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Browse the failure-mode index

19,878 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Outcome and factors affecting prognosis in treat and extend treatment for neovascular age-related macular degeneration-a real world study.

Akkan Aydogmus FS, Gursoy T, Ozdemir O et al. · 2026 · BMC ophthalmology

Background To evaluate the outcome of treat and extend (T&E) for neovascular age related macular degeneration (nAMD) at 12, 18 and 24 months and the impact of clinical characteristics on treatment success defined as extension of treatment…

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Negative / Null Result ReportMedicine

Return to duty after non-surgical treatment of a non-neurological thoracic or lumbar spine fracture in French military patients: a retrospective analysis of 54 patients.

Lines JB, Cungi PJ, Da Silva C et al. · 2026 · BMJ military health

Introduction Non-surgical management of non-neurological thoracic or lumbar spine (TL) fractures seems to provide good results in the civilian population, leading to return to work in most cases. However, data on the military population…

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Negative / Null Result ReportMedicine

Dynamic chitosan-hyaluronic acid hydrogels for extrusion printing: Combined effects of polymer molecular weight and carbon nanofillers

García-García A, Goyoaga M, Nuño F et al. · 2026 · Carbohydrate Polymers.

Despite the increasing interest on self-healing hydrogels in the fabrication of customized scaffolds for tissue engineering applications, their optimal printability is still a challenge due to the weak mechanical stability of dynamic…

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Negative / Null Result ReportMedicine

Impact of atrial arrhythmias on long-term survival in non-small cell lung cancer patients.

Pu Y, Gampa A, Simon C et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Atrial arrhythmias (AA), including atrial fibrillation (AF) and atrial flutter, are a significant clinical problem in oncological patients. The effect of AA on clinical outcome of patients with non-small cell lung cancer (NSCLC) is not…

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Negative / Null Result ReportOpen accessMedicine

Endocrine Disruptive Effects of the Herbicides Linuron, Chloridazon and Metribuzin on Bovine Granulosa Cells.

Kahveci ME, Yigit AA, Kabakci R · 2026 · Reproduction in domestic animals = Zuchthygiene

Linuron, chloridazon and metribuzin are herbicides thought to have potential endocrine disruption (ED) effects. This study investigated the effects of linuron, chloridazon and metribuzin on bovine granulosa cell viability and oestrogen…

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Negative / Null Result ReportMedicine

Development of spirulina-enriched vegan cheese by utilizing soy protein-based emulsion gel as a fat substitute: Effects of spirulina and emulsion gel on texture/rheology, antioxidant and sensory properties.

Kashiri M, Berk B, Yemenicioğlu A · 2026 · International journal of biological macromolecules

This study aimed at utilizing soy protein-based emulsion gel as a fat substitute in spirulina enriched plant-based spreadable cheese (PBC). For this purpose, spirulina enriched vegetable oil-in-water emulsions prepared using soy protein as…

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Negative / Null Result ReportMedicine

Recombinant bovine somatotropin at synchronization initiation, but not at embryo transfer, enhances fertility in embryo-recipient heifers: Associations with follicular, luteal, and embryonic outcomes.

Rebeis LM, Baruselli PS, Harden H et al. · 2026 · Journal of dairy science

The aim of this study was to evaluate the effects of administering 325 mg of recombinant bovine somatotropin (rbST) at the initiation of the synchronization protocol (SYNCd) and/or on the day of embryo transfer (ETd) using a 2 × 2…

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Negative / Null Result ReportMedicine

Impact of parental psychosocial profile on the effectiveness of oral hygiene interventions in preschool children: a randomised controlled clinical trial in a rural population.

