Negative / Null Result ReportOpen accessSocial Sciences
Briony D.
Pulford, Poonam
Gill · 2014 · Judgment and Decision Making
We report a series of experiments investigating the influence of feeling lucky or unlucky on people's choice of known-risk or ambiguous options using the traditional Ellsberg Urns decision-making task. We induced a state of feeling lucky or unlucky in subjects by using a rigged wheel-of-fortune game, which just missed either the bankrupt or the jackpot outcome. In the first experiment a large reversal of the usual ambiguity aversion effect was shown, indicating that feeling lucky made subjects significantly more ambiguity seeking than usual. However, this effect failed to replicate in five ref
View details →Negative / Null Result ReportOpen accessMedicine
Haley Appel, Rogger P Carmen-Orozco, Clayton P Santiago et al. · 2025 · eLife
The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes neurogenesis, recent genetic studies have failed to replicate glia-to-neuron conversion following Ptbp1 loss of function. To evaluate the role of Ptbp1 in developmental neurogenesis in vivo, we conditionally disrupted Ptbp1 in mouse retinal progenitors. Ptbp1 was robustly expressed in both retinal progenitors and Müller glia but absent from p
View details →Negative / Null Result ReportOpen accessSocial Sciences
Mark Nieuwenstein, Hedderik van Rijn · 2012 · Judgment and Decision Making
According to the deliberation without attention (DWA) hypothesis, people facing a difficult choice will make a better decision after a period of distraction than after an equally long period of conscious deliberation, an effect referred to as the unconscious thought advantage (UTA). The status of the DWA hypothesis is controversial, as many studies have tried but failed to replicate the UTA. Here, we report a series of experiments that sought to identify the conditions under which the UTA can be replicated. Our starting point was a recent meta-analysis that identified the conditions under whic
View details →Negative / Null Result ReportOpen accessMedicine
Abraham D. Flaxman, Riley Hazard, Ian Riley et al. · 2020 · BMC Medicine
Abstract We recently published in BMC Medicine an evaluation of the comparative diagnostic performance of InSilicoVA, a software to map the underlying causes of death from verbal autopsy interviews. The developers of this software claim to have failed to replicate our results and appear to have also failed to locate our replication archive for this work. In this Correspondence, we provide feedback on how this might have been done more usefully and offer some suggestions to improve future attempts at reproducible research. We also offer an alternative interpretation of the results presented by
View details →Negative / Null Result ReportOpen accessSocial Sciences
Briony D. Pulford, Poonam Gill · 2014 · Judgment and Decision Making
We report a series of experiments investigating the influence of feeling lucky or unlucky on people’s choice of known-risk or ambiguous options using the traditional Ellsberg Urns decision-making task. We induced a state of feeling lucky or unlucky in subjects by using a rigged wheel-of-fortune game, which just missed either the bankrupt or the jackpot outcome. In the first experiment a large reversal of the usual ambiguity aversion effect was shown, indicating that feeling lucky made subjects significantly more ambiguity seeking than usual. However, this effect failed to replicate in five ref
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Michael Weigl, Qi Shao, Qi Shao et al. · 2023 · Frontiers in Human Neuroscience
In recent years, several cross-cultural studies reported that Westerners focus more on central aspects of a scene (e.g., an object) relative to peripheral aspects (e.g., the background), whereas Easterners more evenly allocate attention to central and peripheral aspects. In memory tasks, Easterners exhibit worse recognition for the central object when peripheral aspects are changed, whereas Westerners are less affected by peripheral changes. However, most of these studies rely on hit rates without correcting for response bias, whereas studies accounting for response bias failed to replicate cu
View details →Negative / Null Result ReportOpen accessLanguage and Literature
Elisa Scerrati, Zachary Estes · 2025 · Language and Cognition
The spatial interference effect, whereby words with implicit spatial associations (e.g., ‘bird’) hinder identification of unrelated visual targets (e.g., a square) at the associated locations (i.e., at the top of a display), has been demonstrated many times in English, although it has failed to replicate several times in Italian. The current study tested whether the replication failures in Italian may be due to insufficient semantic processing of the words. Indeed, while languages with highly inconsistent pronunciations, such as English, are more likely to involve semantic processing during wo
View details →Negative / Null Result ReportOpen accessPharmacy and materia medica
Bazigha K. Al –Temimy, Alaa A. Abdul –Rasool · 2017 · Iraqi Journal of Pharmaceutical Sciences
