Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Barrak Alahmad, Taofik Oyekunle, Claire Strohmeyer et al. · 2025 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Arrhythmia, particularly atrial fibrillation, is on the rise globally. While increased surveillance, aging populations, and other risk factors partially explain this rise, emerging risks such as extreme heat from climate change are underexplored. Methods We used Product Surveillance Registry by Medtronic (2016–2023) in the United States to examine patients with implantable cardioverter‐defibrillator or cardiac resynchronization therapy defibrillator devices. We identified first arrhythmic episodes (atrial tachycardia/fibrillation [AT/AF] or ventricular tachycardia/fibrillation) reco
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Kollipara Sumanth, Uma Sinharoy, Anindita Joardar et al. · 2026 · Annals of Indian Academy of Neurology
Background and Objectives: Epilepsy, with its complex interplay of neurobiological, genetic, and pharmacological factors, continues to challenge neurologists worldwide—particularly in managing drug resistance. This study aimed to evaluate the frequency of the SCN1A and SCN2A gene polymorphisms among patients with epilepsy (PWE) from Eastern India to assess their relationship with clinical profiles, electroencephalography (EEG) findings, and response to antiseizure medication. Methods: In this case–control genetic association study, a total of 110 PWE were assessed for demographic and clinical
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Muller Susan, Bouquot Jerry, Lou Yahuan et al. · 2007 · BMC Cancer
Abstract Background TRAIL plays an important role in host immunosurveillance against tumor progression, as it induces apoptosis of tumor cells but not normal cells, and thus has great therapeutic potential for cancer treatment. TRAIL binds to two cell-death-inducing (DR4 and DR5) and two decoy (DcR1, and DcR2) receptors. Here, we compare the expression levels of TRAIL and its receptors in normal oral mucosa (NOM), oral premalignancies (OPM), and primary and metastatic oral squamous cell carcinomas (OSCC) in order to characterize the changes in their expression patterns during OSCC initiation a
View details →Negative / Null Result ReportOpen accessDermatology
Raissa Massaia Londero Chemello, Elsa Regina Justo Giugliani, Renan Rangel Bonamigo et al. · 2011 · Anais Brasileiros de Dermatologia
FUNDAMENTOS: Não há consenso quanto ao efeito do aleitamento materno no desenvolvimento da dermatite atópica. É necessário aprofundar conhecimentos sobre possíveis fatores envolvidos nessa relação, como a influência do aleitamento materno na colonização do paciente atópico pelo Staphylococcus aureus (S. aureus). OBJETIVO: Avaliar uma potencial associação entre aleitamento materno e colonização pelo S. aureus nas crianças atópicas. MÉTODOS: Estudo transversal envolvendo 79 crianças atópicas de 4-24 meses, de ambos os sexos, em acompanhamento no Ambulatório de Dermatologia Sanitária de Porto Ale
View details →Negative / Null Result ReportOpen accessOtorhinolaryngology
Fery Mai Rafanan, Eduard Alfanta, Romulus Roberto Peter Instrella · 2024 · Philippine Journal of Otolaryngology Head and Neck Surgery
Objective: To investigate the association between the time intervals of key clinical time points and tumor progression (increase in clinical staging) in head and neck cancer patients before and during the pandemic. Methods: Design: Retrospective Cohort Study Setting: Tertiary Government Training Hospital Participants: A total of 81 head and neck cancer patients who consulted at the OPD and underwent elective surgery between January 1, 2018, and December 31, 2022, under the Department of Otorhinolaryngology – Head and Neck Surgery of East Avenue Medical Center were included in the study; 40 pat
View details →Negative / Null Result ReportOpen accessPsychology
Fahri Sezer, Aytekin Gürtepe · 2025 · BMC Psychology
Abstract The primary aim of this study was to investigate the relationships between attachment, social exclusion, and risky behaviors in adolescents. The sample comprised 463 adolescents, aged 13–18, attending various high schools in Turkey. Data were collected using three instruments: the Parent and Peer Attachment Inventory, the Ostracism (Social Exclusion) Scale for Adolescents, and the Risk Behaviors Scale. The results revealed a moderate negative correlation between attachment to mothers and risky behaviors, while a weaker negative correlation was observed between attachment to fathers an
