e-ISSN: Pending

Browse the failure-mode index

19,761 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Clinical Characteristics, Disease Activity, and Patient‐Reported Outcomes in Psoriatic Arthritis Patients With Dactylitis or Enthesitis: Results From the Corrona Psoriatic Arthritis/Spondyloarthritis Registry

Philip J. Mease, Chitra Karki, Jacqueline B. Palmer et al. · 2017 · Arthritis Care & Research

Objective To characterize psoriatic arthritis (PsA) patients with dactylitis or enthesitis and evaluate the associations of these manifestations with disease activity and patient‐reported outcomes. Methods Using the Corrona…

View details →
Negative / Null Result ReportOpen accessMedicine

Increased Risk of Second Primary Malignancy in Pediatric and Young Adult Patients Treated with Radioactive Iodine for Differentiated Thyroid Cancer

Jennifer L. Marti, Kunal Jain, Luc G.T. Morris · 2015 · Thyroid

INTRODUCTION: The long-term sequelae of radioactive iodine (RAI) for differentiated thyroid cancer (DTC) in pediatric and young adult patients are not well-defined. Epidemiologic analyses of second primary malignancy (SPM) risk have only…

View details →
Negative / Null Result ReportOpen accessEnvironmental Science

Towards a set of agrosystem-specific cropland mapping methods to address the global cropland diversity

François Waldner, Diego de Abelleyra, Santiago R. Verón et al. · 2016 · International Journal of Remote Sensing

Accurate cropland information is of paramount importance for crop monitoring. This study compares five existing cropland mapping methodologies over five contrasting Joint Experiment for Crop Assessment and Monitoring (JECAM) sites of medium to large average field size using the time series of 7-day 250 m Moderate Resolution Imaging Spectroradiometer (MODIS) mean composites (red and near-infrared channels). Different strategies were devised to assess the accuracy of the classification methods: confusion matrices and derived accuracy indicators with and without equalizing class proportions, asse

View details →
Negative / Null Result ReportOpen accessMedicine

Cognitive Lifestyle and Long-Term Risk of Dementia and Survival After Diagnosis in a Multicenter Population-based Cohort

Michael Valenzuela, Carol Brayne, Perminder S. Sachdev et al. · 2011 · American Journal of Epidemiology

An active cognitive lifestyle has been linked to dementia incidence and survival, but the separate and combined effects of its subcomponents are not clear. Data were derived from the Medical Research Council Cognitive Function and Ageing…

View details →
Negative / Null Result ReportOpen accessEnvironmental Science

Nonlinear effects of climate on boreal rodent dynamics: mild winters do not negate high‐amplitude cycles

Katri Korpela, María del Mar Delgado, Heikki Henttonen et al. · 2012 · Global Change Biology

Small rodents are key species in many ecosystems. In boreal and subarctic environments, their importance is heightened by pronounced multiannual population cycles. Alarmingly, the previously regular rodent cycles appear to be collapsing…

View details →
Negative / Null Result ReportOpen accessPsychology

Motor Coordination Correlates with Academic Achievement and Cognitive Function in Children

Valter da Rocha Fernandes, Michelle L. Scipião Ribeiro, Thais Regina Ferreira de Melo et al. · 2016 · Frontiers in Psychology

The relationship between exercise and cognition is an important topic of research that only recently began to unravel. Here, we set out to investigate the relation between motor skills, cognitive function, and school performance in 45 students from 8 to 14 years of age. We used a cross-sectional design to evaluate motor coordination (Touch Test Disc), agility (Shuttle Run Speed-running back and forth), school performance (Academic Achievement Test), the Stroop test, and six sub-tests of the Wechsler Intelligence Scale for Children-IV (WISC-IV). We found, that the Touch Test Disc was the best p

View details →
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Debt and Growth: Is There a Magic Threshold?