ABSTRACT: Salbutamol sulphate nebules is considered as the most rapid effective route of administration for treatment of acute attacks of asthma . This study was carried out to formulate a stable formula of salbutamol nebules containing 0.1% (2.5mg / 2.5ml) of the active ingredient in a buffered solution . Stability study in different buffers at pH 3 showed that the longest shelf life was equal to 3.5 years for formula F .In addition the bioequivalency of this formula incomparison to ventolin nebules was measured and it was equal to (± 5.2) %. Also it was found that there was no significant d
View details →Negative / Null Result ReportOpen accessAstrophysics
Chen Du, Yong-Feng Huang, Zhi-Bin Zhang et al. · 2024 · The Astrophysical Journal
Fast radio bursts (FRBs) are bright radio transients with millisecond durations, which typically occur at extragalactic distances. The association of FRB 20200428 with the Galactic magnetar SGR J1935+2154 strongly indicates that they could originate from neutron stars, which naturally leads to the expectation that periodicity connected with the spinning of magnetars should exist in the activities of repeating FRBs. However, previous studies have failed to find any signatures supporting such a conjecture. Here we perform a thorough search for short-timescale periodicity in the four most active
View details →Negative / Null Result ReportOpen accessMedicine
Katie Finning, David A Richards, Victoria A Goodwin et al. · 2019 · BMJ Open
Objectives Physical rehabilitation is a complex process, and trials of rehabilitation interventions are increasing in number but often report null results. This study aimed to establish treatment success rates in physical rehabilitation trials funded by the National Institute of Health Research Health Technology Assessment (NIHR HTA) programme and examine any relationship between treatment success and the quality of intervention development work undertaken.Design This is a mixed methods study.Setting This study was conducted in the UK.Methods The NIHR HTA portfolio was searched for all complet
View details →Negative / Null Result ReportOpen accessPhysics
H. C. Eggers, B. Buschbeck · 2013 · Advances in High Energy Physics
A detailed understanding of all effects and influences on higher-order correlations is essential. At low charged multiplicity, the effect of a non-Poissonian multiplicity distribution can significantly distort correlations. Evidently, the reference samples with respect to which correlations are measured should yield a null result in the absence of correlations. We show how the careful specification of desired properties necessarily leads to an average-of-multinomials reference sample. The resulting internal cumulants and their averaging over several multiplicities fulfill all requirements of c
View details →Negative / Null Result ReportOpen accessPhysics
C. Abel, N. J. Ayres, G. Ban, G. Bison, K. Bodek, V. Bondar, E. Chanel, C. B. Crawford, M. Daum, B. Dechenaux, S. Emmenegger, P. Flaux, W. C. Griffith, P. G. Harris, Y. Kermaidic, K. Kirch, S. Komposch, P. A. Koss, J. Krempel, B. Lauss, T. Lefort, Prajwal MohanMurthy, Oscar Naviliat Cuncic, D. Pais, F. M. Piegsa, Guillaume Pignol, M. Rawlik, D. Ries, Stephanie Roccia, D. Rozpedzik, Philipp Schmidt-Wellenburg, N. Severijns, Y. V. Stadnik, J. A. Thorne, A. Weis, E. Wursten, Jacek Zejma, Geza Zsigmond · 2023 · SciPost Physics
Ultra-low-mass axions are a viable dark matter candidate and may form a coherently oscillating classical field. Nuclear spins in experiments on Earth might couple to this oscillating axion dark-matter field, when propagating on Earth's trajectory through our Galaxy. This spin coupling resembles an oscillating pseudo-magnetic field which modulates the spin precession of nuclear spins. Here we report on the null result of a demonstration experiment searching for a frequency modulation of the free spin-precession signal of \magHg in a 1 $\mu$T magnetic field. Our search covers the axion mass rang
View details →Negative / Null Result ReportOpen accessMedicine
Alexis David James Makin, Afzal Rahman, Marco Bertamini · 2020 · PLoS ONE
Previous work has shown that symmetrical stimuli are judged as lasting longer than asymmetrical ones, even when actual duration is matched. This effect has been replicated with different methods and stimuli types. We aimed to a) replicate the effect of symmetry on subjective duration, and b) assess whether it was further modulated by the number of symmetrical axes. There was no evidence for either effect. This null result cannot be explained by reduced statistical power or enhanced floor or ceiling effects. There is no obvious stimulus-based explanation either. However, we are mindful of the r
View details →Negative / Null Result ReportOpen accessConsciousness. Cognition
Ronald Andringa, Walter R. Boot, Nelson A. Roque et al. · 2018 · Cognitive Research
Abstract Placing one’s hands near an object has been reported to enhance visual processing in a number of ways. We explored whether hand proximity confers an advantage when applied to complex visual search. In one experiment, participants indicated the presence or absence of a target item in a baggage x-ray image by pressing response boxes located at the edge of a tablet computer screen, requiring them to grip the display between their hands. Alternatively, they responded using a mouse held within their lap. Contrary to expectations, hand position did not influence search performance. In a sec
View details →Negative / Null Result ReportOpen accessBotany
Yuliang Liu, Xinye Liu, Xue Wang et al. · 2020 · BMC Plant Biology