Schade AC, Vilella KD, Neves ETB et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

Objective To assess the impact of parental psychosocial profile on the effectiveness of educational interventions aiming to improve oral hygiene among preschool children living in a rural area. Methods A controlled randomised trial…

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Negative / Null Result ReportMedicine

Impact of dietary supplementation of black soldier fly larvae (Hermetia illucens L.) on nutrient digestibility, serum antioxidants, ruminal volatile fatty acids, and abundance of microbial dominant flora in goats

Lu S, Paengkoum S, Chen S et al. · 2025 · Animal Nutrition

This experiment aimed to investigate the potential impact of supplementing different levels of black soldier fly (BSF) on growth performance, serum antioxidants, and ruminal microbiota of goats. Twenty-four native Anglo-Thai male goats…

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Negative / Null Result ReportMedicine

Single- or two-visits endodontic treatment: Impact of irrigants on surface roughness, microhardness, topography, and fracture resistance of root dentin.

Padoin Y, de Pellegrin SF, Castillo DC et al. · 2026 · European journal of oral sciences

This study evaluated the effect of the number of simulated endodontic treatment visits and the type of irrigant on the surface roughness, microhardness, topography, and fracture resistance of root dentin. Bovine roots were distributed into…

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Negative / Null Result ReportOpen accessMedicine

Short course of antimicrobial treatment for uncomplicated enterococcal bacteremia.

Zimmermann V, Fourré N, Senn L et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Purpose Duration of treatment for uncomplicated enterococcal bacteremia is unknown. This study aims to evaluate the clinical outcomes of patients treated with short courses (4-10 days) compared to those receiving longer regimens (11-18…

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Negative / Null Result ReportOpen accessMedicine

Randomized Phase 3 Comparison of a 2-Dose and 3-Dose Regimen of a Detoxified Toxin A/B <i>Clostridioides difficile</i> Vaccine in Adults 50 Years and Older.

Crook G, Lamberth E, Lockhart SP et al. · 2026 · Open forum infectious diseases

This phase 3 trial compared immunogenicity and safety of 2-dose versus 3-dose PF-06425090 Clostridioides difficile vaccine regimens in ≥50-year-olds (N = 1994) at increased C difficile infection risk. Because C difficile toxin-A but not C…

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Negative / Null Result ReportMedicine

The impact of dietary inclusion of tomato pomace silage on feed utilization, health status, milk yield and milk nutritional composition in dairy cows.

Gunun N, Kaewpila C, Kesorn P et al. · 2026 · Animal bioscience

Objective The aim of this study was to evaluate the effect of the inclusion of tomato pomace silage (TPS) on feed intake, nutrient digestibility, blood parameters, immune response, milk yield, and milk nutritional composition in dairy…

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Negative / Null Result ReportMedicine

[The effect of neuroprotectors on the level of BDNF, tumor necrosis factor alpha and apoptosis markers, and in acute cerebrovascular accidents].

Shchulkin AV, Chernykh IV, Abalenikhina YV et al. · 2026 · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

Objective To compare the effects of Mexidol, Cerebrolysin, and Cortexin on the levels of brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNF α ), and apoptosis markers in the rat brain following middle cerebral…

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Negative / Null Result ReportMedicine

Partial replacement of soybean meal with sprouted peas or sprouted soybeans in dairy diets in a dual-flow continuous culture system.

Vicente ACS, Salas-Solis GK, Johnson ML et al. · 2026 · Journal of dairy science

Peas (Pisum sativum L.) have 24% CP and could have the potential to partially replace soybean meal (SBM), which is the most used protein source in dairy diets in the USA. Sprouting can improve nutrient availability via enzymatic and…

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Negative / Null Result ReportMedicine

Impaired growth after immunization with a bivalent oil-adjuvanted vaccine occurs without detectable changes to aerobic capacity in juvenile rainbow trout.

Wallbom N, Khansari AR, Sandblom E et al. · 2026 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

The trade-off between growth and immunity in fish has been assumed to relate to energetic costs associated with immune functions. Here, we hypothesized that immunization with a bivalent mineral oil-adjuvanted vaccine elevates standard…

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