View details →Negative / Null Result ReportOpen accessAgriculture
Nouraldin Moradi, Narges Nazifi, Qodrat Rahimi Miyanaji et al. · 2014 · مجله بیوتکنولوژی کشاورزی
Follicle stimulating hormone receptor (FSHR) and growth differentiation factor 9 (GDF9) both are the most important proteins that affect reproduction process in mammalian. Polymorphism in these genes and their possible relationship with twining trait in Zel (n=150) sheep are investigated in the present study. Blood samples were collected randomly via vein puncture. PCR-RFLP technique for FSHR marker site showed two A and B alleles with the frequency of 93.33 and 6.67 and two genotypes of AA and BB with the frequency of 93.33 and 6.67, respectively. However, the heterozygote AB genotype was not
View details →Negative / Null Result ReportOpen accessChemical technology
Kyung Won Lee, Min-Sook Kang, Seung Jae Lee et al. · 2023 · Foods
This study aimed to identify major dietary patterns associated with abdominal obesity in middle-aged and older Korean adults. Data from the Korean Genome and Epidemiology Study were used. A total of 48,037 Korean adults aged ≥40 years without abdominal obesity at baseline were followed-up. Dietary assessment was conducted using a validated 106-item food-frequency questionnaire, and dietary patterns were identified using factor analysis. Abdominal obesity was defined as a waist circumference of ≥90 cm for men and ≥85 cm for women, according to the Korean Society for the Study of Obesity. Multiv
View details →Negative / Null Result ReportOpen accessMedicine
Alexandria Turner, Mieke L van Driel, Ben Mitchell et al. · 2025 · Family Practice
Abstract Background Inappropriate antibiotic prescription for self-limiting respiratory tract infections (RTIs) by general practitioner (GP) registrars (trainees) is less common than by established GPs but still exceeds evidence-based…
View details →Negative / Null Result ReportOpen accessShipment of goods. Delivery of goods
Theuns F.J. Oosthuizen · 2014 · Journal of Transport and Supply Chain Management
A lack of optimum selection and application of decision-making techniques, in conjunction with suitable decision-making practice and perception of employees in a transport work environment demands attention to improve overall performance. Although multiple decision-making techniques exist, five prevalent techniques were considered in this article, namely the Kepner-Tregoe, Delphi, stepladder, nominal group and brainstorming techniques. A descriptive research design was followed, using an empirical survey which was conducted among 210 workers employed in a transport work environment and studyin
View details →Negative / Null Result ReportOpen accessMedicine
Otobo I Ujah, Omojo C Adaji, Innocent A O Ujah et al. · 2025 · PLoS ONE
Food insecurity (FI) has been identified as a determinant of child development, yet evidence quantifying this association using the newly developed Early Childhood Development Index 2030 (ECDI2030) remains limited. Herein, we provide national estimates of early childhood development (ECD) risks using the ECDI2030 and examined to what extent FI was associated with ECD among children aged 24-59 months in Nigeria. This population based cross-sectional analyses used data from the UNICEF-supported 2021 Multiple Indicator Cluster Survey in Nigeria. The analytic sample comprised children aged 24-59 m
View details →Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases
Rohith N. Thota, Shamasunder H. Acharya, Manohar L. Garg · 2019 · Lipids in Health and Disease
Abstract Background Lowering insulin resistance and dyslipidaemia may not only enhance glycaemic control but also preserve the β-cell function, reducing the overall risk of developing type 2 diabetes (T2D). The current study was aimed to evaluate the effects of curcumin and/or long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) supplementation on glycaemic control and blood lipid levels in individuals at high risk of developing T2D. Methods This was a 2 × 2 factorial, randomised, double-blinded, placebo-controlled study. Participants were allocated to either double placebo (PL) or curcu
View details →Negative / Null Result ReportOpen accessBiology (General)
Aviad Schnapp, Moria Harel, Dalit Cayam-Rand et al. · 2022 · Biomedicines