Abstract Background As global warming becomes increasingly severe, it is urgent that we enhance the heat tolerance of crops. We previously reported that Arabidopsis thaliana PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C9 (AtPLC9) promotes heat tolerance. Results In this study, we ectopically expressed AtPLC9 in rice to examine its potential to improve heat tolerance in this important crop. Whereas AtPLC9 did not improve rice tolerance to salt, drought or cold, transgenic rice did exhibit greater heat tolerance than the wild type. High-throughput RNA-seq revealed extensive and dynamic transcriptome
View details →Negative / Null Result ReportMedicine
Yang G, Milne GL, Nogueira MS et al. · 2026 · International journal of cancer
Despite widespread interest, large randomized controlled trials have failed to demonstrate chemopreventive benefits of antioxidant supplementation, raising concerns about its efficacy and safety. Building on our prior observation of a…
View details →Negative / Null Result ReportMedicine
Samaniego-González E, Podlipnik S, Ribero S et al. · 2026 · Actas dermo-sifiliograficas
Background Management of patients with cutaneous melanoma and positive sentinel lymph node biopsy (SLNB) has shifted toward surveillance rather than complete lymph node dissection (CLND), because CLND has failed to demonstrate a survival…
View details →Negative / Null Result ReportOpen accessMedicine (General)
MM. Tahmasbi, F. Farahmand , AA. Amis · 1999 · Acta Medica Iranica
The resistant* of pateSa against lateral displacement (Le. the stability), was studied tinder a range of conditions in vitro, at a range of knee flexion angles. Muscle forces were applied in physiological directions along the separate quadriceps muscles. Normal muscle actions with constant tension showed constant patellar stability up to sixty degrees knee flexion, and then a significant increase at ninety degrees. A pathological knee was simulated by relaxing vastus medians, and ■ lateral stability then dropped by 47%. Isolated rttlnaeular release in the pathological knee did not improv
View details →Negative / Null Result ReportOpen accessPsychology
Stephanie M Sherman, Timothy P Buckley, Elsa Baena et al. · 2016 · Frontiers in Psychology
Many college students struggle to perform well on exams in the early morning. Although students drink caffeinated beverages to feel more awake, it is unclear whether these actually improve performance. After consuming coffee (caffeinated or decaffeinated), college-age adults completed implicit and explicit memory tasks in the early morning and late afternoon (Experiment 1). During the morning, participants ingesting caffeine demonstrated a striking improvement in explicit memory, but not implicit memory. Caffeine did not alter memory performance in the afternoon. In Experiment 2, participants
View details →Negative / Null Result ReportOpen accessTechnology (General)
Szostek Karol, Szostek Roman · 2023 · Technical Transactions
The work presents the concept of a device for the measurement of the one-way speed of light. The minimum parameters of this device have also been determined based on the Special Theory of Ether without transverse contraction. The Special Theory of Ether is a relativistic theory of kinemat-ics with a universal frame of reference in which light propagates and is an alternative explanation for the null result of the Michelson-Morley experiment. An experiment based on the proposed device can be one of the ways to falsify the Special Theory of Relativity and Special Theory of Ether.
View details →Negative / Null Result ReportOpen accessDentistry
Dragos Epistatu, Octavian-Marius Dinca, Cristian Vladan et al. · 2023 · Dentistry Journal
The aim of this study is to evaluate the long-term changes of sinus lift material. Materials and methods: We included a total number of 35 patients (20 men and 15 women), between 32 and 80 years old, evaluated on a timeframe of up to 11.6 years. Diverse biomaterials were used (allograft, xenograft, alloplastic, combinations of them), with autologous bone in some cases. Results: The appearance of the top plane of the bone over time took a large dome shape (36% of cases), a linear shape (32% of cases), an irregular shape (23% of cases), or had micro domes above the implants (7%). No significant
View details →Negative / Null Result ReportOpen accessInternal medicine
Dae-Yeon Kim, Hee-Soon Park, Dong-Jae Han et al. · 2013 · Kidney Research and Clinical Practice
Renal failure caused by scrub typhus is known to be reversible. In most cases, renal function is almost fully restored after appropriate antibiotic treatment. A 71-year-old man was diagnosed with scrub typhus complicated by renal failure. A renal biopsy revealed histopathologic findings consistent with acute tubulointerstitial nephritis. Renal function did not improve 18 months after discharge and the patient required continuous hemodialysis. Although severe renal failure requiring dialysis is a rare complication of scrub typhus, we describe a case of scrub typhus requiring maintenance hemodia
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Michele Bottosso, Gaia Griguolo, Severine Guiu et al. · 2025 · npj Breast Cancer
