Negative / Null Result ReportMedicine
Feldman S, Basra J, Lawani A et al. · 2025 · Ophthalmic surgery, lasers & imaging retina
Background and objective To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA). Patients and methods Prospective, single-masked,…
View details →Negative / Null Result ReportOpen accessMedicine
Chen H, Huang X, Wang C et al. · 2025 · The Journal of infectious diseases
Assessing the time-varying effectiveness of coronavirus disease 2019 (COVID-19) vaccines is critical to guiding vaccine strategies and public health policies. We developed a Bayesian framework to estimate the waning vaccine effectiveness…
View details →Negative / Null Result ReportMedicine
Horizono J, Mizumoto K, Suico MA et al. · 2025 · Biological & pharmaceutical bulletin
Cyclodextrins (CDs) are cyclic oligosaccharides that encapsulate hydrophobic molecules such as cholesterol. Hydroxypropyl-β-cyclodextrin (HP-β-CD), a cyclic heptasaccharide, has gained attention as a protective agent for chronic kidney…
View details →Negative / Null Result ReportMedicine
Hojo FR, Martins TC, Vieira-Junior WF et al. · 2025 · Operative dentistry
This study evaluated the influence of six resin composite coating agents on color stability and surface roughness after toothbrushing abrasion. Discs (Ø6 mm x 2 mm) of nanofilled resin composite (Filtek Z350XT) were prepared for…
View details →Negative / Null Result Report
Chen A, Chou TY, Chen Y et al. · 2024 · Preprint
Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is a major disease affecting banana production around the globe. To study the movement of Foc in planta and investigate potential physical mechanisms of deterrence, the roots…
View details →Negative / Null Result Report
Giles C, Lee J · 2024 · Preprint
Abstract Nearly 90% of cancer deaths are due to metastasis. Conventional cancer therapeutics including chemotherapy, surgery, and radiotherapy, are effective in treating primary tumors, but may aggravate disseminated tumor cells (DTCs)…
View details →Negative / Null Result ReportMedicine
Beningaza AM, Di Benedetto IMD, Babino L et al. · 2025 · Acta tropica
Chagas disease, vectored by kissing bugs, poses a public health problem across the Americas. The best way for reducing disease transmission is through vector control, which is currently based on the use of insecticides. However,…
View details →Negative / Null Result ReportMedicine
Asadikorayem M, Weber P, Zhang S et al. · 2025 · Biomaterials advances
Osteoarthritis (OA) is one of the most common degenerative joint diseases, with no effective therapeutic options available. In this study, we aimed to develop an interpenetrating, in-situ-forming hydrogel based on biocompatible and…
View details →Negative / Null Result ReportMedicine
Baudat M, Joosten EAJ, Simons SHP · 2025 · Pediatric research
Background While the incidence of neonatal intensive care unit (NICU) admission steadily increases, neonatology lacks evidence of a safe, effective, and preventive analgesic for treating procedural pain. Given its role in nociception and…
View details →Negative / Null Result ReportOpen accessMedicine
Moksi L, Sissala N, Ojala R et al. · 2026 · Journal of orthopaedic surgery and research
Background Avascular necrosis (AVN) of the femoral head is a progressive condition that leads to collapse of the femoral head in 85% of symptomatic patients when left untreated. As it is typically a disease that occurs among the younger…
View details →Negative / Null Result Report
Wongkraisri C, Chusuwanrak K, Laocharoenkeat A et al. · 2024 · Preprint
Abstract Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
View details →Negative / Null Result ReportMedicine
Rajsiglova L, Babic M, Krausova K et al. · 2024 · Journal of immunotoxicology
Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles…
View details →Negative / Null Result ReportOpen accessMedicine
de Araújo IM, Le PT, de Carvalho Picoli C et al. · 2026 · JBMR plus
Caloric restriction (CR) alters energy metabolism and increases systemic glucocorticoid production, contributing to bone loss and bone marrow adipose tissue (BMAT) expansion. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)…
View details →Negative / Null Result ReportMedicine
Damica FZ, Lucas DR, Toledo EB et al. · 2025 · Biochimica et biophysica acta. General subjects
Antimicrobial peptides (AMPs) are promising drugs, though their fungal combat mechanisms remain partly unclear. We designed three AMPs (dAMPs) based on the γ-core of the Vu-Def 1 seed defensin from Vigna unguiculata L. Walp. named RR,…
View details →Negative / Null Result ReportMedicine
Magnuson JR, Bruce CD, Dalton BH et al. · 2024 · Journal of neurophysiology
The increasing descending drive needed to sustain submaximal isometric torque makes it difficult to isolate fatigue-related changes to neural excitability because evoked electromyography (EMG) responses are influenced by the relative…
View details →Negative / Null Result ReportMedicine
Shaidullov I, Bouchareb D, Sorokina D et al. · 2025 · Naunyn-Schmiedeberg's archives of pharmacology
Irritable bowel syndrome (IBS) is a multifactorial disorder, with altered intestinal motility, visceral hypersensitivity, and dysfunction of the gut-brain axis. The aim of our study was to analyze the role of nitric oxide (NO) in the…
View details →Negative / Null Result ReportMedicine
Villa M, Martínez-Vega M, Silva L et al. · 2024 · Pediatric research
Background Neonatal rats can manifest post-stroke mood disorders (PSMD) following middle cerebral artery occlusion (MCAO). We investigated whether cannabidiol (CBD) neuroprotection, previously demonstrated in neonatal rats after MCAO,…
View details →Negative / Null Result ReportOpen access
Hoyle C, Pino RD, Lai SM et al. · 2025 · Preprint
Interleukin (IL)-1α is a pro-inflammatory member of the IL-1 cytokine superfamily and is important for inflammatory responses to infection and injury. Unlike pro-IL-1β, pro-IL-1α is mainly localised to the nucleus upon expression. This is…
View details →Negative / Null Result ReportOpen accessMedicine
Gam S, Hermann AP, Juhl CB et al. · 2026 · Obesity (Silver Spring, Md.)
