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Browse the failure-mode index

19,885 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries.

Rosoff DB, Bell AS, Wagner J et al. · 2024 · Cellular and molecular gastroenterology and hepatology

Background & aims Observational studies have linked lipid-lowering drug targets pro-protein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) with adverse liver outcomes; however, liver disease incidence varies across…

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Negative / Null Result ReportOpen accessMedicine

Establishing validity and measurement invariance of the Claremont Purpose Scale among adolescents from diverse racial-ethnic backgrounds.

Xie H, Ratner K, Estevez M et al. · 2026 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

The Claremont Purpose Scale (CPS) was designed to assess youth purpose, but the English version has not yet undergone rigorous psychometric evaluation among adolescents. Prior validation efforts have also mostly relied on white-majority…

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Negative / Null Result ReportMedicine

Yield of Sleep Deprivation EEG in Suspected Epilepsy. A Retrospective Study.

Guerrero-Aranda A, Enríquez-Zaragoza A, López-Jiménez K et al. · 2024 · Clinical EEG and neuroscience

Background. Sleep is an activation procedure and is considered the most potent and best-documented modulator of seizures and interictal epileptiform discharges (IEDs) on electroencephalogram (EEG). The precise role of sleep deprivation in…

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Negative / Null Result ReportMedicine

Comparisons of extinction, counterconditioning, and novelty-facilitated extinction within ABA vs. ABC renewal designs.

Jozefowiez J, Huff AG, Petruzzo L et al. · 2026 · Journal of experimental psychology. Animal learning and cognition

The expression of an association between a conditioned stimulus (CS) and an aversive unconditioned stimulus (US) can be weakened by presenting the CS by itself (extinction [Ext]), pairing it with an appetitive US (counterconditioning…

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Negative / Null Result ReportMedicine

Perioperative N-acetylcysteine: evidence and indications.

Wilson PR, Bridges KH, Scofield M et al. · 2024 · Pain management

Nonopioid analgesics serve to improve analgesia and limit side effects and risks of perioperative opioids. N-acetylcysteine (NAC), the primary treatment of acetaminophen toxicity, may have perioperative indications, including analgesia.…

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Negative / Null Result Report

Ranschburg Unrepeated

Remouchamps R, Majerus S, Kowialiewski B · 2025 · Preprint

In verbal working memory (WM), the second occurrence of an item in a memory list generally leads to impaired recall performance, a phenomenon called the “Ranschburg effect”. One explanation for this effect is response suppression, by which…

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