Andrea Pescatori, Damiano Sandri, John Simon et al. · 2014 · IMF Working Paper

Using a novel empirical approach and an extensive dataset developed by the Fiscal Affairs Department of the IMF, we find no evidence of any particular debt threshold above which medium-term growth prospects are dramatically compromised.…

View details →
Negative / Null Result ReportOpen accessMedicine

Bevacizumab Prevents Brain Metastases Formation in Lung Adenocarcinoma

Aysegül Ilhan‐Mutlu, Matthias Osswald, Yunxiang Liao et al. · 2016 · Molecular Cancer Therapeutics

Patients with nonsquamous non-small cell lung cancer (nsNSCLC; largely lung adenocarcinoma) are at high risk of developing brain metastases. Preclinical data suggested that anti-VEGF-A therapy may prevent the formation of nsNSCLC brain…

View details →
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Analysis of the determinants of foreign direct investment in Ghana

Michael Asiamah, Daniel Ofori, Jacob Afful · 2019 · Journal of Asian Business and Economic Studies

Purpose The factors that determine foreign direct investment (FDI) are important to policy-makers, investors, the banking industry and the public at large. FDI in Ghana has received increased attention in recent times because its relevance in the Ghanaian economy is too critical to gloss over. The purpose of this paper is to examine the determinants of FDI in Ghana between the period of 1990 and 2015. Design/methodology/approach The study employed a causal research design. The study used the Johansen’s approach to cointegration within the framework of vector autoregressive for the data analysi

View details →
Negative / Null Result ReportOpen accessSocial Sciences

When much more of a difference makes a difference: Social comparison and tournaments in the CEO 's top team

Jason W. Ridge, Federico Aime, Margaret A. White · 2013 · Strategic Management Journal

We integrate the seemingly contradictory theoretical predictions of behavioral and economic perspectives about the relationship between pay disparity and firm performance and show that tournament and social comparison theories are more…

View details →
Negative / Null Result ReportPsychology

The impact of acquiescence on the evaluation of personality structure.

Beatrice Rammstedt, Richard F. Farmer · 2013 · Psychological Assessment

Acquiescence, or the tendency to respond to descriptions of conceptually distinct personality attributes with agreement/affirmation (acceptance acquiescence) or disagreement/opposition (counter-acquiescence), has been widely recognized as…

View details →
Negative / Null Result ReportOpen accessMedicine

Immune Infiltration in Invasive Lobular Breast Cancer

Christine Desmedt, Roberto Salgado, Marco Fornili et al. · 2017 · JNCI Journal of the National Cancer Institute

Background: Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal cancer (IDC). Here, we aimed at evaluating the prevalence, levels, and composition of tumor-infiltrating…

View details →
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

The Impact of Carbon Emissions on Corporate Financial Performance: Evidence from the South African Firms

Fortune Ganda, K. Milondzo · 2018 · Sustainability

The impact of carbon emissions on corporate financial performance within the African corporate setting has remained open and inconclusive, owing primarily to the unavailability of data. However, this paper examines the effect of carbon emissions (Scope 1, Scope 2, and Scope 1 and 2) on the financial performance (ROE, ROI, and ROS) of 63 South African CDP companies for the 2015 fiscal year. Using multiple regression techniques, the paper found overwhelming evidence of a negative relationship between carbon emissions and corporate financial performance. Thus, results indicate that companies whic

View details →
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Uncovering the Genetic History of the Present-Day Greenlandic Population

Ida Moltke, Matteo Fumagalli, Thorfinn Sand Korneliussen et al. · 2014 · The American Journal of Human Genetics

Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200,000 SNPs from more than 10% of the adult Greenlandic population (n = 4,674). We found that recent gene flow from Europe has had a substantial impact on the population: more than 80% of the Greenlanders have some European ancestry (on average ∼25% of their genome). However, we also found that the am

View details →
Negative / Null Result ReportPsychology

Purpose in life and cognitive functioning in adulthood

Nathan A. Lewis, Nicholas A. Turiano, Brennan R. Payne et al. · 2016 · Aging Neuropsychology and Cognition

With an increasingly aging population, more work is needed to identify factors which may promote the maintenance of normal cognitive functioning. The current study tested the concurrent association between sense of purpose in life and the…

View details →
Negative / Null Result ReportSocial Sciences

Explaining the Marginalization of Women in Legislative Institutions

Yann P. Kerevel, Lonna Rae Atkeson · 2013 · The Journal of Politics

Previous research suggests that women tend to be marginalized in legislatures or denied access to important agenda-setting resources that reduce their effectiveness as legislators after gaining office. However, previous studies have not…

View details →
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

The Economics of the Fed Put

Anna Cieślak, Annette Vissing‐Jørgensen · 2020 · Review of Financial Studies

Abstract Since the mid-1990s, negative stock returns comove with downgrades to the Fed’s growth expectations and predict policy accommodations. Textual analysis of FOMC documents reveals that policy makers pay attention to the stock…

