eyes'. In domestic dogs, this expression was suggested to be enhanced by artificial selection and…
View details →Mutale W, Freeborn K, Graybill LA et al. · 2021 · The Lancet. Global health
Background Testing men for HIV during their partner's pregnancy can guide couples-based HIV prevention and treatment, but testing rates remain low. We investigated a combination approach, using evidence-based strategies, to increase HIV…
View details →Terpstra JA, van Beugen S, van der Vaart R et al. · 2026 · Internet interventions
Background Rheumatic and musculoskeletal diseases have a high burden. We aimed to evaluate the effectiveness of a therapist-guided internet-based cognitive-behavioral therapy (iCBT) on pain coping and secondary physical, psychological, and…
View details →Wilkie DJ, Yao Y, Ezenwa MO et al. · 2020 · Journal of pain and symptom management
Context Unrelieved cancer pain at the end of life interferes with achieving patient-centered goals. Objective To compare effects of usual hospice care and PAINRelieveIt® on pain outcomes in patients and their lay caregivers. Methods In a…
View details →Pucha KA, Ma TC, York W et al. · 2023 · Parkinsonism & related disorders
Introduction Impaired autophagy is a pathogenic mechanism in the synucleinopathies. Sirolimus, a potent mTOR inhibitor and autophagy activator, had no beneficial effects in a randomized placebo-controlled trial in patients with multiple…
View details →Thompson KP, Sykes J, Chandakkar P et al. · 2022 · Orphanet journal of rare diseases
Background Vascular malformations in hereditary hemorrhagic telangiectasia (HHT) lead to chronic recurrent bleeding, hemorrhage, stroke, heart failure, and liver disease. There is great interest in identifying novel therapies for epistaxis…
View details →Allen PM, Dedi S, Kumar D et al. · 2012 · Perception
We manipulated the accommodative response using positive and negative lenses to study any association between symptoms of pattern glare and accommodation. Two groups of eighteen young adults were selected from seventy-eight on the basis…
View details →Komarow HD, Wang J, Eisch R et al. · 2025 · The journal of allergy and clinical immunology. Global
Background Indolent systemic mastocytosis is a clonal mast cell disease that results in an increase in mast cells in the skin, bone marrow, and other organ systems. IL-6 has been shown to promote mast cell maturation, proliferation, and…
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