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Browse the failure-mode index

19,878 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

1-year patient-reported outcomes in patients with a documented GLP-1 agonist prescription history prior to total hip arthroplasty: a retrospective cohort study.

Benyamini, Khan, Elmenawi et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy

Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly utilised for metabolic optimisation in surgical patients. Their effect on postoperative patient-reported outcomes (PROMs) and satisfaction following primary total hip…

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Negative / Null Result ReportMedicine

Efficacy of High Flow Nasal Cannula in Reducing Hypoxemia in Children Undergoing Elective Flexible Fibreoptic Bronchoscopy as Compared to Conventional Low Flow Nasal Cannula: A Randomized Controlled Trial.

Rajvanshi, Kumar, Goyal et al. · 2026 · Pediatric pulmonology

Flexible fibreoptic bronchoscopy (FFB) is widely used in pediatric pulmonology, though hypoxemia remains a primary concern during the procedure. High-flow nasal cannula (HFNC) has shown potential in reducing hypoxemia in adults undergoing…

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Negative / Null Result ReportMedicine

Prospective observational comparative study of radiotherapy induced toxicities (xerostomia, skin reaction, and mucositis) between three-dimensional conformal radiotherapy and intensity modulated radiotherapy technique to oral cavity cancer of head and neck.

Dhakar, Ghori, Parihar et al. · 2026 · The Gulf journal of oncology

Oral cavity cancers often require radiotherapy (RT), leading to toxicities such as xerostomia, skin reactions, and mucositis. This study aims to compare these toxicities between three-dimensional conformal radiotherapy (3D-CRT) and…

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Negative / Null Result ReportMedicine

Comparison of Interferon-Based and Interferon-Free Treatments on the Prognosis of Hepatocellular Carcinoma After Hepatitis C Virus-Sustained Virological Response: A Multicenter Study.

Itoh, Iseda, Yoshizumi et al. · 2026 · Cancer medicine

We examine the impact of interferon (IFN)-based and IFN-free treatment on the prognosis of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) sustained virological response (SVR). Clinical information was collected on 311 cases…

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Negative / Null Result ReportMedicine

Oral health-related quality of life after early extraction of primary second molars in children with congenitally missing second premolars: a randomized controlled trial with matched controls.

Naoumova, Nawaia, Krekmanova · 2026 · European journal of orthodontics

Extraction of mandibular primary second molars in patients with congenitally missing second premolars may influence oral health-related quality of life (OHRQoL), yet this has not been previously investigated. To assess the impact of…

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Negative / Null Result ReportMedicine

Utility of Postoperative Thyroid Hormone Levels in Predicting the Diagnosis of Adult Growth Hormone Deficiency in Patients Undergoing Surgery for Nonfunctioning Pituitary Neuroendocrine Tumor: A Pilot Study.

Tsujimoto, Yamashiro, Suzuki et al. · 2026 · International journal of endocrinology

Adult growth hormone deficiency (AGHD) is often diagnosed after surgery for nonfunctioning pituitary neuroendocrine tumor (NF-PitNET). While a growth hormone stimulation test (GHST) is required to establish its diagnosis, it is associated…

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Negative / Null Result ReportMedicine

Task Shifting in Cardiac Ablations Compared With Percutaneous Coronary Interventions: The Japanese Circulation Society Chugoku-Shikoku Regional Survey Subanalysis.

Fukue, Suetomi, Matsuura et al. · 2026 · Circulation reports

As part of work-style reform for physicians, task shifting to non-physician healthcare professionals has been promoted in Japan. We previously reported task shifting results for percutaneous coronary interventions (PCI), but the status in…

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Negative / Null Result ReportMedicine

Robotic Mitral Valve Repair in Patients With Thoracic Deformity.

Tomita, Kakuta, Kainuma et al. · 2026 · Circulation reports

Robotic mitral valve repair (MVr) offers superior visualization and dexterity, potentially overcoming challenges in severe thoracic deformity such as pectus excavatum. This study compared surgical outcomes after MVr in patients with and…

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Negative / Null Result ReportMedicine

The Impact of Kidney Donor Profile Index and Human Leukocyte Antigen Mismatch on Graft Survival in Pediatric Kidney Transplant Recipients.