Autism spectrum disorder (ASD) is often associated with debilitating sleep disturbances. While anecdotal evidence suggests the positive effect of cannabinoids, randomized studies are lacking. Here, we report the effects of cannabinoid treatment on the sleep of 150 children and adolescents with ASD, as part of a double-blind, placebo-controlled study that assessed the impact of cannabinoid treatment on behavior (NCT02956226). Participants were randomly assigned to one of the following three treatments: (1) whole-plant cannabis extract, containing cannabidiol (CBD) and Δ9-Tetrahydrocannabinol (T
View details →Negative / Null Result Report
Patrícia Fernandes Albeirice da Rocha, Luciano Marques dos Santos, Amanda J. Ullman et al. · 2025 · Revista da Sociedade Brasileira de Enfermeiros Pediatras
Objective To assess the feasibility of conducting a randomized clinical trial to evaluate the effectiveness of virtual reality on pain perception in children undergoing peripheral intravenous insertion, compared to traditional clinical…
View details →Negative / Null Result ReportOpen accessMedicine
Sungha Park, Sang-Hyun Ihm, In-Jeong Cho et al. · 2023 · Clinical Hypertension
Abstract Nocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime BP. As efficacy of BP medications wanes during nighttime and early morning, control of nocturnal hypertension and morning hypertension can be difficult. As such, chronotherapy, the dosing of BP medication in the evening, has been an ongoing topic of interest in the field of hypertension. Some studies have shown that chronotherapy is effective in reducing nocturnal BP, improving
View details →Negative / Null Result ReportOpen accessDentistry
Ahmed Hassan Kamil Mustafa, Ahmed Mohammed Suleiman · 2020 · International Journal of Dentistry
Background. Bell’s palsy is an acute idiopathic facial nerve paralysis of sudden onset. It is the most common cause of lower motor neuron facial nerve paralysis with an annual incidence of 15–30 per 100,000 population. The objective of this work is to study the grade of the attack and the associated symptoms of Bell’s palsy in a group of Sudanese patients. The study type is an analytical prospective-based study. The study was carried out at Khartoum Teaching Dental Hospital, Khartoum General Teaching Hospital. In this prospective of the study, 48 patients with Bell’s palsy were evaluated using
View details →Negative / Null Result ReportOpen accessMedicine
Vera Dias, Eunsung Junn, M. Maral Mouradian · 2013 · Journal of Parkinson’s Disease
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential in neurons interfere with several biological processes, ultimately leading to cell death. Evidence has been developed for oxidative and nitrative damage to key cellular components in the PD substantia nigra. A number of sources and mechanisms for the generation of reactive oxygen species (ROS) are recognized including the metabolism of dopamine itself, mitochondrial dysfunction, iron, neuroinflammatory cells, calcium
View details →Negative / Null Result ReportOpen accessMedicine
Lisa Baquet, Helge Hasselmann, Stefan Patra et al. · 2018 · PeerJ
Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist
View details →Negative / Null Result ReportOpen accessMedicine
Longo G, Pacchiarotti G, Pizzigallo C et al. · 2026 · Journal of orthopaedic surgery and research
Introduction The introduction of computer-assisted navigation (CAS) in total knee arthroplasty (TKA) aimed to improve prosthetic alignment and potentially enhance long-term implant survival. However, the actual clinical benefit beyond 10…
View details →Negative / Null Result ReportMedicine
Yoshida K, Hakozaki T, Hasegawa T et al. · 2025 · Journal of clinical monitoring and computing
The aim of the present study was to investigate the utility of the intraoperative high frequency variability index (HFVI) / Analgesia Nociception Index (ANI) for predicting postoperative pain in patients undergoing open liver or pancreatic…
View details →Negative / Null Result ReportMedicine
Lemoine L, Adam V, Salleron J et al. · 2025 · Brachytherapy
Purpose Removal of brachytherapy applicator is routinely performed under premedication including Kalinox® gas inhalation without general anesthesia. The applicator removal is nevertheless associated with discomfort, anxiety or pain. We…
View details →Negative / Null Result ReportOpen accessMedicine