Objective This study aimed to investigate whether a single infusion of 5 mg zoledronic acid, given before bariatric surgery to prevent bone loss, could also hinder the loss of muscle mass, strength, and physical function. Methods In this…
View details →Negative / Null Result ReportOpen accessMedicine
Nilsson KH, Henning P, Lagerquist MK et al. · 2026 · Calcified tissue international
Osteoporosis is characterized by an imbalance in bone remodeling, resulting in bone loss and increased fracture risk. Inflammatory diseases, such as rheumatoid arthritis, are strongly associated with secondary osteoporosis due to…
View details →Negative / Null Result ReportOpen accessMedicine
Leal R, Fragoso P, Venda J et al. · 2025 · Renal failure
Background The optimal immunosuppressive (IS) withdrawal strategy after kidney allograft failure remains unclear. This study evaluated the effects of prolonged calcineurin inhibitor (CNI) therapy on HLA sensitization, graft intolerance…
View details →Negative / Null Result ReportMedicine
Krikelis M, Gazi S, Trovas G et al. · 2024 · Joint bone spine
Introduction Denosumab (Dmab) is widely used for the treatment of post-menopausal osteoporosis. Its discontinuation is sometimes accompanied by multiple vertebral fractures. Romosozumab (Rmab) has not been tested for its ability to prevent…
View details →Negative / Null Result ReportMedicine
Zhou AL, Ward RE · 2024 · Journal of dairy science
The focus of this work is the role milk polar lipids play in affecting gut permeability, systemic inflammation, and lipid metabolism during acute and chronic inflammation induced by a single subcutaneous injection of lipopolysaccharide.…
View details →Negative / Null Result ReportOpen accessMedicine
Karp Z, Czarny J, Adamczewska-Wawrzynowicz K et al. · 2026 · Children (Basel, Switzerland)
Background : Infantile hepatic hemangiomas (IHH) are common benign vascular tumors in infancy with diverse presentations. Methods : We report a 7-week-old infant presenting with hepatosplenomegaly, multiple skin and hepatic hemangiomas,…
View details →Negative / Null Result ReportOpen accessMedicine
Shunyakova J, Reynolds M, Taylor A et al. · 2025 · Frontiers in ophthalmology
Background Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache (ROSAH) syndrome is an autosomal dominant disorder caused by a heterozygous missense mutation in alpha kinase 1 (ALPK1). This series reports the…
View details →Negative / Null Result ReportMedicine
Frouin M, Cavalerie R, Piazza S et al. · 2024 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
A 2.5-year-old spayed female Chihuahua dog was presented with chronic cervical pain and exhibited a "prayer-like position" following a history of a 4-meter fall. CT and MRI revealed a moderate right-sided enlargement of the subdural space…
View details →Negative / Null Result ReportOpen accessMedicine
Le Corre E, Jousserand N, Maurey C et al. · 2026 · Journal of veterinary internal medicine
Background Subclinical bacteriuria (SBU) is frequently encountered in cats with chronic kidney disease (CKD), but it remains unclear if it is associated with survival and disease progression. Hypothesis/objectives To determine the…
View details →Negative / Null Result ReportOpen accessMedicine
Villanova S, Gatti M, Colosio M et al. · 2026 · Nutrients
Background: Astragali radix is a traditional herb known for its antioxidant, anti-inflammatory, and immunomodulatory properties and has gained attention for its potential to support post-exercise recovery. However, the effects of long-term…
View details →Negative / Null Result Report
Chitolina R, Reis CG, Stahlhofer-Buss T et al. · 2023 · Preprint
Epilepsy is a prevalent neurological disorder, affecting approximately 1 to 2% of the global population. The hallmark of epilepsy is the occurrence of epileptic seizures, which are characterized by predictable behavioral changes reflecting…
View details →Negative / Null Result ReportOpen accessMedicine
Hotz JF, Kaindl L, Krebs S et al. · 2026 · European journal of neurology
Introduction Hemiplegic migraine (HM) is a rare subtype of migraine with aura, characterized by transient, unilateral motor weakness. Due to its rarity, treatment strategies are lacking. Monoclonal antibodies targeting the calcitonin…
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