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Browse the failure-mode index

19,878 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Performance of creatinine and cystatin C-based equations to estimate glomerular filtration rate in African children with sickle cell anemia.

Nkoy AB, Mumaka FM, Matoka TT et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Serum creatinine (SCr), the most used biomarker to evaluate glomerular filtration rate (GFR), might be inaccurate in children with sickle cell anemia (SCA). In this context, cystatin C (SCys) could be of interest. This study…

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Negative / Null Result ReportOpen accessMedicine

Genome-resolved metagenomics reveals unexpected diversity and host range of Candidatus Lariskella (Rickettsiales: Midichloriaceae).

Hagenbeek A, Masukagami Y, Palanichamy P et al. · 2026 · BMC genomics

The intracellular endosymbiont Candidatus Lariskella (Alphaproteobacteria, Candidatus Midichloriaceae) has been found across a wide diversity of terrestrial arthropods, including ticks, true bugs, beetles, fleas, wasps and moths. Despite…

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Negative / Null Result ReportMedicine

Polymerase chain reaction fails to detect mixed malaria infections in siblings from Ethiopia.

Hall AD, Whitehurst DA, Mortensen JE et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Malaria remains a significant public health concern in sub-Saharan Africa, particularly in Ethiopia where Plasmodium falciparum and Plasmodium vivax are co-endemic. Most cases in the United States are acquired abroad and imported.…

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Negative / Null Result ReportMedicine

Real-time PCR versus culture of bronchoalveolar lavage fluid for detecting Bordetella bronchiseptica in dogs with persistent lower respiratory signs: a retrospective study of 23 cases.

Atencia S, Mateu N, Rodríguez-Cobos A et al. · 2025 · Veterinary research communications

Bordetella bronchiseptica (Bb) is a frequent pathogen in dogs and a component of the Canine Infectious Respiratory Disease Complex (CIRDC). However, it can also be detected in the lower respiratory tract of healthy animals, complicating…

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Negative / Null Result ReportMedicine

Bactericera maculipennis (Hemiptera: Triozidae) is a vector of "Candidatus Liberibacter solanacearum" to species within the Convolvulaceae (Solanales).

Cooper WR, Ohler B, Wenninger EJ et al. · 2025 · Environmental entomology

Bactericera maculipennis (Crawford) and Bactericera cockerelli (Šulc) (Hemiptera: Triozidae) share hosts within the Solanaceae and Convolvulaceae (Solanales), and both are associated with "Candidatus Liberibacter solanacearum" (Lso). Lso,…

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Negative / Null Result ReportMedicine

Efficacy and safety of chemotherapy combined with iodine-125 seed brachytherapy for intermediate and advanced oncogenic driver gene-negative non-small cell lung cancer.

Xia MH, Liu KC, Zhao W et al. · 2025 · Brachytherapy

Purpose To compare the effectiveness and safety of CT-guided iodine-125 seed brachytherapy in conjunction with chemotherapy against chemotherapy alone for the management of intermediate and advanced non-small cell lung cancer (NSCLC)…

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Negative / Null Result ReportOpen accessMedicine

Phase 1 LITESPARK-001 study of belzutifan in participants with advanced solid tumors: Results of the glioblastoma expansion cohort.

Strowd RE, de la Fuente M, Bauer TM et al. · 2026 · Neuro-oncology advances

Recurrent isocitrate dehydrogenase (IDH) wild-type glioblastoma has no established standard-of-care treatment. Preclinical models have demonstrated that hypoxia-inducible factor-2 alpha (HIF-2α) contributes to stabilizing the hypoxic…

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Negative / Null Result ReportMedicine

Detection of cross-reactivity of antibodies to the N proteins of feline morbillivirus and canine distemper virus in Japanese cat plasma samples.

Khin STMM, Jafar SM, Ju M et al. · 2025 · Journal of virological methods

Feline morbillivirus (FeMV) is a globally emerging virus that has been linked to chronic kidney disease (CKD) in infected cats. Immunological assays, such as enzyme-linked immunosorbent assay (ELISA), are important for studying the virus…

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Negative / Null Result ReportMedicine

Review and practical excursus on the comparison between traditional statics methods and Classification And Regression Tree (CART) in real-life data: Low protein diet compared to Mediterranean diet in patients with chronic kidney disease.

Calabrese V, Metro D, Alibrandi A et al. · 2025 · Nefrologia

The Classification and Regression Tree (CART) is a supervised learning approach useful used to segment the space of and the predictors/features space into smaller homogeneous regions that are, represented in a decision tree. It computes…

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Negative / Null Result ReportOpen accessMedicine

Platelet antibody detection assays: a single-laboratory comparison of MAIPA, PIFT, and microsphere-based multiplex assays Pak-Lx.

Costa TH, Bonet-Bub C, Kutner JM · 2024 · Hematology, transfusion and cell therapy

Background and objectives The identification of platelet antibodies is essential for diagnosing and managing conditions such as fetal and neonatal alloimmune thrombocytopenic purpura, post-transfusion purpura, and immune platelet…

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Negative / Null Result ReportMedicine

Comparative efficacy of pre-moistened sponges and E-swabs for active surveillance of carbapenem-resistant Acinetobacter baumannii carriage.

Epchtien RE, Temkin E, Masarwa S et al. · 2025 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

We evaluated whether skin sampling with E-swabs is an effective alternative to pre-moistened sponges for detecting carbapenem-resistant Acinetobacter baumannii (CRAB) carriage. Skin samples were collected by sponges with enrichment and…

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Negative / Null Result ReportOpen accessMedicine

Using Next Generation Chemiluminescent Probes to Improve the <i>Plasmodium falciparum</i> <i>in vitro</i> Parasite Reduction Ratio (PRR) Assay.

Hellingman A, Göttle NL, Walz A et al. · 2026 · ACS infectious diseases

Malaria remains a major global health threat, and the emergence of partial artemisinin resistance challenges current treatment regimens. Reliable antimalarial screening assays are therefore essential for identifying new drug candidates.…

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Negative / Null Result ReportOpen accessMedicine

Inferior Sinus Venosus Defect: Inconclusive Transesophageal Echocardiography Clarified by Computed Tomography and Intracardiac Echocardiography.

Hashimoto G, Tsukagoshi Y, Saito A et al. · 2026 · JACC. Case reports

Background Inferior sinus venosus (SV) atrial septal defect (ASD) is a rare interatrial communication, found near the inferior vena cava (IVC)-right atrial (RA) junction, that may be overlooked on transesophageal echocardiography (TEE).…

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Negative / Null Result ReportMedicine

Evaluation of loop mediated isothermal amplification, quantitative real-time PCR, conventional PCR methods for identifying Ascaris lumbricoides in human stool samples.

Thakur M, Mewara A, Lakshmi P et al. · 2025 · Diagnostic microbiology and infectious disease

Ascariasis, caused by Ascaris lumbricoides, is a widespread parasitic infection. Traditional diagnostic methods, such as microscopy, can miss infections with low worm burdens, leading to false negatives. This study compares four diagnostic…

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