Özkaya AB, Ghaseminejad Y · 2025 · FEBS open bio
Autophagy plays a critical role in maintaining cellular homeostasis and is implicated in various physiological and pathological processes, including cancer, neurodegeneration, and metabolic disorders. Although typically associated with…
View details →Negative / Null Result ReportOpen accessMedicine
Lee JW, Kim CJ, Lee BK et al. · 2025 · JACC. Advances
Background Distal radial access (DRA) has emerged as an alternative to transradial access (TRA) in coronary procedures. However, evidence supporting its use in ST-segment elevation myocardial infarction (STEMI) remains limited. Objectives…
View details →Negative / Null Result ReportOpen accessMedicine
El-Hajj VG, El Choueiri J, Vasella F et al. · 2026 · Brain & spine
Introduction Central nervous system (CNS) melanocytomas are rare, pigmented tumors derived from leptomeningeal melanocytes. Although generally benign, they can exhibit locally aggressive behavior and recur. Despite increasing recognition,…
View details →Negative / Null Result ReportOpen accessMedicine
Barber D, Wijeratne T, Singh L et al. · 2025 · Life (Basel, Switzerland)
Sporadic Parkinson's Disease (PD) affects 3% of people over 65 years of age. People are living longer, thanks in large part to improvements in global health technology and health access for non-neurological diseases. Consequently,…
View details →Negative / Null Result ReportOpen accessMedicine
Lazarevic Lindblad M, Pålsson E, Lazarevic V et al. · 2026 · Infection prevention in practice
Background Central venous catheters (CVCs) are commonly used in patients with haematological diseases but are associated with infectious complications. The CVC Anti-infection Double Lumen Bundle was introduced in December 2020 to reduce…
View details →Negative / Null Result ReportOpen accessMedicine
Sunwoo JS, Cho YW, Shin WC et al. · 2025 · Journal of clinical neurology (Seoul, Korea)
Background and purpose To evaluate the clinical efficacy and safety of pregabalin in Korean adults with restless legs syndrome (RLS). Methods In this randomized, multicenter, double-blind, placebo-controlled trial, 78 patients with RLS…
View details →Negative / Null Result ReportOpen accessMedicine
Xiuwen Sun, Xiaoling Li, Lingyu Ji et al. · 2018 · PeerJ
Based on the existing research on sound symbolism and crossmodal correspondence, this study proposed an extended research on cross-modal correspondence between various sound attributes and color properties in a group of non-synesthetes. In Experiment 1, we assessed the associations between each property of sounds and colors. Twenty sounds with five auditory properties (pitch, roughness, sharpness, tempo and discontinuity), each varied in four levels, were used as the sound stimuli. Forty-nine colors with different hues, saturation and brightness were used to match to those sounds. Result revea
View details →Negative / Null Result ReportOpen accessAnimal culture
QIAN Ren-dong, WANG Lian-sheng, LUO Qiao-hua et al. · 2023 · Siliao yanjiu
The purpose of the study was to investigate the effects of wheat gluten replacing fish meal on growth performance, serum biochemistry, liver antioxidant and intestinal digestive enzyme activities of Cyprinus carpio . A total of 180 healthy Cyprinus carpio with an initial body weight of (9.16±0.03) g were selected and divided into three experimental groups, with three replicates in each group and 20 fish in each replicate. The control group (CW) was with 5% fish meal, and the experimental groups were with 50% (WA) and 100% (WB) fish meal replaced by wheat gluten. The experiment lasted for 56 d.
View details →Negative / Null Result ReportOpen accessAnimal culture
Hang Wang, Xiaojie Qin, Xia Li et al. · 2020 · Poultry Science
This study was conducted to investigate the effects of air chilling (AC), water chilling (WC), combined chilling consisting of WC for 20 min and AC (CO20), and combined chilling consisting of WC for 30 min and AC (CO30) on the microbiological status, surface color, processing yield, and moisture content of yellow-feathered chicken carcasses. After chilling, the carcasses treated by AC exhibited the highest total viable counts (TVC) (4.7 cfu/cm2), followed by those treated by CO20 and CO30, whereas the carcasses treated by WC showed the lowest (P 0.05) was found among the carcasses treated by C
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