Abstract Brain metastases (BMs) are a common complication of advanced breast cancer (BC), and their management has significantly evolved. We evaluated the clinical impact of these changes dividing patients diagnosed with BCBMs at three Institutions according to year of BMs diagnosis: 2000-2007 (group A), 2008-2014 (group B) and 2015-2022 (group C). Stereotactic radiotherapy increased (p < 0.001), and WBRT decreased (p = 0.010) over time. Among HER2+ BC patients, more received anti-HER2 therapy after BM diagnosis in recent years (p < 0.011). Overall survival (OS) did not improve in the entire c
View details →Negative / Null Result ReportOpen accessOphthalmology
Jemal Zeberga Shifa, Alemayehu Mekonnen Gezmu, Gezahen Negusse Ayane et al. · 2019 · The Pan-American Journal of Ophthalmology
A 22-year-old female patient was diagnosed to have HIV and treated by highly active antiretroviral therapy (HAART) since 2012 had developed a reduction of vision in both eyes secondary to cataract. The cataract was extracted from both eyes with no immediate postoperative complication. During follow-up, it was recognized that she had had bilateral Stage 3 macular hole in both eyes. The visual acuity in both eyes was 6/60 which did not improve with application of pinhole. Pars plana vitrectomy was done and sealed the macular hole in the left eye. The visual acuity remained the same in both eyes
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Alexander C. Lehn, Cullen O'Gorman, Sarah Olson et al. · 2017 · Tremor and Other Hyperkinetic Movements
Background: Orthostatic tremor (OT) was first described in 1977. It is characterized by rapid tremor of 13–18 Hz and can be recorded in the lower limbs and trunk muscles. OT remains difficult to treat, although some success has been reported with deep brain stimulation (DBS). Case Report: We report a 68-year-old male with OT who did not improve significantly after bilateral thalamic stimulation. Discussion: Although some patients were described who improved after DBS surgery, more information is needed about the effect of these treatment modalities on OT, ideally i
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Eggeling-Böcker M, Karabetsos E, Christopoulou M et al. · 2025 · Preprint
Background: Technological advancements, such as the introduction of 5G, offer opportunities but also raise concerns. Although no evidence suggests negative effects of radiofrequency electromagnetic fields (RF-EMF) within defined exposure…
View details →Negative / Null Result ReportOpen accessAnimal culture
Samadi F, Sahneh M · 2015 · Poultry Science Journal
A total of 240, one-day-old quail chicks (Coturnix coturnix japonica) were used to study the effects of Artichoke leaf meal (ALM) and vitamin E in diet on growth performance, ileal microbial populations and intestinal morphology in a 42-d trial. This experiment was performed as a completely randomized design with 4 replicates of 15 quails each, using a 4 × 2 factorial arrangement with diet and gender as the main effects. Four dietary treatments were formulated by addition of 2 levels (1.5 and 3 percent) of ALM and 300 mg/Kg vitamin E to the basal diet. Supplementing basal diet with ALM did not
View details →Negative / Null Result ReportOpen accessComputer Science
Sungjin Park, Seungwoo Ryu, Edward Choi · 2022 · arXiv
Recent success of pre-trained language models (PLMs) has stimulated interest in their ability to understand and work with numbers. Yet, the numerical reasoning over measurements has not been formally studied despite their importance. In this study, we show that PLMs lack the capability required for reasoning over measurements. Furthermore, we find that a language model trained on a measurement-rich corpus shows better performance on understanding measurements. We propose a simple embedding strategy to better distinguish between numbers and units, which leads to a significant improvement in the
View details →Negative / Null Result ReportOpen accessEcology
Sánchez-Ledesma Judith A., Águila Bernardo, Garibay-Orijel Roberto et al. · 2025 · Folia Oecologica
Using ITS1-based metabarcoding, we investigated the structure of the soil fungal communities in the central and peripheral zones of a 25-hectare pecan nut (Carya illinoinensis) orchard located in the arid region of Coahuila, Mexico. While environmental conditions such as soil moisture and temperature varied between zones, physicochemical soil properties (pH, organic carbon, total carbon, organic matter, electrical conductivity, and zinc) remained homogeneous. A total of 4,443 fungal OTUs were detected at 97% similarity. Alpha diversity indices did not differ significantly between zones. The fu
View details →Negative / Null Result ReportOpen accessChemistry
Yu Jia, Cao Yu, Song Hang et al. · 2012 · Journal of the Serbian Chemical Society
Ab initio Hartree-Fock (HF) method and Density Functional Theory (DFT) were used to calculate the optical rotation of 26 chiral compounds. The effects of theory and basis sets used for calculation, solvents influence on the geometry and values of calculated optical rotation were all discussed. The polarizable continuum model, included in the calculation, did not improve the accuracy effectively, but it was superior to γs. Optical rotation of five or sixmembered of cyclic compound has been calculated and 17 pyrrolidine or piperidine derivatives which were calculated by HF and DFT methods gave a
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