View details →
Negative / Null Result ReportOpen accessMedicine

A high eating frequency is associated with an overall healthy lifestyle in middle-aged men and women and reduced likelihood of general and central obesity in men

Isabel Holmbäck, Ulrika Ericson, Bo Gullberg et al. · 2010 · British Journal Of Nutrition

The role of eating frequency in obesity development is debated. Therefore, we investigated the association between eating frequency, BMI and waist circumference (WC), as well as how eating frequency is related to diet composition and…

View details →
Negative / Null Result ReportOpen accessMedicine

A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study

Laura Salvador, Gunasekaran Singaravelu, Calvin B. Harley et al. · 2016 · Rejuvenation Research

TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period. The study was conducted on 117 relatively healthy cytomegalovirus-positive subjects aged 53-87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period (530 ± 180 bp; p = 0.005)

View details →
Negative / Null Result ReportSocial Sciences

Couples as Partners and Parents Over Children's Early Years

Marcia J. Carlson, Natasha Pilkauskas, Sara McLanahan et al. · 2011 · Journal of Marriage and the Family

We used data from the Fragile Families and Child Wellbeing Study to examine how couple relationship quality and parental engagement are linked over children's early years-when they are infants, toddlers, and preschoolers. Our sample…

View details →
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Dynamic complementarities in innovation strategies

James H. Love, Stephen Roper, Priit Vahter · 2014 · Research Policy

Using a panel of Irish manufacturing plants over the period 1991–2008 we test for dynamic complementarities in the joint use of internal R&D and external knowledge sources. We find little evidence, either from considering successive cross-sectional waves of comparable surveys, or in terms of the strategy switch choices of specific plants, that there has been a systematic move towards the joint use of internal and external knowledge in innovation. We then test formally for the presence of complementarities in the joint use of internal R&D and external innovation linkages. In static terms we fin

View details →
Negative / Null Result ReportOpen accessMedicine

Enterococcus faecalis Subverts and Invades the Host Urothelium in Patients with Chronic Urinary Tract Infection

Harry Horsley, James Malone‐Lee, David Holland et al. · 2013 · PLoS ONE

Bacterial urinary tract infections (UTI) are a major growing concern worldwide. Uropathogenic Escherichia coli has been shown to invade the urothelium during acute UTI in mice and humans, forming intracellular reservoirs that can evade antibiotics and the immune response, allowing recurrence at a later date. Other bacterial species, such as Staphylococcus saprophyticus, Klebsiella pneumonia and Salmonella enterica have also been shown to be invasive in acute UTI. However, the role of intracellular infection in chronic UTI causing more subtle lower urinary tract symptoms (LUTS), a particular pr

View details →
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

What explains low adoption of digital payment technologies? Evidence from small-scale merchants in Jaipur, India

Ethan Ligon, Badal Malick, Ketki Sheth et al. · 2019 · PLoS ONE

The availability of digital payment technologies (such as internet banking, mobile money, and credit/debit cards) has rapidly increased in the developing world, and is a cornerstone for financial inclusion initiatives in developing countries. Despite significant efforts to promote digital payments, rates of adoption remain modest in some low-income countries. In particular, the rate of adoption in India remains low despite significant efforts to promote adoption. In this paper, we consider possible reasons for the low rates of adoption among merchants in Jaipur, India with small fixed-location

View details →
Negative / Null Result ReportOpen accessHealth Professions

Daily Text Messaging for Weight Control Among Racial and Ethnic Minority Women: Randomized Controlled Pilot Study

Dori Steinberg, Erica Levine, Sandy Askew et al. · 2013 · Journal of Medical Internet Research

BACKGROUND: Daily self-monitoring of diet and physical activity behaviors is a strong predictor of weight loss success. Text messaging holds promise as a viable self-monitoring modality, particularly among racial/ethnic minority populations. OBJECTIVE: This pilot study evaluated the feasibility of a text messaging intervention for weight loss among predominantly black women. METHODS: Fifty obese women were randomized to either a 6-month intervention using a fully automated system that included daily text messages for self-monitoring tailored behavioral goals (eg, 10,000 steps per day, no sugar

View details →