Ranabothu, Smith, Perkins et al. · 2026 · Pediatric transplantation

Pediatric kidney transplant recipients typically receive low-KDPI deceased donor kidneys but often experience higher HLA mismatches. The relationship between KDPI and HLA mismatch and their combined effect on graft and patient outcomes in…

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Negative / Null Result ReportMedicine

A descriptive, retrospective analysis of the quality of spontaneous adverse event reporting to the Côte d'Ivoire Pharmaceutical and Regulatory Authority and its impact on the causality assessment.

Kamagaté, Jusot, Mory et al. · 2026 · Therapeutic advances in drug safety

In Côte d'Ivoire, pharmacovigilance is not a routine activity in most healthcare facilities and many healthcare professionals have limited knowledge of pharmacovigilance methods. This study aimed to evaluate the quality of adverse…

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Negative / Null Result ReportMedicine

Clinical Performance of Bulk-Fill Versus Incremental Composite Placement Approaches in Vital Posterior Teeth: A 24 Months Randomized Controlled Trial.

Mohammed, Naser, Abozaid · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Composite resin placement technique may influence marginal integrity, polymerization stress distribution, and long-term clinical performance of posterior restorations. This randomized controlled clinical trial evaluated the 24-month…

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Negative / Null Result ReportMedicine

Impact of different domperidone dosages on reflux esophagitis treated with esomeprazole: a randomized controlled trial.

Niu, Bao, Zhao · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

This study aimed to systematically evaluate the efficacy and safety of different doses of domperidone (DOM) combined with esomeprazole (ESM) in the treatment of reflux esophagitis, providing a basis for precise clinical medication. This…

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Negative / Null Result ReportMedicine

Effect of pelvic floor muscle training with or without dynamic neuromuscular stabilization-based breathing on menstrual pain and symptoms of primary dysmenorrhea: a randomized controlled trial.

Yakıt Yeşilyurt, Birinci Olgun, Dağ et al. · 2026 · BMC women's health

Breathing exercises may modulate dysmenorrhea by enhancing relaxation and eliciting analgesic effects. This study investigated the effects of Pelvic Floor Muscle Training (PFMT) with or without Dynamic Neuromuscular Stabilization…

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Negative / Null Result ReportMedicine

Effect of driving pressure-guided individualized PEEP in children undergoing right lateral thoracotomy cardiac surgery with cardiopulmonary bypass on postoperative atelectasis and oxygenation: a randomized controlled trial.

Chen, Song, Zang et al. · 2026 · BMC anesthesiology

Right lateral thoracotomy cardiac surgery induces postoperative atelectasis due to cardiopulmonary bypass (CPB), patient positioning, and mechanical ventilation. Fixed positive end-expiratory pressure (PEEP) may fail to meet pediatric…

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Negative / Null Result ReportMedicine

Choroidal vascularity index in schizophrenia and bipolar disorder.

Yıldız, Çalış, Dokuz et al. · 2026 · Psychiatry research

This study examined differences in choroidal structural parameters, including the choroidal vascularity index, among patients with schizophrenia, bipolar disorder, and healthy controls. This cross-sectional study included 40 patients with…

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Negative / Null Result ReportMedicine

Gemcitabine-Based versus Fluoropyrimidine-Based Chemotherapy and Role of Platinum Combination for First-Line Palliative Systemic Treatment in Advanced Ampullary Adenocarcinoma.

Wonglhow, Wetwittayakhlang, Sunpaweravong et al. · 2026 · Cancer management and research

Ampullary adenocarcinoma is a rare malignancy with limited evidence on the efficacy of systemic chemotherapy for advanced disease. This study aimed to evaluate the treatment outcomes of gemcitabine- and fluoropyrimidine-based regimens and…

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Negative / Null Result ReportMedicine

Immediate placement of intrauterine device after second-trimester medical abortion-Secondary outcomes with one-year follow-up.

Hogmark, Westermark, Envall et al. · 2026 · Acta obstetricia et gynecologica Scandinavica

Intrauterine devices (IUDs) effectively prevent unwanted pregnancies. Little is known about long-term outcomes of women choosing an IUD after second-trimester medical abortion. We performed a 12-month follow-up of a multicenter randomized…

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Negative / Null Result ReportMedicine

The impact of leaflet resection versus leaflet preservation on left ventricular reverse remodelling after mitral valve repair: insights from the UK mini mitral trial.

Rao, Bayliss, Wagnild et al. · 2026 · Journal of cardiothoracic surgery

Mitral valve repair (MVr) promotes left ventricular (LV) reverse remodelling, and subsequent reduction in LV diameters and volumes. The effectiveness of different MVr techniques, Resect (leaflet resection) and Respect (leaflet…

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